Gary D Hammer

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1
    Poda Suresh Babu
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0678, USA
    Endocrinology 143:665-73. 2002
  2. ncbi request reprint Steroidogenic factor-1 is essential for compensatory adrenal growth following unilateral adrenalectomy
    Felix Beuschlein
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0678, USA
    Endocrinology 143:3122-35. 2002
  3. ncbi request reprint Minireview: transcriptional regulation of adrenocortical development
    Gary D Hammer
    Division of Metabolism, Endocrinology, and Metabolism, Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 0678, USA
    Endocrinology 146:1018-24. 2005
  4. ncbi request reprint Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function
    Jonathon N Winnay
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
    Endocrinology 147:1322-32. 2006
  5. pmc Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis
    Bin Xu
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48109 5678, USA
    Mol Cell Biol 29:1719-34. 2009
  6. pmc Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis
    Tobias Else
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 2200, USA
    Cancer Cell 15:465-76. 2009
  7. pmc Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin
    Joanne H Heaton
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Am J Pathol 181:1017-33. 2012
  8. ncbi request reprint Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex
    Brian M Gummow
    University of Michigan Medical School, Department of Molecular and Integrative Physiology, Ann Arbor, Michigan 48109 2200, USA
    Mol Endocrinol 20:2711-23. 2006
  9. ncbi request reprint Genetic analysis of adrenal absence: agenesis and aplasia
    Tobias Else
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, 5568 MSRBII, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0678, USA
    Trends Endocrinol Metab 16:458-68. 2005
  10. pmc T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors
    Jennifer A Kennell
    Program in Cellular and Molecular Biology, Division of Endocrinology and Metabolism, University of Michigan Medical School, 1301 E Catherine Road, Ann Arbor, MI 48109 0622, USA
    Mol Cell Biol 23:5366-75. 2003

Detail Information

Publications56

  1. ncbi request reprint Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1
    Poda Suresh Babu
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0678, USA
    Endocrinology 143:665-73. 2002
    ..These results are consistent with a model in which Dax-1 functions to inhibit SF-1-mediated steroidogenesis in vivo...
  2. ncbi request reprint Steroidogenic factor-1 is essential for compensatory adrenal growth following unilateral adrenalectomy
    Felix Beuschlein
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0678, USA
    Endocrinology 143:3122-35. 2002
    ..Taken together, these results reflect a primary inability of adrenal cortical cells of SF-1(+/-) mice to undergo compensatory adrenal growth in response to uADX...
  3. ncbi request reprint Minireview: transcriptional regulation of adrenocortical development
    Gary D Hammer
    Division of Metabolism, Endocrinology, and Metabolism, Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 0678, USA
    Endocrinology 146:1018-24. 2005
    ....
  4. ncbi request reprint Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function
    Jonathon N Winnay
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
    Endocrinology 147:1322-32. 2006
    ..Collectively, these data are consistent with an indispensable role for SRC-1 in mediating actions of glucocorticoids in pituitary and liver...
  5. pmc Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis
    Bin Xu
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48109 5678, USA
    Mol Cell Biol 29:1719-34. 2009
    ..These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology...
  6. pmc Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis
    Tobias Else
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 2200, USA
    Cancer Cell 15:465-76. 2009
    ..Tumors from Acd(acd/acd) p53(+/-) mice show a striking switch from the classic spectrum of p53(-/-) mice toward carcinomas. The acd mouse model provides further support for an in vivo role of telomere deprotection in tumorigenesis...
  7. pmc Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin
    Joanne H Heaton
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Am J Pathol 181:1017-33. 2012
    ..Our results are consistent with a model in which dysregulation of one pathway may result in adrenal hyperplasia, but accumulation of a second or multiple alterations is necessary for tumorigenesis...
  8. ncbi request reprint Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex
    Brian M Gummow
    University of Michigan Medical School, Department of Molecular and Integrative Physiology, Ann Arbor, Michigan 48109 2200, USA
    Mol Endocrinol 20:2711-23. 2006
    ..These data indicate that GR provides feedback regulation of adrenocortical steroid production through synergistic activation of Dax-1 with SF-1, which is antagonized by ACTH activation of the adrenal cortex...
  9. ncbi request reprint Genetic analysis of adrenal absence: agenesis and aplasia
    Tobias Else
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, 5568 MSRBII, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0678, USA
    Trends Endocrinol Metab 16:458-68. 2005
    ..Recent advancements in the field of human and mouse genetics have accumulated evidence for a host of novel factors involved in these processes, such as the hedgehog signaling network and peptides derived from proopiomelanocortin...
  10. pmc T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors
    Jennifer A Kennell
    Program in Cellular and Molecular Biology, Division of Endocrinology and Metabolism, University of Michigan Medical School, 1301 E Catherine Road, Ann Arbor, MI 48109 0622, USA
    Mol Cell Biol 23:5366-75. 2003
    ..Thus, we propose that TCF-4N inhibits coactivation by beta-catenin of TCF/LEF transcription factors and potentiates the coactivation by beta-catenin of other transcription factors, such as SF-1 and C/EBPalpha...
  11. pmc Upregulated JAG1 enhances cell proliferation in adrenocortical carcinoma
    Derek P Simon
    Cellular and Molecular Biology Training Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 18:2452-64. 2012
    ..The purpose of this study was to examine the expression and molecular significance of JAG1, a ligand for the Notch developmental signaling pathway, in adrenocortical carcinoma (ACC)...
  12. pmc Aged PROP1 deficient dwarf mice maintain ACTH production
    Igor O Nasonkin
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e28355. 2011
    ..These studies suggest that the mouse model differs from the human patients who display progressive hormone loss and hypocortisolism...
  13. doi request reprint Proposal for modification of the ENSAT staging system for adrenocortical carcinoma using tumor grade
    Barbra S Miller
    Division of Endocrine Surgery, University of Michigan, Ann Arbor, MI, USA
    Langenbecks Arch Surg 395:955-61. 2010
    ..We hypothesized that incorporating tumor grade into the current European Network for the Study of Adrenal Tumors (ENSAT) staging system would improve the ability to more accurately predict time to recurrence and death...
  14. pmc Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice
    Felix Beuschlein
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Biol 23:3951-64. 2003
    ....
  15. ncbi request reprint Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery
    Brendan D Looyenga
    Cellular and Molecular Biology Graduate Program, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Mol Endocrinol 21:2440-57. 2007
    ..Together these observations imply that activin/Smad3 signaling is necessary for efficient signaling by FSH in Inha-/- tumor cells and that interruption of this pathway uncouples FSH from its intracellular mitogenic effectors...
  16. ncbi request reprint Origin and identity of adrenocortical tumors in inhibin knockout mice: implications for cellular plasticity in the adrenal cortex
    Brendan D Looyenga
    Cellular and Molecular Biology Graduate Program, Division of Endocrinology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Mol Endocrinol 20:2848-63. 2006
    ..These data suggest that Inha-/- adrenocortical tumors cells are derived from pluripotent adrenocortical progenitor cells that adopt a gonadal fate due to the convergent loss of inhibin and chronic exposure to elevated gonadotropins...
  17. pmc Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus
    Michelle A Wood
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA
    Development 140:4522-32. 2013
    ....
  18. pmc Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex
    Kenneth T Krill
    Program in Cellular and Molecular Biology, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Endocrinol 27:754-68. 2013
    ..Together these data suggest a role for miRNA-mediated regulation of a subset of genes that are essential for normal adrenal growth and homeostasis...
  19. doi request reprint Worsening central sarcopenia and increasing intra-abdominal fat correlate with decreased survival in patients with adrenocortical carcinoma
    Barbra S Miller
    Division of Endocrine Surgery, Section of General Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
    World J Surg 36:1509-16. 2012
    ....
  20. doi request reprint Tpp1/Acd maintains genomic stability through a complex role in telomere protection
    Tobias Else
    Department of Internal Medicine, Division of Endocrinology and Metabolism, The University of Michigan, Ann Arbor, MI 48109, USA
    Chromosome Res 15:1001-13. 2007
    ..Together, these studies show that Tpp1/Acd plays a vital role in telomere protection, but likely has additional functions yet to be defined...
  21. pmc Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma
    Ferdous M Barlaskar
    Department of Internal Medicine Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, 1502 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
    J Clin Endocrinol Metab 94:204-12. 2009
    ..Drug therapy for adrenocortical carcinoma (ACC), a rare and lethal malignancy, is largely empirical and ineffective. New treatments directed at molecular targets critical to the pathophysiology of ACC may prove more efficacious...
  22. pmc GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer
    Richard L Watson
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA
    Neoplasia 12:357-65. 2010
    ..In turn, release of cytosolic membrane beta-catenin with subsequent nuclear translocation promotes survival. Both GSK3beta and beta-catenin have been implicated in cancer cell proliferation and resistance to death...
  23. ncbi request reprint Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene
    Brian M Gummow
    Department of Molecular and Integrative Physiology, Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:26572-9. 2003
    ..These data support the recent observation that beta-catenin can participate in nuclear receptor-mediated transcriptional activation and extend the findings to the monomer binding class of orphan nuclear receptors...
  24. ncbi request reprint Recent insights into organogenesis of the adrenal cortex
    Catherine E Keegan
    Dept Pediatrics, Division of Genetics, University of Michigan Medical School, 5552 MSRB II, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0678, USA
    Trends Endocrinol Metab 13:200-8. 2002
    ..Here, we outline the developmental milestones of the adrenal cortex with recent contributions to the field, focusing on factors that have been shown to play a role in vivo in humans and mice...
  25. pmc Adjuvant therapies and patient and tumor characteristics associated with survival of adult patients with adrenocortical carcinoma
    Tobias Else
    Department of Internal Medicine T E, G D H, Division of Metabolism, Endocrinology, and Diabetes, Department of Radiation Oncology A S, S J, and Division of Endocrine Surgery B S M, Section of General Surgery, University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48106 and University of Michigan Medical School A R W, Ann Arbor, Michigan 48109
    J Clin Endocrinol Metab 99:455-61. 2014
    ..Studies regarding outcome and prognostic factors rely on fairly small studies. Here we summarize the experience with patients with a diagnosis of adrenocortical carcinoma from a large tertiary referral center...
  26. ncbi request reprint Transcutaneous biopsy of adrenocortical carcinoma is rarely helpful in diagnosis, potentially harmful, but does not affect patient outcome
    Andrew R Williams
    University of Michigan Medical School1301 Catherine Street, Ann Arbor, Michigan 48109, USADivision of MetabolismEndocrinology and Diabetes MEND, Department of Internal Medicine, University of Michigan Hospital and Health Systems, NI3 A17, 300 North Ingalls, Ann Arbor, Michigan 48109 5419, USA
    Eur J Endocrinol 170:829-35. 2014
    ..Adrenocortical carcinoma (ACC) is a rare malignancy with high recurrence and mortality rates. The utility, sensitivity, and effect on patient outcome of transcutaneous adrenal biopsy (TAB) for single, large, adrenal masses are unclear...
  27. pmc Adrenocortical carcinoma
    Tobias Else
    MEND Division of Metabolism, Endocrinology, and Diabetes T E, T J G, G D H, Division of Molecular Medicine and Genetics V M R, Department of Internal Medicine Departments of Radiation Oncology A S, J S, Pathology T J G, and Radiology A K, E M C and Division of Endocrine Surgery B S M, Section of General Surgery, A C K, Department of Surgery, University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48109
    Endocr Rev 35:282-326. 2014
    ..This review focuses on evidence gained from recent basic science and clinical research and provides perspectives from the experience of a large multidisciplinary clinic dedicated to the care of patients with ACC. ..
  28. pmc Adrenocortical carcinoma is a lynch syndrome-associated cancer
    Victoria M Raymond
    University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 31:3012-8. 2013
    ..The association of adult-onset ACC with inherited cancer predisposition syndromes is poorly understood. Our study sought to define the prevalence of Lynch syndrome (LS) among patients with ACC...
  29. pmc Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA
    Victoria R Kelly
    Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Endocrinol 24:2281-91. 2010
    ..Thus, our results indicate that Dax1 plays an important role in the maintenance of pluripotency in mES cells through interaction with LRH-1 and transcriptional activation of Oct4 and other genes...
  30. ncbi request reprint Novel polymorphisms and lack of mutations in the ACD gene in patients with ACTH resistance syndromes
    Catherine E Keegan
    Department of Pediatrics, Division of Genetics, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Clin Endocrinol (Oxf) 67:168-74. 2007
    ..The human homolog of the Acd gene, mutated in a mouse model of adrenal insufficiency, was sequenced in 25 patients with a clinical diagnosis of familial glucocorticoid deficiency or triple A syndrome...
  31. pmc Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells
    Jose L Garcia-Perez
    Department of Human Genetics, 1241 East Catherine Street, University of Michigan Medical School, Ann Arbor, Michigan 48109 5618, USA
    Nature 466:769-73. 2010
    ..Thus, our data indicate that ECs differ from many differentiated cells in their ability to silence reporter genes delivered by L1 retrotransposition...
  32. doi request reprint Resection of adrenocortical carcinoma is less complete and local recurrence occurs sooner and more often after laparoscopic adrenalectomy than after open adrenalectomy
    Barbra S Miller
    Division of Endocrine Surgery, Section of General Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA
    Surgery 152:1150-7. 2012
    ..Controversy surrounds the use of laparoscopy for resection of adrenocortical carcinoma. We evaluated the hypothesis that outcome is equivalent in patients undergoing laparoscopic adrenalectomy versus open adrenalectomy...
  33. pmc Adrenocortical stem and progenitor cells: implications for adrenocortical carcinoma
    Derek P Simon
    Cellular and Molecular Biology Training Program, University of Michigan, Ann Arbor, MI 48109, United States
    Mol Cell Endocrinol 351:2-11. 2012
    ..A more complete understanding of adrenocortical stem/progenitor cell biology will invariably aid in characterization of the molecular details of ACC tumorigenesis and may offer new options for therapeutic intervention...
  34. pmc SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation
    Wei Hsiung Yang
    Department of Internal Medicine, Division of Metabolism, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Mol Cell Biol 29:613-25. 2009
    ..Based on these observations, we propose a coordinated modification model in which inhibition of SF-1-mediated transcription by SUMOylation in adrenocortical cancer cells is mediated through reduced CDK7-induced phosphorylation of SF-1...
  35. ncbi request reprint Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation
    Jonathon N Winnay
    Department of Molecular and Integrative Pysiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
    Mol Endocrinol 20:147-66. 2006
    ..In addition, the current study demonstrates that specific enzymatic activities are capable of regulating distinct facets of a highly ordered transcriptional response...
  36. pmc Evidence of adrenal failure in aging Dax1-deficient mice
    Joshua O Scheys
    Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Endocrinology 152:3430-9. 2011
    ....
  37. pmc In search of adrenocortical stem and progenitor cells
    Alex C Kim
    Department of Internal Medicine, Division of Metabolism, Ann Arbor, Michigan 48109 2200, USA
    Endocr Rev 30:241-63. 2009
    ..Together, the work provides a framework for the emerging somatic stem cell field as it relates to the adrenal gland...
  38. ncbi request reprint IMAGe association and congenital adrenal hypoplasia: no disease-causing mutations found in the ACD gene
    Janna E Hutz
    Department of Pediatrics, Division of Genetics, University of Michigan, Ann Arbor, MI, USA
    Mol Genet Metab 88:66-70. 2006
    ..Sequencing of ACD in 15 patients revealed no coding mutations, but three novel SNPs were identified...
  39. pmc Adrenocortical stem and progenitor cells: unifying model of two proposed origins
    Michelle A Wood
    University of Michigan, 109 Zina Pitcher Place, 1528 Biomedical Science Research Building, Ann Arbor, MI 48109, United States
    Mol Cell Endocrinol 336:206-12. 2011
    ....
  40. pmc Prevalence of germline TP53 mutations in a prospective series of unselected patients with adrenocortical carcinoma
    Victoria M Raymond
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 5419, USA
    J Clin Endocrinol Metab 98:E119-25. 2013
    ..Although existing criteria advocate for TP53 testing in all patients with ACC regardless of age at diagnosis, the overall prevalence of germline mutations in patients diagnosed with ACC has not been well studied...
  41. ncbi request reprint Mechanistic roles of inhibin as a tumor suppressor in the adrenal cortex
    Brendan Looyenga
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocr Res 30:585-6. 2004
  42. ncbi request reprint The Combination of Insulin-Like Growth Factor Receptor 1 (IGF1R) Antibody Cixutumumab and Mitotane as a First-Line Therapy for Patients with Recurrent/Metastatic Adrenocortical Carcinoma: a Multi-institutional NCI-Sponsored Trial
    Antonio M Lerario
    Division of Metabolism, Endocrinology and Diabetes, Medical School, University of Michigan, 109 Zina Pitcher Place, 1528 BSRB, Ann Arbor, MI, 48109, USA
    Horm Cancer 5:232-9. 2014
    ..Although the regimen demonstrated activity in some patients, the relatively low therapeutic efficacy precluded further studies with this combination of drugs. ..
  43. doi request reprint Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma
    Irina Y Dobrosotskaya
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Endocr Pract 17:e59-62. 2011
    ..To describe successful long-term tumor control in metastatic adrenocortical carcinoma, a relatively rare tumor with limited treatment options outside of surgery...
  44. doi request reprint Evaluation of telomere length maintenance mechanisms in adrenocortical carcinoma
    Tobias Else
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 2200, USA
    J Clin Endocrinol Metab 93:1442-9. 2008
    ..Telomere maintenance mechanisms (TMMs) are critical for the persistence of the malignant phenotype, but little is known about these mechanisms or their diagnostic value in adrenocortical lesions...
  45. ncbi request reprint The role of radiologic studies in the evaluation and management of primary hyperaldosteronism
    Matthew L White
    Division of Endocrine Surgery, Department of Surgery, University of Michigan, Ann Arbor, Mich, USA
    Surgery 144:926-33; discussion 933. 2008
    ..Surgical treatment of primary hyperaldosteronism (PHA) requires demonstration of unilateral adrenal hypersecretion. Optimal methods for interpretation of imaging and invasive testing are still in development...
  46. ncbi request reprint Management of adrenocortical carcinoma
    Jonathan R Strosberg
    University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    J Natl Compr Canc Netw 7:752-8; quiz 759. 2009
    ..This article describes the basic diagnostic and prognostic issues in adrenal cancer management, and presents detailed rationales for therapeutic management...
  47. ncbi request reprint Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator
    Catherine E Keegan
    Department of Pediatrics, Division of Genetics, University of Michigan, Ann Arbor, MI 48109 0789, USA
    Hum Mol Genet 14:113-23. 2005
    ..This is the first report to show that a telomeric regulator is required for proper urogenital ridge differentiation, axial skeleton specification and limb patterning in mice...
  48. ncbi request reprint Transsphenoidal microsurgery for Cushing's disease: initial outcome and long-term results
    Gary D Hammer
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor, Michigan 48109 0678, USA
    J Clin Endocrinol Metab 89:6348-57. 2004
    ..These results suggest that patients with persistent Cushing's disease require early and aggressive intervention to attempt to prevent this excess mortality...
  49. ncbi request reprint The molecular genetics of adrenocortical carcinoma
    Ferdous M Barlaskar
    Cellular and Molecular Biology Graduate Program, University of Michigan, BSRB 1502, Ann Arbor, MI 48109 2200, USA
    Rev Endocr Metab Disord 8:343-8. 2007
  50. ncbi request reprint Ectopic pro-opiomelanocortin syndrome
    Felix Beuschlein
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, 5560A MSRB II, 1150 West Medical Center Dr, Ann Arbor, MI 48109 0678, USA
    Endocrinol Metab Clin North Am 31:191-234. 2002
    ..Diagnostic imaging, including conventional radiological techniques and somatostatin receptor scintigraphy, aids in the correct localization and eventual treatment of ectopic POMC production...
  51. ncbi request reprint Telomere protection by mammalian Pot1 requires interaction with Tpp1
    Dirk Hockemeyer
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nat Struct Mol Biol 14:754-61. 2007
    ....
  52. ncbi request reprint Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development
    Susan Y Park
    Division of Endocrinology and Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Development 132:2415-23. 2005
    ..Thus, although Sf1 and Dax1 function as transcriptional antagonists for many target genes in vitro, they act independently or cooperatively in vivo during male gonadal development...
  53. ncbi request reprint Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis
    Urs D Lichtenauer
    Division of Endocrine Research, Department of Medicine Innenstadt, University Hospital Munich, Ziemssenstrasse 1, D 80336 Munich, Germany
    Endocrinology 148:693-704. 2007
    ....
  54. ncbi request reprint Gonadectomy in mice of the inbred strain CE/J induces proliferation of sub-capsular adrenal cells expressing gonadal marker genes
    Inga K Johnsen
    Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert Ludwigs Universität, D 79106 Freiburg, Germany
    J Endocrinol 190:47-57. 2006
    ..The distinct expression pattern of this cell population is consistent with a defect in the differentiation of these cells into a cell population with functional properties that otherwise define a gonadal endocrine phenotype...
  55. doi request reprint Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex
    Alex C Kim
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0678 USA
    Development 135:2593-602. 2008
    ..These results define crucial roles for beta-catenin--presumably as part of the Wnt canonical signaling pathway--in both embryonic development of the adrenal cortex and in maintenance of the adult organ...
  56. pmc Adrenocortical cells with stem/progenitor cell properties: recent advances
    Alex C Kim
    University of Michigan Medical School, Cell and Molecular Biology Training Program, 1502 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, United States
    Mol Cell Endocrinol 265:10-6. 2007
    ..In this review, we discuss historic developmental studies together with recent molecular examinations that aim to characterize such populations of cells...