Marc S Halfon
Affiliation: University at Buffalo
Kazemian M, Suryamohan K, Chen J, Zhang Y, Samee M, Halfon M, et al
. Evidence for deep regulatory similarities in early developmental programs across highly diverged insects. Genome Biol Evol. 2014;6:2301-20 pubmed publisher
..Our work represents an important step toward being able to trace the evolutionary history of gene regulatory networks and defining the mechanisms underlying insect evolution. ..
Asma H, Halfon M. Computational enhancer prediction: evaluation and improvements. BMC Bioinformatics. 2019;20:174 pubmed publisher
Zhou Y, Popadowski S, Deutschman E, Halfon M. Distinct roles and requirements for Ras pathway signaling in visceral versus somatic muscle founder specification. Development. 2019;146: pubmed publisher
..Our findings fit with a growing body of data that point to a complex interplay between the Ras pathway, ETS transcription factors, and enhancer binding as a crucial mechanism for determining unique responses to Ras signaling. ..
Halfon M. Studying Transcriptional Enhancers: The Founder Fallacy, Validation Creep, and Other Biases. Trends Genet. 2019;35:93-103 pubmed publisher
..I discuss how they can lead to interpretative errors and an unduly narrow focus on certain aspects of enhancer biology to the potential exclusion of others. ..
Kazemian M, Halfon M. CRM Discovery Beyond Model Insects. Methods Mol Biol. 2019;1858:117-139 pubmed publisher
Halfon M, Arnosti D. New tools, resources for gene regulatory analysis in Drosophila. Fly (Austin). 2007;1:123-4 pubmed
Halfon M, Zhu Q, Brennan E, Zhou Y. Erroneous attribution of relevant transcription factor binding sites despite successful prediction of cis-regulatory modules. BMC Genomics. 2011;12:578 pubmed publisher
..Our study underscores the importance of empirical validation of computational results even when these results are in line with expectation. ..
Suryamohan K, Hanson C, Andrews E, Sinha S, SCHEEL M, Halfon M. Redeployment of a conserved gene regulatory network during Aedes aegypti development. Dev Biol. 2016;416:402-13 pubmed publisher
Halfon M. Perspectives on Gene Regulatory Network Evolution. Trends Genet. 2017;33:436-447 pubmed publisher
..Advances in methods to discover related CRMs in diverse insect species, a critical requirement for detailed GRN characterization, are also described. ..