Research Topics
Genomes and Genes
Species | Stephen R HammesSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
The further redefining of steroid-mediated signalingStephen R Hammes
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8857, USA
Proc Natl Acad Sci U S A 100:2168-70. 2003
Extranuclear steroid receptors: nature and actionsStephen R Hammes
Department of Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
Endocr Rev 28:726-41. 2007..In this review, we highlight the significant progress that has been made in these areas...- Steroids and oocyte maturation--a new look at an old storyStephen R Hammes
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8857, USA
Mol Endocrinol 18:769-75. 2004..A detailed appreciation of the steroid-activated signaling pathways in frog and mammalian oocytes may therefore prove useful in understanding both normal and abnormal ovarian development in humans... - Specific modulation of nongenomic androgen signaling in the ovaryStacy N White
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8857, USA
Steroids 70:352-60. 2005..These results suggest that SARMs may serve as useful tools for specifically regulating nongenomic androgen signaling both in vitro and in vivo... - Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferationAritro Sen
Division of Endocrinology and Metabolism, University of Rochester Medical Center, Rochester, NY, USA
J Clin Invest 122:2469-81. 2012..Paxillin is therefore a potential biomarker for prostate cancer proliferation and a possible therapeutic target for prostate cancer treatment... - The modulator of nongenomic actions of the estrogen receptor (MNAR) regulates transcription-independent androgen receptor-mediated signaling: evidence that MNAR participates in G protein-regulated meiosis in Xenopus laevis oocytesDerek Haas
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
Mol Endocrinol 19:2035-46. 2005..Androgen binding to AR might then release this inhibition, allowing maturation to occur. Thus, MNAR may augment multiple nongenomic signals, depending upon the context and cell type in which it is expressed... - Nongenomic steroid-triggered oocyte maturation: of mice and frogsJames Deng
Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United States
Steroids 74:595-601. 2009.... - Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cellsAritro Sen
Department of Medicine, Division of Endocrinology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 285:28787-95. 2010..Thus, paxillin may prove to be a novel diagnostic or therapeutic target in prostate cancer... - Testosterone and progesterone rapidly attenuate plasma membrane Gbetagamma-mediated signaling in Xenopus laevis oocytes by signaling through classical steroid receptorsKristen Evaul
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
Mol Endocrinol 21:186-96. 2007.... - The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X. laevis oocytesJames Deng
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Mol Endocrinol 22:1853-65. 2008.... - Cross-talk between G protein-coupled and epidermal growth factor receptors regulates gonadotropin-mediated steroidogenesis in Leydig cellsKristen Evaul
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
J Biol Chem 283:27525-33. 2008..These results suggest that GPCR-EGF receptor cross-talk is a conserved regulator of gonadotropin-induced steroidogenesis in the gonads, although the mechanisms of EGF receptor trans-activation may vary... - G beta gamma signaling reduces intracellular cAMP to promote meiotic progression in mouse oocytesArvind Gill
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8857, USA
Steroids 72:117-23. 2007.... - Paxillin regulates steroid-triggered meiotic resumption in oocytes by enhancing an all-or-none positive feedback kinase loopMelissa Rasar
Department of Internal Medicine, Division of Endocrinology and Metabolism, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
J Biol Chem 281:39455-64. 2006..These experiments reveal a novel and critical function for Paxillin in meiosis and support the notion that Paxillin may be a general modulator of mitogen-activated protein kinase signaling... 
Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biologyAritro Sen
Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Steroids 76:822-8. 2011....- GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesisTamara J Strauss
Departments of Internal Medicine Pathology and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75930, USA
Reproduction 141:173-81. 2011..Together, these data imply that the somatic cell protein GLP-1 is not necessary for many pregranulosa cell functions but is required for germ cell survival... - Selective modulation of genomic and nongenomic androgen responses by androgen receptor ligandsLindsey B Lutz
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8857, USA
Mol Endocrinol 17:1106-16. 2003..nongenomic signaling may be useful in delineating the roles of these pathways in mediating androgen responses and might lead to the development of novel compounds that specifically modulate these signals in vivo... - Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturationMichelle Jamnongjit
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX 75390-8857, USA
Proc Natl Acad Sci U S A 102:16257-62. 2005..We present a model whereby steroid production may serve as one of many integrated signals triggered by EGFR signaling to promote oocyte maturation in gonadotropin-stimulated follicles... - Central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancerLin Yang
Department of Urology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9110, USA
Mol Endocrinol 26:550-61. 2012..These data suggest a novel mechanism of AR activation in the absence of androgens in PCa cells. Our data indicate that disruption of the complex between AR and PELP1 may be a viable therapeutic strategy in advanced PCa... - Xenopus laevis CYP17 regulates androgen biosynthesis independent of the cofactor cytochrome b5Wei-Hsiung Yang
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
J Biol Chem 280:10196-201. 2005..CYP17 may therefore have evolved from a general producer of sex steroids in lower vertebrates to a more tightly regulated producer of both sex steroids and glucocorticoids in mammals... - Androgens promote maturation and signaling in mouse oocytes independent of transcription: a release of inhibition model for mammalian oocyte meiosisArvind Gill
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8857, USA
Mol Endocrinol 18:97-104. 2004.... - Granulosa cell-specific androgen receptors are critical regulators of ovarian development and functionAritro Sen
Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Mol Endocrinol 24:1393-403. 2010..These GC-specific ARs appear to promote preantral follicle growth and prevent follicular atresia; thus they are essential for normal follicular development and fertility... - GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovaryLiliana Carbajal
Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Mol Endocrinol 25:1055-65. 2011..These results may have implications with regard to EGFR inhibitor use in various cancers as well as in polycystic ovarian syndrome, where excess LH-driven ovarian androgen production might be controlled by MMP2/9 inhibition... - The physiology of the Xenopus laevis ovaryMelissa A Rasar
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, USA
Methods Mol Biol 322:17-30. 2006.... - Oocyte maturation: the coming of age of a germ cellMichelle Jamnongjit
Department of Internal Medicine, Division of Endocrinology and Metabolism, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
Semin Reprod Med 23:234-41. 2005.... - Ovarian steroids: the good, the bad, and the signals that raise themMichelle Jamnongjit
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8857, USA
Cell Cycle 5:1178-83. 2006..The following review will address these advances, focusing on how this rapidly expanding knowledge base can be used to better understand female reproduction, and to further improve treatments for common diseases of infertility... - Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen productionWei-Hsiung Yang
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8857, USA
J Biol Chem 278:9552-9. 2003..The requirement of oocytes for ovarian androgen production further introduces the unusual paradigm whereby germ cells may be responsible for producing important steroids used to mediate their own maturation... - Minireview: Recent advances in extranuclear steroid receptor actionsStephen R Hammes
Department of Medicine, University of Rochester, Rochester, New York 14642, USA
Endocrinology 152:4489-95. 2011.... - GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell developmentShanru Li
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Biol 301:106-16. 2007.... - Expression of the germ cell-specific transcription factor ALF in Xenopus oocytes compensates for translational inactivation of the somatic factor TFIIASangYoon Han
Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 75080, USA
J Biol Chem 278:45586-93. 2003..Overall, the results show that the translationally regulated reciprocal expression of ALF and TFIIA allows for the production of an active TFIIA-like general transcription factor throughout oogenesis... - Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancerCarol A Lange
Department of Medicine Division of Hematology, Oncology, and Transplant, USA
Annu Rev Physiol 69:171-99. 2007....