Research Topics

Genomes and Genes


Michael F Hammer


Affiliation: University of Arizona
Country: USA


  1. Veeramah K, Gutenkunst R, Woerner A, Watkins J, Hammer M. Evidence for increased levels of positive and negative selection on the X chromosome versus autosomes in humans. Mol Biol Evol. 2014;31:2267-82 pubmed publisher
  2. Sprissler R, Bina R, Kasoff W, Witte M, Bernas M, Walter C, et al. Leukocyte expression profiles reveal gene sets with prognostic value for seizure-free outcome following stereotactic laser amygdalohippocampotomy. Sci Rep. 2019;9:1086 pubmed publisher
    ..These results suggest that pre-operative leukocyte expression profiles have prognostic value for seizure outcome following SLAH. ..
  3. Veeramah K, Woerner A, Johnstone L, Gut I, Gut M, Marques Bonet T, et al. Examining phylogenetic relationships among gibbon genera using whole genome sequence data using an approximate bayesian computation approach. Genetics. 2015;200:295-308 pubmed publisher
    ..Whole genome sequencing of additional individuals will be vital for inferring the extent of gene flow among species after the separation of the gibbon genera. ..
  4. Quinto Cortés C, Woerner A, Watkins J, Hammer M. Modeling SNP array ascertainment with Approximate Bayesian Computation for demographic inference. Sci Rep. 2018;8:10209 pubmed publisher
    ..Our inference framework is applicable to those cases and will help with the demographic inference. ..
  5. Hammer M, Woerner A, Mendez F, Watkins J, Cox M, Wall J. The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes. Nat Genet. 2010;42:830-1 pubmed publisher
    ..This pattern may be explained by stronger locally acting selection on X-linked genes compared with autosomal genes, combined with larger effective population sizes for females than for males. ..
  6. Sprissler R, Wagnon J, Bunton Stasyshyn R, Meisler M, Hammer M. Altered gene expression profile in a mouse model of SCN8A encephalopathy. Exp Neurol. 2017;288:134-141 pubmed publisher
    ..The data support the view that gain-of-function mutations of SCN8A lead to pathogenic alterations in brain function contributing to encephalopathy. ..