K J Hamann

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Apoptosis of viral-infected airway epithelial cells limit viral production and is altered by corticosteroid exposure
    Gurpreet K Singhera
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research Critical Care Group, St, Paul s Hospital, University of British Columbia, Vancouver, British Columbia, V6Z 1Y6, Canada
    Respir Res 7:78. 2006
  2. ncbi Expression of Fas (CD95) and FasL (CD95L) in human airway epithelium
    K J Hamann
    Section of Pulmonary and Critical Care Medicine, Division of Biological Sciences, University of Chicago, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 19:537-42. 1998
  3. ncbi Fas cross-linking induces apoptosis in human airway smooth muscle cells
    K J Hamann
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Lung Cell Mol Physiol 278:L618-24. 2000
  4. ncbi Selective regulation of expression of surface adhesion molecules Mac-1, L-selectin, and VLA-4 on human eosinophils and neutrophils
    S P Neeley
    Department of Medicine, University of Chicago, IL 60637
    Am J Respir Cell Mol Biol 8:633-9. 1993
  5. ncbi Role of very late adhesion integrins in mediating repair of human airway epithelial cell monolayers after mechanical injury
    S R White
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Division of Biological Sciences, University of Chicago, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 20:787-96. 1999
  6. ncbi Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma
    Jiankun Tong
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 203:1173-84. 2006
  7. ncbi Fas resistance of leukemic eosinophils is due to activation of NF-kappa B by Fas ligation
    Yimin Qin
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 169:3536-44. 2002
  8. ncbi Augmentation of stimulated eosinophil degranulation by VLA-4 (CD49d)-mediated adhesion to fibronectin
    S P Neeley
    Department of Medicine, University of Chicago, Illinois 60637
    Am J Respir Cell Mol Biol 11:206-13. 1994
  9. ncbi Human fetal retinal pigment epithelial cells induce apoptosis in allogenic T-cells in a Fas ligand and PGE2 independent pathway
    K A Rezai
    Department of Ophthalmology and Visual Science, University of Chicago, Illinois 60637, USA
    Curr Eye Res 18:430-9. 1999
  10. ncbi Genetic deletion of NOS3 increases lethal cardiac dysfunction following mouse cardiac arrest
    David G Beiser
    Emergency Resuscitation Center, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Ave, MC 5068, Chicago, IL 60637, USA
    Resuscitation 82:115-21. 2011

Research Grants

  1. Mechanisms of Hypothermic Protection from Ischemia/Reperfusion Cardiac Injury
    Kimm J Hamann; Fiscal Year: 2010
  2. Oxidants & Caspases: Initiation of Reperfusion Injury
    Kimm Hamann; Fiscal Year: 2009
  3. Mechanisms of Hypothermic Protection from Ischemia/Reperfusion Cardiac Injury
    Kimm Hamann; Fiscal Year: 2007
  4. Eosinophil-Airway Epithelial Fas-FasL Interactions
    Kimm Hamann; Fiscal Year: 2004
  5. CARDIAC OXIDANTS & APOPTOSIS: LESSONS OF PRECONDITIONING
    Kimm Hamann; Fiscal Year: 2003

Collaborators

Detail Information

Publications21

  1. ncbi Apoptosis of viral-infected airway epithelial cells limit viral production and is altered by corticosteroid exposure
    Gurpreet K Singhera
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research Critical Care Group, St, Paul s Hospital, University of British Columbia, Vancouver, British Columbia, V6Z 1Y6, Canada
    Respir Res 7:78. 2006
    ..Both features may contribute to the development of asthma. Excessive damage and loss of epithelial cells are characteristic in asthma and may result from viral infection...
  2. ncbi Expression of Fas (CD95) and FasL (CD95L) in human airway epithelium
    K J Hamann
    Section of Pulmonary and Critical Care Medicine, Division of Biological Sciences, University of Chicago, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 19:537-42. 1998
    ..We demonstrate that both Fas and FasL are expressed by human airway epithelial cell subtypes. Expression of these molecules may play an important role in regulation of the inflammatory response...
  3. ncbi Fas cross-linking induces apoptosis in human airway smooth muscle cells
    K J Hamann
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Lung Cell Mol Physiol 278:L618-24. 2000
    ..These data represent the first demonstration that Fas is expressed on HASM and suggest a mechanism by which Fas-mediated apoptosis could act to oppose excess smooth muscle accumulation during airway remodeling in asthma...
  4. ncbi Selective regulation of expression of surface adhesion molecules Mac-1, L-selectin, and VLA-4 on human eosinophils and neutrophils
    S P Neeley
    Department of Medicine, University of Chicago, IL 60637
    Am J Respir Cell Mol Biol 8:633-9. 1993
    ..5 +/- 4.2% decrease in eosinophil L-selectin expression (P < 0.001) but had no effect on L-selectin expression in neutrophils. Eosinophil VLA-4 expression was not altered by any stimulus.(ABSTRACT TRUNCATED AT 250 WORDS)..
  5. ncbi Role of very late adhesion integrins in mediating repair of human airway epithelial cell monolayers after mechanical injury
    S R White
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Division of Biological Sciences, University of Chicago, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 20:787-96. 1999
    ..These differences may become important if the matrix protein composition of airway basement membrane changes in disease states such as asthma...
  6. ncbi Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma
    Jiankun Tong
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 203:1173-84. 2006
    ....
  7. ncbi Fas resistance of leukemic eosinophils is due to activation of NF-kappa B by Fas ligation
    Yimin Qin
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 169:3536-44. 2002
    ..These data suggest that the resistance of these leukemic eosinophils to Fas-mediated killing is due to induced NF-kappaB activation...
  8. ncbi Augmentation of stimulated eosinophil degranulation by VLA-4 (CD49d)-mediated adhesion to fibronectin
    S P Neeley
    Department of Medicine, University of Chicago, Illinois 60637
    Am J Respir Cell Mol Biol 11:206-13. 1994
    ..02). Similarly, treatment with HP2/1 caused a decrease in eosinophil adhesion to FN-coated styrene from 12,693 +/- 1,866 to 6,206 +/- 852 adherent cells/FN-coated well (P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)..
  9. ncbi Human fetal retinal pigment epithelial cells induce apoptosis in allogenic T-cells in a Fas ligand and PGE2 independent pathway
    K A Rezai
    Department of Ophthalmology and Visual Science, University of Chicago, Illinois 60637, USA
    Curr Eye Res 18:430-9. 1999
    ..To evaluate the inhibitory effect of human fetal retinal pigment epithelium (HFRPE) on the activation of human T-cells...
  10. ncbi Genetic deletion of NOS3 increases lethal cardiac dysfunction following mouse cardiac arrest
    David G Beiser
    Emergency Resuscitation Center, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Ave, MC 5068, Chicago, IL 60637, USA
    Resuscitation 82:115-21. 2011
    ..We studied the role of NO signaling on cardiovascular outcomes following cardiac arrest and resuscitation using endothelial NO synthase knockout (NOS3(-/-)) mice...
  11. ncbi Fas ligand expression on T cells is sufficient to prevent prolonged airway inflammation in a murine model of asthma
    Jiankun Tong
    Department of Medicine, University of Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 43:342-8. 2010
    ....
  12. ncbi Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest
    David G Beiser
    Sect of Emergency Medicine, 5841 S Maryland Ave, MC 5068, Chicago, IL 60637, USA
    Am J Physiol Heart Circ Physiol 298:H1761-8. 2010
    ..In conclusion, TH improves post-ROSC cardiac function and increases Akt phosphorylation in WT, but not Akt1(+/-), mice. The Akt1 isoform appears necessary for TH-mediated cardioprotection...
  13. ncbi TNF-alpha induces transient resistance to Fas-induced apoptosis in eosinophilic acute myeloid leukemia cells
    Yimin Qin
    Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Mol Immunol 4:43-52. 2007
    ....
  14. ncbi Human fetal retinal pigment epithelium induces apoptosis in human T-cell line Jurkat which is independent from its expression of TRAIL
    Lili Farrokh-Siar
    Department of Ophthalmology, University of Chicago, IL 60637, USA
    Curr Eye Res 24:206-13. 2002
    ..To evaluate whether human fetal retinal pigment epithelial (HFRPE) cells express TRAIL (tumor necrosis factor related apoptosis inducing ligand). The role of TRAIL in HFRPE induced apoptosis was evaluated...
  15. ncbi Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest
    Danhong Zhao
    Emergency Resuscitation Center, University of Chicago Hospitals, Chicago, IL 60637, USA
    Resuscitation 77:242-9. 2008
    ..We hypothesized that a short delay in resuscitation to induce hypothermia before ROSC, even at the expense of more prolonged ischemia, may yield both physiological and survival advantages...
  16. ncbi Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants
    Zuo Hui Shao
    Section of Emergency Medicine, Department of Medicine, Emergency Resuscitation Center, University of Chicago, Chicago, IL, USA
    Am J Physiol Heart Circ Physiol 298:H2164-73. 2010
    ..We conclude that TH cardioprotection is mediated by enhanced Akt/HSP27 phosphorylation and enhanced NO generation, resulting in the attenuation of ROS generation and the maintenance of DeltaPsim following ischemia-reperfusion...
  17. ncbi Inflammation and cell-cell interactions in airway hyperresponsiveness
    A R Leff
    Department of Medicine, University of Chicago, Illinois 60637
    Am J Physiol 260:L189-206. 1991
    ..The recognition of inflammation as the essential component to airway hyperresponsiveness provides a fresh approach to a difficult problem and suggests a host of novel therapies for human asthma...
  18. ncbi Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2
    Shigeharu Myou
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Immunology 107:77-85. 2002
    ..We find that avidity caused by integrin surface clustering - rather than conformational change or up-regulation of CD11b/CD18 - causes PMA stimulated adhesion of AML cells...
  19. ncbi Hypothermia-induced cardioprotection using extended ischemia and early reperfusion cooling
    Zuo Hui Shao
    The Emergency Resuscitation Center, Sections of Emergency Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 292:H1995-2003. 2007
    ..Such protection appears to be mediated by increased NO generation via activation of protein kinase Cepsilon; nitric oxide synthase...
  20. ncbi Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion
    Yimin Qin
    Department of Medicine MC6076, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Heart Circ Physiol 286:H2280-6. 2004
    ..These data suggest that active caspase-2 initiates cytochrome c release after reperfusion and that it is critical for the I/R-induced apoptosis in this model...
  21. ncbi Reperfusion, not simulated ischemia, initiates intrinsic apoptosis injury in chick cardiomyocytes
    Terry L Vanden Hoek
    Sections of Emergency Medicine and Pulmonary/Critical Care, Department of Medicine and Emergency Resuscitation Center, University of Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 284:H141-50. 2003
    ..These results suggest that reperfusion oxidants initiate cytochrome c release within minutes, and apoptosis within hours, significant enough to increase cell death and contractile dysfunction...

Research Grants17

  1. Mechanisms of Hypothermic Protection from Ischemia/Reperfusion Cardiac Injury
    Kimm J Hamann; Fiscal Year: 2010
    ....
  2. Oxidants & Caspases: Initiation of Reperfusion Injury
    Kimm Hamann; Fiscal Year: 2009
    ....
  3. Mechanisms of Hypothermic Protection from Ischemia/Reperfusion Cardiac Injury
    Kimm Hamann; Fiscal Year: 2007
    ....
  4. Eosinophil-Airway Epithelial Fas-FasL Interactions
    Kimm Hamann; Fiscal Year: 2004
    ..abstract_text> ..
  5. CARDIAC OXIDANTS & APOPTOSIS: LESSONS OF PRECONDITIONING
    Kimm Hamann; Fiscal Year: 2003
    ..Results from these studies have the potential to improve post-resuscitation care following cardiac arrest and other ischemic diseases such as myocardial infarction and stroke. ..