FREDERICK HAMEL

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Redox regulation of insulin degradation by insulin-degrading enzyme
    Crystal M Cordes
    Research Service, Omaha Veterans Affairs Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e18138. 2011
  2. doi request reprint Preliminary report: inhibition of cellular proteasome activity by free fatty acids
    Frederick G Hamel
    Omaha VA Medical Center, Omaha, NE 68105, USA
    Metabolism 58:1047-9. 2009
  3. ncbi request reprint Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cells
    F G Hamel
    Research Service, VA Medical Center, Omaha, NE 68105, USA
    Diabetes Obes Metab 8:661-8. 2006
  4. ncbi request reprint Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes
    F G Hamel
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Endocrinology 142:2702-6. 2001
  5. ncbi request reprint Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors
    F G Hamel
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    J Endocrinol Invest 26:1088-94. 2003
  6. ncbi request reprint In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters
    Frederick G Hamel
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Endocrinology 144:2404-8. 2003
  7. ncbi request reprint Control of proteolysis: hormones, nutrients, and the changing role of the proteasome
    Frederick G Hamel
    Research Service, Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, 68105, USA
    Curr Opin Clin Nutr Metab Care 7:255-8. 2004
  8. ncbi request reprint Relaxin receptors in hepatic stellate cells and cirrhotic liver
    Robert G Bennett
    Department of Medical Research, Veterans Affairs Medical Center, 4001 Woolworth Avenue, Omaha, NE 68105, USA
    Biochem Pharmacol 73:1033-40. 2007
  9. ncbi request reprint Long-term effects of a PPAR-gamma agonist, pioglitazone, on neointimal hyperplasia and endothelial regrowth in insulin resistant rats
    Cyrus V Desouza
    Omaha Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Vascul Pharmacol 46:188-94. 2007
  10. ncbi request reprint Inhibition of proteasome activity by selected amino acids
    Frederick G Hamel
    Research Service, Department of Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Metabolism 52:810-4. 2003

Research Grants

Detail Information

Publications15

  1. pmc Redox regulation of insulin degradation by insulin-degrading enzyme
    Crystal M Cordes
    Research Service, Omaha Veterans Affairs Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e18138. 2011
    ....
  2. doi request reprint Preliminary report: inhibition of cellular proteasome activity by free fatty acids
    Frederick G Hamel
    Omaha VA Medical Center, Omaha, NE 68105, USA
    Metabolism 58:1047-9. 2009
    ..This mechanism may be applicable to whole animals and represents a means to integrate hormonal and nutrient signals on the control of protein degradation...
  3. ncbi request reprint Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cells
    F G Hamel
    Research Service, VA Medical Center, Omaha, NE 68105, USA
    Diabetes Obes Metab 8:661-8. 2006
    ....
  4. ncbi request reprint Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes
    F G Hamel
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Endocrinology 142:2702-6. 2001
    ..The antibody eliminated the inhibitory effect of insulin. We conclude that insulin inhibits peroxisomal fatty acid oxidation by a mechanism requiring IDE...
  5. ncbi request reprint Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors
    F G Hamel
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    J Endocrinol Invest 26:1088-94. 2003
    ..These results suggest insulin actions are mediated by multiple and redundant effector systems, but that receptor tyrosine kinase activity is not required for inhibition of protein degradation...
  6. ncbi request reprint In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters
    Frederick G Hamel
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Endocrinology 144:2404-8. 2003
    ..This mechanism may contribute to the hyperinsulinemia and insulin resistance seen with elevated fatty acids and obesity...
  7. ncbi request reprint Control of proteolysis: hormones, nutrients, and the changing role of the proteasome
    Frederick G Hamel
    Research Service, Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, 68105, USA
    Curr Opin Clin Nutr Metab Care 7:255-8. 2004
    ..We will examine some recent data regarding the mechanisms for control of the peptidolytic activities of the proteasome, and possible implications for signal transduction and integration...
  8. ncbi request reprint Relaxin receptors in hepatic stellate cells and cirrhotic liver
    Robert G Bennett
    Department of Medical Research, Veterans Affairs Medical Center, 4001 Woolworth Avenue, Omaha, NE 68105, USA
    Biochem Pharmacol 73:1033-40. 2007
    ..Cirrhosis also caused increased expression of both receptors. Therefore, agents that stimulate LGR8 and LGR7 may be therapeutically useful to limit the activation of hepatic stellate cells in liver injury...
  9. ncbi request reprint Long-term effects of a PPAR-gamma agonist, pioglitazone, on neointimal hyperplasia and endothelial regrowth in insulin resistant rats
    Cyrus V Desouza
    Omaha Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Vascul Pharmacol 46:188-94. 2007
    ..PPAR-gamma agonists like pioglitazone decrease insulin resistance and have been shown to reduce neointimal hyperplasia in the short-term. However long-term studies on endothelial regrowth and neointimal hyperplasia have not been done...
  10. ncbi request reprint Inhibition of proteasome activity by selected amino acids
    Frederick G Hamel
    Research Service, Department of Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Metabolism 52:810-4. 2003
    ....
  11. ncbi request reprint Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats
    Jennifer L Larsen
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Transplantation 82:466-70. 2006
    ..Tacrolimus-sirolimus immunosuppression has improved islet graft survival but may affect islet function...
  12. ncbi request reprint Neointimal hyperplasia and vascular endothelial growth factor expression are increased in normoglycemic, insulin resistant, obese fatty rats
    Cyrus V Desouza
    Research Service, Omaha Veterans Affairs Medical Center, Section of Diabetes, Endocrinology and Metabolism, University of Nebraska Medical Center, Omaha, NE 68105, USA
    Atherosclerosis 184:283-9. 2006
    ..We studied NH and VEGF expression in an obese, insulin resistant, but normoglycemic rat model, after carotid balloon injury...
  13. ncbi request reprint An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures
    Robert G Bennett
    Department of Internal Medicine, University of Nebraska Medical Center, and Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Diabetes 52:2315-20. 2003
    ..IDE inhibition by bacitracin impaired amylin degradation, increased amyloid formation, and increased amylin-induced cytotoxicity, suggesting a role for IDE in amylin clearance and the prevention of amylin aggregation...
  14. ncbi request reprint Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines
    Thomas L Freeman
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Chem Res Toxicol 18:817-24. 2005
    ..These data suggest that cigarette smoke may promote the modification of proteins, like those associated with oxidized low-density lipoprotein, and may contribute to smoking-related disease...
  15. ncbi request reprint Biological activity of a fragment of insulin
    William C Duckworth
    Endocrinology Section, Carl T Hayden VA Medical Center, Phoenix, AZ, USA
    Biochem Biophys Res Commun 318:1019-24. 2004
    ..This supports a biologically important effect of insulin metabolism and insulin degradation products on insulin action on non-glucose pathways...

Research Grants3

  1. HIV Protease Inhibitors: Insulin Resistance & Insulysin
    FREDERICK HAMEL; Fiscal Year: 2005
    ..If insulin-degrading enzyme is involved, HIV protease inhibitors could be developed or screened for minimal reactivity with IDE. ..
  2. HIV Protease Inhibitors: Insulin Resistance & Insulysin
    FREDERICK HAMEL; Fiscal Year: 2006
    ..If insulin-degrading enzyme is involved, HIV protease inhibitors could be developed or screened for minimal reactivity with IDE. ..
  3. HIV Protease Inhibitors: Insulin Resistance & Insulysin
    FREDERICK HAMEL; Fiscal Year: 2007
    ..If insulin-degrading enzyme is involved, HIV protease inhibitors could be developed or screened for minimal reactivity with IDE. ..