John E Hall

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. pmc Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins
    John E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Biol Chem 285:17271-6. 2010
  2. ncbi request reprint Obesity hypertension: role of leptin and sympathetic nervous system
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Hypertens 14:103S-115S. 2001
  3. ncbi request reprint Mechanisms of obesity-associated cardiovascular and renal disease
    John E Hall
    Department of Physiology and Biophysics, and Center for Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Med Sci 324:127-37. 2002
  4. ncbi request reprint Mechanisms of hypertension and kidney disease in obesity
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Ann N Y Acad Sci 892:91-107. 1999
  5. ncbi request reprint The kidney, hypertension, and obesity
    John E Hall
    Department of Physiology and Biophysics and Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 41:625-33. 2003
  6. ncbi request reprint Historical perspective of the renin-angiotensin system
    John E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Mol Biotechnol 24:27-39. 2003
  7. ncbi request reprint Impact of the obesity epidemic on hypertension and renal disease
    John E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Curr Hypertens Rep 5:386-92. 2003
  8. ncbi request reprint Angiotensin II and long-term arterial pressure regulation: the overriding dominance of the kidney
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    J Am Soc Nephrol 10:S258-65. 1999
  9. doi request reprint Hypertension and cardiovascular disease in women
    John E Hall
    Department of Physiology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 51:951. 2008
  10. ncbi request reprint Is obesity a major cause of chronic kidney disease?
    John E Hall
    Department of Physiology and Biophysics and Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson, MS, USA
    Adv Ren Replace Ther 11:41-54. 2004

Collaborators

Detail Information

Publications97

  1. pmc Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins
    John E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Biol Chem 285:17271-6. 2010
    ....
  2. ncbi request reprint Obesity hypertension: role of leptin and sympathetic nervous system
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Hypertens 14:103S-115S. 2001
    ....
  3. ncbi request reprint Mechanisms of obesity-associated cardiovascular and renal disease
    John E Hall
    Department of Physiology and Biophysics, and Center for Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Med Sci 324:127-37. 2002
    ....
  4. ncbi request reprint Mechanisms of hypertension and kidney disease in obesity
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Ann N Y Acad Sci 892:91-107. 1999
    ..Because obesity is the main cause of Type 2 diabetes and an important cause of human essential hypertension, it seems likely that obesity is also one of the most important risk factors for end-stage renal disease...
  5. ncbi request reprint The kidney, hypertension, and obesity
    John E Hall
    Department of Physiology and Biophysics and Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 41:625-33. 2003
    ..Although there are many unanswered questions about the mechanisms of obesity hypertension and renal disease, this is one of the most promising areas for future research, especially in view of the growing, worldwide "epidemic" of obesity...
  6. ncbi request reprint Historical perspective of the renin-angiotensin system
    John E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Mol Biotechnol 24:27-39. 2003
    ....
  7. ncbi request reprint Impact of the obesity epidemic on hypertension and renal disease
    John E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Curr Hypertens Rep 5:386-92. 2003
    ..Special considerations for the obese patient, in addition to adequately controlling the blood pressure, include correction of the metabolic abnormalities and protection of the kidneys from further injury...
  8. ncbi request reprint Angiotensin II and long-term arterial pressure regulation: the overriding dominance of the kidney
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    J Am Soc Nephrol 10:S258-65. 1999
    ..Blockade of the RAS has proved to be a powerful therapeutic tool for lowering BP and improving kidney function in disorders such as hypertension, congestive heart failure, and chronic renal disease...
  9. doi request reprint Hypertension and cardiovascular disease in women
    John E Hall
    Department of Physiology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 51:951. 2008
  10. ncbi request reprint Is obesity a major cause of chronic kidney disease?
    John E Hall
    Department of Physiology and Biophysics and Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson, MS, USA
    Adv Ren Replace Ther 11:41-54. 2004
    ..Special considerations for the obese patient, in addition to adequately controlling the blood pressure, include correction of the metabolic abnormalities and protection of the kidneys from further injury...
  11. ncbi request reprint Obesity-associated hypertension and kidney disease
    John E Hall
    Department of Physiology and Biophysics and Center of Excellence in Cardiovascular Renal Research, Jackson, Mississippi, USA
    Curr Opin Nephrol Hypertens 12:195-200. 2003
    ..Our objective is to review the mechanisms that link obesity with hypertension and altered kidney function...
  12. pmc Impact of obesity on renal structure and function in the presence and absence of hypertension: evidence from melanocortin-4 receptor-deficient mice
    Jussara M do Carmo
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 297:R803-12. 2009
    ....
  13. pmc Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons
    Jussara M do Carmo
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi
    Am J Physiol Regul Integr Comp Physiol 305:R359-68. 2013
    ..In contrast, while activation of MC4R in Pomc neurons facilitates the BP response to acute stress, our data do not support a major role of MC4R in Pomc neurons in regulating baseline BP and HR...
  14. ncbi request reprint Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia
    Lakshmi S Tallam
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Hypertension 46:326-32. 2005
    ....
  15. doi request reprint Hypertension: physiology and pathophysiology
    John E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Compr Physiol 2:2393-442. 2012
    ....
  16. pmc Chronic effects of centrally administered adiponectin on appetite, metabolism and blood pressure regulation in normotensive and hypertensive rats
    Mirian Bassi
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
    Peptides 37:1-5. 2012
    ..These results suggest that adiponectin, acting via its direct actions on the CNS, has a small effect to reduce appetite and insulin levels, but it has no long-term action to reduce BP or HR, or to alter whole body metabolic rate...
  17. pmc Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons
    Jussara M do Carmo
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216, USA
    Hypertension 57:918-26. 2011
    ....
  18. pmc A functional melanocortin system may be required for chronic CNS-mediated antidiabetic and cardiovascular actions of leptin
    Alexandre A da Silva
    Department of Physiology and Biophysics and Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Diabetes 58:1749-56. 2009
    ..We recently showed that leptin has powerful central nervous system (CNS)-mediated antidiabetic and cardiovascular actions. This study tested whether the CNS melanocortin system mediates these actions of leptin in diabetic rats...
  19. pmc Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats
    Alexandre A da Silva
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Hypertension 51:884-90. 2008
    ..These results also support the hypothesis that weight gain does not raise arterial pressure in the absence of a functional MC3/4-R...
  20. pmc Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin
    John H Dubinion
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 61:1066-74. 2013
    ..These results indicate that Stat3 signaling in POMC neurons is essential for leptin-mediated increases in MAP, but not for anorexic or thermogenic effects of leptin...
  21. ncbi request reprint Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin
    Alexandre A da Silva
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 450, USA
    Hypertension 43:1312-7. 2004
    ..Thus, MC3/4-R antagonism completely blocked the chronic cardiovascular, satiety, and metabolic effects of leptin, suggesting that the hypothalamic melanocortin system plays an important role in mediating these actions of leptin...
  22. ncbi request reprint Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin
    Lakshmi S Tallam
    Department of Physiology, School of Medicine, University of Mississippi Medical Center, Jackson, Miss 39216, USA
    Hypertension 48:58-64. 2006
    ..Thus, a functional MC4R is essential for the chronic cardiovascular and metabolic actions of leptin...
  23. ncbi request reprint Role of endothelin-1 in blood pressure regulation in a rat model of visceral obesity and hypertension
    Alexandre A da Silva
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Hypertension 43:383-7. 2004
    ..Endothelin-1 appears to play an important role in the maintenance of arterial pressure in rats fed HF and NF diets, but it does not appear to contribute to increased MAP in this model of diet-induced hypertension...
  24. ncbi request reprint Chronic antidiabetic and cardiovascular actions of leptin: role of CNS and increased adrenergic activity
    Alexandre A da Silva
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1275-82. 2006
    ..These findings provide new insights into novel pathways for long-term control of glucose homeostasis and cardiovascular regulation...
  25. pmc Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation
    Fouad A Zouein
    Department of Pharmacology and Toxicology, and Center for Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, School of Medicine, Jackson, MS, USA
    Hypertens Res 36:496-503. 2013
    ..Loss of STAT3 may impair cardiac function in the hypertensive heart due to defective myofibrillar structure and remodeling that may lead to heart failure...
  26. pmc Role of leptin and central nervous system melanocortins in obesity hypertension
    Alexandre A da Silva
    Department of Physiology and Biophysics, Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson, Mississippi, USA
    Curr Opin Nephrol Hypertens 22:135-40. 2013
    ..Our goal is to review the mechanisms that link obesity with hypertension, with special emphasis on the role of leptin and the brain melanocortin system in driving sympathetic activation in obesity...
  27. ncbi request reprint Cardiovascular, renal, and metabolic responses to chronic central administration of agouti-related peptide
    Lakshmi S Tallam
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Hypertension 44:853-8. 2004
    ..These results demonstrate that increased central nervous system AGRP levels produce chronic reductions in MAP and HR despite marked increases in food intake and weight gain that normally tend to raise arterial pressure...
  28. pmc Chronic central leptin infusion restores cardiac sympathetic-vagal balance and baroreflex sensitivity in diabetic rats
    Jussara M do Carmo
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Heart Circ Physiol 295:H1974-81. 2008
    ....
  29. ncbi request reprint Does obesity induce resistance to the long-term cardiovascular and metabolic actions of melanocortin 3/4 receptor activation?
    Alexandre A da Silva
    Department of Physiology and Biophysics, Center of Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 9216 4505, USA
    Hypertension 47:259-64. 2006
    ..Thus, the metabolic and cardiovascular actions of chronic MC3/4-R activation are preserved in diet-induced obesity, supporting a potential role for the hypothalamic melanocortin system in obesity hypertension...
  30. pmc Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway
    Jussara M do Carmo
    Department of Physiology and Biophysics, Center of Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA
    IUBMB Life 65:692-8. 2013
    ..g., leptin) and activation of CNS pathways (e.g., MC4R) that regulate energy balance, SNS activity and BP represents an important target for treating obesity and its metabolic and cardiovascular consequences...
  31. pmc Activation of the central melanocortin system contributes to the increased arterial pressure in obese Zucker rats
    Jussara M do Carmo
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 302:R561-7. 2012
    ..These results suggest that in obese Zucker rats the CNS melanocortin system contributes to elevated BP independent of leptin receptor activation...
  32. pmc Systemic but not central nervous system nitric oxide synthase inhibition exacerbates the hypertensive effects of chronic melanocortin-3/4 receptor activation
    Jussara M do Carmo
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Hypertension 57:428-34. 2011
    ..These results suggest that reduction in peripheral, but not CNS, nitric oxide production augments MAP sensitivity to CNS melanocortin 3/4 receptor activation...
  33. ncbi request reprint Chronic central nervous system hyperinsulinemia and regulation of arterial pressure and food intake
    Jiankang Liu
    Department of Physiology and Biophysics, and Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Hypertens 24:1391-5. 2006
    ..The goal of the present study was to determine whether chronic increases in CNS levels of insulin, in the absence of changes in plasma insulin concentration, decrease food intake and raise arterial pressure in rats...
  34. ncbi request reprint Role of adrenergic activity in pressor responses to chronic melanocortin receptor activation
    Jay J Kuo
    Department of Physiology and Biophysics, 2500 N State St, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Hypertension 43:370-5. 2004
    ..These results indicate that the chronic actions of MC3/4-R activation on MAP and HR are mediated by adrenergic activation...
  35. pmc Inhibitor κB kinase 2 is a myosin light chain kinase in vascular smooth muscle
    Zhekang Ying
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
    Circ Res 113:562-70. 2013
    ..Inhibitor κB kinase 2 (IKK2)-deficient mouse embryonic fibroblasts demonstrate abnormal morphology and migration, suggesting that IKK2 may be involved in MLC phosphorylation...
  36. ncbi request reprint Chronic cardiovascular and renal actions of leptin during hyperinsulinemia
    Jay J Kuo
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1037-42. 2003
    ..Insulin raised heart rate (HR) by 17 +/- 5 beats/min, whereas leptin + insulin increased HR by 34 +/- 5 beats/min. Thus leptin appears to increase the effects of insulin to suppress appetite and to raise arterial pressure and HR...
  37. doi request reprint Chronic blood pressure and appetite responses to central leptin infusion in rats fed a high fat diet
    John H Dubinion
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Hypertens 29:758-62. 2011
    ..Most studies, however, have tested only the acute responses to leptin administration. This study tested whether feeding a high-fat diet causes resistance to the appetite and cardiovascular responses to chronic central leptin infusion...
  38. ncbi request reprint Pathophysiology and treatment of obesity hypertension
    Marion R Wofford
    Division of Hypertension, Department of Medicine, Center of Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA
    Curr Pharm Des 10:3621-37. 2004
    ..Special considerations for the obese patient, in addition to adequately controlling the blood pressure, include correcting the metabolic abnormalities and protecting the kidneys from further injury...
  39. pmc Enhanced blood pressure and appetite responses to chronic central melanocortin-3/4 receptor blockade in dietary-induced obesity
    John H Dubinion
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Hypertens 28:1466-70. 2010
    ....
  40. pmc Cardiomyocyte-specific deletion of leptin receptors causes lethal heart failure in Cre-recombinase-mediated cardiotoxicity
    Michael E Hall
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Am J Physiol Regul Integr Comp Physiol 303:R1241-50. 2012
    ..These observations indicate that leptin plays an important role in regulating cardiac function in the setting of cardiac stress caused by Cre-recombinase expression, likely through actions on cardiomyocyte energy metabolism...
  41. pmc Obesity promotes melanoma tumor growth: role of leptin
    Elizabeth L Brandon
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
    Cancer Biol Ther 8:1871-9. 2009
    ..Although tumor growth does not require host leptin, melanoma tumor growth may be accelerated by leptin...
  42. ncbi request reprint Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration
    Rogerio B de Paula
    Department of Physiology and Biophysics and Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 43:41-7. 2004
    ..These observations indicate that ALDO plays an important role in the pathogenesis of obesity hypertension...
  43. ncbi request reprint Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function
    Jay J Kuo
    Department of Physiology and Biophysics, Center of Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 41:768-74. 2003
    ..These observations are consistent with the hypothesis that an intact hypothalamic MC3/4-R may be necessary for excess weight gain to raise arterial pressure...
  44. pmc The role of the sympathetic nervous system in obesity-related hypertension
    Alexandre A da Silva
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Curr Hypertens Rep 11:206-11. 2009
    ....
  45. ncbi request reprint Role of sympathetic nervous system and neuropeptides in obesity hypertension
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Braz J Med Biol Res 33:605-18. 2000
    ..Although the role of these mechanisms in human obesity has not been elucidated, this remains a fruitful area for further investigation, especially in view of the current "epidemic" of obesity in most industrialized countries...
  46. ncbi request reprint Cytokine gene expression profiles in kidney medulla and cortex of obese hypertensive dogs
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Kidney Int 66:713-21. 2004
    ..The molecular mechanisms linking abnormal kidney function and obesity hypertension are poorly understood. This study compared gene expression profiles in the kidney medulla and cortex of obese and lean dogs...
  47. ncbi request reprint Mechanisms of abnormal renal sodium handling in obesity hypertension
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505, USA
    Am J Hypertens 10:49S-55S. 1997
    ..The quantitative importance of these intrarenal changes and their interrelationship with neurohumoral activation in obesity is an important area for further investigation...
  48. ncbi request reprint Increased expression of vascular endothelial growth factor and capillary density in hearts of spontaneously hypertensive rats
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Microcirculation 11:689-97. 2004
    ....
  49. ncbi request reprint Chronic cardiovascular and renal actions of leptin: role of adrenergic activity
    Megan Carlyle
    Department of Physiology and Biophysics and Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 39:496-501. 2002
    ..However, the chronic effects of leptin on insulin and glucose regulation do not appear to be altered by alpha- and beta-adrenergic receptor blockade...
  50. pmc Endothelin-A receptor blockade slows the progression of renal injury in experimental renovascular disease
    Silvia Kelsen
    Dept of Physiology and Biophysics, Dept of Medicine, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 301:F218-25. 2011
    ..These results support a role for ET-1/ET-A as a potential therapeutic target in chronic RVD...
  51. ncbi request reprint Underweight rather than overweight is associated with higher prevalence of hypertension: BP vs BMI in haemodialysis population
    Abdulla K Salahudeen
    Department of Medicine and Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Nephrol Dial Transplant 19:427-32. 2004
    ..Alternatively, malnutrition through proinflammatory and antiendothelial mechanisms may contribute to hypertension in malnourished, underweight patients on haemodialysis, whereas the converse may be true in overweight patients...
  52. ncbi request reprint Chronic adrenergic receptor blockade does not prevent hyperinsulinemia-induced hypertension in rats
    H L Keen
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505, USA
    Am J Hypertens 9:1192-9. 1996
    ..All variables returned toward control after stopping insulin. These results suggest that increased adrenergic activity is not required for chronic hyperinsulinemia to raise blood pressure in rats...
  53. pmc Direct recording of renal sympathetic nerve activity in unrestrained, conscious mice
    Shereen M Hamza
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
    Hypertension 60:856-64. 2012
    ..05). Thus, we demonstrate an accessible and effective method for direct assessment of RSNA in conscious, unrestrained mice...
  54. ncbi request reprint Obesity, physical inactivity, and risk for cardiovascular disease
    Patricia M Dubbert
    University of Mississippi School of Medicine, Jackson, USA
    Am J Med Sci 324:116-26. 2002
    ..The Jackson Heart Study will provide important and unique information relevant to many unanswered questions about obesity, physical inactivity, and obesity in African Americans...
  55. pmc Obesity, metabolic syndrome and diabetic nephropathy
    Christine Maric
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Miss 39216 4505, USA
    Contrib Nephrol 170:28-35. 2011
    ..This chapter compares and contrasts factors involved in the development of glomerular hemodynamic and kidney pathological processes associated with diabetes and obesity...
  56. ncbi request reprint Distribution of renal medullary hyaluronan in lean and obese rabbits
    T M Dwyer
    Departments of Physiology and Biophysics and Pathology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Kidney Int 58:721-9. 2000
    ..In obese dogs, the IM is also expanded, with hyaluronan (HA) content being 2.4 times control...
  57. ncbi request reprint Is insulin resistance linked to hypertension?
    M W Brands
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216, USA
    Clin Exp Pharmacol Physiol 25:70-6. 1998
    ....
  58. ncbi request reprint Enhanced vascular reactivity and Ca2+ entry with low-salt diet: effect of obesity
    R A Khalil
    Department of Physiology and Biophysics and The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Hypertension 34:882-8. 1999
    ..The enhancement of the Ca2+ influx-stress relationship with low-salt diet, particularly in the obese rabbits, suggests activation of other contractile mechanisms in addition to Ca2+ entry...
  59. ncbi request reprint Abnormal kidney function as a cause and a consequence of obesity hypertension
    J E Hall
    Department of Physiology and Biophysics and The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Clin Exp Pharmacol Physiol 25:58-64. 1998
    ..Because of the high prevalence of obesity in most industrialized countries, unravelling these mechanisms will likely provide a better understanding of the pathophysiology of human essential hypertension and chronic renal failure...
  60. ncbi request reprint The altered structure of renal papillary outflow tracts in obesity
    T M Dwyer
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Ultrastruct Pathol 24:251-7. 2000
    ....
  61. ncbi request reprint Inhibition of NO synthesis enhances chronic cardiovascular and renal actions of leptin
    J J Kuo
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA
    Hypertension 37:670-6. 2001
    ..These results indicate that impaired NO synthesis mildly enhances the chronic renal hemodynamic and hypertensive effects of leptin but markedly amplifies the tachycardia caused by hyperleptinemia...
  62. ncbi request reprint Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects
    M R Wofford
    Department of Medicine, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Hypertens 14:694-8. 2001
    ....
  63. ncbi request reprint Resistance to metabolic actions of insulin and its role in hypertension
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505
    Am J Hypertens 7:772-88. 1994
    ..However, insulin resistance and compensatory hyperinsulinemia may contribute to increased risk of other cardiovascular diseases associated with hypertension, such as coronary artery disease...
  64. ncbi request reprint Rapid hypotensive response to fasting in spontaneously hypertensive rats
    S M Fitzgerald
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA
    Am J Hypertens 14:1123-7. 2001
    ..Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function...
  65. pmc The brain melanocortin system, sympathetic control, and obesity hypertension
    Alexandre A da Silva
    Department of Physiology and Biophysics, Mississippi Center for Obesity Research, and Cardiovascular Renal Research Center, The University of Mississippi Medical Center, Jackson, Mississippi
    Physiology (Bethesda) 29:196-202. 2014
    ..In addition, we highlight potential mechanisms by which the brain melanocortin system modulates metabolic and cardiovascular functions. ..
  66. ncbi request reprint Renal perfusion pressure is an important determinant of sodium and calcium excretion in DOC-salt hypertension
    M W Brands
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216, USA
    Am J Hypertens 11:1199-207. 1998
    ..Thus, increased RPP is important in restoring sodium balance and in maintaining the calciuresis in DOC-salt hypertension; however, other mechanisms also are important, particularly during the onset of hypertension...
  67. ncbi request reprint Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation
    Michael E Hall
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi and Department of Medicine Division of Cardiology, University of Mississippi Medical Center, Jackson, Mississippi
    Am J Physiol Endocrinol Metab 307:E316-25. 2014
    ..However, we found no evidence that leptin directly causes LVH. ..
  68. pmc Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic mice
    Michael E Hall
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, Jackson, MS 39216, USA
    Am J Physiol Heart Circ Physiol 301:H253-60. 2011
    ....
  69. ncbi request reprint Inhibition of thromboxane synthesis attenuates insulin hypertension in rats
    H L Keen
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Hypertens 10:1125-31. 1997
    ..These results suggest that full expression of hypertension and renal vasoconstriction during hyperinsulinemia in rats is dependent on a normal ability to synthesize thromboxane...
  70. ncbi request reprint Functional and structural changes in the kidney in the early stages of obesity
    J R Henegar
    Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA
    J Am Soc Nephrol 12:1211-7. 2001
    ....
  71. ncbi request reprint Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats
    S M Fitzgerald
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216-4505, USA
    Am J Physiol Regul Integr Comp Physiol 281:R547-52. 2001
    ..Thus feeding OM rats HF diet led to obesity, cardiac and renal hypertrophy, and hyperinsulinemia but only a slight increase in mean arterial pressure...
  72. ncbi request reprint Exaggerated pressor and chronotropic response to chronic hyperinsulinemia in SH versus WKY rats
    M W Brands
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505
    Am J Hypertens 7:75-81. 1994
    ..The change in heart rate from control was 5 +/- 5 and 21 +/- 9 beats per minute in the WKY and SH rats on day 1 of insulin, and this difference also diminished with time.(ABSTRACT TRUNCATED AT 250 WORDS)..
  73. pmc Aldosterone blunts tubuloglomerular feedback by activating macula densa mineralocorticoid receptors
    Yiling Fu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
    Hypertension 59:599-606. 2012
    ..We conclude that MRs are expressed in macula densa cells and can be activated by aldosterone, which increases nitric oxide production in the macula densa and blunts the TGF response...
  74. ncbi request reprint The hemodynamic response to chronic hyperinsulinemia in conscious dogs
    M W Brands
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505
    Am J Hypertens 4:164-8. 1991
    ..These data suggest that, in addition to promoting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect...
  75. ncbi request reprint Renal function in one-kidney, one-clip hypertension and low renin essential hypertension
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505
    Am J Hypertens 4:523S-533S. 1991
    ..These abnormalities, along with preglomerular vasoconstriction, may explain many of the characteristics of LRHT...
  76. ncbi request reprint High-fructose diet does not raise 24-hour mean arterial pressure in rats
    M W Brands
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505
    Am J Hypertens 7:104-9. 1994
    ..Thus, a change in dietary simple sugar content from 5% dextrose to 66% fructose did not change MAP or alter blood pressure variability or sodium sensitivity.(ABSTRACT TRUNCATED AT 250 WORDS)..
  77. ncbi request reprint Integration and regulation of cardiovascular function
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol 277:S174-86. 1999
    ..Finally, I have highlighted the importance of two principles that I believe are often underemphasized in teaching physiology: mass balance and time dependence of physiological control systems...
  78. pmc Annexins V and XII alter the properties of planar lipid bilayers seen by conductance probes
    Y Sokolov
    Department of Physiology and Biophysics, University of California, Irvine, Irvine, California 92697 4560, USA
    J Gen Physiol 115:571-82. 2000
    ....
  79. ncbi request reprint Kinetic analysis of cardiac transcriptome regulation during chronic high-fat diet in dogs
    Pierre Philip-Couderc
    Unité de Recherches sur les Obésités, Institut National de la Santé et de la Recherche Médicale U586, Centre Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, Toulouse, France
    Physiol Genomics 19:32-40. 2004
    ..These results also suggest some novel regulatory pathways for cardiac adaptation to obesity...
  80. ncbi request reprint Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Cou
    Thomas G Pickering
    Hypertension 45:142-61. 2005
    ..There is increasing evidence that a failure of blood pressure to fall during the night may be associated with increased risk. In obese patients and children, the use of an appropriate cuff size is of paramount importance...
  81. ncbi request reprint The national high blood pressure education program: thirty years and counting
    Daniel W Jones
    Hypertension 39:941-2. 2002
  82. ncbi request reprint Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Cou
    Thomas G Pickering
    Circulation 111:697-716. 2005
    ..There is increasing evidence that a failure of blood pressure to fall during the night may be associated with increased risk. In obese patients and children, the use of an appropriate cuff size is of paramount importance...
  83. ncbi request reprint Task Force on Strategic Research Direction: Basic Science Subgroup key science topics report
    Joseph Loscalzo
    Circulation 106:e149-61. 2002
  84. ncbi request reprint World Hypertension Day 2007
    Daniel W Jones
    Hypertension 49:939-40. 2007
  85. doi request reprint Hypertension: pathways to success
    Daniel W Jones
    Hypertension 51:1249-51. 2008
  86. ncbi request reprint The pioneering use of systems analysis to study cardiac output regulation
    John E Hall
    Am J Physiol Regul Integr Comp Physiol 287:R1009-11. 2004
    ..Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180: 463-468, 1955 (http://ajplegacy.physiology.org/cgi/reprint/180/3/463)...
  87. ncbi request reprint Recommendations for blood pressure measurement in humans and experimental animals: part 2: blood pressure measurement in experimental animals: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart A
    Theodore W Kurtz
    Arterioscler Thromb Vasc Biol 25:e22-33. 2005
    ..Selection of the methods to be used should ultimately be guided by the study objectives to insure that the techniques chosen are appropriate for the experimental questions being explored...
  88. ncbi request reprint Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research, Professional and Public Education Subcommittee
    Theodore W Kurtz
    Arterioscler Thromb Vasc Biol 25:478-9. 2005
  89. ncbi request reprint Recommendations for blood pressure measurement in humans and experimental animals. Part 2: Blood pressure measurement in experimental animals: a statement for professionals from the subcommittee of professional and public education of the American Heart A
    Theodore W Kurtz
    Hypertension 45:299-310. 2005
    ..Selection of the methods to be used should ultimately be guided by the study objectives to insure that the techniques chosen are appropriate for the experimental questions being explored...
  90. doi request reprint Hypertension: update 2008
    John E Hall
    Hypertension 52:425-8. 2008
  91. ncbi request reprint Racial and ethnic differences in blood pressure: biology and sociology
    Daniel W Jones
    Circulation 114:2757-9. 2006
  92. ncbi request reprint What can we do about the "epidemic" of obesity
    John E Hall
    Am J Hypertens 15:657-9. 2002
  93. ncbi request reprint Recommendations for blood pressure measurement in humans: an AHA scientific statement from the Council on High Blood Pressure Research Professional and Public Education Subcommittee
    Thomas G Pickering
    Columbia University College of Physicians and Surgeons, Behavioral Cardiovascular Health and Hypertension Program, 622 West 168th Street, PH9 946, New York, NY 10032, USA
    J Clin Hypertens (Greenwich) 7:102-9. 2005
  94. ncbi request reprint In memoriam. Arthur C. Guyton (1919-2003)
    John E Hall
    University of Mississippi, USA
    Physiologist 46:126-8. 2003
  95. ncbi request reprint Obesity and hypertension: two epidemics or one?
    Kevin P Davy
    Dept of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Am J Physiol Regul Integr Comp Physiol 286:R803-13. 2004
    ..The potential role of abdominal obesity is considered throughout our review. We refer to relevant animal literature for supportive evidence and where little or no data in humans are available...
  96. ncbi request reprint Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure and evidence from new hypertension trials
    Daniel W Jones
    Hypertension 43:1-3. 2004
  97. ncbi request reprint The promise of translational physiology
    John E Hall
    Am J Physiol Renal Physiol 283:F207-8. 2002