Aldric Hama

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Combination Drug Therapy for Pain following Chronic Spinal Cord Injury
    Aldric Hama
    The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, 1095 SW 14th Terrace, Miami, FL 33136, USA
    Pain Res Treat 2012:840486. 2012
  2. ncbi Use of naturally occurring peptides for neuropathic spinal cord injury pain
    Aldric Hama
    University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Curr Protein Pept Sci 14:218-30. 2013
  3. pmc Combinations of intrathecal gamma-amino-butyrate receptor agonists and N-methyl-d-aspartate receptor antagonists in rats with neuropathic spinal cord injury pain
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Eur J Pharmacol 683:101-8. 2012
  4. doi The antinociceptive effect of the asthma drug ibudilast in rat models of peripheral and central neuropathic pain
    Aldric T Hama
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurotrauma 29:600-10. 2012
  5. pmc Centrally mediated antinociceptive effects of cannabinoid receptor ligands in rat models of nociception
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Pharmacol Biochem Behav 100:340-6. 2011
  6. pmc Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Brain Res 1412:44-54. 2011
  7. pmc Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami Leonard M Miller School of Medicine, Miami, FL 33136, USA
    J Rehabil Res Dev 46:135-43. 2009
  8. pmc Antinociceptive effects of the marine snail peptides conantokin-G and conotoxin MVIIA alone and in combination in rat models of pain
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami, Miller School of Medicine, 1095 NW 14th Terrace, R 48, Miami, FL 33136, USA
    Neuropharmacology 56:556-63. 2009
  9. ncbi FK506 reduces the severity of cutaneous hypersensitivity in rats with a spinal cord contusion
    Jan Voda
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Neurosci Res 58:95-9. 2007
  10. ncbi Behavioral characterization and effect of clinical drugs in a rat model of pain following spinal cord compression
    Aldric Hama
    University of Miami, Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Brain Res 1185:117-28. 2007

Collaborators

Detail Information

Publications17

  1. pmc Combination Drug Therapy for Pain following Chronic Spinal Cord Injury
    Aldric Hama
    The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, 1095 SW 14th Terrace, Miami, FL 33136, USA
    Pain Res Treat 2012:840486. 2012
    ..At the same time, there are mechanisms that distinguish SCI from peripheral neuropathic pain, so novel combination therapies will be needed...
  2. ncbi Use of naturally occurring peptides for neuropathic spinal cord injury pain
    Aldric Hama
    University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Curr Protein Pept Sci 14:218-30. 2013
    ..Combinations of conopeptides with currently available drugs as well as with other conopeptides could be an effective means of reducing neuropathic SCI pain...
  3. pmc Combinations of intrathecal gamma-amino-butyrate receptor agonists and N-methyl-d-aspartate receptor antagonists in rats with neuropathic spinal cord injury pain
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Eur J Pharmacol 683:101-8. 2012
    ..By engaging diverse pain modulating systems at the spinal level, combination drug treatment may be a useful approach in treating neuropathic SCI pain...
  4. doi The antinociceptive effect of the asthma drug ibudilast in rat models of peripheral and central neuropathic pain
    Aldric T Hama
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurotrauma 29:600-10. 2012
    ..Ibudilast could be useful for the treatment of neuropathic pain of central as well as peripheral origin...
  5. pmc Centrally mediated antinociceptive effects of cannabinoid receptor ligands in rat models of nociception
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Pharmacol Biochem Behav 100:340-6. 2011
    ..Thus, HE could be a useful analgesic peptide with a novel spinal mechanism of action...
  6. pmc Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Brain Res 1412:44-54. 2011
    ..Although such a mechanism could be useful in other models of pain with a significant inflammatory component, the current data indicate that activation of CB1 receptors is needed to ameliorate neuropathic SCI pain...
  7. pmc Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami Leonard M Miller School of Medicine, Miami, FL 33136, USA
    J Rehabil Res Dev 46:135-43. 2009
    ..These data suggest that the sustained efficacy of a CB receptor agonist for pain could depend on the pain state. Such agonists may hold promise for long-term use in alleviating chronic SCI pain...
  8. pmc Antinociceptive effects of the marine snail peptides conantokin-G and conotoxin MVIIA alone and in combination in rat models of pain
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami, Miller School of Medicine, 1095 NW 14th Terrace, R 48, Miami, FL 33136, USA
    Neuropharmacology 56:556-63. 2009
    ..These data suggest that a combination of these peptides may be analgesic across diverse clinical pains with limited untoward side effects, and particularly potent for reducing spinal cord injury pain...
  9. ncbi FK506 reduces the severity of cutaneous hypersensitivity in rats with a spinal cord contusion
    Jan Voda
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Neurosci Res 58:95-9. 2007
    ..The data also suggest that motor and sensory dysfunctions resulting from SCI are mediated by distinct mechanisms, requiring the use of multiple therapeutic interventions...
  10. ncbi Behavioral characterization and effect of clinical drugs in a rat model of pain following spinal cord compression
    Aldric Hama
    University of Miami, Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Brain Res 1185:117-28. 2007
    ..Thus, the model may be useful for rapid screening and clinical translation of promising SCI pain therapies...
  11. pmc Spinal subarachnoid adrenal medullary transplants reduce hind paw swelling and peripheral nerve transport following formalin injection in rats
    Uri Herzberg
    Miami Project to Cure Paralysis, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Brain Res 1198:85-92. 2008
    ..These data demonstrate that spinal adrenal transplants can attenuate the formalin-evoked response by modulating primary afferent responses...
  12. ncbi Enhancement of morphine antinociception with the peptide N-methyl-D-aspartate receptor antagonist [Ser1]-histogranin in the rat formalin test
    Aldric Hama
    Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, FL 33136, USA
    Brain Res 1095:59-64. 2006
    ..Thus, enhancement of opiate efficacy is possible using a novel peptide NMDA receptor modulator with a potentially improved safety profile...
  13. pmc Altered antinociceptive efficacy of tramadol over time in rats with painful peripheral neuropathy
    Aldric Hama
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, Miami, FL 33136, USA
    Eur J Pharmacol 559:32-7. 2007
    ..Alteration in antinociceptive mechanism over time may explain the inconsistency in efficacy of this and other analgesic drugs in chronic pain patients...
  14. pmc Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury
    Aldric Hama
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Exp Neurol 204:454-7. 2007
    ..These data indicate that a CB(1)-selective agonist may be novel therapeutic treatment for clinical SCI pain...
  15. doi Antinociceptive effect of riluzole in rats with neuropathic spinal cord injury pain
    Aldric Hama
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurotrauma 28:127-34. 2011
    ..Although the exact mechanism of action is not clear, there is a predominant supraspinal component of riluzole-induced antinociception in SCI rats...
  16. ncbi Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats
    Aldric Hama
    Miami Project to Cure Paralysis, University of Miami School of Medicine, Louis Pope LIFE Center, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Eur J Pharmacol 459:49-58. 2003
    ....
  17. ncbi Selective antihyperalgesic effect of [Ser1] histogranin on complete Freund's adjuvant-induced hyperalgesia in rats
    Aldric Hama
    Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL, USA
    Pain 95:15-21. 2002
    ..These results indicate that SH has selective and modest antinociceptive effects on inflammatory pain and suggests that novel histogranin analogs may be safe and useful adjuncts in the management of chronic pain...