Charles Halsted

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Aberrant hepatic methionine metabolism and gene methylation in the pathogenesis and treatment of alcoholic steatohepatitis
    Charles H Halsted
    Department of Internal Medicine, University of California, Davis, 451 E Health Sciences Drive, Room 6323, Davis, CA 95616, USA
    Int J Hepatol 2012:959746. 2012
  2. ncbi request reprint B-Vitamin dependent methionine metabolism and alcoholic liver disease
    Charles H Halsted
    Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA
    Clin Chem Lab Med 51:457-65. 2013
  3. pmc Vitamin-dependent methionine metabolism and alcoholic liver disease
    Charles H Halsted
    Department of Internal Medicine, Genome and Biomedical Research Facility, University of California, Davis, CA, USA
    Adv Nutr 2:421-7. 2011
  4. doi request reprint Perspectives on obesity and sweeteners, folic acid fortification and vitamin D requirements
    Charles H Halsted
    Department of Internal Medicine, Genome and Biomedical Science Facility, University of California Davis, Davis, CA 65616, USA
    Fam Pract 25:i44-9. 2008
  5. ncbi request reprint Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study
    Charles H Halsted
    Genome and Biomedical Sciences Facility, University of California Davis, Davis, CA 95616, USA
    Am J Clin Nutr 86:514-21. 2007
  6. ncbi request reprint Clinical nutrition education--relevance and role models
    C H Halsted
    Division of Clinical Nutrition and Metabolism, School of Medicine, University of California, Davis 95616, USA
    Am J Clin Nutr 67:192-6. 1998
  7. ncbi request reprint Nutrition and alcoholic liver disease
    Charles H Halsted
    Department of Internal Medicine and Nutrition, University of California Davis, Davis, California 95616, USA
    Semin Liver Dis 24:289-304. 2004
  8. ncbi request reprint Dietary supplements and functional foods: 2 sides of a coin?
    Charles H Halsted
    Department of Internal Medicine and Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 77:1001S-1007S. 2003
  9. pmc Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig
    Charles H Halsted
    Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 99:10072-7. 2002
  10. ncbi request reprint Metabolic interactions of alcohol and folate
    Charles H Halsted
    Department of Internal Medicine, University of California, Davis, 95616, USA
    J Nutr 132:2367S-2372S. 2002

Research Grants

  1. EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
    Charles Halsted; Fiscal Year: 2007
  2. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2006
  3. EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
    Charles Halsted; Fiscal Year: 2006
  4. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2005
  5. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2005
  6. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2004
  7. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2004
  8. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2003
  9. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2003
  10. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2002

Detail Information

Publications34

  1. pmc Aberrant hepatic methionine metabolism and gene methylation in the pathogenesis and treatment of alcoholic steatohepatitis
    Charles H Halsted
    Department of Internal Medicine, University of California, Davis, 451 E Health Sciences Drive, Room 6323, Davis, CA 95616, USA
    Int J Hepatol 2012:959746. 2012
    ..The efficacy of supplemental SAM in the prevention of ASH in animal models and in the clinical treatment of ASH will be discussed...
  2. ncbi request reprint B-Vitamin dependent methionine metabolism and alcoholic liver disease
    Charles H Halsted
    Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA
    Clin Chem Lab Med 51:457-65. 2013
    ....
  3. pmc Vitamin-dependent methionine metabolism and alcoholic liver disease
    Charles H Halsted
    Department of Internal Medicine, Genome and Biomedical Research Facility, University of California, Davis, CA, USA
    Adv Nutr 2:421-7. 2011
    ..The review will conclude with descriptions of studies on the efficacy of SAM in the treatment of ALD and with discussion of potentially fruitful future avenues of research...
  4. doi request reprint Perspectives on obesity and sweeteners, folic acid fortification and vitamin D requirements
    Charles H Halsted
    Department of Internal Medicine, Genome and Biomedical Science Facility, University of California Davis, Davis, CA 65616, USA
    Fam Pract 25:i44-9. 2008
    ..A recent fracture risk prevention trial showed that the 4-year incidence of all cancers was reduced in US women who received high supplemental doses of both calcium and vitamin D...
  5. ncbi request reprint Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study
    Charles H Halsted
    Genome and Biomedical Sciences Facility, University of California Davis, Davis, CA 95616, USA
    Am J Clin Nutr 86:514-21. 2007
    ..Previous studies provided conflicting results on the effect of the GCPII 1561C-->T polymorphism on folate and total homocysteine (tHcy) concentrations...
  6. ncbi request reprint Clinical nutrition education--relevance and role models
    C H Halsted
    Division of Clinical Nutrition and Metabolism, School of Medicine, University of California, Davis 95616, USA
    Am J Clin Nutr 67:192-6. 1998
    ....
  7. ncbi request reprint Nutrition and alcoholic liver disease
    Charles H Halsted
    Department of Internal Medicine and Nutrition, University of California Davis, Davis, California 95616, USA
    Semin Liver Dis 24:289-304. 2004
    ..Targeted metabolic treatments include supplementation with S-adenosylmethionine (SAM) or phosphatidylcholine derivatives, each with promising experimental bases but inconclusive clinical trials...
  8. ncbi request reprint Dietary supplements and functional foods: 2 sides of a coin?
    Charles H Halsted
    Department of Internal Medicine and Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 77:1001S-1007S. 2003
    ..Practicing physicians are advised to stay abreast of these emerging findings in order to best advise their patients on the value of health-promoting diets in disease prevention...
  9. pmc Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig
    Charles H Halsted
    Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 99:10072-7. 2002
    ..Steatohepatitis occurred in five of six pigs in FDE but not in the other groups. In summary, folate deficiency enhances perturbations in hepatic methionine metabolism and DNA damage while promoting alcoholic liver injury...
  10. ncbi request reprint Metabolic interactions of alcohol and folate
    Charles H Halsted
    Department of Internal Medicine, University of California, Davis, 95616, USA
    J Nutr 132:2367S-2372S. 2002
    ..At the same time, folate deficiency accelerates alcohol-induced changes in hepatic methionine metabolism while promoting enhanced oxidative liver injury and the histopathology of ALD...
  11. ncbi request reprint Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II
    C H Halsted
    Department of Internal Medicine, School of Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 273:20417-24. 1998
    ..The discovery of the jejunal folylpoly-gamma-carboxypeptidase gene provides a framework for future studies on relationships among these proteins and on the molecular regulation of intestinal folate absorption...
  12. ncbi request reprint Folate deficiency, methionine metabolism, and alcoholic liver disease
    Charles H Halsted
    University of California, Davis, 95616, USA
    Alcohol 27:169-72. 2002
    ..The finding of steatonecrosis and focal inflammation only in the combined diet group supports the suggestion that folate deficiency promotes and folate sufficiency protects against the early onset of methionine cycle-mediated ALD...
  13. ncbi request reprint S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet
    Jesus A Villanueva
    Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Alcohol Clin Exp Res 31:1934-43. 2007
    ....
  14. pmc Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig
    Charles H Halsted
    University of California, Davis, California and National Toxicological Research Center, Jefferson, Arkansas, USA
    Trans Am Clin Climatol Assoc 113:151-62; discussion 162-3. 2002
    ..Thus, the development of ALD is linked to abnormal methionine metabolism and is accelerated in the presence of folate deficiency...
  15. ncbi request reprint Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs
    Farah Esfandiari
    Department of Internal Medicine, University of California Davis, Davis, California 95616, USA
    Am J Physiol Gastrointest Liver Physiol 289:G54-63. 2005
    ....
  16. ncbi request reprint Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population
    Angela M Devlin
    Department of Internal Medicine, University of California, Davis, Davis, CA, USA
    Am J Clin Nutr 83:708-13. 2006
    ..Homocysteine concentrations are influenced by vitamin status and genetics, especially several polymorphisms in folate-metabolizing genes...
  17. pmc Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease
    Valentina Medici
    Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA
    J Hepatol 53:551-7. 2010
    ..The aim of this clinical study was to determine the relationship between serum levels of methionine metabolites in chronic alcoholics and the risk and pathological severity of ALD...
  18. ncbi request reprint S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet
    Farah Esfandiari
    Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA
    Alcohol Clin Exp Res 31:1231-9. 2007
    ....
  19. pmc Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse
    Farah Esfandiari
    Department of Internal Medicine, 5303 Genome and Biomedical Science Facility, 451 E Health Sciences Drive, University of California, Davis, Davis, CA 95616, USA
    Hepatology 51:932-41. 2010
    ..The messenger RNA expression of the histone H3K9 methyltransferase EHMT2 (G9a) was selectively decreased in ethanol-fed mice...
  20. pmc Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease
    Angela M Zivkovic
    Department of Entomology, University of California Davis, Davis, California 95616, USA
    Alcohol Clin Exp Res 33:751-8. 2009
    ..It is unclear whether lipid synthesis, lipid export, or a combination of both is contributing to hepatic steatosis in ASH...
  21. ncbi request reprint Chronic ethanol perturbs testicular folate metabolism and dietary folate deficiency reduces sex hormone levels in the Yucatan micropig
    Lynn M Wallock-Montelius
    Children s Hospital Oakland Research Institute, Oakland, California 94609, and Department of Internal Medicine, University of California, Davis 95616, USA
    Biol Reprod 76:455-65. 2007
    ..Furthermore, methionine synthase may influence the hormonal regulation of spermatogenesis...
  22. ncbi request reprint Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease
    Jesus A Villanueva
    Department of Internal Medicine, University of California, Davis, California 95616, USA
    Alcohol Clin Exp Res 30:1262-70. 2006
    ....
  23. ncbi request reprint Victor Herbert, MD, 1927-2002
    Charles H Halsted
    American Journal of Clinical Nutrition, 3247 Meyer Hall, University of California, Davis, One Shields Avenue, Davis, CA 95616 E mail
    Am J Clin Nutr 77:757-9. 2003
  24. ncbi request reprint Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo
    Shan Shan Zhan
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Clinical Nutrition and Vascular Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Hepatology 43:435-43. 2006
    ..In conclusion, these data provide a mechanistic link between phagocytosis of apoptotic bodies, production of oxidative radicals, and the activation of hepatic stellate cells...
  25. ncbi request reprint Postnatal ontogeny of intestinal GCPII and the RFC in pig
    Tracy B Shafizadeh
    Department of Internal Medicine, University of California, Davis, CA, USA
    Am J Physiol Gastrointest Liver Physiol 296:G476-81. 2009
    ..These findings show that intestinal GCPII and intestinal and hepatic RFC all exhibit ontogenic changes in the pig that are reflected in postnatal folate status...
  26. ncbi request reprint gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine
    Tracy B Shafizadeh
    Department of Internal Medicine, Clinical Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 137:1149-53. 2007
    ..gamma-GH folate hydrolase is abundant in rat postprandial pancreatic secretions and appears to hydrolyze dietary folates in the intestinal lumen prior to intestinal absorption...
  27. ncbi request reprint Hepatic transmethylation reactions in micropigs with alcoholic liver disease
    Jesus A Villanueva
    Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA
    Hepatology 39:1303-10. 2004
    ..These novel effects on transmethylation reactions may be implicated in the pathogenesis of alcoholic liver disease...
  28. ncbi request reprint Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk
    Isabelle Morin
    Departments of Pediatrics and Human Genetics, McGill University, Montreal Children s Hospital Research Institute, 4060 Ste Catherine West, Room 200, Montreal, Canada H3Z 2Z3
    Mol Genet Metab 79:197-200. 2003
    ....
  29. ncbi request reprint Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 86:14-24. 2007
    ..Additionally, decreased concentrations of homocysteine can down-regulate endoplasmic reticulum stress, which leads to the attenuation of apoptosis and fatty acid synthesis...
  30. ncbi request reprint Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia
    Joshua L Roffman
    Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 63:42-8. 2008
    ..We examined whether the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C functional polymorphisms contribute to negative symptoms...
  31. pmc Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Am J Med Genet B Neuropsychiatr Genet 141:947-56. 2006
    ..We propose that an increased vulnerability to oxidative stress (endogenous or environmental) may contribute to the development and clinical manifestations of autism...
  32. pmc M-30 and 4HNE are sequestered in different aggresomes in the same hepatocytes
    Fataneh Amidi
    Department of Pathology, Harbor UCLA Medical Center, 1000 W Carson St Torrance, CA 90509, USA
    Exp Mol Pathol 83:296-300. 2007
    ..The results indicate that the formation of M-30 and 4HNE aggresomes occurs through different pathways of liver cell injury in both types of steatohepatitis...
  33. pmc Cloning of a pig homologue of the human lactoferrin receptor: expression and localization during intestinal maturation in piglets
    Yalin Liao
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Comp Biochem Physiol A Mol Integr Physiol 148:584-90. 2007
    ..These findings suggest a mechanism by which pig Lf can be internalized in the intestine...
  34. ncbi request reprint Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia
    Joshua L Roffman
    Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
    Schizophr Res 92:181-8. 2007
    ..This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this relationship...

Research Grants11

  1. EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
    Charles Halsted; Fiscal Year: 2007
    ..By confirming the relationship of abnormal methionine metabolism to clinical, biochemical, and pathologic disease severity, the study will establish a metabolic basis for determining the efficacy of SAM intervention in ALD. ..
  2. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2006
    ..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. ..
  3. EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
    Charles Halsted; Fiscal Year: 2006
    ..By confirming the relationship of abnormal methionine metabolism to clinical, biochemical, and pathologic disease severity, the study will establish a metabolic basis for determining the efficacy of SAM intervention in ALD. ..
  4. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2005
    ..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. ..
  5. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2005
    ..abstract_text> ..
  6. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2004
    ..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. ..
  7. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2004
    ..abstract_text> ..
  8. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2003
    ..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. ..
  9. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2003
    ..abstract_text> ..
  10. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2002
    ..abstract_text> ..
  11. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2001
    ..abstract_text> ..