Research Topics
| SCOTT DAVID HALPERNSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
Re-examining ethical obligations in the intensive care unit: HIV disclosure to surrogatesAnthony T Vernillo
New York University College of Dentistry, Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York, New York 10010, USA
Crit Care 11:125. 2007..We also provide a tabulation of individual US state laws relevant to disclosure of HIV status...
Nonconsented human immunodeficiency virus testing among critically ill patients: intensivists' practices and the influence of state lawsScott D Halpern
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 423 Guardian Dr, 711 Blockley Hall, Philadelphia, PA 19104 6021, USA
Arch Intern Med 167:2323-8. 2007..Human immunodeficiency virus (HIV) testing can improve care for many critically ill patients, but state laws and institutional policies may impede such testing when patients cannot provide consent...- Regulated payments for living kidney donation: an empirical assessment of the ethical concernsScott D Halpern
University of Pennsylvania School of Medicine and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104 6021, USA
Ann Intern Med 152:358-65. 2010..Although regulated payments to encourage living kidney donation could reduce morbidity and mortality among patients waiting for a kidney transplant, doing so raises several ethical concerns... - No child left behind: Enrolling children and adults simultaneously in critical care randomized trialsScott D Halpern
Division of Pulmonary, Allergy, and Critical Care Medicine SDH, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Crit Care Med 37:2638-41. 2009..We sought to evaluate the ethical, methodologic, and practical arguments for and against studying critical care interventions in adults and children simultaneously rather than sequentially... 
The ethics of randomized clinical trials in pulmonary arterial hypertensionScott D Halpern
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Proc Am Thorac Soc 5:631-5. 2008....- Misclassification of pulmonary hypertension due to reliance on pulmonary capillary wedge pressure rather than left ventricular end-diastolic pressureScott D Halpern
Division of Pulmonary, Allergy and Critical CareMedicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Chest 136:37-43. 2009..We sought to determine the calibration, discrimination, and diagnostic accuracy of PCWP, using simultaneously measured left ventricular end-diastolic pressure (LVEDP) as the "gold standard.".. - Terminal withdrawal of life-sustaining supplemental oxygenScott D Halpern
Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
JAMA 296:1397-400. 2006 - Development of an e-mail database of US intensive care physiciansScott D Halpern
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Crit Care 22:28-31. 2007..We sought to develop an e-mail database for all intensivists associated with US training programs in critical care medicine (academic intensivists) and to determine the feasibility of using this database to survey intensivists... - Harnessing the power of default options to improve health careScott D Halpern
Department of Medicine, The Leonard Davis Institute of Health Economics, the Center for Bioethics, University of Pennsylvania, Philadelphia 19104-6021, USA
N Engl J Med 357:1340-4. 2007 - Preevent vaccination against smallpox: a survey of pediatric emergency health care providersWorth W Everett
Department of Emergency Medicine, Hospital of the University of Pennsylvania, Centers for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
Pediatr Infect Dis J 23:332-7. 2004..A greater understanding of the knowledge, attitudes and beliefs of pediatric health care workers toward preevent smallpox vaccination will assist in the development of future bioterrorism preparedness programs... - Informing candidates for solid-organ transplantation about donor risk factorsScott D Halpern
Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, USA
N Engl J Med 358:2832-7. 2008 - Determinants of transplant surgeons' willingness to provide organs to patients infected with HBV, HCV or HIVScott D Halpern
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6021, USA
Am J Transplant 5:1319-25. 2005..HIV-infected patients should have equal access to organs unless or until evidence emerges that they fare substantially worse than other potential recipients... - HIV testing without consent in critically ill patientsScott D Halpern
Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
JAMA 294:734-7. 2005 - Towards evidence based bioethicsScott D Halpern
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine; 115 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA
BMJ 331:901-3. 2005 - Incentive models to increase living kidney donation: encouraging without coercingAjay K Israni
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Am J Transplant 5:15-20. 2005..We recommend the use of the expense reimbursement model along with these safeguards, in order to increase rates of living kidney donation... - Utility of the systemic inflammatory response syndrome (SIRS) criteria in predicting the onset of septic shock in hospitalized patients with hematologic malignanciesAnthony Mato
Hematology and Oncology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Cancer Biol Ther 8:1095-1100. 2009..The systemic inflammatory response syndrome (SIRS) criteria have not been validated in patients with hematologic malignancies (HM)... - Prospective preference assessment: a method to enhance the ethics and efficiency of randomized controlled trialsScott D Halpern
Center for Clinical Epidemiology and Biostatistics, Center for Bioethics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Control Clin Trials 23:274-88. 2002..It is concluded that PPA is a feasible approach to a more democratic and efficient research process and that its adoption would be consistent with current trends in health care... - The continuing unethical conduct of underpowered clinical trialsScott D Halpern
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 108 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
JAMA 288:358-62. 2002..In both cases, investigators must inform prospective subjects that their participation may only indirectly contribute to future health care benefits... - Physicians' preferences for active-controlled versus placebo-controlled trials of new antihypertensive drugsScott D Halpern
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
J Gen Intern Med 17:689-95. 2002..To evaluate physicians' preferences for referring patients to, and using information from, active-controlled trials (ACTs) versus placebo-controlled trials (PCTs) of new antihypertensive drugs... - Determinants of the decision to accept a kidney from a donor at increased risk for blood-borne viral infectionPETER P REESE
University of Pennsylvania, Renal Division, Department of Medicine, Philadelphia, PA, USA
Clin J Am Soc Nephrol 5:917-23. 2010..This study aimed to identify the proportion of kidney transplant candidates that would accept a kidney from a DIRVI and the factors that influenced this decision... - Evaluating preference effects in partially unblinded, randomized clinical trialsScott D Halpern
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 108 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
J Clin Epidemiol 56:109-15. 2003..It is concluded that investigators could use these methods to quantify potential preference effects in partially unblinded RCTs, and thereby more accurately estimate the specific effects of treatments... - Smallpox vaccination: a national survey of emergency health care providersWorth W Everett
Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
Acad Emerg Med 10:606-11. 2003..Although emergency health care providers are among the first targeted for vaccination, little is known about how these providers view the risks and benefits of SP vaccination... - Hypertensive patients' willingness to participate in placebo-controlled trials: implications for recruitment efficiencyScott D Halpern
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Am Heart J 146:985-92. 2003.... - Willingness of dialysis patients to participate in a randomized controlled trial of daily dialysisAjay K Israni
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Kidney Int 65:990-8. 2004..However, there is concern that difficulties recruiting patients may prevent the successful completion of such trials if patients believe the inconveniences of daily dialysis outweigh any potential health benefits... - Empirical assessment of whether moderate payments are undue or unjust inducements for participation in clinical trialsScott D Halpern
Department of Medicine, Centers for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
Arch Intern Med 164:801-3. 2004..Paying patients to participate in clinical trials is ethically controversial. However, there has been no empirical documentation regarding whether payment represents an undue or unjust inducement... - Decisions devoid of data?Scott D Halpern
School of Medicine, University of Pennsylvania, USA
Am J Bioeth 6:55-6; discussion W51-3. 2006 - Commentary: Improving response rates to mailed surveys: what do we learn from randomized controlled trials?Scott D Halpern
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
Int J Epidemiol 32:637-8. 2003 - Randomized trial of 5 dollars versus 10 dollars monetary incentives, envelope size, and candy to increase physician response rates to mailed questionnairesScott D Halpern
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Med Care 40:834-9. 2002..Including smaller incentives in more questionnaires may maximize total responses... - Solid-organ transplantation in HIV-infected patientsScott D Halpern
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
N Engl J Med 347:284-7. 2002 - Willingness of patients to switch from conventional to daily hemodialysis: looking before we leapScott D Halpern
Department of Medicine, University of Pennsylvania, Philadelphia, USA
Am J Med 116:606-12. 2004.... - Inadequate hepatitis B vaccination and post-exposure evaluation among transplant surgeons: prevalence, correlates, and implicationsScott D Halpern
Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
Ann Surg 244:305-9. 2006..Requiring documentation of HBV vaccination and immunity to maintain operating room privileges may protect surgeons, their patients, and operating room staff... - The future of the orthopaedic clinician-scientist: part II: Identification of factors that may influence orthopaedic residents' intent to perform researchJaimo Ahn
Department of Orthopaedic Surgery, 3400 Spruce Street, 2 Silverstein, Philadelphia, PA 19104, USA
J Bone Joint Surg Am 92:1041-6. 2010..Therefore, we sought to assess resident opinions regarding plans and incentives for future research and the opinions of academic chairs who must support them... - Epidemiologic studies of adverse effects of anti-retroviral drugs: how well is statistical power reportedScott D Halpern
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:155-61. 2005..Future research is needed to determine whether the observed paucity of industry-sponsored observational studies of anti-retroviral ADEs extends to other clinical areas, and if so, to identify the causes of this phenomenon... - Evidence-based equipoise and research responsivenessScott D Halpern
Am J Bioeth 6:1-4. 2006 - Research recruitment via camouflaged sampling: addressing the legal and ethical aspects of privacy concernsHilary M Wandall
Merck and Co, Inc, NJ, USA
Pharmacoepidemiol Drug Saf 17:798-800. 2008 - Post-call accidentsScott D Halpern
N Engl J Med 352:1491-2; author reply 1491-2. 2005 - Response to Willingness to participate and enroll in a phase 3 preventive HIV-1 vaccine trialScott D Halpern
J Acquir Immune Defic Syndr 33:412. 2003 - Reporting enrollment in clinical trialsScott D Halpern
Ann Intern Med 137:1007-8; author reply 1007-8. 2002 - Re: "Ethics and sample size"Scott D Halpern
Am J Epidemiol 162:195-6; author reply 196. 2005
Research Grants
- Comparative Efficacy, Acceptance and Effectiveness of Health Incentive StructuresSCOTT DAVID HALPERN; Fiscal Year: 2010..This work will both clarify mechanisms by which incentives alter behaviors, and will identify better ways to reduce smoking and other important causes of preventable death. ..