K Michael Hambidge

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Zinc homeostasis in Malawian children consuming a high-phytate, maize-based diet
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, USA
    Am J Clin Nutr 75:1057-61. 2002
  2. ncbi request reprint Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants
    Nancy F Krebs
    Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Clin Nutr 84:1340-3. 2006
  3. pmc Home birth attendants in low income countries: who are they and what do they do?
    Ana Garces
    IMSALUD, Guatemala City, Guatemala
    BMC Pregnancy Childbirth 12:34. 2012
  4. ncbi request reprint Evaluation of zinc metabolism with use of stable-isotope techniques: implications for the assessment of zinc status
    K M Hambidge
    Department of Pediatrics and University of Colorado Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Clin Nutr 68:410S-413S. 1998
  5. pmc Absorption of calcium from tortilla meals prepared from low-phytate maize
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 82:84-7. 2005
  6. ncbi request reprint Measurements of zinc absorption: application and interpretation in research designed to improve human zinc nutriture
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Box C225, 4200 E 9th Av, Denver, Colorado, 80262, USA
    Int J Vitam Nutr Res 75:385-93. 2005
  7. ncbi request reprint Zinc absorption from low-phytate hybrids of maize and their wild-type isohybrids
    K Michael Hambidge
    University of Colorado Health Sciences Center, Department of Pediatrics, Section of Nutrition, Denver 80262, USA
    Am J Clin Nutr 79:1053-9. 2004
  8. ncbi request reprint Changes in zinc absorption during development
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Pediatr 149:S64-8. 2006
  9. ncbi request reprint Zinc deficiency: a special challenge
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    J Nutr 137:1101-5. 2007
  10. ncbi request reprint Underwood Memorial Lecture: human zinc homeostasis: good but not perfect
    Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 133:1438S-42S. 2003

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Zinc homeostasis in Malawian children consuming a high-phytate, maize-based diet
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, USA
    Am J Clin Nutr 75:1057-61. 2002
    ..The gastrointestinal tract plays a central role in absorbing and conserving zinc, yet it has not been carefully studied in such children...
  2. ncbi request reprint Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants
    Nancy F Krebs
    Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Clin Nutr 84:1340-3. 2006
    ..Small-for-gestational-age (SGA) infants are susceptible to postnatal zinc deficiency, but whether this susceptibility is due to intrauterine factors or to high postnatal growth requirements is unknown...
  3. pmc Home birth attendants in low income countries: who are they and what do they do?
    Ana Garces
    IMSALUD, Guatemala City, Guatemala
    BMC Pregnancy Childbirth 12:34. 2012
    ..Nearly half the world's babies are born at home. We sought to evaluate the training, knowledge, skills, and access to medical equipment and testing for home birth attendants across 7 international sites...
  4. ncbi request reprint Evaluation of zinc metabolism with use of stable-isotope techniques: implications for the assessment of zinc status
    K M Hambidge
    Department of Pediatrics and University of Colorado Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Clin Nutr 68:410S-413S. 1998
    ..Further, judicious application of zinc stable-isotope techniques could make an important contribution to progress toward the eradication of zinc deficiency in infants and young children in the developing world...
  5. pmc Absorption of calcium from tortilla meals prepared from low-phytate maize
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 82:84-7. 2005
    ..Bioavailability of calcium is, however, compromised by phytate, which is present in large quantities in maize kernels and is only modestly reduced by nixtamalization...
  6. ncbi request reprint Measurements of zinc absorption: application and interpretation in research designed to improve human zinc nutriture
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Box C225, 4200 E 9th Av, Denver, Colorado, 80262, USA
    Int J Vitam Nutr Res 75:385-93. 2005
    ..They also suggest the potential utility of measurements of the quantity of zinc absorbed when evaluating the zinc status of populations...
  7. ncbi request reprint Zinc absorption from low-phytate hybrids of maize and their wild-type isohybrids
    K Michael Hambidge
    University of Colorado Health Sciences Center, Department of Pediatrics, Section of Nutrition, Denver 80262, USA
    Am J Clin Nutr 79:1053-9. 2004
    ....
  8. ncbi request reprint Changes in zinc absorption during development
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Pediatr 149:S64-8. 2006
    ..Normal homeostatic mechanisms in the premature infant prevented efficient absorption of the quantity of Zn required or/and optimal conservation of endogenous Zn...
  9. ncbi request reprint Zinc deficiency: a special challenge
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    J Nutr 137:1101-5. 2007
    ..Barriers to acceptability and availability of affordable meat are considered, but these are neither universal nor irresolvable in all populations...
  10. ncbi request reprint Underwood Memorial Lecture: human zinc homeostasis: good but not perfect
    Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 133:1438S-42S. 2003
    ....
  11. ncbi request reprint Biomarkers of trace mineral intake and status
    Michael Hambidge
    University of Colorado Health Science Center, Denver, CO 80262, USA
    J Nutr 133:948S-955S. 2003
    ..Also of special current interest is full definition of the potential of plasma-soluble transferrin receptor concentrations as the biomarker of choice for the detection of early functional iron deficiency...
  12. ncbi request reprint Intestinal excretion of endogenous zinc in Guatemalan school children
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 137:1747-9. 2007
    ..Supported by other recent childhood data, these results suggest that the current estimates of EFZ(PR) used in the calculation of Zn requirements for children are misleadingly low...
  13. ncbi request reprint Interrelationships of key variables of human zinc homeostasis: relevance to dietary zinc requirements
    M Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Annu Rev Nutr 21:429-52. 2001
    ..This applies especially to the positive relationship between endogenous fecal zinc and total absorbed zinc, which is the essential starting point in estimating physiologic and, from there, dietary requirements...
  14. pmc Zinc absorption during late pregnancy in rural southern Ethiopia
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 84:1102-6. 2006
    ..Little is yet known about zinc absorption in late pregnancy, and no information on absorption from the total diet is available...
  15. pmc Dietary reference intakes for zinc may require adjustment for phytate intake based upon model predictions
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado, School of Medicine, Denver, CO 80262, USA
    J Nutr 138:2363-6. 2008
    ..4 mg Zn/d. Extrapolation of the model suggested, for example, that with 900 mg/d phytate, 100 mg dietary Zn is required to attain 6.4 mg absorbed Zn/d. Experimental studies with higher Zn intakes are required to test these predictions...
  16. pmc Zinc bioavailability and homeostasis
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Denver, CO, USA
    Am J Clin Nutr 91:1478S-1483S. 2010
    ..The effects of phytate on intestinal losses of endogenous zinc merit further investigation but are probably not of the same magnitude as its inhibitory effects on absorption of exogenous zinc...
  17. pmc Comparison of complementary feeding strategies to meet zinc requirements of older breastfed infants
    Nancy F Krebs
    Department of Pediatrics, Section of Nutrition, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Clin Nutr 96:30-5. 2012
    ..The low zinc intake from human milk at ∼6 mo of age predicts the dependence on complementary foods (CF) to meet the zinc requirements of older breastfed-only infants...
  18. ncbi request reprint Dysprosium as a nonabsorbable fecal marker in studies of zinc homeostasis
    Xiao Yang Sheng
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 82:1017-23. 2005
    ..Dysprosium is a nonabsorbable rare earth element that has had successful application as a marker for fecal excretion of unabsorbed zinc...
  19. ncbi request reprint Zinc absorption from a low-phytic acid maize
    Christina L Adams
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80220, USA
    Am J Clin Nutr 76:556-9. 2002
    ..These low-phytic acid grains provide a strategy for improving the mineral (eg, zinc) status in populations that are dependent on grains, including maize (Zea mays L.), as major dietary staples...
  20. ncbi request reprint Meat as a first complementary food for breastfed infants: feasibility and impact on zinc intake and status
    Nancy F Krebs
    Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Pediatr Gastroenterol Nutr 42:207-14. 2006
    ..This study was undertaken to assess the feasibility and effects of consuming either meat or iron-fortified infant cereal as the first complementary food...
  21. pmc Randomized controlled trial of meat compared with multimicronutrient-fortified cereal in infants and toddlers with high stunting rates in diverse settings
    Nancy F Krebs
    Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Clin Nutr 96:840-7. 2012
    ..Improved complementary feeding is cited as a critical factor for reducing stunting. Consumption of meats has been advocated, but its efficacy in low-resource settings has not been tested...
  22. ncbi request reprint Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis
    Nancy F Krebs
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 133:1498S-501S. 2003
    ..We conclude that the amount of absorbed zinc is not tightly regulated, and that endogenous fecal zinc is dependent on and responsive to the zinc status of the organism...
  23. ncbi request reprint Zinc absorption as a function of the dose of zinc sulfate in aqueous solution
    Cuong D Tran
    Section of Nutrition, Department of Pediatrics, The University of Colorado Health Science Center, Denver, USA
    Am J Clin Nutr 80:1570-3. 2004
    ..Zinc supplements are used extensively in medicine and research and for public health purposes in the prevention and treatment of zinc deficiency. However, little is known about the efficiency of zinc utilization after different doses...
  24. pmc Mathematical model of zinc absorption: effects of dietary calcium, protein and iron on zinc absorption
    Leland V Miller
    Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Box C252, 12700 E 19th Avenue, Aurora, CO, 80045, USA
    Br J Nutr 109:695-700. 2013
    ..Furthermore, the model provides a meaningful foundation for efforts to model nutrient interactions in mineral absorption. ..
  25. pmc The use of dysprosium to measure endogenous zinc excretion in feces eliminates the necessity of complete fecal collections
    Leland V Miller
    University of Colorado Denver, Department of Pediatrics, Aurora, CO 80045, USA
    J Nutr 140:1524-8. 2010
    ..We found that the measurement of the sample Dy:Zn ratio was useful for selecting samples for measurement. We conclude that the Dy method of determining EFZ is a valid and less burdensome alternative to current techniques...
  26. ncbi request reprint Community-based dietary phytate reduction and its effect on iron status in Malawian children
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Ann Trop Paediatr 22:133-6. 2002
    ..Phytate was removed by soaking maize flour in excess water with phytase and decanting the water before cooking the flour. Iron status, as measured by soluble transferrin receptor and zinc protoporphyrin, was improved but not normal...
  27. doi request reprint A reduced phytate diet does not reduce endogenous fecal zinc in children on a habitual high-phytate diet
    Gregg Kennedy
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    J Pediatr Gastroenterol Nutr 51:678-9. 2010
    ..0 and afterward was 7.6. EFZ was similar before and after dietary phytate reduction, 1.15 ± 0.33 and 1.17 ± 0.16 mg/day, respectively. EFZ was not affected by dietary phytate in this population...
  28. pmc Infant stunting is associated with short maternal stature
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 54:117-9. 2012
    ..Maternal height is independently associated with infant LAZ and stunting (LAZ <-2) at both 6 and 12 months (P < 0.001) and with linear growth velocity from 6 to 12 months (P = 0.0023)...
  29. ncbi request reprint Complementary feeding: clinically relevant factors affecting timing and composition
    Nancy F Krebs
    Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80252, USA
    Am J Clin Nutr 85:639S-645S. 2007
    ....
  30. ncbi request reprint Zinc homeostasis during lactation in a population with a low zinc intake
    Lei Sian
    Section of Nutrition, The Department of Pediatrics, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 75:99-103. 2002
    ....
  31. pmc Infant responsiveness, alertness, haemoglobin and growth in rural Sidama, Ethiopia
    Nicki L Aubuchon-Endsley
    Department of Psychology, Oklahoma State University, Stillwater, Oklahoma, USA Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma, USA Institute of Nutrition, Food Science, and Technologies, Hawassa University, Awassa, Ethiopia Department of Human Development and Family Science, Oklahoma State University, Stillwater, Oklahoma, USA Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Matern Child Nutr 9:483-98. 2013
    ....
  32. pmc Effects of different complementary feeding regimens on iron status and enteric microbiota in breastfed infants
    Nancy F Krebs
    Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 163:416-23. 2013
    ..To compare iron status in breastfed infants randomized to groups receiving complementary feeding regimens that provided iron from fortified infant cereals or meats, and to examine the development of the enteric microbiota in these groups...
  33. pmc Micronutrient bioavailability: Dietary Reference Intakes and a future perspective
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Clin Nutr 91:1430S-1432S. 2010
    ..These factors, it is argued, are best considered separately from even a broad definition of bioavailability and have the potential to provide new insights into some micronutrient requirements...
  34. pmc Preconception maternal nutrition: a multi-site randomized controlled trial
    K Michael Hambidge
    University of Colorado Denver, Aurora, CO, USA
    BMC Pregnancy Childbirth 14:111. 2014
    ....
  35. pmc A mathematical model of zinc absorption in humans as a function of dietary zinc and phytate
    Leland V Miller
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 137:135-41. 2007
    ..The model was judged to be valid and of immediate value for studying and predicting absorption. A version of the model incorporating a passive absorption mechanism was not supported by the available data...
  36. pmc Complementary feeding: a Global Network cluster randomized controlled trial
    Nancy F Krebs
    University of Colorado Denver, Aurora, CO, USA
    BMC Pediatr 11:4. 2011
    ..Animal source foods in particular are cited as essential to achieve micronutrient requirements. The efficacy of the recommendation for regular meat consumption, however, has not been systematically evaluated...
  37. doi request reprint Physiological requirements for zinc
    K Michael Hambidge
    Pediatric Nutrition, University of Colorado Denver, Aurora, CO, USA
    Int J Vitam Nutr Res 81:72-8. 2011
    ..The lessons to be learned from this review are discussed together with suggestions for future action by IOM as well as a constructive role for IZiNCG...
  38. ncbi request reprint Zinc metabolism and homeostasis: the application of tracer techniques to human zinc physiology
    N E Krebs
    Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    Biometals 14:397-412. 2001
    ....
  39. ncbi request reprint Human zinc metabolism: advances in the modeling of stable isotope data
    L V Miller
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
    Adv Exp Med Biol 445:253-69. 1998
    ..While identifiability could not be demonstrated a priori due to the model's complexity, parameter statistics for the fitted models did show most parameters to be adequately identified a posteriori...
  40. ncbi request reprint Development of a compartmental model of human zinc metabolism: identifiability and multiple studies analyses
    L V Miller
    Section of Nutrition, Department of Pediatrics and Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1671-84. 2000
    ..The model was judged to be valid based on criteria described elsewhere...
  41. ncbi request reprint Zinc, low birth weight, and breastfeeding
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Pediatrics 112:1419-20. 2003
  42. doi request reprint Training traditional birth attendants on the WHO Essential Newborn Care reduces perinatal mortality
    Ana Garces
    IMSALUD, Guatemala City, Guatemala
    Acta Obstet Gynecol Scand 91:593-7. 2012
    ....
  43. pmc Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia
    Rosalind S Gibson
    Department of Human Nutrition, University of Otago, Dunedin, New Zealand 9015
    J Nutr 138:581-6. 2008
    ..Despite some early functional vitamin B-12 deficiency, there was no macrocytic anemia. Consumption of fermented enset may have increased vitamin B-12 levels in diet and plasma...
  44. ncbi request reprint Inadequate intakes of dietary zinc among pregnant women from subsistence households in Sidama, Southern Ethiopia
    Yewelsew Abebe
    College of Agriculture, Hawassa University, Awassa, Ethiopia
    Public Health Nutr 11:379-86. 2008
    ..To assess the prevalence of zinc inadequacy based on dietary intakes and plasma zinc concentrations and, simultaneously, the prevalence of inadequate intakes of energy, protein, calcium and iron...
  45. ncbi request reprint The use of zinc stable isotopes in the study of iron-zinc interactions in Chilean women
    Manuel Ruz
    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
    Food Nutr Bull 23:209-12. 2002
    ..This may be attributable to impairment of zinc status by the iron supplements as evidenced by a trend for lower plasma zinc and EZP...
  46. ncbi request reprint Zinc homeostasis in premature infants does not differ between those fed preterm formula or fortified human milk
    Sanju Jalla
    Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Pediatr Res 56:615-20. 2004
    ..Current zinc intakes from fortified human milk or formula are associated with acceptable weight gain, but whether the observed net zinc absorption was optimal in the human milk group cannot be definitively determined from these data...
  47. ncbi request reprint Major variables of zinc homeostasis in Chinese toddlers
    Xiao Yang Sheng
    Department of Child and Adolescent Health, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Am J Clin Nutr 84:389-94. 2006
    ..The data required for this approach have not been available for toddlers, whose requirements have been estimated by extrapolation from other age groups...
  48. ncbi request reprint Zinc and pneumonia
    K Michael Hambidge
    Am J Clin Nutr 83:991-2. 2006
  49. ncbi request reprint Longitudinal measurements of zinc absorption in Peruvian children consuming wheat products fortified with iron only or iron and 1 of 2 amounts of zinc
    Daniel Lopez de Romaña
    Program in International Nutrition and the Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 81:637-47. 2005
    ..Information is needed on the fractional absorption of zinc (FAZ) and absorbed zinc (AZ) during prolonged exposure to zinc-fortified foods...
  50. ncbi request reprint Zinc absorption in Guatemalan schoolchildren fed normal or low-phytate maize
    Manolo Mazariegos
    Center for Studies of Sensory Impairments, Aging, and Metabolism, Guatemala City, Guatemala
    Am J Clin Nutr 83:59-64. 2006
    ..Poor bioavailability of zinc from high-phytate diets is an important contributory factor to zinc deficiency in low-income populations...

Research Grants4

  1. Complementary feeding: a Global Network cluster randomized controlled trial
    K Hambidge; Fiscal Year: 2007
    ..A positive multi-country outcome of this trial will demonstrate the broad effectiveness of a BCC education model for achieving a local, food-based approach for adequate complementary feeding. ..
  2. Agriculture, Maternal-Infant Nutrition & Public Health
    K Hambidge; Fiscal Year: 2006
    ..abstract_text> ..
  3. Zn & Maternal-Infant Brain Function in S. Ethiopia: Randomized Controlled Trials
    K Hambidge; Fiscal Year: 2007
    ....