Edward D Hall

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Medical Center, Lexington, KY 40536 0509, USA
    Exp Neurol 238:176-82. 2012
  2. ncbi request reprint Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 22:252-65. 2005
  3. pmc Neuroprotection and acute spinal cord injury: a reappraisal
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536, USA
    NeuroRx 1:80-100. 2004
  4. pmc Antioxidant therapies for traumatic brain injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Neurotherapeutics 7:51-61. 2010
  5. doi request reprint Evolution of post-traumatic neurodegeneration after controlled cortical impact traumatic brain injury in mice and rats as assessed by the de Olmos silver and fluorojade staining methods
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 25:235-47. 2008
  6. ncbi request reprint Lack of a gender difference in post-traumatic neurodegeneration in the mouse controlled cortical impact injury model
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 22:669-79. 2005
  7. ncbi request reprint Drug development in spinal cord injury: what is the FDA looking for?
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, KY 40515, USA
    J Rehabil Res Dev 40:81-91. 2003
  8. ncbi request reprint Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 21:9-20. 2004
  9. pmc Antioxidant therapies for acute spinal cord injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40506, USA
    Neurotherapeutics 8:152-67. 2011
  10. pmc Pharmacological evidence for a role of peroxynitrite in the pathophysiology of spinal cord injury
    Yiqin Xiong
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    Exp Neurol 216:105-14. 2009

Research Grants

Collaborators

Detail Information

Publications39

  1. pmc Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Medical Center, Lexington, KY 40536 0509, USA
    Exp Neurol 238:176-82. 2012
    ....
  2. ncbi request reprint Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 22:252-65. 2005
    ....
  3. pmc Neuroprotection and acute spinal cord injury: a reappraisal
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536, USA
    NeuroRx 1:80-100. 2004
    ....
  4. pmc Antioxidant therapies for traumatic brain injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Neurotherapeutics 7:51-61. 2010
    ....
  5. doi request reprint Evolution of post-traumatic neurodegeneration after controlled cortical impact traumatic brain injury in mice and rats as assessed by the de Olmos silver and fluorojade staining methods
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 25:235-47. 2008
    ....
  6. ncbi request reprint Lack of a gender difference in post-traumatic neurodegeneration in the mouse controlled cortical impact injury model
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 22:669-79. 2005
    ....
  7. ncbi request reprint Drug development in spinal cord injury: what is the FDA looking for?
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, KY 40515, USA
    J Rehabil Res Dev 40:81-91. 2003
    ....
  8. ncbi request reprint Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 21:9-20. 2004
    ....
  9. pmc Antioxidant therapies for acute spinal cord injury
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40506, USA
    Neurotherapeutics 8:152-67. 2011
    ..Although these results have provided considerable validation of oxidative damage as a clinically practical neuroprotective target, there is a need for the discovery of safer and more effective antioxidant compounds for acute SCI...
  10. pmc Pharmacological evidence for a role of peroxynitrite in the pathophysiology of spinal cord injury
    Yiqin Xiong
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    Exp Neurol 216:105-14. 2009
    ....
  11. pmc Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury
    Ying Deng
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, KY 40536 0509, USA
    Exp Neurol 205:154-65. 2007
    ....
  12. pmc Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal
    Indrapal N Singh
    Spinal Cord and Brain Injury Research Center SCoBIRC, Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    J Cereb Blood Flow Metab 33:593-9. 2013
    ..In another cohort, PZ administration increased spared cortical tissue from 86% to 97% (P<0.03). These results suggest that PZ's neuroprotective effect is due to mitochondrial protection by scavenging of LP-derived 4-HNE...
  13. pmc Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals
    Ayman G Mustafa
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurochem 114:271-80. 2010
    ..The results demonstrate that LOO(*) radicals contribute to secondary brain mitochondrial dysfunction after TBI by propagating LP and protein nitrative damage in cellular and mitochondrial membranes...
  14. pmc Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage
    Yiqin Xiong
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA
    Free Radic Res 43:604-12. 2009
    ....
  15. ncbi request reprint Role of peroxynitrite in secondary oxidative damage after spinal cord injury
    Yiqin Xiong
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, KY 40536, USA
    J Neurochem 100:639-49. 2007
    ..Scavengers of PON, or its derived free radical species, may provide an improved antioxidant neuroprotective approach for the treatment of post-traumatic oxidative damage in the injured spinal cord...
  16. pmc A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model
    Stephanie N Thompson
    University of Kentucky Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 27:2233-43. 2010
    ..Accordingly, the combination of a calpain inhibitor with a compound such as cyclosporine A may be needed to achieve the optimal degree of post-TBI neuroprotection...
  17. doi request reprint Neuroprotective effects of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model
    Ying Deng-Bryant
    Spinal Cord and Brain Injury Research Center and Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0509, USA
    J Cereb Blood Flow Metab 28:1114-26. 2008
    ..However, the modest neuroprotective effect of tempol suggests that multitarget combination strategies may be needed to interfere with posttraumatic secondary injury to a degree worthy of clinical translation...
  18. ncbi request reprint Post-Injury Administration of Mitochondrial Uncouplers Increases Tissue Sparing and Improves Behavioral Outcome following Traumatic Brain Injury in Rodents
    Jignesh D Pandya
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 24:798-811. 2007
    ....
  19. ncbi request reprint Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers
    Indrapal N Singh
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    J Neurosci Res 85:2216-23. 2007
    ....
  20. ncbi request reprint Time course of post-traumatic mitochondrial oxidative damage and dysfunction in a mouse model of focal traumatic brain injury: implications for neuroprotective therapy
    Indrapal N Singh
    Spinal Cord and Brain Injury Research Center and Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0509, USA
    J Cereb Blood Flow Metab 26:1407-18. 2006
    ..g. ONOO(-)+H(+) --> ONOOH --> (*)NO(2)+(*)OH) may be particularly effective for the treatment of TBI, although the therapeutic window for this neuroprotective approach might only be 3 h...
  21. ncbi request reprint Relationship of calpain-mediated proteolysis to the expression of axonal and synaptic plasticity markers following traumatic brain injury in mice
    Stephanie N Thompson
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky, USA
    Exp Neurol 201:253-65. 2006
    ..If true, then calpain inhibition may lead to both neuroprotective effects and an enhancement of neuronal plasticity/repair mechanisms post-TBI...
  22. pmc Lipid peroxidation-derived reactive aldehydes directly and differentially impair spinal cord and brain mitochondrial function
    Radhika A Vaishnav
    Spinal Cord and Brain Injury Research Center SCoBIRC, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 27:1311-20. 2010
    ..Furthermore, they suggest that protein modification by these lipid peroxidation products may directly contribute to post-traumatic mitochondrial damage, with spinal cord mitochondria showing a greater sensitivity than those in brain...
  23. pmc Pharmacological inhibition of lipid peroxidation attenuates calpain-mediated cytoskeletal degradation after traumatic brain injury
    Ayman G Mustafa
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurochem 117:579-88. 2011
    ..These results demonstrate the relationship between post-TBI LP, disruptions in neuronal Ca(2+) homeostasis and calpain-mediated cytoskeletal damage...
  24. pmc Temporal and spatial dynamics of peroxynitrite-induced oxidative damage after spinal cord contusion injury
    Kimberly M Carrico
    Spinal Cord and Brain Injury Research Center SCoBIRC, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    J Neurotrauma 26:1369-78. 2009
    ....
  25. doi request reprint Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model
    Mona Bains
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, USA
    J Neurochem 125:125-32. 2013
    ..Such conclusions need to be verified in the human clinical situation...
  26. pmc Selective death of newborn neurons in hippocampal dentate gyrus following moderate experimental traumatic brain injury
    Xiang Gao
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci Res 86:2258-70. 2008
    ..This selective vulnerability of newborn immature dentate neurons may contribute to the persistent impairment of learning and memory post-TBI and provide an innovative target for neuroprotective treatment strategies...
  27. pmc Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo
    Darren M Miller
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    Free Radic Biol Med 57:1-9. 2013
    ..Ongoing studies will determine the therapeutic efficacy of Nrf2-ARE activators to attenuate traumatic brain injury-induced pathophysiology...
  28. pmc Comparative neuroprotective effects of cyclosporin A and NIM811, a nonimmunosuppressive cyclosporin A analog, following traumatic brain injury
    Lamin H A N Mbye
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Cereb Blood Flow Metab 29:87-97. 2009
    ....
  29. pmc Therapeutic window analysis of the neuroprotective effects of cyclosporine A after traumatic brain injury
    Patrick G Sullivan
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 28:311-8. 2011
    ..However, the drug appears to retain some protective efficacy even when initiated as late as 8 h post-injury...
  30. doi request reprint Antioxidant therapies in traumatic brain and spinal cord injury
    Mona Bains
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40506, USA
    Biochim Biophys Acta 1822:675-84. 2012
    ..This article is part of a Special Issue entitled: Antioxidants and antioxidant treatment in disease...
  31. ncbi request reprint Mitochondrial uncoupling as a therapeutic target following neuronal injury
    P G Sullivan
    Spinal Cord and Brain Injury Research Center and Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536 0305, USA
    J Bioenerg Biomembr 36:353-6. 2004
    ..These findings raise the possibility that mitochondrial uncoupling could be a potential novel treatment for acute CNS injuries...
  32. ncbi request reprint Identification and characterization of PEBP as a calpain substrate
    Qinghua Chen
    Department of Gerontology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurochem 99:1133-41. 2006
    ..Together these data identify PEBP as a potential in vivo calpain substrate and indicate that increased PEBP levels may contribute to impaired proteasome function...
  33. ncbi request reprint Pathobiology of dynorphins in trauma and disease
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Front Biosci 10:216-35. 2005
    ..Evidence outlined in this review suggests that a variety of CNS pathologies alter dynorphin biogenesis. Such alterations are likely maladaptive and contribute to secondary injury and the pathogenesis of disease...
  34. doi request reprint Measurement of oxygen radicals and lipid peroxidation in neural tissues
    Edward D Hall
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, USA
    Curr Protoc Neurosci . 2009
    ..Accordingly, the purpose of this unit is to provide a variety of methods for the measurement of hydroxyl radical formation and/or LP in nervous tissue or biofluids...
  35. ncbi request reprint Multifaceted roles of sphingosine-1-phosphate: how does this bioactive sphingolipid fit with acute neurological injury?
    Indrapal N Singh
    Spinal Cord and Brain Injury Research Center SCoBIRC and Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurosci Res 86:1419-33. 2008
    ..On the other hand, antagonists of certain Sph-1-P-related activity might possess proregenerative effects via promotion of neurite growth and inhibition of astrogliotic scarring...
  36. ncbi request reprint Cytoskeletal protein degradation and neurodegeneration evolves differently in males and females following experimental head injury
    Nancy C Kupina
    CNS Pharmacology, Pfizer Global Research and Development Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Exp Neurol 180:55-73. 2003
    ..Evidence of a protracted time course of cytoskeletal degradation, especially in females, suggests a potential for an extended treatment-duration following TBI...
  37. ncbi request reprint Neuroimmunophilin ligand V-10,367 is neuroprotective after 24-hour delayed administration in a mouse model of diffuse traumatic brain injury
    Nancy C Kupina
    CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor, Michigan, USA
    J Cereb Blood Flow Metab 22:1212-21. 2002
    ..In the context of this mouse model of TBI, the therapeutic window for V-10,367's positive effects is at least 24 hours after injury, which, in the case of TBI models, is largely unprecedented for a neuroprotective compound...
  38. ncbi request reprint Time course of production of hydroxyl free radical after subarachnoid hemorrhage in dogs
    R Loch MacDonald
    Section of Neurosurgery, Pritzker School of Medicine, MC3026, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Life Sci 75:979-89. 2004
    ..The correlation with vasospasm implicates free radicals and lipid peroxidation in this phase of vasospasm...
  39. pmc Clinical trials in head injury
    Raj K Narayan
    Department of Neurosurgery, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    J Neurotrauma 19:503-57. 2002
    ..This paper is an attempt to summarize the key points made at the workshop. It is hoped that these lessons will enhance the planning and design of future efforts in this important field of research...

Research Grants9

  1. Peroxynitrite-Induced Oxidative Damage in TBI
    Edward Hall; Fiscal Year: 2007
    ..abstract_text> ..
  2. Therapeutic Strategies for Neurodegeneration Training Grant
    Edward Hall; Fiscal Year: 2007
    ..Recruitment of women and minorities will be emphasized. ..