Research Topics
| Michael HambidgeSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
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Detail Information
Publications
Zinc homeostasis in Malawian children consuming a high-phytate, maize-based dietMark J Manary
Department of Pediatrics, Washington University School of Medicine, St Louis, USA
Am J Clin Nutr 75:1057-61. 2002..The gastrointestinal tract plays a central role in absorbing and conserving zinc, yet it has not been carefully studied in such children...- Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infantsNancy F Krebs
Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
Am J Clin Nutr 84:1340-3. 2006..Small-for-gestational-age (SGA) infants are susceptible to postnatal zinc deficiency, but whether this susceptibility is due to intrauterine factors or to high postnatal growth requirements is unknown... - Evaluation of zinc metabolism with use of stable-isotope techniques: implications for the assessment of zinc statusK M Hambidge
Department of Pediatrics and University of Colorado Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
Am J Clin Nutr 68:410S-413S. 1998..Further, judicious application of zinc stable-isotope techniques could make an important contribution to progress toward the eradication of zinc deficiency in infants and young children in the developing world... - Zinc absorption from low-phytate hybrids of maize and their wild-type isohybridsK Michael Hambidge
University of Colorado Health Sciences Center, Department of Pediatrics, Section of Nutrition, Denver 80262, USA
Am J Clin Nutr 79:1053-9. 2004.... 
Absorption of calcium from tortilla meals prepared from low-phytate maizeK Michael Hambidge
Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Clin Nutr 82:84-7. 2005..Bioavailability of calcium is, however, compromised by phytate, which is present in large quantities in maize kernels and is only modestly reduced by nixtamalization...- Measurements of zinc absorption: application and interpretation in research designed to improve human zinc nutritureK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Box C225, 4200 E 9th Av, Denver, Colorado, 80262, USA
Int J Vitam Nutr Res 75:385-93. 2005..They also suggest the potential utility of measurements of the quantity of zinc absorbed when evaluating the zinc status of populations... - Zinc absorption during late pregnancy in rural southern EthiopiaK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
Am J Clin Nutr 84:1102-6. 2006..Little is yet known about zinc absorption in late pregnancy, and no information on absorption from the total diet is available... - Changes in zinc absorption during developmentK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Pediatr 149:S64-8. 2006..Normal homeostatic mechanisms in the premature infant prevented efficient absorption of the quantity of Zn required or/and optimal conservation of endogenous Zn... - Zinc deficiency: a special challengeK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80220, USA
J Nutr 137:1101-5. 2007..Barriers to acceptability and availability of affordable meat are considered, but these are neither universal nor irresolvable in all populations... - Intestinal excretion of endogenous zinc in Guatemalan school childrenK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Nutr 137:1747-9. 2007..Supported by other recent childhood data, these results suggest that the current estimates of EFZ(PR) used in the calculation of Zn requirements for children are misleadingly low... - Dietary reference intakes for zinc may require adjustment for phytate intake based upon model predictionsK Michael Hambidge
Department of Pediatrics, Section of Nutrition, University of Colorado, School of Medicine, Denver, CO 80262, USA
J Nutr 138:2363-6. 2008..4 mg Zn/d. Extrapolation of the model suggested, for example, that with 900 mg/d phytate, 100 mg dietary Zn is required to attain 6.4 mg absorbed Zn/d. Experimental studies with higher Zn intakes are required to test these predictions... - Underwood Memorial Lecture: human zinc homeostasis: good but not perfectMichael Hambidge
Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Nutr 133:1438S-42S. 2003.... - Biomarkers of trace mineral intake and statusMichael Hambidge
University of Colorado Health Science Center, Denver, CO 80262, USA
J Nutr 133:948S-955S. 2003..Also of special current interest is full definition of the potential of plasma-soluble transferrin receptor concentrations as the biomarker of choice for the detection of early functional iron deficiency... - Interrelationships of key variables of human zinc homeostasis: relevance to dietary zinc requirementsM Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Annu Rev Nutr 21:429-52. 2001..This applies especially to the positive relationship between endogenous fecal zinc and total absorbed zinc, which is the essential starting point in estimating physiologic and, from there, dietary requirements... - Zinc absorption from a low-phytic acid maizeChristina L Adams
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80220, USA
Am J Clin Nutr 76:556-9. 2002..30 +/- 0.13 and 0.17 +/- 0.11, respectively (P < 0.005). CONCLUSION: Substitution of a low-phytic acid grain in a maize-based diet is associated with a substantial increase in zinc absorption... - Zinc homeostasis during lactation in a population with a low zinc intakeLei Sian
Section of Nutrition, The Department of Pediatrics, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Clin Nutr 75:99-103. 2002.... - Human zinc metabolism: advances in the modeling of stable isotope dataL V Miller
Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
Adv Exp Med Biol 445:253-69. 1998..While identifiability could not be demonstrated a priori due to the model's complexity, parameter statistics for the fitted models did show most parameters to be adequately identified a posteriori... - Zinc metabolism and homeostasis: the application of tracer techniques to human zinc physiologyN E Krebs
Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
Biometals 14:397-412. 2001.... - Development of a compartmental model of human zinc metabolism: identifiability and multiple studies analysesL V Miller
Section of Nutrition, Department of Pediatrics and Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Physiol Regul Integr Comp Physiol 279:R1671-84. 2000..The model was judged to be valid based on criteria described elsewhere... 
Training traditional birth attendants on the WHO Essential Newborn Care reduces perinatal mortalityAna Garces
IMSALUD, Guatemala City, Guatemala
Acta Obstet Gynecol Scand 91:593-7. 2012....- Complementary feeding: clinically relevant factors affecting timing and compositionNancy F Krebs
Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80252, USA
Am J Clin Nutr 85:639S-645S. 2007.... - Inadequate intakes of dietary zinc among pregnant women from subsistence households in Sidama, Southern EthiopiaYewelsew Abebe
College of Agriculture, Hawassa University, Awassa, Ethiopia
Public Health Nutr 11:379-86. 2008..To assess the prevalence of zinc inadequacy based on dietary intakes and plasma zinc concentrations and, simultaneously, the prevalence of inadequate intakes of energy, protein, calcium and iron... - A mathematical model of zinc absorption in humans as a function of dietary zinc and phytateLeland V Miller
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Nutr 137:135-41. 2007..The model was judged to be valid and of immediate value for studying and predicting absorption. A version of the model incorporating a passive absorption mechanism was not supported by the available data... - Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern EthiopiaRosalind S Gibson
Department of Human Nutrition, University of Otago, Dunedin, New Zealand 9015
J Nutr 138:581-6. 2008..Despite some early functional vitamin B-12 deficiency, there was no macrocytic anemia. Consumption of fermented enset may have increased vitamin B-12 levels in diet and plasma... - Major variables of zinc homeostasis in Chinese toddlersXiao Yang Sheng
Department of Child and Adolescent Health, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Am J Clin Nutr 84:389-94. 2006..The data required for this approach have not been available for toddlers, whose requirements have been estimated by extrapolation from other age groups... - Exchangeable zinc pool size in infants is related to key variables of zinc homeostasisNancy F Krebs
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Nutr 133:1498S-501S. 2003..We conclude that the amount of absorbed zinc is not tightly regulated, and that endogenous fecal zinc is dependent on and responsive to the zinc status of the organism... - Zinc homeostasis in premature infants does not differ between those fed preterm formula or fortified human milkSanju Jalla
Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
Pediatr Res 56:615-20. 2004..Current zinc intakes from fortified human milk or formula are associated with acceptable weight gain, but whether the observed net zinc absorption was optimal in the human milk group cannot be definitively determined from these data... - Zinc absorption as a function of the dose of zinc sulfate in aqueous solutionCuong D Tran
Section of Nutrition, Department of Pediatrics, The University of Colorado Health Science Center, Denver, USA
Am J Clin Nutr 80:1570-3. 2004..Zinc supplements are used extensively in medicine and research and for public health purposes in the prevention and treatment of zinc deficiency. However, little is known about the efficiency of zinc utilization after different doses... - Longitudinal measurements of zinc absorption in Peruvian children consuming wheat products fortified with iron only or iron and 1 of 2 amounts of zincDaniel Lopez de Romaña
Program in International Nutrition and the Department of Nutrition, University of California, Davis 95616, USA
Am J Clin Nutr 81:637-47. 2005..Information is needed on the fractional absorption of zinc (FAZ) and absorbed zinc (AZ) during prolonged exposure to zinc-fortified foods... - Community-based dietary phytate reduction and its effect on iron status in Malawian childrenMark J Manary
Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
Ann Trop Paediatr 22:133-6. 2002..Phytate was removed by soaking maize flour in excess water with phytase and decanting the water before cooking the flour. Iron status, as measured by soluble transferrin receptor and zinc protoporphyrin, was improved but not normal... - Dysprosium as a nonabsorbable fecal marker in studies of zinc homeostasisXiao-Yang Sheng
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Clin Nutr 82:1017-23. 2005..95) with those from the fecal monitoring and dual-isotope-tracer ratio methods. CONCLUSION: Administration of dysprosium is a useful means of determining the completeness of fecal collections and of measuring zinc absorption... - Zinc absorption in Guatemalan schoolchildren fed normal or low-phytate maizeManolo Mazariegos
Center for Studies of Sensory Impairments, Aging, and Metabolism, Guatemala City, Guatemala
Am J Clin Nutr 83:59-64. 2006..Poor bioavailability of zinc from high-phytate diets is an important contributory factor to zinc deficiency in low-income populations... - Meat as a first complementary food for breastfed infants: feasibility and impact on zinc intake and statusNancy F Krebs
Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Pediatr Gastroenterol Nutr 42:207-14. 2006..This study was undertaken to assess the feasibility and effects of consuming either meat or iron-fortified infant cereal as the first complementary food... - Zinc and pneumoniaK Michael Hambidge
Am J Clin Nutr 83:991-2. 2006 - The use of zinc stable isotopes in the study of iron-zinc interactions in Chilean womenManuel Ruz
Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
Food Nutr Bull 23:209-12. 2002..This may be attributable to impairment of zinc status by the iron supplements as evidenced by a trend for lower plasma zinc and EZP... - Zinc, low birth weight, and breastfeedingK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Pediatrics 112:1419-20. 2003
Research Grants
- Complementary feeding: a Global Network cluster randomized controlled trialK Hambidge; Fiscal Year: 2007..A positive multi-country outcome of this trial will demonstrate the broad effectiveness of a BCC education model for achieving a local, food-based approach for adequate complementary feeding. ..
- Agriculture, Maternal-Infant Nutrition & Public HealthK Hambidge; Fiscal Year: 2006..abstract_text> ..
- Zn & Maternal-Infant Brain Function in S. Ethiopia: Randomized Controlled TrialsK Hambidge; Fiscal Year: 2007....