Research Topics
Genomes and Genes
| Gary D HammerSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1Poda Suresh Babu
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0678, USA
Endocrinology 143:665-73. 2002..These results are consistent with a model in which Dax-1 functions to inhibit SF-1-mediated steroidogenesis in vivo...- Steroidogenic factor-1 is essential for compensatory adrenal growth following unilateral adrenalectomyFelix Beuschlein
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0678, USA
Endocrinology 143:3122-35. 2002..Taken together, these results reflect a primary inability of adrenal cortical cells of SF-1(+/-) mice to undergo compensatory adrenal growth in response to uADX... - Minireview: transcriptional regulation of adrenocortical developmentGary D Hammer
Division of Metabolism, Endocrinology, and Metabolism, Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 0678, USA
Endocrinology 146:1018-24. 2005.... - Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis functionJonathon N Winnay
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
Endocrinology 147:1322-32. 2006..Collectively, these data are consistent with an indispensable role for SRC-1 in mediating actions of glucocorticoids in pituitary and liver... 
Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesisTobias Else
Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 2200, USA
Cancer Cell 15:465-76. 2009..Tumors from Acd(acd/acd) p53(+/-) mice show a striking switch from the classic spectrum of p53(-/-) mice toward carcinomas. The acd mouse model provides further support for an in vivo role of telomere deprotection in tumorigenesis...- Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesisBin Xu
Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48109 5678, USA
Mol Cell Biol 29:1719-34. 2009..These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology... - Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-cateninJoanne H Heaton
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
Am J Pathol 181:1017-33. 2012..Our results are consistent with a model in which dysregulation of one pathway may result in adrenal hyperplasia, but accumulation of a second or multiple alterations is necessary for tumorigenesis... - Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortexBrian M Gummow
University of Michigan Medical School, Department of Molecular and Integrative Physiology, Ann Arbor, Michigan 48109 2200, USA
Mol Endocrinol 20:2711-23. 2006..These data indicate that GR provides feedback regulation of adrenocortical steroid production through synergistic activation of Dax-1 with SF-1, which is antagonized by ACTH activation of the adrenal cortex... - Genetic analysis of adrenal absence: agenesis and aplasiaTobias Else
Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, 5568 MSRBII, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0678, USA
Trends Endocrinol Metab 16:458-68. 2005..Recent advancements in the field of human and mouse genetics have accumulated evidence for a host of novel factors involved in these processes, such as the hedgehog signaling network and peptides derived from proopiomelanocortin... - T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factorsJennifer A Kennell
Program in Cellular and Molecular Biology, Division of Endocrinology and Metabolism, University of Michigan Medical School, 1301 E Catherine Road, Ann Arbor, MI 48109 0622, USA
Mol Cell Biol 23:5366-75. 2003..Thus, we propose that TCF-4N inhibits coactivation by beta-catenin of TCF/LEF transcription factors and potentiates the coactivation by beta-catenin of other transcription factors, such as SF-1 and C/EBPalpha... 
Upregulated JAG1 enhances cell proliferation in adrenocortical carcinomaDerek P Simon
Cellular and Molecular Biology Training Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
Clin Cancer Res 18:2452-64. 2012..The purpose of this study was to examine the expression and molecular significance of JAG1, a ligand for the Notch developmental signaling pathway, in adrenocortical carcinoma (ACC)...- Aged PROP1 deficient dwarf mice maintain ACTH productionIgor O Nasonkin
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 6:e28355. 2011..These studies suggest that the mouse model differs from the human patients who display progressive hormone loss and hypocortisolism... - Proposal for modification of the ENSAT staging system for adrenocortical carcinoma using tumor gradeBarbra S Miller
Division of Endocrine Surgery, University of Michigan, Ann Arbor, MI, USA
Langenbecks Arch Surg 395:955-61. 2010..We hypothesized that incorporating tumor grade into the current European Network for the Study of Adrenal Tumors (ENSAT) staging system would improve the ability to more accurately predict time to recurrence and death... - Origin and identity of adrenocortical tumors in inhibin knockout mice: implications for cellular plasticity in the adrenal cortexBrendan D Looyenga
Cellular and Molecular Biology Graduate Program, Division of Endocrinology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Mol Endocrinol 20:2848-63. 2006..These data suggest that Inha-/- adrenocortical tumors cells are derived from pluripotent adrenocortical progenitor cells that adopt a gonadal fate due to the convergent loss of inhibin and chronic exposure to elevated gonadotropins... - Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machineryBrendan D Looyenga
Cellular and Molecular Biology Graduate Program, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Mol Endocrinol 21:2440-57. 2007..Together these observations imply that activin/Smad3 signaling is necessary for efficient signaling by FSH in Inha-/- tumor cells and that interruption of this pathway uncouples FSH from its intracellular mitogenic effectors... - Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient miceFelix Beuschlein
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Cell Biol 23:3951-64. 2003.... - Worsening central sarcopenia and increasing intra-abdominal fat correlate with decreased survival in patients with adrenocortical carcinomaBarbra S Miller
Division of Endocrine Surgery, Section of General Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
World J Surg 36:1509-16. 2012.... - GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancerRichard L Watson
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA
Neoplasia 12:357-65. 2010..In turn, release of cytosolic membrane beta-catenin with subsequent nuclear translocation promotes survival. Both GSK3beta and beta-catenin have been implicated in cancer cell proliferation and resistance to death... - Recent insights into organogenesis of the adrenal cortexCatherine E Keegan
Dept Pediatrics, Division of Genetics, University of Michigan Medical School, 5552 MSRB II, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0678, USA
Trends Endocrinol Metab 13:200-8. 2002..Here, we outline the developmental milestones of the adrenal cortex with recent contributions to the field, focusing on factors that have been shown to play a role in vivo in humans and mice... - Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinomaFerdous M Barlaskar
Department of Internal Medicine Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, 1502 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
J Clin Endocrinol Metab 94:204-12. 2009..Drug therapy for adrenocortical carcinoma (ACC), a rare and lethal malignancy, is largely empirical and ineffective. New treatments directed at molecular targets critical to the pathophysiology of ACC may prove more efficacious... - Tpp1/Acd maintains genomic stability through a complex role in telomere protectionTobias Else
Department of Internal Medicine, Division of Endocrinology and Metabolism, The University of Michigan, Ann Arbor, MI 48109, USA
Chromosome Res 15:1001-13. 2007..Together, these studies show that Tpp1/Acd plays a vital role in telomere protection, but likely has additional functions yet to be defined... - Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha geneBrian M Gummow
Department of Molecular and Integrative Physiology, Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 278:26572-9. 2003..These data support the recent observation that beta-catenin can participate in nuclear receptor-mediated transcriptional activation and extend the findings to the monomer binding class of orphan nuclear receptors... - Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRAVictoria R Kelly
Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Endocrinol 24:2281-91. 2010..Thus, our results indicate that Dax1 plays an important role in the maintenance of pluripotency in mES cells through interaction with LRH-1 and transcriptional activation of Oct4 and other genes... - Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cellsJose L Garcia-Perez
Department of Human Genetics, 1241 East Catherine Street, University of Michigan Medical School, Ann Arbor, Michigan 48109 5618, USA
Nature 466:769-73. 2010..Thus, our data indicate that ECs differ from many differentiated cells in their ability to silence reporter genes delivered by L1 retrotransposition... - Novel polymorphisms and lack of mutations in the ACD gene in patients with ACTH resistance syndromesCatherine E Keegan
Department of Pediatrics, Division of Genetics, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
Clin Endocrinol (Oxf) 67:168-74. 2007..The human homolog of the Acd gene, mutated in a mouse model of adrenal insufficiency, was sequenced in 25 patients with a clinical diagnosis of familial glucocorticoid deficiency or triple A syndrome... - Resection of adrenocortical carcinoma is less complete and local recurrence occurs sooner and more often after laparoscopic adrenalectomy than after open adrenalectomyBarbra S Miller
Division of Endocrine Surgery, Section of General Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA
Surgery 152:1150-7. 2012..Controversy surrounds the use of laparoscopy for resection of adrenocortical carcinoma. We evaluated the hypothesis that outcome is equivalent in patients undergoing laparoscopic adrenalectomy versus open adrenalectomy... - Adrenocortical stem and progenitor cells: implications for adrenocortical carcinomaDerek P Simon
Cellular and Molecular Biology Training Program, University of Michigan, Ann Arbor, MI 48109, United States
Mol Cell Endocrinol 351:2-11. 2012..A more complete understanding of adrenocortical stem/progenitor cell biology will invariably aid in characterization of the molecular details of ACC tumorigenesis and may offer new options for therapeutic intervention... - Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activationJonathon N Winnay
Department of Molecular and Integrative Pysiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
Mol Endocrinol 20:147-66. 2006..In addition, the current study demonstrates that specific enzymatic activities are capable of regulating distinct facets of a highly ordered transcriptional response... - Evidence of adrenal failure in aging Dax1-deficient miceJoshua O Scheys
Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Endocrinology 152:3430-9. 2011.... - SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylationWei Hsiung Yang
Department of Internal Medicine, Division of Metabolism, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
Mol Cell Biol 29:613-25. 2009..Based on these observations, we propose a coordinated modification model in which inhibition of SF-1-mediated transcription by SUMOylation in adrenocortical cancer cells is mediated through reduced CDK7-induced phosphorylation of SF-1... - Adrenocortical stem and progenitor cells: unifying model of two proposed originsMichelle A Wood
University of Michigan, 109 Zina Pitcher Place, 1528 Biomedical Science Research Building, Ann Arbor, MI 48109, United States
Mol Cell Endocrinol 336:206-12. 2011.... - IMAGe association and congenital adrenal hypoplasia: no disease-causing mutations found in the ACD geneJanna E Hutz
Department of Pediatrics, Division of Genetics, University of Michigan, Ann Arbor, MI, USA
Mol Genet Metab 88:66-70. 2006..Sequencing of ACD in 15 patients revealed no coding mutations, but three novel SNPs were identified... - In search of adrenocortical stem and progenitor cellsAlex C Kim
Department of Internal Medicine, Division of Metabolism, Ann Arbor, Michigan 48109 2200, USA
Endocr Rev 30:241-63. 2009..Together, the work provides a framework for the emerging somatic stem cell field as it relates to the adrenal gland... - Mechanistic roles of inhibin as a tumor suppressor in the adrenal cortexBrendan Looyenga
University of Michigan, Ann Arbor, Michigan 48109, USA
Endocr Res 30:585-6. 2004 - Management of adrenocortical carcinomaJonathan R Strosberg
University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
J Natl Compr Canc Netw 7:752-8; quiz 759. 2009..This article describes the basic diagnostic and prognostic issues in adrenal cancer management, and presents detailed rationales for therapeutic management... - The role of radiologic studies in the evaluation and management of primary hyperaldosteronismMatthew L White
Division of Endocrine Surgery, Department of Surgery, University of Michigan, Ann Arbor, Mich, USA
Surgery 144:926-33; discussion 933. 2008..Surgical treatment of primary hyperaldosteronism (PHA) requires demonstration of unilateral adrenal hypersecretion. Optimal methods for interpretation of imaging and invasive testing are still in development... - Evaluation of telomere length maintenance mechanisms in adrenocortical carcinomaTobias Else
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 2200, USA
J Clin Endocrinol Metab 93:1442-9. 2008..Telomere maintenance mechanisms (TMMs) are critical for the persistence of the malignant phenotype, but little is known about these mechanisms or their diagnostic value in adrenocortical lesions... - Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinomaIrina Y Dobrosotskaya
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
Endocr Pract 17:e59-62. 2011..To describe successful long-term tumor control in metastatic adrenocortical carcinoma, a relatively rare tumor with limited treatment options outside of surgery... - Transsphenoidal microsurgery for Cushing's disease: initial outcome and long-term resultsGary D Hammer
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor, Michigan 48109 0678, USA
J Clin Endocrinol Metab 89:6348-57. 2004..These results suggest that patients with persistent Cushing's disease require early and aggressive intervention to attempt to prevent this excess mortality... - The molecular genetics of adrenocortical carcinomaFerdous M Barlaskar
Cellular and Molecular Biology Graduate Program, University of Michigan, BSRB 1502, Ann Arbor, MI 48109-2200, USA
Rev Endocr Metab Disord 8:343-8. 2007 - Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulatorCatherine E Keegan
Department of Pediatrics, Division of Genetics, University of Michigan, Ann Arbor, MI 48109-0789, USA
Hum Mol Genet 14:113-23. 2005..This is the first report to show that a telomeric regulator is required for proper urogenital ridge differentiation, axial skeleton specification and limb patterning in mice... - Prevalence of germline TP53 mutations in a prospective series of unselected patients with adrenocortical carcinomaVictoria M Raymond
Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 5419, USA
J Clin Endocrinol Metab 98:E119-25. 2013..Although existing criteria advocate for TP53 testing in all patients with ACC regardless of age at diagnosis, the overall prevalence of germline mutations in patients diagnosed with ACC has not been well studied... - Ectopic pro-opiomelanocortin syndromeFelix Beuschlein
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, 5560A MSRB II, 1150 West Medical Center Dr, Ann Arbor, MI 48109-0678, USA
Endocrinol Metab Clin North Am 31:191-234. 2002..Diagnostic imaging, including conventional radiological techniques and somatostatin receptor scintigraphy, aids in the correct localization and eventual treatment of ectopic POMC production... - Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis developmentSusan Y Park
Division of Endocrinology and Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Development 132:2415-23. 2005..Thus, although Sf1 and Dax1 function as transcriptional antagonists for many target genes in vitro, they act independently or cooperatively in vivo during male gonadal development... - Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesisUrs D Lichtenauer
Division of Endocrine Research, Department of Medicine Innenstadt, University Hospital Munich, Ziemssenstrasse 1, D 80336 Munich, Germany
Endocrinology 148:693-704. 2007.... - Telomere protection by mammalian Pot1 requires interaction with Tpp1Dirk Hockemeyer
Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Nat Struct Mol Biol 14:754-61. 2007.... - Gonadectomy in mice of the inbred strain CE/J induces proliferation of sub-capsular adrenal cells expressing gonadal marker genesInga K Johnsen
Division of Endocrinology and Metabolism, Department of Internal Medicine II, , D-79106 Freiburg, Germany
J Endocrinol 190:47-57. 2006..The distinct expression pattern of this cell population is consistent with a defect in the differentiation of these cells into a cell population with functional properties that otherwise define a gonadal endocrine phenotype... - Adrenocortical cells with stem/progenitor cell properties: recent advancesAlex C Kim
University of Michigan Medical School, Cell and Molecular Biology Training Program, 1502 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, United States
Mol Cell Endocrinol 265:10-6. 2007..In this review, we discuss historic developmental studies together with recent molecular examinations that aim to characterize such populations of cells... - Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortexAlex C Kim
Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0678 USA
Development 135:2593-602. 2008..These results define crucial roles for beta-catenin--presumably as part of the Wnt canonical signaling pathway--in both embryonic development of the adrenal cortex and in maintenance of the adult organ...