Scott Hammond

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Fragile X-related protein and VIG associate with the RNA interference machinery
    Amy A Caudy
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA
    Genes Dev 16:2491-6. 2002
  2. pmc The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina Chapel Hill, North Carolina 27599, USA
    Nat Genet 38:228-33. 2006
  3. ncbi request reprint RNAi, microRNAs, and human disease
    Scott M Hammond
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Chemother Pharmacol 58:s63-8. 2006
  4. pmc MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs
    Liqin Du
    Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA
    J Exp Clin Cancer Res 29:75. 2010
  5. pmc microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007
  6. ncbi request reprint MicroRNAs as oncogenes
    Scott M Hammond
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Curr Opin Genet Dev 16:4-9. 2006
  7. ncbi request reprint Dicing and slicing: the core machinery of the RNA interference pathway
    Scott M Hammond
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    FEBS Lett 579:5822-9. 2005
  8. ncbi request reprint MicroRNA therapeutics: a new niche for antisense nucleic acids
    Scott M Hammond
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Mol Med 12:99-101. 2006
  9. pmc HMGA2, microRNAs, and stem cell aging
    Scott M Hammond
    Department of Cell and Developmental Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell 135:1013-6. 2008
  10. pmc Extensive post-transcriptional regulation of microRNAs and its implications for cancer
    J Michael Thomson
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genes Dev 20:2202-7. 2006

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc Fragile X-related protein and VIG associate with the RNA interference machinery
    Amy A Caudy
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA
    Genes Dev 16:2491-6. 2002
    ..The possibility that dFXR, and potentially FMRP, use, at least in part, an RNAi-related mechanism for target recognition suggests a potentially important link between RNAi and human disease...
  2. pmc The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina Chapel Hill, North Carolina 27599, USA
    Nat Genet 38:228-33. 2006
    ..Together, our studies suggest a molecular mechanism in which miRNAs participate in transcriptional circuits that control skeletal muscle gene expression and embryonic development...
  3. ncbi request reprint RNAi, microRNAs, and human disease
    Scott M Hammond
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Chemother Pharmacol 58:s63-8. 2006
    ..In addition, the lymphomas had reduced apoptosis and were more disseminated into secondary regions. This work establishes noncoding RNAs, and specifically miRNAs, as oncogenes in human cancers...
  4. pmc MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs
    Liqin Du
    Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA
    J Exp Clin Cancer Res 29:75. 2010
    ..However, the role of miRNAs in the pathogenesis and diagnosis of small cell carcinoma (SCLC), the majority of which represent the most aggressive lung tumors, has not been investigated...
  5. pmc microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007
    ..They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer...
  6. ncbi request reprint MicroRNAs as oncogenes
    Scott M Hammond
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Curr Opin Genet Dev 16:4-9. 2006
    ..Although the connection of miRNAs with cancer has been suspected for several years, four recent studies have confirmed the suspicion that miRNAs regulate cell proliferation and apoptosis, and play a role in cancer...
  7. ncbi request reprint Dicing and slicing: the core machinery of the RNA interference pathway
    Scott M Hammond
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    FEBS Lett 579:5822-9. 2005
    ..Silencing is effected by the RNA-induced silencing complex and its RNaseH core enzyme Argonaute. This review describes the discovery of these machines and discusses future lines of work on this amazing biochemical pathway...
  8. ncbi request reprint MicroRNA therapeutics: a new niche for antisense nucleic acids
    Scott M Hammond
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Mol Med 12:99-101. 2006
    ..A recent article by Stoffel and colleagues has demonstrated remarkably effective inhibition of miRNAs in vivo, thus providing an entry point into the promising new arena of miRNA therapeutics...
  9. pmc HMGA2, microRNAs, and stem cell aging
    Scott M Hammond
    Department of Cell and Developmental Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell 135:1013-6. 2008
    ..2008; Nishino et al., 2008; Sanna et al., 2008; Weedon et al., 2008) link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood...
  10. pmc Extensive post-transcriptional regulation of microRNAs and its implications for cancer
    J Michael Thomson
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genes Dev 20:2202-7. 2006
    ..These data uncover a novel regulatory step in miRNA function and provide a mechanism for miRNA down-regulation in cancer...
  11. doi request reprint Lin-28: an early embryonic sentinel that blocks Let-7 biogenesis
    Martin A Newman
    Department of Cell and Developmental Biology, School of Medicine, Linberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Int J Biochem Cell Biol 42:1330-3. 2010
    ..The studies leading to the discovery of the Let-7 block by Lin-28 and questions regarding the biochemical mechanism behind Lin-28-mediated microRNA silencing are discussed...
  12. pmc Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
    Martin A Newman
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    RNA 14:1539-49. 2008
    ..Our findings outline a microRNA post-transcriptional regulatory network and establish a novel role for the miRNA precursor loop in the regulated production of mature Let-7...
  13. pmc Emerging paradigms of regulated microRNA processing
    Martin A Newman
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genes Dev 24:1086-92. 2010
    ..The second paradigm is specific to miRNA families, and requires interaction between RNA-binding proteins and cis-regulatory sequences within miRNA precursor loops...
  14. ncbi request reprint Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors
    Keith Woods
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 282:2130-4. 2007
    ..We propose a model whereby miR-17-92 promotes cell proliferation by shifting the E2F transcriptional balance away from the pro-apoptotic E2F1 and toward the proliferative E2F3 transcriptional network...
  15. ncbi request reprint A custom microarray platform for analysis of microRNA gene expression
    J Michael Thomson
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nat Methods 1:47-53. 2004
    ..This microarray technology enables comprehensive investigation of microRNA expression, and furthers our understanding of this class of recently discovered noncoding RNAs...
  16. pmc Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy
    Mariko Tatsuguchi
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Mol Cell Cardiol 42:1137-41. 2007
    ..Conversely, introduction of functional miR-21 or miR-18b into cardiomyocytes represses myocyte hypertrophy. Together, our studies point to miRNAs as critical regulators of cardiac hypertrophy...
  17. pmc Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:2111-6. 2008
    ..Together, our studies demonstrate essential roles for Dicer in cardiac contraction and indicate that miRNAs play critical roles in normal cardiac function and under pathological conditions...
  18. ncbi request reprint Microarray analysis of miRNA gene expression
    J Michael Thomson
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina, USA
    Methods Enzymol 427:107-22. 2007
    ..This chapter will describe a simple, low-cost microarray platform optimized for miRNA expression analysis...
  19. ncbi request reprint RNA interference: a promising approach to antiviral therapy?
    Jose M Silva
    Trends Mol Med 8:505-8. 2002
  20. ncbi request reprint A micrococcal nuclease homologue in RNAi effector complexes
    Amy A Caudy
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 425:411-4. 2003
    ..Tudor-SN is the first RISC subunit to be identified that contains a recognizable nuclease domain, and could therefore contribute to the RNA degradation observed in RNAi...
  21. ncbi request reprint Argonaute2 is the catalytic engine of mammalian RNAi
    Jidong Liu
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 305:1437-41. 2004
    ..Thus, our evidence supports a model in which Argonaute contributes "Slicer" activity to RISC, providing the catalytic engine for RNAi...
  22. ncbi request reprint MicroRNAs regulate brain morphogenesis in zebrafish
    Antonio J Giraldez
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 308:833-8. 2005
    ..Injection of miR-430 miRNAs rescues the brain defects in MZdicer mutants, revealing essential roles for miRNAs during morphogenesis...
  23. pmc Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish
    Viravuth P Yin
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 22:728-33. 2008
    ..The Mps1 kinase, an established positive regulator of blastemal proliferation, is an in vivo target of miR-133. Our findings identify miRNA depletion as a new regulatory mechanism for complex tissue regeneration...
  24. ncbi request reprint Soaking up small RNAs
    Scott M Hammond
    Nat Methods 4:694-5. 2007
  25. ncbi request reprint MicroRNAs as tumor suppressors
    Scott M Hammond
    Nat Genet 39:582-3. 2007
  26. ncbi request reprint A microRNA polycistron as a potential human oncogene
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 435:828-33. 2005
    ..Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene...
  27. ncbi request reprint microRNA detection comes of age
    Scott M Hammond
    Nat Methods 3:12-3. 2006
  28. pmc Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells
    Yun Lu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 310:442-53. 2007
    ..Together, these studies suggest that mir-17-92 normally promotes the high proliferation and undifferentiated phenotype of lung epithelial progenitor cells...

Research Grants6

  1. Stable suppression of gene function in mammals by RNAi
    Scott Hammond; Fiscal Year: 2002
    ..proposed commercial application: not available ..
  2. A Link between RNAi and Fragile X Mental Retardation
    Scott Hammond; Fiscal Year: 2009
    ..While this project focuses on FMRP regulation of neuronal genes, it will provide a general framework for studies on all aspects of RNAi regulation of mammalian cellular pathways. ..