Stephen R Hammes

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc The further redefining of steroid-mediated signaling
    Stephen R Hammes
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8857, USA
    Proc Natl Acad Sci U S A 100:2168-70. 2003
  2. ncbi request reprint Extranuclear steroid receptors: nature and actions
    Stephen R Hammes
    Department of Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Endocr Rev 28:726-41. 2007
  3. ncbi request reprint Steroids and oocyte maturation--a new look at an old story
    Stephen R Hammes
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8857, USA
    Mol Endocrinol 18:769-75. 2004
  4. ncbi request reprint Specific modulation of nongenomic androgen signaling in the ovary
    Stacy N White
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8857, USA
    Steroids 70:352-60. 2005
  5. pmc Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation
    Aritro Sen
    Division of Endocrinology and Metabolism, University of Rochester Medical Center, Rochester, NY, USA
    J Clin Invest 122:2469-81. 2012
  6. pmc The modulator of nongenomic actions of the estrogen receptor (MNAR) regulates transcription-independent androgen receptor-mediated signaling: evidence that MNAR participates in G protein-regulated meiosis in Xenopus laevis oocytes
    Derek Haas
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 19:2035-46. 2005
  7. ncbi request reprint Testosterone and progesterone rapidly attenuate plasma membrane Gbetagamma-mediated signaling in Xenopus laevis oocytes by signaling through classical steroid receptors
    Kristen Evaul
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 21:186-96. 2007
  8. pmc Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells
    Aritro Sen
    Department of Medicine, Division of Endocrinology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:28787-95. 2010
  9. pmc Nongenomic steroid-triggered oocyte maturation: of mice and frogs
    James Deng
    Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United States
    Steroids 74:595-601. 2009
  10. pmc Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression
    Aritro Sen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642
    Proc Natl Acad Sci U S A 111:3008-13. 2014

Collaborators

Detail Information

Publications33

  1. pmc The further redefining of steroid-mediated signaling
    Stephen R Hammes
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8857, USA
    Proc Natl Acad Sci U S A 100:2168-70. 2003
  2. ncbi request reprint Extranuclear steroid receptors: nature and actions
    Stephen R Hammes
    Department of Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Endocr Rev 28:726-41. 2007
    ..In this review, we highlight the significant progress that has been made in these areas...
  3. ncbi request reprint Steroids and oocyte maturation--a new look at an old story
    Stephen R Hammes
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8857, USA
    Mol Endocrinol 18:769-75. 2004
    ..A detailed appreciation of the steroid-activated signaling pathways in frog and mammalian oocytes may therefore prove useful in understanding both normal and abnormal ovarian development in humans...
  4. ncbi request reprint Specific modulation of nongenomic androgen signaling in the ovary
    Stacy N White
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8857, USA
    Steroids 70:352-60. 2005
    ..These results suggest that SARMs may serve as useful tools for specifically regulating nongenomic androgen signaling both in vitro and in vivo...
  5. pmc Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation
    Aritro Sen
    Division of Endocrinology and Metabolism, University of Rochester Medical Center, Rochester, NY, USA
    J Clin Invest 122:2469-81. 2012
    ..Paxillin is therefore a potential biomarker for prostate cancer proliferation and a possible therapeutic target for prostate cancer treatment...
  6. pmc The modulator of nongenomic actions of the estrogen receptor (MNAR) regulates transcription-independent androgen receptor-mediated signaling: evidence that MNAR participates in G protein-regulated meiosis in Xenopus laevis oocytes
    Derek Haas
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 19:2035-46. 2005
    ..Androgen binding to AR might then release this inhibition, allowing maturation to occur. Thus, MNAR may augment multiple nongenomic signals, depending upon the context and cell type in which it is expressed...
  7. ncbi request reprint Testosterone and progesterone rapidly attenuate plasma membrane Gbetagamma-mediated signaling in Xenopus laevis oocytes by signaling through classical steroid receptors
    Kristen Evaul
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 21:186-96. 2007
    ....
  8. pmc Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells
    Aritro Sen
    Department of Medicine, Division of Endocrinology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:28787-95. 2010
    ..Thus, paxillin may prove to be a novel diagnostic or therapeutic target in prostate cancer...
  9. pmc Nongenomic steroid-triggered oocyte maturation: of mice and frogs
    James Deng
    Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United States
    Steroids 74:595-601. 2009
    ....
  10. pmc Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression
    Aritro Sen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642
    Proc Natl Acad Sci U S A 111:3008-13. 2014
    ..Furthermore, this study demonstrates mechanisms that might contribute to the unregulated follicle growth seen in diseases of excess androgens such as polycystic ovary syndrome. ..
  11. pmc The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X. laevis oocytes
    James Deng
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Mol Endocrinol 22:1853-65. 2008
    ....
  12. pmc Cross-talk between G protein-coupled and epidermal growth factor receptors regulates gonadotropin-mediated steroidogenesis in Leydig cells
    Kristen Evaul
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    J Biol Chem 283:27525-33. 2008
    ..These results suggest that GPCR-EGF receptor cross-talk is a conserved regulator of gonadotropin-induced steroidogenesis in the gonads, although the mechanisms of EGF receptor trans-activation may vary...
  13. doi request reprint GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis
    Tamara J Strauss
    Departments of Internal Medicine Pathology and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75930, USA
    Reproduction 141:173-81. 2011
    ..Together, these data imply that the somatic cell protein GLP-1 is not necessary for many pregranulosa cell functions but is required for germ cell survival...
  14. pmc G beta gamma signaling reduces intracellular cAMP to promote meiotic progression in mouse oocytes
    Arvind Gill
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8857, USA
    Steroids 72:117-23. 2007
    ....
  15. doi request reprint Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology
    Aritro Sen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Steroids 76:822-8. 2011
    ....
  16. ncbi request reprint Paxillin regulates steroid-triggered meiotic resumption in oocytes by enhancing an all-or-none positive feedback kinase loop
    Melissa Rasar
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
    J Biol Chem 281:39455-64. 2006
    ..These experiments reveal a novel and critical function for Paxillin in meiosis and support the notion that Paxillin may be a general modulator of mitogen-activated protein kinase signaling...
  17. ncbi request reprint Selective modulation of genomic and nongenomic androgen responses by androgen receptor ligands
    Lindsey B Lutz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 17:1106-16. 2003
    ..nongenomic signaling may be useful in delineating the roles of these pathways in mediating androgen responses and might lead to the development of novel compounds that specifically modulate these signals in vivo...
  18. pmc Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation
    Michelle Jamnongjit
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX 75390 8857, USA
    Proc Natl Acad Sci U S A 102:16257-62. 2005
    ..We present a model whereby steroid production may serve as one of many integrated signals triggered by EGFR signaling to promote oocyte maturation in gonadotropin-stimulated follicles...
  19. doi request reprint Central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancer
    Lin Yang
    Department of Urology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9110, USA
    Mol Endocrinol 26:550-61. 2012
    ..These data suggest a novel mechanism of AR activation in the absence of androgens in PCa cells. Our data indicate that disruption of the complex between AR and PELP1 may be a viable therapeutic strategy in advanced PCa...
  20. ncbi request reprint Androgens promote maturation and signaling in mouse oocytes independent of transcription: a release of inhibition model for mammalian oocyte meiosis
    Arvind Gill
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 18:97-104. 2004
    ....
  21. pmc Xenopus laevis CYP17 regulates androgen biosynthesis independent of the cofactor cytochrome b5
    Wei Hsiung Yang
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 280:10196-201. 2005
    ..CYP17 may therefore have evolved from a general producer of sex steroids in lower vertebrates to a more tightly regulated producer of both sex steroids and glucocorticoids in mammals...
  22. pmc Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function
    Aritro Sen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 24:1393-403. 2010
    ..These GC-specific ARs appear to promote preantral follicle growth and prevent follicular atresia; thus they are essential for normal follicular development and fertility...
  23. pmc GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovary
    Liliana Carbajal
    Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 25:1055-65. 2011
    ..These results may have implications with regard to EGFR inhibitor use in various cancers as well as in polycystic ovarian syndrome, where excess LH-driven ovarian androgen production might be controlled by MMP2/9 inhibition...
  24. ncbi request reprint The physiology of the Xenopus laevis ovary
    Melissa A Rasar
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, USA
    Methods Mol Biol 322:17-30. 2006
    ....
  25. pmc Ovarian steroids: the good, the bad, and the signals that raise them
    Michelle Jamnongjit
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
    Cell Cycle 5:1178-83. 2006
    ..The following review will address these advances, focusing on how this rapidly expanding knowledge base can be used to better understand female reproduction, and to further improve treatments for common diseases of infertility...
  26. pmc Oocyte maturation: the coming of age of a germ cell
    Michelle Jamnongjit
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Semin Reprod Med 23:234-41. 2005
    ....
  27. pmc Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs
    Hen Prizant
    Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 27:1403-14. 2013
    ..This mouse model may improve our understanding of LAM and leiomyomas and might lead to novel therapeutic strategies for both diseases. ..
  28. ncbi request reprint Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen production
    Wei Hsiung Yang
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    J Biol Chem 278:9552-9. 2003
    ..The requirement of oocytes for ovarian androgen production further introduces the unusual paradigm whereby germ cells may be responsible for producing important steroids used to mediate their own maturation...
  29. pmc Targeted approaches toward understanding and treating pulmonary lymphangioleiomyomatosis (LAM)
    Stephen R Hammes
    Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Horm Cancer 4:70-7. 2013
    ..This minireview summarizes recent progress in understanding LAM pathophysiology, including the latest preclinical and clinical studies, and insights regarding the role of hormones in LAM...
  30. pmc Minireview: Recent advances in extranuclear steroid receptor actions
    Stephen R Hammes
    Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Endocrinology 152:4489-95. 2011
    ....
  31. pmc GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development
    Shanru Li
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 301:106-16. 2007
    ....
  32. ncbi request reprint Expression of the germ cell-specific transcription factor ALF in Xenopus oocytes compensates for translational inactivation of the somatic factor TFIIA
    SangYoon Han
    Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 75080, USA
    J Biol Chem 278:45586-93. 2003
    ..Overall, the results show that the translationally regulated reciprocal expression of ALF and TFIIA allows for the production of an active TFIIA-like general transcription factor throughout oogenesis...
  33. ncbi request reprint Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer
    Carol A Lange
    Department of Medicine Division of Hematology, Oncology, and Transplant, USA
    Annu Rev Physiol 69:171-99. 2007
    ....