B G Hall

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc The rtn gene of Proteus vulgaris is actually from Escherichia coli
    B G Hall
    University of Rochester, New York 14627, USA
    J Bacteriol 179:2433-4. 1997
  2. pmc On the specificity of adaptive mutations
    B G Hall
    Biology Department, University of Rochester, New York 14627, USA
    Genetics 145:39-44. 1997
  3. ncbi Determining the evolutionary potential of a gene
    B G Hall
    Biology Department, University of Rochester, New York 14627
    Mol Biol Evol 15:1055-61. 1998
  4. pmc Physical map location of the asc (formerly sac) operon of Escherichia coli K-12
    B G Hall
    Department of Biology, University of Rochester, New York 14627
    J Bacteriol 173:5250. 1991
  5. ncbi Activation of the bgl operon by adaptive mutation
    B G Hall
    Biology Department, University of Rochester, New York 14627, USA
    Mol Biol Evol 15:1-5. 1998
  6. ncbi Experimental evolution of Ebg enzyme provides clues about the evolution of catalysis and to evolutionary potential
    B G Hall
    Biology Dept, University of Rochester, NY 14627, USA
    FEMS Microbiol Lett 174:1-8. 1999
  7. ncbi Predicting evolutionary potential. I. Predicting the evolution of a lactose-PTS system in Escherichia coli
    B G Hall
    Department of Biology, University of Rochester, New York 14625 0222, USA
    Mol Biol Evol 18:1389-400. 2001
  8. pmc Adaptive mutagenesis at ebgR is regulated by PhoPQ
    B G Hall
    Biology Department, University of Rochester, Rochester, New York 14627 0211, USA
    J Bacteriol 180:2862-5. 1998
  9. ncbi Evolutionary potential of the ebgA gene
    B G Hall
    Biology Department, University of Rochester, New York 14627, USA
    Mol Biol Evol 12:514-7. 1995
  10. ncbi Transposable elements as activators of cryptic genes in E. coli
    B G Hall
    Biology Department, University of Rochester, NY 14627, USA
    Genetica 107:181-7. 1999

Collaborators

Detail Information

Publications43

  1. pmc The rtn gene of Proteus vulgaris is actually from Escherichia coli
    B G Hall
    University of Rochester, New York 14627, USA
    J Bacteriol 179:2433-4. 1997
    ..It was not possible to verify the presence of rtn in P. vulgaris...
  2. pmc On the specificity of adaptive mutations
    B G Hall
    Biology Department, University of Rochester, New York 14627, USA
    Genetics 145:39-44. 1997
    ..Here I use the ebg system to provide evidence that when selection is applied to one specific nucleotide site within a gene, mutation occurs at that site but not at an alternative and equally mutable site within the same gene...
  3. ncbi Determining the evolutionary potential of a gene
    B G Hall
    Biology Department, University of Rochester, New York 14627
    Mol Biol Evol 15:1055-61. 1998
    ..The evolutionary potential of Ebg is thus limited to those two replacements...
  4. pmc Physical map location of the asc (formerly sac) operon of Escherichia coli K-12
    B G Hall
    Department of Biology, University of Rochester, New York 14627
    J Bacteriol 173:5250. 1991
  5. ncbi Activation of the bgl operon by adaptive mutation
    B G Hall
    Biology Department, University of Rochester, New York 14627, USA
    Mol Biol Evol 15:1-5. 1998
    ..coli...
  6. ncbi Experimental evolution of Ebg enzyme provides clues about the evolution of catalysis and to evolutionary potential
    B G Hall
    Biology Dept, University of Rochester, NY 14627, USA
    FEMS Microbiol Lett 174:1-8. 1999
    ..Studies of the catalytic mechanism of Ebg beta-galactosidase have allowed the widely accepted Albery and Knowles model for the evolution of catalysis to be rejected...
  7. ncbi Predicting evolutionary potential. I. Predicting the evolution of a lactose-PTS system in Escherichia coli
    B G Hall
    Department of Biology, University of Rochester, New York 14625 0222, USA
    Mol Biol Evol 18:1389-400. 2001
    ..In contrast, biochemical data predict that the cryptic bglB gene, which also currently specifies a phospho-beta-glucosidase, is most likely to evolve into a phospho-beta-galactosidase...
  8. pmc Adaptive mutagenesis at ebgR is regulated by PhoPQ
    B G Hall
    Biology Department, University of Rochester, Rochester, New York 14627 0211, USA
    J Bacteriol 180:2862-5. 1998
    ..The finding that it is regulated implies that adaptive mutagenesis does not simply result from a failure of various error correction mechanisms during prolonged starvation...
  9. ncbi Evolutionary potential of the ebgA gene
    B G Hall
    Biology Department, University of Rochester, New York 14627, USA
    Mol Biol Evol 12:514-7. 1995
  10. ncbi Transposable elements as activators of cryptic genes in E. coli
    B G Hall
    Biology Department, University of Rochester, NY 14627, USA
    Genetica 107:181-7. 1999
    ..In at least one case, IS elements activate an operon during starvation only if the substrate for that operon is present in the environment. It appears that E. coli has managed to take advantage of IS elements for its own benefit...
  11. ncbi Adaptive mutagenesis: a process that generates almost exclusively beneficial mutations
    B G Hall
    Biology Department, University of Rochester, NY 14627, USA
    Genetica 102:109-25. 1998
    ..A model to explain that specificity and new evidence in support of that model are considered, as are potential roles of adaptive mutagenesis in evolution and practical aspects of adaptive mutagenesis...
  12. ncbi Molecular population genetics of Escherichia coli: DNA sequence diversity at the celC, crr, and gutB loci of natural isolates
    B G Hall
    Department of Biology, University of Rochester, New York 14627
    Mol Biol Evol 9:654-65. 1992
    ..It is surprising that the inducible glucitol-specific enzyme, which is functional, is more variable than the cellobiose-specific enzyme, which is cryptic; the latter might be expected to be under less (if any) purifying selection...
  13. ncbi Nucleotide sequence, function, activation, and evolution of the cryptic asc operon of Escherichia coli K12
    B G Hall
    Biology Department, University of Rochester, New York 14627
    Mol Biol Evol 9:688-706. 1992
    ..The duplications that gave rise to these paralogous genes are estimated to have occurred approximately 320 Mya, a time that predates the divergence of E. coli and Salmonella typhimurium...
  14. pmc Experimental evolution of a new enzymatic function. II. Evolution of multiple functions for ebg enzyme in E. coli
    B G Hall
    Genetics 89:453-65. 1978
    ..I conclude that divergence of functions catalyzed by an enzyme need not require gene duplication...
  15. pmc Transgalactosylation activity of ebg beta-galactosidase synthesizes allolactose from lactose
    B G Hall
    J Bacteriol 150:132-40. 1982
    ..The evolutionary implications of this new function are discussed...
  16. pmc Evolution of a regulated operon in the laboratory
    B G Hall
    Genetics 101:335-44. 1982
    ..The resulting fully evolved ebg operon regulates its own expression, and also regulates the synthesis of the lactose permease...
  17. pmc Catalysis by the large subunit of the second beta-galactosidase of Escherichia coli in the absence of the small subunit
    S V Calugaru
    Department of Chemistry M C 111, University of Illinois at Chicago 60607 7061, USA
    Biochem J 312:281-6. 1995
    ..The very significant kinetic effect of this inadvertant site-undirected mutagenesis indicates that quite large kinetic effects of amino-acid replacements in enzymes may have no obvious mechanistic significance...
  18. pmc Cellobiose-6-phosphate hydrolase (CelF) of Escherichia coli: characterization and assignment to the unusual family 4 of glycosylhydrolases
    J Thompson
    Microbial Biochemistry and Genetics Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA
    J Bacteriol 181:7339-45. 1999
    ..Comparative sequence alignments provide tentative identification of the NAD(+)-binding domain (residues 7 to 40) and catalytically important glutamyl residues (Glu(112) and Glu(356)) of CelF...
  19. pmc Large changes of transition-state structure during experimental evolution of an enzyme
    K Srinivasan
    Department of Chemistry, University of Illinois, Chicago 60607 7061
    Biochem J 291:15-7. 1993
    ..3 as a consequence of the two amino-acid changes together, and then increases slightly to 7.3 as a consequence of a third single evolutionary change involving three further amino-acid changes...
  20. pmc Catalytic consequences of experimental evolution: catalysis by a 'third-generation' evolvant of the second beta-galactosidase of Escherichia coli, ebgabcde, and by ebgabcd, a 'second-generation' evolvant containing two supposedly 'kinetically silent' muta
    S Krishnan
    Department of Chemistry M C 111, University of Illinois at Chicago 60607 7061, USA
    Biochem J 312:971-7. 1995
    ..J. Biochem. 206, 289-295 and previous papers] to the Albery-Knowles theory of the evolution of enzyme kinetic activity...
  21. pmc A pseudouridine synthase required for the formation of two universally conserved pseudouridines in ribosomal RNA is essential for normal growth of Escherichia coli
    S Raychaudhuri
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Florida 33101, USA
    RNA 4:1407-17. 1998
    ....
  22. pmc Larger increases in sensitivity to paracatalytic inactivation than in catalytic competence during experimental evolution of the second beta-galactosidase of Escherichia coli
    S V Calugaru
    Department of Chemistry M C 111, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL60607 7061, USA
    Biochem J 325:117-21. 1997
    ....
  23. ncbi Changes in the substrate specificities of an enzyme during directed evolution of new functions
    B G Hall
    Biochemistry 20:4042-9. 1981
    ..The single, double, or triple substitutions in the enzymes did not detectably alter the thermal stability of ebg enzyme...
  24. pmc Evolution of a new enzymatic function by recombination within a gene
    B G Hall
    Proc Natl Acad Sci U S A 77:3529-33. 1980
    ..We show that the sites for class I and class II mutations lie about 1 kilobase, or about a third of the gene, apart in ebgA. Implications of these findings with respect to the evolution of new metabolic functions discussed...
  25. pmc The catalytic consequences of experimental evolution. Studies on the subunit structure of the second (ebg) beta-galactosidase of Escherichia coli, and on catalysis by ebgab, an experimental evolvant containing two amino acid substitutions
    A C Elliott
    Department of Organic Chemistry, University of Bristol, U K
    Biochem J 282:155-64. 1992
    ..9. The alpha- and beta-deuterium secondary isotope effects on the hydrolysis of the galactosyl-enzyme of 1.08 and 1.00 are difficult to reconcile with the pyranose ring in this intermediate being in the 4C1 conformation...
  26. pmc Characterization and nucleotide sequence of the cryptic cel operon of Escherichia coli K12
    L L Parker
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269
    Genetics 124:455-71. 1990
    ..We conclude that the genes for these two enzyme IIIs diverged much more recently than did their hosts, indicating that E. coli and S. aureus have undergone relatively recent exchange of chromosomal genes...
  27. pmc DNA sequence analysis of artificially evolved ebg enzyme and ebg repressor genes
    B G Hall
    Molecular and Cell Biology, University of Connecticut, Storrs 06268
    Genetics 123:635-48. 1989
    ..coli from Klebsiella. One case of a triple substitution as the consequence of a single event is reported, and the implications of that observation for mechanisms of spontaneous mutagenesis are discussed...
  28. pmc IS103, a new insertion element in Escherichia coli: characterization and distribution in natural populations
    B G Hall
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269 3044
    Genetics 121:423-31. 1989
    ..coli population despite its presence on plasmids suggests that plasmids tend to remain within closely related strains and that transfer to distantly related strains is inhibited...
  29. ncbi Maintenance of the cellobiose utilization genes of Escherichia coli in a cryptic state
    B G Hall
    Molecular and Cell Biology Department, University of Connecticut, Storrs 06268
    Mol Biol Evol 3:389-402. 1986
    ..coli populations. This alternation of environments and fitnesses was predicted by the model for cryptic-gene maintenance that was previously published...
  30. pmc Functional genes for cellobiose utilization in natural isolates of Escherichia coli
    B G Hall
    J Bacteriol 169:2713-7. 1987
    ....
  31. pmc A fourth Escherichia coli gene system with the potential to evolve beta-glucoside utilization
    L L Parker
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06268
    Genetics 119:485-90. 1988
    ..We have designated this gene system the sac locus. The sac locus is a fourth set of genes with the potential for evolving to provide beta-glucoside utilization...
  32. pmc Biochemical genetics of the cryptic gene system for cellobiose utilization in Escherichia coli K12
    M Kricker
    Genetics 115:419-29. 1987
    ..Other strains inducibly express a gene which specifies transport of arbutin but not the other beta-glucosides. The arbutin transport gene, arbT, maps outside of the cel locus...
  33. pmc Cryptic genes for cellobiose utilization in natural isolates of Escherichia coli
    B G Hall
    Genetics 115:431-9. 1987
    ..coli populations, and that all of these are normally cryptic. It is estimated that in any random isolate the probability of any particular cluster having been irreversibly inactivated by the accumulation of random mutations is about 0.5...
  34. pmc A mutant Ebg enzyme that converts lactose into an inducer of the lac operon
    S J Rolseth
    J Bacteriol 142:1036-9. 1980
    ..We report here the isolation of a mutant Ebg beta-galactosidase which is capable of converting lactose into an inducer of the lac operon...
  35. ncbi Directed evolution of cellobiose utilization in Escherichia coli K12
    M Kricker
    University of Connecticut, Storrs 06268
    Mol Biol Evol 1:171-82. 1984
    ..A fourth gene at an unknown location increases the growth rate on cellobiose. The cel genes constitute a second cryptic system for beta-glucoside utilization in E. coli K12...
  36. pmc Regulation of newly evolved enzymes. IV. Directed evolution of the Ebg repressor
    B G Hall
    Genetics 90:673-81. 1978
    ..Selection of ebgR+L mutants is discussed within the framework of directed evolution of a regulatory function...
  37. pmc The ebg operon consists of at least two genes
    B G Hall
    J Bacteriol 144:1208-11. 1980
    ..Insertion of the transposable elements Tn5 and Tn9 into ebgA eliminates the expression of ebgB, suggesting that ebgB is distal to ebgA. Ultraviolet light mapping confirms that gene order. The function of the ebgB gene product is unknown...
  38. ncbi Sequence of the ebgR gene of Escherichia coli: evidence that the EBG and LAC operons are descended from a common ancestor
    H W Stokes
    Molecular and Cell Biology Department, University of Connecticut, Storrs 06268
    Mol Biol Evol 2:478-83. 1985
    ..The map position of these two operons supports the notion that these operons diverged following a genome duplication event in an ancestor of Escherichia coli...
  39. ncbi Sequence of the ebgA gene of Escherichia coli: comparison with the lacZ gene
    H W Stokes
    Molecular and Cell Biology Department, University of Connecticut, Storrs 06268
    Mol Biol Evol 2:469-77. 1985
    ..This selection is independent of, and in addition to, selection based on codon usage or on function of the gene products...
  40. pmc Chromosomal mutation for citrate utilization by Escherichia coli K-12
    B G Hall
    J Bacteriol 151:269-73. 1982
    ..It is capable of utilizing cis- and trans-aconitate, but only if it is preinduced by growth on citrate...
  41. ncbi Experimental evolution of a new enzymatic function. Kinetic analysis of the ancestral (ebg) and evolved (ebg) enzymes
    B G Hall
    J Mol Biol 107:71-84. 1976
  42. pmc Regulation of newly evolved enzymes. III Evolution of the ebg repressor during selection for enhanced lactase activity
    B G Hall
    Genetics 85:193-201. 1977
    ..We conclude, therefore, that the evolution of lactose utilization requires both a structural and a regulatory mutation...
  43. pmc Mechanisms of activation of the cryptic cel operon of Escherichia coli K12
    L L Parker
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06268
    Genetics 124:473-82. 1990
    ..The preferred mechanism of activation appears to be strain dependent, since one of the parents yielded 94% insertionally activated alleles, while another yielded 100% point mutation activated alleles...