Randal Halfmann

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Prion formation by a yeast GLFG nucleoporin
    Randal Halfmann
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Prion 6:391-9. 2012
  2. doi request reprint Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits
    Randal Halfmann
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Science 330:629-32. 2010
  3. pmc Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins
    Randal Halfmann
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Mol Cell 43:72-84. 2011
  4. pmc Prions are a common mechanism for phenotypic inheritance in wild yeasts
    Randal Halfmann
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 482:363-8. 2012
  5. pmc Prions, protein homeostasis, and phenotypic diversity
    Randal Halfmann
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Trends Cell Biol 20:125-33. 2010
  6. pmc A systematic survey identifies prions and illuminates sequence features of prionogenic proteins
    Simon Alberti
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 137:146-58. 2009
  7. pmc A method for probing the mutational landscape of amyloid structure
    Charles W O'Donnell
    Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA
    Bioinformatics 27:i34-42. 2011
  8. doi request reprint Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast
    Simon Alberti
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Methods Enzymol 470:709-34. 2010

Collaborators

Detail Information

Publications8

  1. pmc Prion formation by a yeast GLFG nucleoporin
    Randal Halfmann
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Prion 6:391-9. 2012
    ..Furthermore, we demonstrate that Nup100 can form bona fide prions, thus establishing a previously undiscovered ability of yeast GLFG nucleoporins to adopt this conformational state in vivo...
  2. doi request reprint Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits
    Randal Halfmann
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Science 330:629-32. 2010
    ..With intimate ties to protein homeostasis and a remarkable sensitivity to stress, prions are a robust mechanism that links environmental extremes with the acquisition and inheritance of new traits...
  3. pmc Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins
    Randal Halfmann
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Mol Cell 43:72-84. 2011
    ..Molecular simulations focusing on intrinsic folding differences between Qs and Ns suggest that their different behaviors are due to the enhanced turn-forming propensity of Ns over Qs...
  4. pmc Prions are a common mechanism for phenotypic inheritance in wild yeasts
    Randal Halfmann
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 482:363-8. 2012
    ..Fully one-third of wild strains harboured them. These, too, created diverse, often beneficial phenotypes. Thus, prions broadly govern heritable traits in nature, in a manner that could profoundly expand adaptive opportunities...
  5. pmc Prions, protein homeostasis, and phenotypic diversity
    Randal Halfmann
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Trends Cell Biol 20:125-33. 2010
    ..In this article, we suggest that these qualities allow prions to act as 'bet-hedging' devices that facilitate the adaptation of yeasts to stressful environments, and might speed the evolution of new traits...
  6. pmc A systematic survey identifies prions and illuminates sequence features of prionogenic proteins
    Simon Alberti
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 137:146-58. 2009
    ..The self-perpetuating states of these proteins present a vast source of heritable phenotypic variation that increases the adaptability of yeast populations to diverse environments...
  7. pmc A method for probing the mutational landscape of amyloid structure
    Charles W O'Donnell
    Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA
    Bioinformatics 27:i34-42. 2011
    ..Experimental structure determination has proven extremely difficult with only a handful of NMR-based models proposed, suggesting a need for computational methods...
  8. doi request reprint Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast
    Simon Alberti
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Methods Enzymol 470:709-34. 2010
    ..Here, we provide a range of biochemical, cell biological and yeast genetic methods that are currently used in our laboratory to study protein aggregation and the formation of amyloids and prions...