Garth Hall

Summary

Affiliation: University of Massachusetts
Country: USA

Publications

  1. ncbi request reprint Neurofibrillary degeneration can be arrested in an in vivo cellular model of human tauopathy by application of a compound which inhibits tau filament formation in vitro
    Garth F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell, MA 01854, USA
    J Mol Neurosci 19:253-60. 2002
  2. ncbi request reprint Modeling tauopathy: a range of complementary approaches
    Garth F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell, Massachusetts 01854, USA
    Biochim Biophys Acta 1739:224-39. 2005
  3. doi request reprint Interneuronal transfer of human tau between Lamprey central neurons in situ
    Wonhee Kim
    Department of Biological Sciences, Center for Cellular Neuroscience and Neurodegeneration Research, University of Massachusetts Lowell, Lowell, MA, USA
    J Alzheimers Dis 19:647-64. 2010
  4. pmc Death or secretion? The demise of a plausible assumption about CSF-tau in Alzheimer Disease?
    Garth F Hall
    Department of Biological Sciences University of Massachusetts Lowell MA, USA
    Commun Integr Biol 5:623-6. 2012
  5. pmc Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model
    Sangmook Lee
    Department of Biological Sciences, Center for Cellular Neuroscience and Neurodegeneration Research, University of Massachusetts Lowell, Lowell, MA 01854, USA
    Int J Alzheimers Dis 2012:172837. 2012
  6. pmc Is tau ready for admission to the prion club?
    Garth F Hall
    Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA, USA
    Prion 6:223-33. 2012
  7. ncbi request reprint Neuronal morphology, axonal integrity, and axonal regeneration in situ are regulated by cytoskeletal phosphorylation in identified lamprey central neurons
    G F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell, Massachusetts 01854, USA
    Microsc Res Tech 48:32-46. 2000
  8. pmc Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy
    G F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell 01854, USA
    Am J Pathol 158:235-46. 2001
  9. ncbi request reprint The single neurofilament subunit of the lamprey forms filaments and regulates axonal caliber and neuronal size in vivo
    G F Hall
    Center for Cellular Neuroscience and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts, Lowell 02115, USA
    Cell Motil Cytoskeleton 46:166-82. 2000
  10. ncbi request reprint Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease
    G F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell, Massachusetts 01854, USA
    J Cell Sci 113:1373-87. 2000

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Neurofibrillary degeneration can be arrested in an in vivo cellular model of human tauopathy by application of a compound which inhibits tau filament formation in vitro
    Garth F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell, MA 01854, USA
    J Mol Neurosci 19:253-60. 2002
    ....
  2. ncbi request reprint Modeling tauopathy: a range of complementary approaches
    Garth F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell, Massachusetts 01854, USA
    Biochim Biophys Acta 1739:224-39. 2005
    ..In particular, we focus on the complementary advantages and limitations of various approaches to constructing tauopathy models presently in use with respect to those of murine transgenic tauopathy models...
  3. doi request reprint Interneuronal transfer of human tau between Lamprey central neurons in situ
    Wonhee Kim
    Department of Biological Sciences, Center for Cellular Neuroscience and Neurodegeneration Research, University of Massachusetts Lowell, Lowell, MA, USA
    J Alzheimers Dis 19:647-64. 2010
    ....
  4. pmc Death or secretion? The demise of a plausible assumption about CSF-tau in Alzheimer Disease?
    Garth F Hall
    Department of Biological Sciences University of Massachusetts Lowell MA, USA
    Commun Integr Biol 5:623-6. 2012
    ..Here we examine this issue directly and explore some of the broader implications of this study for our understanding of AD pathogenesis and the prospects for improving its diagnosis and treatment...
  5. pmc Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model
    Sangmook Lee
    Department of Biological Sciences, Center for Cellular Neuroscience and Neurodegeneration Research, University of Massachusetts Lowell, Lowell, MA 01854, USA
    Int J Alzheimers Dis 2012:172837. 2012
    ..The implications for the diagnosis and treatment of human disease are discussed...
  6. pmc Is tau ready for admission to the prion club?
    Garth F Hall
    Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA, USA
    Prion 6:223-33. 2012
    ....
  7. ncbi request reprint Neuronal morphology, axonal integrity, and axonal regeneration in situ are regulated by cytoskeletal phosphorylation in identified lamprey central neurons
    G F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell, Massachusetts 01854, USA
    Microsc Res Tech 48:32-46. 2000
    ..The implications of these results for the respective roles of MTs, MAPs, and NFs in axonal regeneration in the vertebrate CNS are discussed...
  8. pmc Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy
    G F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell 01854, USA
    Am J Pathol 158:235-46. 2001
    ..This sequence is independent of the tau isoform used, the presence of epitope tags and the method used to overexpress tau, and thus has important implications for the cytopathogenesis of human neurofibrillary disease...
  9. ncbi request reprint The single neurofilament subunit of the lamprey forms filaments and regulates axonal caliber and neuronal size in vivo
    G F Hall
    Center for Cellular Neuroscience and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts, Lowell 02115, USA
    Cell Motil Cytoskeleton 46:166-82. 2000
    ..We conclude that NF180 normally plays a critical role in determining axonal caliber in ABCs and may influence neuronal size in situations where NFs accumulate in the soma, such as after axonal injury...
  10. ncbi request reprint Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease
    G F Hall
    Department of Biological Sciences, University of Massachusetts, Lowell, Massachusetts 01854, USA
    J Cell Sci 113:1373-87. 2000
    ..These results suggest that tau filament formation may be responsible for many key cytopathological features of neurofibrillary degeneration, possibly via the loss of microtubule based intracellular transport...
  11. doi request reprint Exonic point mutations of human tau enhance its toxicity and cause characteristic changes in neuronal morphology, tau distribution and tau phosphorylation in the lamprey cellular model of tauopathy
    Sangmook Lee
    Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA, USA
    J Alzheimers Dis 16:99-111. 2009
    ....
  12. ncbi request reprint The glutamate-rich region of the larger lamprey neurofilament sidearm is essential for proper neurofilament architecture
    Sangmook Lee
    Center for Cellular Neuroscience and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA
    Brain Res 1231:1-5. 2008
    ..We present evidence that, like mammalian NFs, the glutamate-rich region of NF-180 sidearm plays a critical role in NF architecture...
  13. doi request reprint Secretion of human tau fragments resembling CSF-tau in Alzheimer's disease is modulated by the presence of the exon 2 insert
    Wonhee Kim
    Center for Cellular Neuroscience and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA
    FEBS Lett 584:3085-8. 2010
    ..These results suggest that tau secretion may play a hitherto unsuspected role in AD and related tauopathies...

Research Grants8

  1. IN SITU NEURONAL MODEL OF PHF/TAU ACCUMULATION IN AD
    Garth Hall; Fiscal Year: 1999
    ....
  2. An in situ Neuronal Model of PHF-TAU Accumulation in AD
    Garth Hall; Fiscal Year: 2002
    ..abstract_text> ..
  3. An in situ Neuronal Model of PHF-TAU Accumulation in AD
    Garth Hall; Fiscal Year: 2003
    ..abstract_text> ..
  4. An in situ Neuronal Model of PHF-TAU Accumulation in AD
    Garth Hall; Fiscal Year: 2004
    ..abstract_text> ..
  5. IN SITU NEURONAL MODEL OF PHF/TAU ACCUMULATION IN AD
    Garth Hall; Fiscal Year: 2000
    ....
  6. An in situ Neuronal Model of PHF-TAU Accumulation in AD
    Garth Hall; Fiscal Year: 2001
    ..abstract_text> ..