Jennifer L Hall

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks
    Jennifer L Hall
    Lillehei Heart Institute, Univ of Minnesota, Minneapolis 55455, USA
    Physiol Genomics 17:283-91. 2004
  2. ncbi request reprint IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells
    Jennifer L Hall
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Am J Physiol Endocrinol Metab 283:E465-71. 2002
  3. doi request reprint Chronic treatment with clenbuterol modulates endothelial progenitor cells and circulating factors in a murine model of cardiomyopathy
    James E Rider
    Lillehei Heart Institute, University of Minnesota, 312 Church Street, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 2:182-90. 2009
  4. pmc Sprouty1 inhibits angiogenesis in association with up-regulation of p21 and p27
    Sangjin Lee
    Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA
    Mol Cell Biochem 338:255-61. 2010
  5. ncbi request reprint Identification and regulation of Sprouty1, a negative inhibitor of the ERK cascade, in the human heart
    Robert C Huebert
    Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Physiol Genomics 18:284-9. 2004
  6. pmc Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function
    Nathan J Charles
    Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell Biochem 342:57-62. 2010
  7. pmc Smooth muscle specific deletion of Ndst1 leads to decreased vessel luminal area and no change in blood pressure in conscious mice
    Kim Ramil C Montaniel
    Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, 6 242 NHH, 312 Church St SE, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 5:274-9. 2012
  8. ncbi request reprint Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy
    Jennifer L Hall
    Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Mayo Mail Code 508, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Eur Heart J 28:613-27. 2007
  9. ncbi request reprint Loss of redox factor 1 decreases NF-kappaB activity and increases susceptibility of endothelial cells to apoptosis
    Zhanjun Guan
    Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Arterioscler Thromb Vasc Biol 25:96-101. 2005
  10. doi request reprint Changes in expression of proteoglycan core proteins and heparan sulfate enzymes in the developing and adult murine aorta
    Neeta Adhikari
    Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, USA
    J Cardiovasc Transl Res 4:313-20. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks
    Jennifer L Hall
    Lillehei Heart Institute, Univ of Minnesota, Minneapolis 55455, USA
    Physiol Genomics 17:283-91. 2004
    ..This unbiased gene discovery approach in paired human heart samples has the potential to provide critical clues to the next generation of therapeutic treatments aimed at heart failure...
  2. ncbi request reprint IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells
    Jennifer L Hall
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Am J Physiol Endocrinol Metab 283:E465-71. 2002
    ..Taken together, these findings demonstrate that upregulation of glucose transport through either IGF-I or increased GLUT1 content stimulates glucose flux through both nonoxidative and oxidative pathways in VSMC...
  3. doi request reprint Chronic treatment with clenbuterol modulates endothelial progenitor cells and circulating factors in a murine model of cardiomyopathy
    James E Rider
    Lillehei Heart Institute, University of Minnesota, 312 Church Street, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 2:182-90. 2009
    ..This is the first evidence that a beta 2 agonist increases EPC proliferation in the bone marrow in a preclinical model of heart failure...
  4. pmc Sprouty1 inhibits angiogenesis in association with up-regulation of p21 and p27
    Sangjin Lee
    Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA
    Mol Cell Biochem 338:255-61. 2010
    ..01). These findings shed new light on downstream signaling pathways associated with Spry1 anti-proliferative responses, and provide new evidence that hypoxia stimulates Spry1 expression...
  5. ncbi request reprint Identification and regulation of Sprouty1, a negative inhibitor of the ERK cascade, in the human heart
    Robert C Huebert
    Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Physiol Genomics 18:284-9. 2004
    ....
  6. pmc Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function
    Nathan J Charles
    Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell Biochem 342:57-62. 2010
    ..In summary, targeted up-regulation of Spry1 in cardiac myocytes is not sufficient to alter cell or tissue remodeling consistent with the lack of an effect on ERK1/2 activity...
  7. pmc Smooth muscle specific deletion of Ndst1 leads to decreased vessel luminal area and no change in blood pressure in conscious mice
    Kim Ramil C Montaniel
    Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, 6 242 NHH, 312 Church St SE, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 5:274-9. 2012
    ..In conclusion, deletion of N-deacetylase-N-sulfotransferase1 in smooth muscle did not influence any of the blood pressure parameters measured despite significant decrease in aorta and thoracodorsal artery luminal area...
  8. ncbi request reprint Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy
    Jennifer L Hall
    Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Mayo Mail Code 508, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Eur Heart J 28:613-27. 2007
    ..The aim of this study was to identify common genes and signalling pathways whose expression was associated with reversal of heart failure and restoration of ventricular function...
  9. ncbi request reprint Loss of redox factor 1 decreases NF-kappaB activity and increases susceptibility of endothelial cells to apoptosis
    Zhanjun Guan
    Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Arterioscler Thromb Vasc Biol 25:96-101. 2005
    ..The aim of this project was to test the hypothesis that redox factor 1 (Ref-1) was a critical upstream determinant of NF-kappaB-dependent survival signaling pathways in the vessel wall...
  10. doi request reprint Changes in expression of proteoglycan core proteins and heparan sulfate enzymes in the developing and adult murine aorta
    Neeta Adhikari
    Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, USA
    J Cardiovasc Transl Res 4:313-20. 2011
    ..These findings may have important biological significance in the specific cell-defined roles of proteoglycan and heparan sulfate related targets in vascular development, maintenance, and response to various perturbations...
  11. ncbi request reprint A role for muscle LIM protein (MLP) in vascular remodeling
    Xiaohong Wang
    Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 508, Minneapolis, MN 55455, USA
    J Mol Cell Cardiol 40:503-9. 2006
    ..This is consistent with earlier findings demonstrating a role for MLP in striated muscle remodeling in response to load and stretch...
  12. ncbi request reprint Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1+/- mice
    David L Basi
    Lillehei Heart Institute, Univ of Minnesota, 420 Delaware St, Minneapolis, MN 55455, USA
    Am J Physiol Heart Circ Physiol 292:H516-21. 2007
    ..In sum, loss of a single allele of Ref-1 is sufficient to reduce intimal lesion formation and to alter circulating cytokine and growth factor expression...
  13. pmc Alterations in heparan sulfate in the vessel in response to vascular injury in the mouse
    Neeta Adhikari
    Lillehei Heart Institute, 4 242 NHH, 312 Church St SE, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 1:236-40. 2008
    ..These findings may be important as the foundation of altered growth factor and chemokine binding in the process of vascular remodeling...
  14. pmc Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure
    David R Fermin
    Lillehei Heart Institute, Division of Cardiology, Developmental Biology Center, University of Minnesota, Minneapolis, USA
    Circ Cardiovasc Genet 1:117-25. 2008
    ..We report the first comprehensive analysis of gene expression differences by sex and age in left ventricular samples from 102 patients with dilated cardiomyopathy...
  15. doi request reprint Translating genetic discoveries to improvements in cardiovascular care: the path to personalized medicine
    Jennifer L Hall
    Lillehei Heart Institute, University of Minnesota, 4 Nils Hasselmo Hall, 321 Church Street, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 1:37-40. 2008
    ..Unraveling the code on these chromosomes may reveal a deeper insight into the mechanisms underlying disease and the design of new therapeutics to prevent or slow the progression of the disease...
  16. pmc Increase in GLUT1 in smooth muscle alters vascular contractility and increases inflammation in response to vascular injury
    Neeta Adhikari
    University of Minnesota, Minneapolis, MN 55455, USA
    Arterioscler Thromb Vasc Biol 31:86-94. 2011
    ..The goal of this study was to test the contributing role of increasing glucose uptake in vascular smooth muscle cells (VSMCs) in vascular complications and disease...
  17. pmc Clinical, molecular, and genomic changes in response to a left ventricular assist device
    Jennifer L Hall
    Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, 55455, USA
    J Am Coll Cardiol 57:641-52. 2011
    ....
  18. pmc A review of genetics, arterial stiffness, and blood pressure in African Americans
    Jennifer L Hall
    Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, 4 106 NHH, 312 Church Street, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 5:302-8. 2012
    ..This paper reviews the genetic findings to date in the area of arterial stiffness and blood pressure in African Americans with an emphasis on the current limitations and new efforts to move the field forward...
  19. doi request reprint Building a program in translational genomics
    Jennifer L Hall
    Lillehei Heart Institute, 312 Church Street, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 1:283-7. 2008
    ..The benefits of developing a translational genomics program will be outlined from a clinical perspective, a research perspective, and a consumer perspective...
  20. doi request reprint Discovery of an intricate balance. Gene transcription, cell cycle, and apoptosis
    Jennifer L Hall
    Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Circ Res 102:395-7. 2008
  21. doi request reprint Translating clinical research to the bedside: the Minnesota model
    Jennifer L Hall
    Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA
    J Cardiovasc Transl Res 1:292-4. 2008
    ..We will give a brief overview of this model and the steps to success which can be duplicated by other states and countries...
  22. ncbi request reprint The role of [beta]-transducin repeat-containing protein ([beta]-TrCP) in the regulation of NF-[kappa]B in vascular smooth muscle cells
    Xiaohong Wang
    Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
    Arterioscler Thromb Vasc Biol 24:85-90. 2004
    ..We hypothesized that the E3-ligase, beta-transducin repeat-containing protein 1 (beta-TrCP1), was a rate-determining mediator that regulates the ubiquitin-mediated degradation of IkappaBalpha (in VSMC)...
  23. ncbi request reprint A role for the beta-catenin/T-cell factor signaling cascade in vascular remodeling
    Xiaohong Wang
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA
    Circ Res 90:340-7. 2002
    ..In conclusion, beta-catenin and Tcf-4 play a dual role in vascular remodeling by inhibiting VSMC apoptosis and promoting proliferation...
  24. ncbi request reprint LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells
    Xiaohong Wang
    Lillehei Heart Institute, Univ of Minnesota, 420 Delaware St, Minneapolis, MN 55455, USA
    Am J Physiol Heart Circ Physiol 287:H2376-83. 2004
    ..In conclusion, these findings provide the first evidence of a role for an LDL receptor-related protein in the regulation of VSMC proliferation and survival through the evolutionary conserved Wnt signaling cascade...
  25. ncbi request reprint Alterations of gene expression in failing myocardium following left ventricular assist device support
    Yingjie Chen
    Department of Medicine Cardiovascular Division, University of Minnesota Health Sciences Center, Minneapolis, Minnesota 55455, USA
    Physiol Genomics 14:251-60. 2003
    ..Increased eNOS and DDAH1 expression after LVAD support may contribute to improved endothelial function of the failing hearts...
  26. ncbi request reprint Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis
    Martin E Cullen
    National Heart and Lung Institute, Imperial College London, Heart Science Centre, Harefield, Middlesex, UB9 6JH, UK
    Circulation 114:I16-20. 2006
    ..The aim of this study was to evaluate the expression and role of AGAT expression in heart failure and recovery...
  27. ncbi request reprint Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support
    Emma J Birks
    Royal Brompton and Harefield Hospital NHS Trust, Harefield, Middlesex, UB9 6JH, UK
    Circulation 112:I57-64. 2005
    ..The exact molecular mechanisms involved in myocardial recovery remain unknown. Cytoskeletal proteins are essential for the structure and function of the cardiac myocyte and might play a major role...
  28. ncbi request reprint Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy
    Paul J R Barton
    National Heart and Lung Institute, Imperial College London, Heart Science Centre, London, UK
    Circulation 112:I46-50. 2005
    ..We recently found that clenbuterol induces insulin-like growth factor I (IGF-I) in cardiac myocytes in vitro. The purpose of this study is to examine IGF-I expression in recovery patients after combination therapy...
  29. ncbi request reprint Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury
    Neeta Adhikari
    Cardiovascular Division, University of Minnesota, Mayo Mail Code 508, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Curr Atheroscler Rep 8:252-60. 2006
    ....
  30. ncbi request reprint Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy
    Michelle M Kittleson
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 110:3444-51. 2004
    ..We hypothesized that gene expression differentiates ischemic and nonischemic cardiomyopathy, demonstrating that gene expression profiling by clinical parameters is feasible in cardiology...