Research Topics
| Michael J HallerSummaryAffiliation: University of Florida Country: USA Publications
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Publications
Predictors of control of diabetes: monitoring may be the keyMichael J Haller
Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
J Pediatr 144:660-1. 2004..Frequent self-monitoring of blood glucose promotes long-term metabolic control...
Adverse impact of temperature and humidity on blood glucose monitoring reliability: a pilot studyMichael J Haller
Division of Pediatric Endocrinology, University of Florida, Gainesville, Florida 32610, USA
Diabetes Technol Ther 9:1-9. 2007..We performed a study to determine if the effect of temperature and humidity on glucose values could be accurately predicted...
Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetesMichael J Haller
Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, FL, USA
Pediatr Diabetes 8:193-8. 2007..To assess the ability of reactive hyperemia-peripheral artery tonometry (RH-PAT) to serve as a surrogate marker of endothelial dysfunction in children with type 1 diabetes (T1D)...
Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?Emmanuelle S Topiol
University of Florida, Department of Pediatrics, Division of Endocrinology, PO Box 100296, Gainesville, FL, 32610, USA
Int J Pediatr Endocrinol 2012:21. 2012..In addition to reviewing the management and genetics of NDM we discuss the potential for overlapping genetic or embryologic abnormalities to explain the concurrence of CDH and NDM...
Efforts to prevent and halt autoimmune beta cell destructionMichael J Haller
Division of Endocrinology, Department of Pediatrics, University of Florida, PO Box 100296, Gainesville, FL 32610, USA
Endocrinol Metab Clin North Am 39:527-39. 2010....
Autologous umbilical cord blood transfusion in very young children with type 1 diabetesMichael J Haller
Department of Pediatrics, The University of Florida, Gainesville, Florida, USA
Diabetes Care 32:2041-6. 2009..We conducted an open-label phase I study using autologous umbilical cord blood infusion to ameliorate type 1 diabetes...
The road not taken: a path to curing type 1 diabetes?Michael J Haller
Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
Eur J Immunol 39:2054-8. 2009....
Pediatric Atorvastatin in Diabetes Trial (PADIT): a pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitusMichael J Haller
Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
J Pediatr Endocrinol Metab 22:65-8. 2009..Secondary analysis demonstrated potential reduction of arterial stiffness following atorvastatin therapy (p = 0.06). Additional long-term prospective studies with larger numbers of patients are needed...
Autologous umbilical cord blood infusion for type 1 diabetesMichael J Haller
Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
Exp Hematol 36:710-5. 2008..Herein, we describe the scientific and therapeutic rationale underlying efforts utilizing umbilical cord blood (UCB) as a therapy for ameliorating the progression of this autoimmune disease...
Type 1 diabetes intervention trials 2007: where are we and where are we going?Michael J Haller
Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
Curr Opin Endocrinol Diabetes Obes 14:283-7. 2007..This review explores the lessons learned from recent type 1 diabetes interventional studies, sets out controversial issues and seeks to provide a roadmap for future interventions...
Endocrine complications of childhood cancer therapy: evaluation and managementMichael J Haller
Department of Pediatrics, University of Florida School of Medicine, Gainesville, FL 32610, USA
Pediatr Endocrinol Rev 4:196-204. 2007..The following review will identify endocrinopathies associated with different chemotherapy and radiation protocols and will review lifelong screening and treatment strategies for endocrine complications of childhood cancer...
Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptideMichael J Haller
Department of Pediatrics, University of Florida, Gainesville, Florida, USA
Diabetes Care 34:2567-9. 2011..Having previously reported on the first 15 patients reaching 1 year of follow-up, herein we report on the complete cohort after 2 years of follow-up...
Serum superoxide dismutase activity and nitric oxide do not correlate with arterial stiffness in children with type 1 diabetes mellitusMichael J Haller
Division of Pediatric Endocrinology, Department of Pediatrics University of Florida, Gainesville 32610, USA
J Pediatr Endocrinol Metab 19:267-9. 2006
Arterial thrombosis resulting in amputation in a child with poorly controlled type 1 diabetes and heterozygous Factor V Leiden mutationMichael J Haller
Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, FL, USA
Pediatr Diabetes 7:229-31. 2006..This report emphasizes the need to test for thrombophilic defects in children with thrombosis or with a family history of thrombosis. Good metabolic control is especially important in children with T1DM and known thrombophilic defects...
Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetesMichael J Haller
Pediatric Endocrinology, P O Box 100296, Gainesville, FL 32610, USA
Diabetes Care 27:2911-7. 2004..To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index with the simple noninvasive technique of radial artery tonometry...
Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive areaSong Xue
Department of Pathology, University of Florida, Gainesville, FL 32610, USA
J Diabetes Complications 24:163-7. 2010....
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetesDiego Ize-Ludlow
Department of Pediatrics, Division of Pediatric Endocrinology, Diabetes and Metabolism, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Diabetes 60:2086-91. 2011..A progressive decline in insulin responses to glucose was noted in individuals before the onset of type 1 diabetes. We determined whether such abnormalities occurred in prediabetic NOD mice-the prototypic model for human type 1 diabetes...
Development of autoantibodies in the TrialNet Natural History StudyKendra Vehik
University of South Florida, Pediatrics Epidemiology Center, Tampa, FL, USA
Diabetes Care 34:1897-901. 2011....
Type 1 diabetes: current concepts in epidemiology, pathophysiology, clinical care, and researchMary Joyce Gan
Department of Pediatrics, University of Florida, Gainesville, FL, USA
Curr Probl Pediatr Adolesc Health Care 42:269-91. 2012..Herein, we provide a comprehensive review of the natural history, pathophysiology, and contemporary management of T1D. In addition, recent advances in T1D research are discussed...
Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequencySong Xue
Department of Pathology, University of Florida, Florida 32010, USA
Ann N Y Acad Sci 1150:152-6. 2008..Taken collectively, these data suggest that in addition to its potential effects on beta cell proliferation, Ex-4 may also act as a regulator of the immune response...
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic miceMatthew J Parker
Department of Pathology, University of Florida, Gainesville, Florida, USA
Diabetes 58:2277-84. 2009....
Type 1 diabetes mellitus: etiology, presentation, and managementMichael J Haller
Division of Pediatric Endocrinology, University of Florida College of Medicine, PO Box 100296, Gainesville, FL 32610, USA
Pediatr Clin North Am 52:1553-78. 2005..Finally, the article discusses the future of diabetes screening programs and the progress toward the ultimate goal of curing type 1 diabetes...
Vascular dysfunction in glycogen storage disease type IAngelina V Bernier
Division of Pediatric Endocrinology and Glycogen Storage Disease Program, Department of Pediatrics, University of Florida, Gainesville, FL 32610 0296, USA
J Pediatr 154:588-91. 2009..To determine cardiovascular disease risk in a larger cohort of patients with glycogen storage disease (GSD) I through the use of noninvasive measures of arterial function and anatomy...
Serum monocyte chemoattractant protein-1 concentrations associate with diabetes status but not arterial stiffness in children with type 1 diabetesIssam Zineh
Department of Pharmacy Practice and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, Florida, USA
Diabetes Care 32:465-7. 2009..We tested whether inflammatory monocyte chemoattractant protein (MCP)-1 concentrations correlate with arterial stiffness or type 1 diabetes status...
Assessing the in vitro suppressive capacity of regulatory T cellsTodd M Brusko
Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA
Immunol Invest 36:607-28. 2007..As further immunomodulatory therapies are explored, the need for additional methodologies to understand the cellular and molecular mechanisms of immune regulation conferred by Treg will play an increasingly important role...
Arterial stiffness, lipoprotein particle size, and lipoprotein particle concentration in children with type 1 diabetesLisa M Gallo
Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, Florida, USA
J Pediatr Endocrinol Metab 23:661-7. 2010..To determine if lipoprotein particle abnormalities correlate with arterial stiffness in children with type 1 diabetes (T1D)...
Diabetic ketoacidosis at diabetes onset: still an all too common threat in youthGeorgeanna J Klingensmith
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO, USA
J Pediatr 162:330-4.e1. 2013..To define the demographic and clinical characteristics of children at the onset of type 1 diabetes (T1D), with particular attention to the frequency of diabetic ketoacidosis (DKA)...
NOS3 polymorphisms are associated with arterial stiffness in children with type 1 diabetesIssam Zineh
Department of Pharmacy Practice and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, Florida, USA
Diabetes Care 30:689-93. 2007..We hypothesized that polymorphisms in the NOS3 gene may be associated with the differences seen in arterial stiffness within the population of children with type 1 diabetes...
Islet autoantibody seroconversion in the DPT-1 study: justification for repeat screening throughout childhoodKendra Vehik
Pediatrics Epidemiology Center, University of South Florida, Tampa, Florida, USA
Diabetes Care 34:358-62. 2011..Our aim was to determine the timing of seroconversion to diabetes-associated autoantibody (DAA) positivity and risk in first- and second-degree relatives of patients with type 1 diabetes...
Update on global intervention studies in type 1 diabetesJane L Chiang
Division of Endocrinology, Department of Pediatrics, Stanford University, 300 Pasteur Drive, G 313, Stanford, CA 94305, USA Electronic address
Endocrinol Metab Clin North Am 41:695-712. 2012..This article updates the principles used to design prevention and intervention trials, reviews clinical trials, addresses controversial issues, and provides a framework for future efforts to interdict this condition...
Tanner stage 4 breast development in adults: forensic implicationsArlan L Rosenbloom
Division of Endocrinology, Department of Pediatrics, University of Florida College of Medicine, 1701 SW 16th Ave, PO Box 100296, Gainesville, FL 32608, USA
Pediatrics 130:e978-81. 2012..Clinical experience does not support this notion, but there are no relevant studies. We sought to estimate how frequently TS 4 might be interpreted from nonclinical images by individual forensic experts...
Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapyJean Y Park
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 93:26-31. 2008..Acquired generalized lipodystrophy (AGL) is marked by severe insulin resistance and hypertriglyceridemia. Rarely, AGL and type 1 diabetes (T1D) coexist...
Correlation between radial artery tonometry- and fingertip tonometry-derived augmentation index in children with type 1 diabetesMichael J Haller
Diab Vasc Dis Res 4:66. 2007
Cytokines and type 1 diabetes complications: casual or causal association?Michael J Haller
Pediatr Diabetes 9:1-2. 2008
CD3-antibody therapy in new-onset type 1 diabetes mellitusMichael J Haller
N Engl J Med 353:2086-7; author reply 2086-7. 2005
