Research Topics
Genomes and GenesSpecies | FREDERICK HAMELSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytesF G Hamel
Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
Endocrinology 142:2702-6. 2001..The antibody eliminated the inhibitory effect of insulin. We conclude that insulin inhibits peroxisomal fatty acid oxidation by a mechanism requiring IDE...- Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cellsF G Hamel
Research Service, VA Medical Center, Omaha, NE 68105, USA
Diabetes Obes Metab 8:661-8. 2006.... 
Preliminary report: inhibition of cellular proteasome activity by free fatty acidsFrederick G Hamel
Omaha VA Medical Center, Omaha, NE 68105, USA
Metabolism 58:1047-9. 2009..This mechanism may be applicable to whole animals and represents a means to integrate hormonal and nutrient signals on the control of protein degradation...- Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptorsF G Hamel
Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
J Endocrinol Invest 26:1088-94. 2003..These results suggest insulin actions are mediated by multiple and redundant effector systems, but that receptor tyrosine kinase activity is not required for inhibition of protein degradation... - In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioestersFrederick G Hamel
Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
Endocrinology 144:2404-8. 2003..This mechanism may contribute to the hyperinsulinemia and insulin resistance seen with elevated fatty acids and obesity... - An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell culturesRobert G Bennett
Department of Internal Medicine, University of Nebraska Medical Center, and Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
Diabetes 52:2315-20. 2003..IDE inhibition by bacitracin impaired amylin degradation, increased amyloid formation, and increased amylin-induced cytotoxicity, suggesting a role for IDE in amylin clearance and the prevention of amylin aggregation... - Relaxin receptors in hepatic stellate cells and cirrhotic liverRobert G Bennett
Department of Medical Research, Veterans Affairs Medical Center, 4001 Woolworth Avenue, Omaha, NE 68105, USA
Biochem Pharmacol 73:1033-40. 2007..Cirrhosis also caused increased expression of both receptors. Therefore, agents that stimulate LGR8 and LGR7 may be therapeutically useful to limit the activation of hepatic stellate cells in liver injury... - Long-term effects of a PPAR-gamma agonist, pioglitazone, on neointimal hyperplasia and endothelial regrowth in insulin resistant ratsCyrus V Desouza
Omaha Veterans Affairs Medical Center, Omaha, NE 68105, USA
Vascul Pharmacol 46:188-94. 2007..PPAR-gamma agonists like pioglitazone decrease insulin resistance and have been shown to reduce neointimal hyperplasia in the short-term. However long-term studies on endothelial regrowth and neointimal hyperplasia have not been done... - Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley ratsJennifer L Larsen
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Transplantation 82:466-70. 2006..Tacrolimus-sirolimus immunosuppression has improved islet graft survival but may affect islet function... - Neointimal hyperplasia and vascular endothelial growth factor expression are increased in normoglycemic, insulin resistant, obese fatty ratsCyrus V Desouza
Research Service, Omaha Veterans Affairs Medical Center, Section of Diabetes, Endocrinology and Metabolism, University of Nebraska Medical Center, Omaha, NE 68105, USA
Atherosclerosis 184:283-9. 2006..We studied NH and VEGF expression in an obese, insulin resistant, but normoglycemic rat model, after carotid balloon injury... - Inhibition of proteasome activity by selected amino acidsFrederick G Hamel
Research Service, Department of Veterans Affairs Medical Center, Omaha, NE 68105, USA
Metabolism 52:810-4. 2003.... - Control of proteolysis: hormones, nutrients, and the changing role of the proteasomeFrederick G Hamel
Research Service, Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, 68105, USA
Curr Opin Clin Nutr Metab Care 7:255-8. 2004..We will examine some recent data regarding the mechanisms for control of the peptidolytic activities of the proteasome, and possible implications for signal transduction and integration... - Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysinesThomas L Freeman
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Chem Res Toxicol 18:817-24. 2005..These data suggest that cigarette smoke may promote the modification of proteins, like those associated with oxidized low-density lipoprotein, and may contribute to smoking-related disease... - Biological activity of a fragment of insulinWilliam C Duckworth
Endocrinology Section, Carl T Hayden VA Medical Center, Phoenix, AZ, USA
Biochem Biophys Res Commun 318:1019-24. 2004..This supports a biologically important effect of insulin metabolism and insulin degradation products on insulin action on non-glucose pathways...
Research Grants
- HIV Protease Inhibitors: Insulin Resistance & InsulysinFREDERICK HAMEL; Fiscal Year: 2007..If insulin-degrading enzyme is involved, HIV protease inhibitors could be developed or screened for minimal reactivity with IDE. ..