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Genomes and Genes | Jennifer L HallSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
IGF-I promotes a shift in metabolic flux in vascular smooth muscle cellsJennifer L Hall
Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
Am J Physiol Endocrinol Metab 283:E465-71. 2002..Taken together, these findings demonstrate that upregulation of glucose transport through either IGF-I or increased GLUT1 content stimulates glucose flux through both nonoxidative and oxidative pathways in VSMC...- Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networksJennifer L Hall
Lillehei Heart Institute, Univ of Minnesota, Minneapolis 55455, USA
Physiol Genomics 17:283-91. 2004..This unbiased gene discovery approach in paired human heart samples has the potential to provide critical clues to the next generation of therapeutic treatments aimed at heart failure... 
Chronic treatment with clenbuterol modulates endothelial progenitor cells and circulating factors in a murine model of cardiomyopathyJames E Rider
Lillehei Heart Institute, University of Minnesota, 312 Church Street, Minneapolis, MN 55455, USA
J Cardiovasc Transl Res 2:182-90. 2009..This is the first evidence that a beta 2 agonist increases EPC proliferation in the bone marrow in a preclinical model of heart failure...
Sprouty1 inhibits angiogenesis in association with up-regulation of p21 and p27Sangjin Lee
Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA
Mol Cell Biochem 338:255-61. 2010..01). These findings shed new light on downstream signaling pathways associated with Spry1 anti-proliferative responses, and provide new evidence that hypoxia stimulates Spry1 expression...- Identification and regulation of Sprouty1, a negative inhibitor of the ERK cascade, in the human heartRobert C Huebert
Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
Physiol Genomics 18:284-9. 2004.... - Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or functionNathan J Charles
Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA
Mol Cell Biochem 342:57-62. 2010..In summary, targeted up-regulation of Spry1 in cardiac myocytes is not sufficient to alter cell or tissue remodeling consistent with the lack of an effect on ERK1/2 activity... - Smooth muscle specific deletion of Ndst1 leads to decreased vessel luminal area and no change in blood pressure in conscious miceKim Ramil C Montaniel
Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, 6 242 NHH, 312 Church St SE, Minneapolis, MN 55455, USA
J Cardiovasc Transl Res 5:274-9. 2012..In conclusion, deletion of N-deacetylase-N-sulfotransferase1 in smooth muscle did not influence any of the blood pressure parameters measured despite significant decrease in aorta and thoracodorsal artery luminal area... - Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapyJennifer L Hall
Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Mayo Mail Code 508, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Eur Heart J 28:613-27. 2007..The aim of this study was to identify common genes and signalling pathways whose expression was associated with reversal of heart failure and restoration of ventricular function... - Loss of redox factor 1 decreases NF-kappaB activity and increases susceptibility of endothelial cells to apoptosisZhanjun Guan
Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA
Arterioscler Thromb Vasc Biol 25:96-101. 2005..CONCLUSIONS: These findings establish a role for Ref-1 as an upstream determinant of NF-kappaB and A20-dependent signaling and endothelial survival in the vessel wall... - Changes in expression of proteoglycan core proteins and heparan sulfate enzymes in the developing and adult murine aortaNeeta Adhikari
Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, USA
J Cardiovasc Transl Res 4:313-20. 2011..These findings may have important biological significance in the specific cell-defined roles of proteoglycan and heparan sulfate related targets in vascular development, maintenance, and response to various perturbations... - A role for muscle LIM protein (MLP) in vascular remodelingXiaohong Wang
Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 508, Minneapolis, MN 55455, USA
J Mol Cell Cardiol 40:503-9. 2006..This is consistent with earlier findings demonstrating a role for MLP in striated muscle remodeling in response to load and stretch... - Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1+/- miceDavid L Basi
Lillehei Heart Institute, Univ of Minnesota, 420 Delaware St, Minneapolis, MN 55455, USA
Am J Physiol Heart Circ Physiol 292:H516-21. 2007..In sum, loss of a single allele of Ref-1 is sufficient to reduce intimal lesion formation and to alter circulating cytokine and growth factor expression... - Alterations in heparan sulfate in the vessel in response to vascular injury in the mouseNeeta Adhikari
Lillehei Heart Institute, 4 242 NHH, 312 Church St SE, Minneapolis, MN 55455, USA
J Cardiovasc Transl Res 1:236-40. 2008..These findings may be important as the foundation of altered growth factor and chemokine binding in the process of vascular remodeling... - Sex and age dimorphism of myocardial gene expression in nonischemic human heart failureDavid R Fermin
Lillehei Heart Institute, Division of Cardiology, Developmental Biology Center, University of Minnesota, Minneapolis, USA
Circ Cardiovasc Genet 1:117-25. 2008..We report the first comprehensive analysis of gene expression differences by sex and age in left ventricular samples from 102 patients with dilated cardiomyopathy... - Translating genetic discoveries to improvements in cardiovascular care: the path to personalized medicineJennifer L Hall
Lillehei Heart Institute, University of Minnesota, 4 Nils Hasselmo Hall, 321 Church Street, Minneapolis, MN 55455, USA
J Cardiovasc Transl Res 1:37-40. 2008..Unraveling the code on these chromosomes may reveal a deeper insight into the mechanisms underlying disease and the design of new therapeutics to prevent or slow the progression of the disease... - Increase in GLUT1 in smooth muscle alters vascular contractility and increases inflammation in response to vascular injuryNeeta Adhikari
University of Minnesota, Minneapolis, MN 55455, USA
Arterioscler Thromb Vasc Biol 31:86-94. 2011..The goal of this study was to test the contributing role of increasing glucose uptake in vascular smooth muscle cells (VSMCs) in vascular complications and disease... - Clinical, molecular, and genomic changes in response to a left ventricular assist deviceJennifer L Hall
Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, 55455, USA
J Am Coll Cardiol 57:641-52. 2011.... - A review of genetics, arterial stiffness, and blood pressure in African AmericansJennifer L Hall
Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, 4 106 NHH, 312 Church Street, Minneapolis, MN 55455, USA
J Cardiovasc Transl Res 5:302-8. 2012..This paper reviews the genetic findings to date in the area of arterial stiffness and blood pressure in African Americans with an emphasis on the current limitations and new efforts to move the field forward... - Building a program in translational genomicsJennifer L Hall
Lillehei Heart Institute, 312 Church Street, Minneapolis, MN 55455, USA
J Cardiovasc Transl Res 1:283-7. 2008..The benefits of developing a translational genomics program will be outlined from a clinical perspective, a research perspective, and a consumer perspective... - Discovery of an intricate balance. Gene transcription, cell cycle, and apoptosisJennifer L Hall
Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA
Circ Res 102:395-7. 2008 - Translating clinical research to the bedside: the Minnesota modelJennifer L Hall
Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA
J Cardiovasc Transl Res 1:292-4. 2008..We will give a brief overview of this model and the steps to success which can be duplicated by other states and countries... - The role of [beta]-transducin repeat-containing protein ([beta]-TrCP) in the regulation of NF-[kappa]B in vascular smooth muscle cellsXiaohong Wang
Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
Arterioscler Thromb Vasc Biol 24:85-90. 2004..We hypothesized that the E3-ligase, beta-transducin repeat-containing protein 1 (beta-TrCP1), was a rate-determining mediator that regulates the ubiquitin-mediated degradation of IkappaBalpha (in VSMC)... - A role for the beta-catenin/T-cell factor signaling cascade in vascular remodelingXiaohong Wang
Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA
Circ Res 90:340-7. 2002..In conclusion, beta-catenin and Tcf-4 play a dual role in vascular remodeling by inhibiting VSMC apoptosis and promoting proliferation... - LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cellsXiaohong Wang
Lillehei Heart Institute, Univ of Minnesota, 420 Delaware St, Minneapolis, MN 55455, USA
Am J Physiol Heart Circ Physiol 287:H2376-83. 2004..In conclusion, these findings provide the first evidence of a role for an LDL receptor-related protein in the regulation of VSMC proliferation and survival through the evolutionary conserved Wnt signaling cascade... - Alterations of gene expression in failing myocardium following left ventricular assist device supportYingjie Chen
Department of Medicine (Cardiovascular Division, University of Minnesota Health Sciences Center, Minneapolis, Minnesota 55455, USA
Physiol Genomics 14:251-60. 2003..Increased eNOS and DDAH1 expression after LVAD support may contribute to improved endothelial function of the failing hearts... - Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesisMartin E Cullen
National Heart and Lung Institute, Imperial College London, Heart Science Centre, Harefield, Middlesex, UB9 6JH, UK
Circulation 114:I16-20. 2006..The aim of this study was to evaluate the expression and role of AGAT expression in heart failure and recovery... - Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device supportEmma J Birks
Royal Brompton and Harefield Hospital NHS Trust, Harefield, Middlesex, UB9 6JH, UK
Circulation 112:I57-64. 2005..CONCLUSIONS: Myocardial recovery was associated with a specific pattern of changes in sarcomeric, nonsarcomeric, and membrane-associated proteins, which could have important implications in understanding the mechanisms involved... - Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapyPaul J R Barton
National Heart and Lung Institute, Imperial College London, Heart Science Centre, London, UK
Circulation 112:I46-50. 2005..We recently found that clenbuterol induces insulin-like growth factor I (IGF-I) in cardiac myocytes in vitro. The purpose of this study is to examine IGF-I expression in recovery patients after combination therapy... - Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injuryNeeta Adhikari
Cardiovascular Division, University of Minnesota, Mayo Mail Code 508, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Curr Atheroscler Rep 8:252-60. 2006.... - Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathyMichelle M Kittleson
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 110:3444-51. 2004..This strongly supports ongoing efforts to incorporate expression profiling-based biomarkers in determining prognosis and response to therapy in heart failure...