Marie Louise Hammarskjold
Affiliation: University of Virginia
Matume N, Tebit D, Gray L, Turner S, Rekosh D, Bessong P, et al
. Characterization of APOBEC3 variation in a population of HIV-1 infected individuals in northern South Africa. BMC Med Genet. 2019;20:21 pubmed publisher
..In the case of all of these genes, the polymorphisms were generally present at higher frequencies than reported in other 1000 genome populations and in the ExAC exome consortium database . ..
Sherpa C, Rausch J, Le Grice S, Hammarskjold M, Rekosh D. The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication. Nucleic Acids Res. 2015;43:4676-86 pubmed publisher
..Using subgenomic reporters, as well as HIV replication assays, we demonstrate that the five stem-loop form of the RRE promotes greater functional Rev/RRE activity compared to the four stem-loop counterpart. ..
Matume N, Tebit D, Gray L, Hammarskjold M, Rekosh D, Bessong P. Next generation sequencing reveals a high frequency of CXCR4 utilizing viruses in HIV-1 chronically infected drug experienced individuals in South Africa. J Clin Virol. 2018;103:81-87 pubmed publisher
..99; p?=?.008). The effectiveness of Maraviroc as a component in salvage therapy may be compromised for a significant number of chronically infected patients harboring CXCR4 utilizing viruses. ..
Li Y, Bor Y, Fitzgerald M, Lee K, Rekosh D, Hammarskjold M. An NXF1 mRNA with a retained intron is expressed in hippocampal and neocortical neurons and is translated into a protein that functions as an Nxf1 cofactor. Mol Biol Cell. 2016;27:3903-3912 pubmed
..We also show that sNxf1 forms heterodimers in conjunction with the full-length Nxf1 and that sNxf1 can replace Nxt1 to enhance the expression of CTE-containing mRNA and promote its association with polyribosomes. ..
Wang B, Rekosh D, Hammarskjold M. Evolutionary conservation of a molecular machinery for export and expression of mRNAs with retained introns. RNA. 2015;21:426-37 pubmed publisher
..This demonstrates that all essential functional components for expression of mRNA with retained introns have been conserved from fish to man. ..
Hammarskjold M, Rekosh D. SR proteins: To shuttle or not to shuttle, that is the question. J Cell Biol. 2017;216:1875-1877 pubmed publisher
..2017. J. Cell Biol https://doi.org/10.1083/jcb.201610051) show that SRSF2 and SRSF5, previously thought to be nuclear, shuttle with messenger RNA to the cytoplasm in pluripotent P19 cells, but not in differentiated cells. ..