Affiliation: University of California
- Hammaker D, Firestein G. "Go upstream, young man": lessons learned from the p38 saga. Ann Rheum Dis. 2010;69 Suppl 1:i77-82 pubmed publisher..Alternative strategies, such as targeting kinases higher in the signalling cascade or using less selective compounds, might be more successful as suggested by the efficacy seen with Syk and JAK inhibitors. ..
- Hammaker D, Boyle D, Inoue T, Firestein G. Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2007;9:R57 pubmed..The data identify TAK1 as a pivotal upstream kinase and potential therapeutic target to modulate synoviocyte activation in RA. ..