MeiLan K Han

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study
    MeiLan K Han
    University of Michigan Health System, Ann Arbor, MI, USA Electronic address
    Lancet Respir Med 2:548-56. 2014
  2. ncbi request reprint GOLD 2011 disease severity classification in COPDGene: a prospective cohort study
    MeiLan K Han
    Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA Electronic address
    Lancet Respir Med 1:43-50. 2013
  3. pmc Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
    Craig P Hersh
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 14:42. 2013
  4. pmc Sildenafil preserves exercise capacity in patients with idiopathic pulmonary fibrosis and right-sided ventricular dysfunction
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Chest 143:1699-708. 2013
  5. pmc Significance of the microbiome in obstructive lung disease
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5360, USA
    Thorax 67:456-63. 2012
  6. pmc Racial differences in quality of life in patients with COPD
    MeiLan K Han
    University of Michigan Health System, 3916 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Chest 140:1169-76. 2011
  7. ncbi request reprint Pharmacotherapeutic approaches to preventing acute exacerbations of chronic obstructive pulmonary disease
    MeiLan K Han
    University of Michigan, Division of Pulmonary and Critical Care, Taubman, Ann Arbor, MI, USA
    Proc Am Thorac Soc 8:356-62. 2011
  8. doi request reprint Chronic obstructive pulmonary disease phenotypes: the future of COPD
    MeiLan K Han
    University of Michigan Pulmonary and Critical Care, 1500 E Medical Center Drive, 3916 Taubman, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 182:598-604. 2010
  9. pmc Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes
    MeiLan K Han
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Radiology 261:274-82. 2011
  10. pmc Gender influences Health-Related Quality of Life in IPF
    MeiLan K Han
    University of Michigan Health System, Pulmonary and Critical Care Medicine, Room 3916 Taubman Center, Ann Arbor, MI 48109 5360, USA
    Respir Med 104:724-30. 2010

Detail Information

Publications38

  1. ncbi request reprint Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study
    MeiLan K Han
    University of Michigan Health System, Ann Arbor, MI, USA Electronic address
    Lancet Respir Med 2:548-56. 2014
    ..The role of the lung microbiome in the pathogenesis of idiopathic pulmonary fibrosis is unknown. We investigated whether unique microbial signatures were associated with progression of idiopathic pulmonary fibrosis...
  2. ncbi request reprint GOLD 2011 disease severity classification in COPDGene: a prospective cohort study
    MeiLan K Han
    Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA Electronic address
    Lancet Respir Med 1:43-50. 2013
    ..We aimed to assess both the influence of symptom instrument choice on patient category assignment and prospective exacerbation risk by category...
  3. pmc Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
    Craig P Hersh
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 14:42. 2013
    ..We sought to determine if measurements using paired inspiratory and expiratory CT scans may be better able to separate gas trapping due to emphysema from gas trapping due to small airway disease...
  4. pmc Sildenafil preserves exercise capacity in patients with idiopathic pulmonary fibrosis and right-sided ventricular dysfunction
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Chest 143:1699-708. 2013
    ..Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with pulmonary vasculopathy...
  5. pmc Significance of the microbiome in obstructive lung disease
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5360, USA
    Thorax 67:456-63. 2012
    ..Whether we can manipulate bacterial communities to improve clinical outcomes remains to be seen...
  6. pmc Racial differences in quality of life in patients with COPD
    MeiLan K Han
    University of Michigan Health System, 3916 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Chest 140:1169-76. 2011
    ..We hypothesized that HRQL in COPD differs by race and sought to identify factors associated with those differences...
  7. ncbi request reprint Pharmacotherapeutic approaches to preventing acute exacerbations of chronic obstructive pulmonary disease
    MeiLan K Han
    University of Michigan, Division of Pulmonary and Critical Care, Taubman, Ann Arbor, MI, USA
    Proc Am Thorac Soc 8:356-62. 2011
    ..As new therapies are developed, it will be helpful to know in which patient phenotypes they are most effective and how they compare in efficacy and side-effect profiles with inhaled coricosteroids, bronchodilators, or their combination...
  8. doi request reprint Chronic obstructive pulmonary disease phenotypes: the future of COPD
    MeiLan K Han
    University of Michigan Pulmonary and Critical Care, 1500 E Medical Center Drive, 3916 Taubman, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 182:598-604. 2010
    ..We have much yet to learn, but establishing a common language for future research will facilitate our understanding and management of the complexity implicit to this disease...
  9. pmc Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes
    MeiLan K Han
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Radiology 261:274-82. 2011
    ....
  10. pmc Gender influences Health-Related Quality of Life in IPF
    MeiLan K Han
    University of Michigan Health System, Pulmonary and Critical Care Medicine, Room 3916 Taubman Center, Ann Arbor, MI 48109 5360, USA
    Respir Med 104:724-30. 2010
    ..HRQL in IPF patients is impaired. Data from other respiratory diseases led us to hypothesize that significant gender differences in HRQL in IPF also exist...
  11. doi request reprint Clinical significance of radiologic characterizations in COPD
    MeiLan K Han
    University of Michigan Health System, Ann Arbor, Michigan 48109 5360, USA
    COPD 6:459-67. 2009
    ..Future research should clarify whether CT parameters complement BODE score in influencing survival...
  12. doi request reprint Prevalence and clinical correlates of bronchoreversibility in severe emphysema
    M K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109 0360, USA
    Eur Respir J 35:1048-56. 2010
    ..Improvements in FVC, however, were demonstrated in the majority of patients...
  13. doi request reprint Sex differences in physiological progression of idiopathic pulmonary fibrosis
    M K Han
    University of Michigan Health System, Ann Arbor, MI, USA
    Eur Respir J 31:1183-8. 2008
    ..These data suggest that differences in disease progression contribute to, but do not completely explain, better survival of females with idiopathic pulmonary fibrosis...
  14. ncbi request reprint Spirometry utilization for COPD: how do we measure up?
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, USA
    Chest 132:403-9. 2007
    ..COPD is a significant cause of morbidity and mortality. Guidelines recommend the confirmation of a COPD diagnosis with spirometry. Limited evidence exists, however, documenting the frequency of spirometry use in clinical practice...
  15. ncbi request reprint Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15
    Christine M Freeman
    Pulmonary and Critical Care Medicine Section, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, 48105 2303, USA
    J Immunol 184:6504-13. 2010
    ..These findings suggest that the production of proinflammatory cytokines and cytotoxic molecules by lung-resident CD8(+) T cells contributes to COPD pathogenesis...
  16. pmc Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease
    Carlos H Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5360, USA
    Thorax 67:399-406. 2012
    ..The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George's Respiratory Questionnaire (SGRQ) and Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index (BODE)...
  17. pmc Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease
    Cristine E Berry
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 142:704-11. 2012
    ..However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment...
  18. pmc Gender differences in symptoms and care delivery for chronic obstructive pulmonary disease
    Carlos H Martinez
    University of Michigan Health System, Ann Arbor, Michigan 48109 5360, USA
    J Womens Health (Larchmt) 21:1267-74. 2012
    ..Morbidity and mortality for women with chronic obstructive pulmonary disease (COPD) are increasing, and little is known about gender differences in perception of COPD care...
  19. pmc Lung CD8+ T cells in COPD have increased expression of bacterial TLRs
    Christine M Freeman
    Research Service, Department of Veterans Affairs Healthcare System, Ann Arbor, MI 48105, USA
    Respir Res 14:13. 2013
    ..Toll-like receptors (TLRs) on T cells can modulate their responses, however, the extent and significance of TLR expression by lung T cells, NK cells, or NKT cells in chronic obstructive pulmonary disease (COPD) is unknown...
  20. pmc Longitudinal change in the BODE index predicts mortality in severe emphysema
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 178:491-9. 2008
    ..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...
  21. pmc Effect of emphysema on CT scan measures of airway dimensions in smokers
    Alejandro A Diaz
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 143:687-93. 2013
    ..We aimed to first determine whether the stronger association of subsegmental vs segmental WA% with FEV1 % predicted is mitigated by emphysema and, second, to assess the relationships among emphysema, WA%, and total bronchial area (TBA)...
  22. pmc Gender and chronic obstructive pulmonary disease: why it matters
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Respir Crit Care Med 176:1179-84. 2007
    ....
  23. doi request reprint Lung microbiome predicts disease progression in idiopathic pulmonary fibrosis
    MeiLan K Han
    1 Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, Michigan and
    Ann Am Thorac Soc 11:S79-80. 2014
    ..Disease progression appears to be associated with the presence of Streptococcus and Staphylococcus. Further data will be needed to understand the clinical significance of this finding. ..
  24. pmc Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent
    Christine M Freeman
    Research Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
    PLoS ONE 9:e96421. 2014
    ..ClinicalTrials.gov as NCT00281229...
  25. pmc Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression
    Craig J Galban
    Department of Radiology, University of Michigan, Ann Arbor, MI, USA
    Nat Med 18:1711-5. 2012
    ..PRM's ability to differentiate between specific COPD phenotypes will allow for more accurate diagnosis of individual patients, complementing standard clinical techniques...
  26. pmc The clinical impact of non-obstructive chronic bronchitis in current and former smokers
    Carlos H Martinez
    Pulmonary and Critical Care Division, University of Michigan Health System, Ann Arbor, MI, USA Electronic address
    Respir Med 108:491-9. 2014
    ..As the clinical significance of chronic bronchitis among smokers without airflow obstruction is unclear, we sought to determine morbidity associated with this disorder...
  27. pmc Analysis of the lung microbiome in the "healthy" smoker and in COPD
    John R Erb-Downward
    University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e16384. 2011
    ..These studies are further demonstration of the pulmonary microbiome and highlight global and micro-anatomic changes in these bacterial communities in severe COPD patients...
  28. pmc Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort
    Carlos H Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Medical Center Drive, 3916 Taubman Center, Box 0360, 1500 E, Ann Arbor, MI 48109 0360, USA
    Respir Res 15:62. 2014
    ..The coexistence of gastroesophageal reflux disease (GERD) and COPD has been recognized, but there has been no comprehensive evaluation of the impact of GERD on COPD-related health status and patient-centered outcomes...
  29. pmc Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease
    Christine M Freeman
    Pulmonary and Critical Care Medicine Section, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Am J Respir Crit Care Med 180:1179-88. 2009
    ..Dendritic cells (DCs) have not been well studied in chronic obstructive pulmonary disease (COPD), yet their integral role in activating and differentiating T cells makes them potential participants in COPD pathogenesis...
  30. pmc Internet access and use by COPD patients in the National Emphysema/COPD Association Survey
    Carlos H Martinez
    Division of Pulmonary and Critical Care, University of Michigan Health System, 3916 Tubman Center, 1500 E, Medical Center Drive, Box 0360, Ann Arbor, USA
    BMC Pulm Med 14:66. 2014
    ..We tested two hypotheses: Internet access is associated with socio-demographic disparities and frequency of use is related to perceived needs...
  31. ncbi request reprint Pulmonary diseases and the heart
    MeiLan K Han
    University of Michigan Health System, Ann Arbor, MI, USA
    Circulation 116:2992-3005. 2007
    ....
  32. doi request reprint Relationship between anxiety, depression, and health satisfaction among veterans with PTSD
    Sheila A M Rauch
    VA Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA
    J Affect Disord 121:165-8. 2010
    ..This study aims to examine the effects of depression and anxiety on health satisfaction in veterans with PTSD...
  33. ncbi request reprint Respiratory irregularity and stress hormones in panic disorder: exploring potential linkages
    James L Abelson
    Department of Psychiatry, Trauma, Stress and Anxiety Research Group, Drive, University of Michigan, Ann Arbor, Michigan, USA
    Depress Anxiety 25:885-7. 2008
    ..Follow-up work is needed to directly test this hypothesis...
  34. doi request reprint HPA axis, respiration and the airways in stress--a review in search of intersections
    James L Abelson
    Stress and Anxiety Research Group, Department of Psychiatry Trauma, University of Michigan, Ann Arbor, MI 48109, USA
    Biol Psychol 84:57-65. 2010
    ..Given the importance of both systems to an organism's ability to survive and adapt in challenging and changing environments, further study of their interactions is needed...
  35. pmc Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial/mesenchymal phenotypes: implications for treatment of fibrotic diseases
    Ragini Vittal
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    J Pharmacol Exp Ther 321:35-44. 2007
    ....
  36. doi request reprint Contribution of the environment and comorbidities to chronic obstructive pulmonary disease phenotypes
    Carlos H Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 5360, USA
    Med Clin North Am 96:713-27. 2012
    ..New research tools from the fields of epidemiology, immunology, imaging, and data analysis will be helpful in accomplishing this goal...
  37. pmc Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA
    COPD 8:21-9. 2011
    ..Leukotrienes have been implicated in the pathogenesis of acute exacerbations of COPD, but leukotriene modifiers have not been studied as a possible therapy for exacerbations...
  38. ncbi request reprint Role of infection and antimicrobial therapy in acute exacerbations of chronic obstructive pulmonary disease
    Fernando J Martinez
    The University of Michigan Health System, 1500 East Medical Center Drive, 3916 Taubman Center, Box 0360, Ann Arbor, MI 48109, USA
    Expert Rev Anti Infect Ther 4:101-24. 2006
    ..In the future, preventing exacerbations will likely become increasingly accepted as an additional therapeutic goal in chronic obstructive pulmonary disease patients...