Jessica A Hamerman

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog
    Jessica A Hamerman
    Department of Immunology, University of Washington, Seattle, WA 98185, USA
    J Immunol 168:2415-23. 2002
  2. pmc Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells
    Natalia V Giltiay
    Department of Immunology and 2 Division of Rheumatology, School of Medicine, University of Washington, Seattle, WA 98195
    J Exp Med 210:2773-89. 2013
  3. pmc TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury
    Gabriela Campanholle
    Division of Nephrology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e68640. 2013
  4. pmc Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice
    Xizhang Sun
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 190:2536-43. 2013
  5. pmc β(2) integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation
    Nathan K Yee
    Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA
    Eur J Immunol 43:779-92. 2013
  6. pmc DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
    J Immunol 184:6522-8. 2010
  7. pmc Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung
    Anupam Jhingran
    Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cell Rep 2:1762-73. 2012
  8. pmc Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling
    Matthew B Buechler
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 190:886-91. 2013
  9. pmc B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K
    Minjian Ni
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    Proc Natl Acad Sci U S A 109:267-72. 2012
  10. pmc The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells
    Jessica A Hamerman
    Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA
    Immunol Rev 232:42-58. 2009

Collaborators

  • Clifford A Lowell
  • Edward A Clark
  • Ruedi Aebersold
  • Sina A Gharib
  • Silvia Bolland
  • Tobias M Hohl
  • Laura L Koth
  • Lewis L Lanier
  • Arthur Haas
  • A Aderem
  • Ananda W Goldrath
  • Matthew B Buechler
  • Keith B Elkon
  • Xizhang Sun
  • Thomas H Teal
  • Kouetsu Ogasawara
  • Natalia V Giltiay
  • Nathan K Yee
  • Lena Tanaka
  • Gabriela Campanholle
  • Anupam Jhingran
  • Minjian Ni
  • Ching Liang Chu
  • Mathieu Epardaud
  • Jim Kim
  • Lauren I Richie Ehrlich
  • Melissa Lodoen
  • Simona Zompi
  • Adelheid Cerwenka
  • Charles E Alpers
  • Akio Kobayashi
  • Denny Liggitt
  • Kelly L Hudkins
  • Craig P Chappell
  • Alice E Wiedeman
  • Kristen Mittelsteadt
  • Nalini Agrawal
  • Nikita Kolhatkar
  • Jeffrey A Ledbetter
  • Jeremy S Duffield
  • Shunsaku Nakagawa
  • Jinoh Kim
  • Alice Wiedeman
  • William A Altemeier
  • Thereza Imanishi-Kari
  • Jay W Heinecke
  • Shuei Liong Lin
  • Brahm H Segal
  • Kerry S Campbell
  • Michelle Toft
  • Sue E Knoblaugh
  • Debra K Kumasaka
  • Katrina B Mar
  • Alexander W MacFarlane
  • Xin Lin
  • Lisa Y Ngo
  • Yoichiro Iwakura
  • Shannon J Turley
  • Ai ris Yonekura
  • Mark P Rubinstein
  • Kuan Yin Shen
  • Roderick Bronson
  • Yen Ling Yu
  • Angelique Bellemare-Pelletier
  • Kutlu G Elpek
  • Sang Mo Kang
  • Jonathan Benjamin
  • Feng Chun Liu
  • Catherine K Chang
  • Tracy Hayden
  • Alessandra Zingoni
  • Rayna Takaki
  • James P Allison
  • Shunsuke Chikuma
  • Helene Bour-Jordan
  • Edina Schweighoffer
  • Edward S Mocarski
  • Hisashi Arase
  • Thomas Pertel
  • Taian Chen
  • Victor L J Tybulewicz
  • Jeffrey A Bluestone
  • Francesco Colucci
  • James P Di Santo
  • Honor Hsin
  • Claude Carnaud
  • Jeffrey P Houchins
  • Sebastian Joyce
  • Wilfred Ajayi
  • Christopher A O'Callaghan

Detail Information

Publications22

  1. ncbi request reprint Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog
    Jessica A Hamerman
    Department of Immunology, University of Washington, Seattle, WA 98185, USA
    J Immunol 168:2415-23. 2002
    ..Macrophage activation is accompanied by the activation of a variety of proteases. It is of interest that a member of the serine protease inhibitor family is concomitantly induced and modified by a ubiquitin-like protein...
  2. pmc Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells
    Natalia V Giltiay
    Department of Immunology and 2 Division of Rheumatology, School of Medicine, University of Washington, Seattle, WA 98195
    J Exp Med 210:2773-89. 2013
    ..Our results demonstrate that initial TLR7 stimulation of B cells occurs at the T1 stage of differentiation in the splenic RP and suggest that dysregulation of TLR7 expression in T1 cells can result in production of autoantibodies. ..
  3. pmc TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury
    Gabriela Campanholle
    Division of Nephrology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e68640. 2013
    ..To conclude, TREM-1, TLR2/4 and MyD88 signaling pathways are redundant in myeloid cell activation in kidney injury, but the latter appear to regulate activation of mesenchymal cells. ..
  4. pmc Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice
    Xizhang Sun
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 190:2536-43. 2013
    ....
  5. pmc β(2) integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation
    Nathan K Yee
    Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA
    Eur J Immunol 43:779-92. 2013
    ..Thus, β(2) integrins limit TLR signaling by inhibiting NF-κB pathway activation and promoting p38 MAPK activation, thereby fine-tuning TLR-induced inflammatory responses...
  6. pmc DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
    J Immunol 184:6522-8. 2010
    ..These findings indicate that DAP12, possibly through association with TREM2, contributes to alveolar macrophage chemotaxis and recruitment to the lung and may mediate macrophage accumulation in lung diseases such as emphysema...
  7. pmc Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung
    Anupam Jhingran
    Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cell Rep 2:1762-73. 2012
    ....
  8. pmc Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling
    Matthew B Buechler
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 190:886-91. 2013
    ..This study shows that type I IFN can act upon myeloid progenitors to promote the development of emergency GMP, which leads to an expansion of their progeny in the periphery...
  9. pmc B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K
    Minjian Ni
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    Proc Natl Acad Sci U S A 109:267-72. 2012
    ..Therefore, BCAP is an essential activator of the PI3K pathway downstream of TLR signaling, providing a brake to limit potentially pathogenic excessive TLR responses...
  10. pmc The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells
    Jessica A Hamerman
    Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA
    Immunol Rev 232:42-58. 2009
    ..In this review, we discuss the newly described receptors that utilize DAP12 and/or FcRgamma adapters to modulate innate immune responses...
  11. pmc Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
    Jessica A Hamerman
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143, USA
    Nat Immunol 6:579-86. 2005
    ..These data suggest that one or more DAP12-pairing receptors negatively regulate signaling through TLRs...
  12. ncbi request reprint Impairment of NK cell function by NKG2D modulation in NOD mice
    Kouetsu Ogasawara
    Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue HSE 420, Box 0414, San Francisco, CA 94143, USA
    Immunity 18:41-51. 2003
    ..Modulation of NKG2D was mostly dependent on the YxxM motif of DAP10, the NKG2D-associated adaptor that activates phosphoinositide 3 kinase. These results suggest that NK cells may be desensitized by exposure to NKG2D ligands...
  13. doi request reprint Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells
    Mathieu Epardaud
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Res 68:2972-83. 2008
    ....
  14. ncbi request reprint Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D
    Adelheid Cerwenka
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 168:3131-4. 2002
    ..Ligands of the human NKG2D receptor are remarkably polymorphic, suggesting that these may also serve as minor histocompatibility Ags...
  15. ncbi request reprint The activating immunoreceptor NKG2D and its ligands are involved in allograft transplant rejection
    Jim Kim
    Transplantation Research Laboratory, Division of Transplantation, Department of Surgery, University of California, San Francisco, CA 94143, USA
    J Immunol 179:6416-20. 2007
    ..Notably, NKG2D blockade did not deplete CD8(+) T cells or NK1.1(+) cells nor affect their migration to the allografts. These results establish a functional role of NKG2D and its ligands in the rejection of solid organ transplants...
  16. ncbi request reprint Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
    Jessica A Hamerman
    Department of Microbiology and Immunology, University of California San Francisco, 514 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 177:2051-5. 2006
    ..A TREM-2 Fc fusion protein bound to macrophages, indicating that macrophages express a TREM-2 ligand. Thus, the interaction of TREM-2 and its ligand results in an inhibitory signal that can reduce the inflammatory response...
  17. ncbi request reprint Inhibition of immune responses by ITAM-bearing receptors
    Jessica A Hamerman
    Department of Microbiology and Immunology, Cancer Research Institute, University of California, Box 0414, HSE1001, San Francisco, CA 94143 0414, USA
    Sci STKE 2006:re1. 2006
    ..Here, we discuss these new negative roles for signaling by receptors that associate with ITAM-bearing adaptors in myeloid and other cell types within the immune system...
  18. ncbi request reprint Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells
    Lauren I Richie Ehrlich
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 174:1922-31. 2005
    ..It is, therefore, likely that NKG2D acts as a costimulatory molecule only under restricted conditions or requires additional cofactors...
  19. ncbi request reprint Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor
    Jessica A Hamerman
    Department of Microbiology and Immunology, and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 172:2001-5. 2004
    ..RAE-1-NKG2D interactions provide a mechanism by which NK cells and infected macrophages communicate directly during an innate immune response to infection...
  20. pmc NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules
    Melissa Lodoen
    Department of Microbiology and Immunology, Box 0414, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 197:1245-53. 2003
    ..These experiments demonstrate that gp40 impairs NK cell recognition of virus-infected cells through disrupting the RAE-1-NKG2D interaction...
  21. ncbi request reprint NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases
    Simona Zompi
    Department of Immunology, Pasteur Institute, 25 28 rue Dr Roux, 75015 Paris, France
    Nat Immunol 4:565-72. 2003
    ....
  22. pmc Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma
    Ching Liang Chu
    Immunology Research Center, National Health Research Institutes, Taiwan
    Eur J Immunol 38:166-73. 2008
    ....