Steven Hamilton

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample
    Eric J Peters
    Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e1872. 2008
  2. pmc Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies
    S I Shyn
    Department of Psychiatry and Institute for Human Genetics, University of California, San Francisco, CA, USA
    Mol Psychiatry 16:202-15. 2011
  3. pmc Analysis of four DLX homeobox genes in autistic probands
    Steven P Hamilton
    Department of Psychiatry, University of California, San Francisco, CA, USA
    BMC Genet 6:52. 2005
  4. ncbi request reprint Investigation of polymorphisms in the CREM gene in panic disorder
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Med Genet B Neuropsychiatr Genet 126:111-5. 2004
  5. ncbi request reprint A family with X-linked anophthalmia: exclusion of SOX3 as a candidate gene
    Anne Slavotinek
    Department of Pediatrics, Division of Clinical Genetics, University of California, San Francisco, California 94143 0748, USA
    Am J Med Genet A 138:89-94. 2005
  6. ncbi request reprint Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University, New York, NY, USA
    Biol Psychiatry 51:591-601. 2002
  7. ncbi request reprint A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci
    Abby J Fyer
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 60:388-401. 2006
  8. pmc Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
    Jie Huang
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:1254-63. 2010
  9. pmc Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:2550-5. 2003
  10. pmc Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder
    Holly A Garriock
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Am J Psychiatry 167:565-73. 2010

Research Grants

  1. Pharmacogenomics of Antidepressant Response
    Steven Hamilton; Fiscal Year: 2006
  2. Pharmacogenomics of Antidepressant Response
    Steven Hamilton; Fiscal Year: 2007
  3. Genetic Determinants of COMT Expression
    Steven Hamilton; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. pmc Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample
    Eric J Peters
    Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e1872. 2008
    ..We sought to determine whether clinical response or tolerance to the Selective Serotonin Reuptake Inhibitor (SSRI) citalopram is associated with genetic polymorphisms in potentially relevant pharmacokinetic enzymes...
  2. pmc Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies
    S I Shyn
    Department of Psychiatry and Institute for Human Genetics, University of California, San Francisco, CA, USA
    Mol Psychiatry 16:202-15. 2011
    ..On the basis of previous biological evidence, we consider GRM7 a strong MDD candidate gene. Larger samples will be required to determine whether any common SNPs are significantly associated with MDD...
  3. pmc Analysis of four DLX homeobox genes in autistic probands
    Steven P Hamilton
    Department of Psychiatry, University of California, San Francisco, CA, USA
    BMC Genet 6:52. 2005
    ..We investigated the role that sequence variants in DLX genes play in autism by in-depth resequencing of these genes in 161 autism probands from the AGRE collection...
  4. ncbi request reprint Investigation of polymorphisms in the CREM gene in panic disorder
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Med Genet B Neuropsychiatr Genet 126:111-5. 2004
    ..These findings provide little additional evidence for a susceptibility locus for panic disorder either within the CREM gene or in a nearby region of chromosome 10p11 in our sample...
  5. ncbi request reprint A family with X-linked anophthalmia: exclusion of SOX3 as a candidate gene
    Anne Slavotinek
    Department of Pediatrics, Division of Clinical Genetics, University of California, San Francisco, California 94143 0748, USA
    Am J Med Genet A 138:89-94. 2005
    ..We have improved the definition of the phenotype in males with anophthalmia linked to the ANOP1 locus, as microcephaly, ocular colobomas, and severe renal malformations have not been described in families linked to ANOP1...
  6. ncbi request reprint Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University, New York, NY, USA
    Biol Psychiatry 51:591-601. 2002
    ....
  7. ncbi request reprint A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci
    Abby J Fyer
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 60:388-401. 2006
    ..Panic disorder (PD) is a common illness with a definite but "complex" genetic contribution and estimated heritability of 30-46%...
  8. pmc Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
    Jie Huang
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:1254-63. 2010
    ..The purpose of this study was to apply genomewide association study (GWAS) analysis to address the specificity of genetic effects on these disorders...
  9. pmc Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:2550-5. 2003
    ....
  10. pmc Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder
    Holly A Garriock
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Am J Psychiatry 167:565-73. 2010
    ....
  11. pmc Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response
    Eric J Peters
    Department of Psychiatry and Institute for Human Genetics, University of California, San Francisco, CA, USA
    Pharmacogenet Genomics 19:1-10. 2009
    ..It appears that genetic variation in these five genes has a marginal effect on response to citalopram, although a previously observed association was supported and awaits replication in an independent sample...
  12. pmc A genomewide association study of citalopram response in major depressive disorder
    Holly A Garriock
    Department of Psychiatry and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Biol Psychiatry 67:133-8. 2010
    ..We have carried out a genomewide association study to determine whether common DNA variation influences antidepressant response...
  13. ncbi request reprint Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample
    Jeffrey B Kraft
    Department of Psychiatry and Center for Human Genetics, University of California, San Francisco, California 94143 0984, USA
    Biol Psychiatry 61:734-42. 2007
    ..We sought to replicate our previous findings that SLC6A4 is associated with response to a selective serotonin reuptake inhibitor (SSRI) in a large case-control study...
  14. ncbi request reprint Sequence analysis of the serotonin transporter and associations with antidepressant response
    Jeffrey B Kraft
    Department of Psychiatry and Center for Human Genetics, University of California San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Biol Psychiatry 58:374-81. 2005
    ..We sought to test further the hypothesis that SLC6A4 is associated with SSRI response by resequencing this gene in subjects with major depression...
  15. ncbi request reprint Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, New York City, NY 10032, USA
    Neuropsychopharmacology 29:558-65. 2004
    ....
  16. ncbi request reprint Large-scale SNP genotyping with canine buccal swab DNA
    Melanie Lee Chang
    Department of Psychiatry and Institute for Human Genetics, Langley Porter Psychiatric Institute, University of California San Francisco, Box 0984 NGL, San Francisco, CA 94143 0984, USA
    J Hered 98:428-37. 2007
    ..These results demonstrate the suitability of amplified canine buccal samples for high-throughput multiplex genotyping and confirm extensive LD in the dog...
  17. doi request reprint Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder
    Laura M Hodges
    Department of Psychiatry, Institute for Human Genetics, University of California, San Francisco, 94143 0984, USA
    Am J Med Genet B Neuropsychiatr Genet 150:65-73. 2009
    ..Further exploration of the GRP and TACR1 findings in large case-control PD samples may provide more definitive evidence implicating these loci in the genetic etiology of PD...
  18. pmc Array-based whole-genome survey of dog saliva DNA yields high quality SNP data
    Jennifer S Yokoyama
    Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 5:e10809. 2010
    ..We thus investigated an animal-based saliva collection method for ease of use and quality of DNA obtained and tested the performance of saliva-extracted canine DNA on genome-wide genotyping arrays...
  19. ncbi request reprint Early-onset fearful panic attack: a possible prodrome of early-onset severe psychopathology
    Renee D Goodwin
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 43, New York, NY 10032, USA
    Compr Psychiatry 43:22-7. 2002
    ..Replication of these findings in other epidemiologic and clinical samples is needed...
  20. ncbi request reprint Schizophrenia candidate genes: are we really coming up blank?
    Steven P Hamilton
    Am J Psychiatry 165:420-3. 2008
  21. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
    ....

Research Grants5

  1. Pharmacogenomics of Antidepressant Response
    Steven Hamilton; Fiscal Year: 2006
    ..These findings could provide steps toward our ability to define clinically useful genetic predictors of pharmacological treatment and apply them to patient populations. ..
  2. Pharmacogenomics of Antidepressant Response
    Steven Hamilton; Fiscal Year: 2007
    ..These findings could provide steps toward our ability to define clinically useful genetic predictors of pharmacological treatment and apply them to patient populations. ..
  3. Genetic Determinants of COMT Expression
    Steven Hamilton; Fiscal Year: 2007
    ..This in vitro work may be useful for the understanding of the genetic contribution of COMT to disease susceptibility, particularly with regard to the cis regulation of the COMT locus. ..