Lisa L Hall

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Biol 186:491-507. 2009
  2. ncbi request reprint The cell biology of a novel chromosomal RNA: chromosome painting by XIST/Xist RNA initiates a remodeling cascade
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Semin Cell Dev Biol 14:369-78. 2003
  3. pmc X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected
    Lisa L Hall
    Department of Cell Biology, U Mass Med School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 216:445-52. 2008
  4. doi request reprint A long noncoding RNA mediates both activation and repression of immune response genes
    Susan Carpenter
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 341:789-92. 2013
  5. ncbi request reprint BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin
    Gayle J Pageau
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Biochem 100:835-50. 2007
  6. pmc Molecular anatomy of a speckle
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, 01655, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:664-75. 2006
  7. pmc An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 99:8677-82. 2002
  8. pmc Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice
    Jongdae Shin
    Program in Gene Function and Expression, University of Massachusetts Medical School UMMS, Worcester, Massachusetts 01605, USA
    Nature 467:977-81. 2010
  9. ncbi request reprint Unbalanced X;autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655 0106, USA
    Hum Mol Genet 11:3157-65. 2002
  10. pmc Stable C0T-1 repeat RNA is abundant and is associated with euchromatic interphase chromosomes
    Lisa L Hall
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell 156:907-19. 2014

Collaborators

Detail Information

Publications20

  1. pmc AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Biol 186:491-507. 2009
    ..Results suggest a model of multiple distinct anchor points for XIST RNA. This study advances understanding of RNA chromosome binding and the roles of AURKB and demonstrates a novel approach to manipulate and study XIST RNA...
  2. ncbi request reprint The cell biology of a novel chromosomal RNA: chromosome painting by XIST/Xist RNA initiates a remodeling cascade
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Semin Cell Dev Biol 14:369-78. 2003
    ....
  3. pmc X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected
    Lisa L Hall
    Department of Cell Biology, U Mass Med School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 216:445-52. 2008
    ..The many epigenetic anomalies seen indicate that maintenance of fully unspecialized cells, which have not formed Xi facultative heterochromatin, is a delicate epigenetic balance difficult to maintain in culture...
  4. doi request reprint A long noncoding RNA mediates both activation and repression of immune response genes
    Susan Carpenter
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 341:789-92. 2013
    ..Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response. ..
  5. ncbi request reprint BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin
    Gayle J Pageau
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Biochem 100:835-50. 2007
    ..We provide preliminary evidence that this may occur as part of a wider failure of heterochromatin maintenance in some cancers...
  6. pmc Molecular anatomy of a speckle
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, 01655, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:664-75. 2006
    ..Conditions that disperse SC35 also disperse poly(A) RNA, whereas the splicing factor ASF/SF2 can be dispersed under conditions in which SC35 or SRm300 remain as intact components of a core domain...
  7. pmc An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 99:8677-82. 2002
    ..These results have fundamental significance for understanding genomic programming in early development...
  8. pmc Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice
    Jongdae Shin
    Program in Gene Function and Expression, University of Massachusetts Medical School UMMS, Worcester, Massachusetts 01605, USA
    Nature 467:977-81. 2010
    ..These results assign crucial functions to the maternal deposit of Rnf12/RLIM for the initiation of imprinted XCI...
  9. ncbi request reprint Unbalanced X;autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin
    Lisa L Hall
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655 0106, USA
    Hum Mol Genet 11:3157-65. 2002
    ..Hence compromised interaction with XIST RNA may be a primary cause of incomplete or unstable autosomal inactivation...
  10. pmc Stable C0T-1 repeat RNA is abundant and is associated with euchromatic interphase chromosomes
    Lisa L Hall
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell 156:907-19. 2014
    ..These findings impact two "black boxes" of genome science: the poorly understood diversity of noncoding RNA and the unexplained abundance of repetitive elements. ..
  11. ncbi request reprint The disappearing Barr body in breast and ovarian cancers
    Gayle J Pageau
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nat Rev Cancer 7:628-33. 2007
    ..We suggest that heterochromatic instability is a common but largely unexplored mechanism, leading to widespread genomic misregulation and the evolution of some cancers...
  12. pmc The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences
    Christine Moulton Clemson
    Department of Cell Biology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 103:7688-93. 2006
    ..Instead of acting at a local gene level, XIST RNA appears to interact with and silence core architectural elements to effectively condense and shut down the Xi...
  13. pmc A multifaceted FISH approach to study endogenous RNAs and DNAs in native nuclear and cell structures
    Meg Byron
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, USA
    Curr Protoc Hum Genet . 2013
    ..Solutions to several common technical pitfalls are discussed, as are cautions regarding the judicious use of digital imaging and the rigors of analyzing and interpreting complex molecular cytological results...
  14. ncbi request reprint c-Myc localization within the nucleus: evidence for association with the PML nuclear body
    Kelly P Smith
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    J Cell Biochem 93:1282-96. 2004
    ..This work provides a comprehensive study of c-Myc distribution and also presents the first evidence of a relationship between turnover of this oncoprotein and PML nuclear bodies, known to break down in certain cancers...
  15. pmc Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells
    John T Butler
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, 01655, USA
    J Cell Biochem 107:609-21. 2009
    ..Findings demonstrate that pluripotent hES cells have a markedly different overall nuclear architecture, remodeling of which is linked to early epigenomic programming and involves formation of unique PML-defined structures...
  16. pmc Translating dosage compensation to trisomy 21
    Jun Jiang
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Nature 500:296-300. 2013
    ..Successful trisomy silencing in vitro also surmounts the major first step towards potential development of 'chromosome therapy'. ..
  17. pmc Word frequency analysis reveals enrichment of dinucleotide repeats on the human X chromosome and [GATA]n in the X escape region
    John A McNeil
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Genome Res 16:477-84. 2006
    ..Results suggest a new paradigm whereby a regional escape from X inactivation is due to the presence of elements that prevent heterochromatinization, rather than the lack of other elements that promote it...
  18. pmc Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells
    Rajini Mudhasani
    Department of Cell Biology, University of Massachusetts Medical School, North Worcester, MA 01655, USA
    J Cell Biol 181:1055-63. 2008
    ..These results reveal that loss of miRNA biogenesis activates a DNA damage checkpoint, up-regulates p19(Arf)-p53 signaling, and induces senescence in primary cells...
  19. ncbi request reprint Characterization of expression at the human XIST locus in somatic, embryonal carcinoma, and transgenic cell lines
    Jennifer C Chow
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T1Z3, Canada
    Genomics 82:309-22. 2003
    ..These analyses reveal similarities to and differences from the murine Xist and Tsix transcripts and generate a complex picture of developmentally regulated transcription through the region...
  20. pmc Inducible XIST-dependent X-chromosome inactivation in human somatic cells is reversible
    Jennifer C Chow
    Department of Medical Genetics, Molecular Epigenetics Group, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 104:10104-9. 2007
    ....