Dale Buchanan Hales

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi Arginine vasopressin inhibition of cytochrome P450c17 and testosterone production in mouse Leydig cells
    D B Hales
    Department of Physiology and Biophysics, University of Illinois at Chicago 60612 7342, USA
    Endocrine 8:19-28. 1998
  2. ncbi Role of cytokines in testicular function
    D B Hales
    Department of Physiology and Biophysics, University of Illinois at Chicago, 60612 7342, USA
    Endocrine 10:201-17. 1999
  3. ncbi Testicular macrophage modulation of Leydig cell steroidogenesis
    Dale Buchanan Hales
    Department of Physiology and Biophysics M C901, University of Illinois at Chicago, Chicago, IL 60612 7342, USA
    J Reprod Immunol 57:3-18. 2002
  4. ncbi Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus)
    Dale Buchanan Hales
    Department of Physiology and Biophysics, University of Illinois College of Medicine at Chicago, 835 S Wolcott Ave, Chicago, IL 60612 7342, USA
    Endocrine 33:235-44. 2008
  5. ncbi Mitochondrial function in Leydig cell steroidogenesis
    Dale B Hales
    Department of Physiology and Biophysics, University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612 7342, USA
    Ann N Y Acad Sci 1061:120-34. 2005
  6. ncbi Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis
    Thorsten Diemer
    Department of Physiology and Biophysics, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612 7342, USA
    Endocrinology 144:2882-91. 2003
  7. ncbi E-cadherin expression in ovarian cancer in the laying hen, Gallus domesticus, compared to human ovarian cancer
    Kristine Ansenberger
    Department of Physiology and Biophysics M C 901, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA
    Gynecol Oncol 113:362-9. 2009
  8. ncbi Decreased severity of ovarian cancer and increased survival in hens fed a flaxseed-enriched diet for 1 year
    Kristine Ansenberger
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA
    Gynecol Oncol 117:341-7. 2010
  9. ncbi Selenium-Binding Protein 1 expression in ovaries and ovarian tumors in the laying hen, a spontaneous model of human ovarian cancer
    Karen Stammer
    Department of Pharmacology, Rush University Medical Center, Chicago, IL 60612, USA
    Gynecol Oncol 109:115-21. 2008
  10. ncbi Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis
    John A Allen
    Department of Physiology and Biophysics (MC 901, University of Illinois at Chicago, Chicago, Illinois 60612-7342, USA
    Endocrinology 147:3924-35. 2006

Research Grants

  1. Therapeutic Efficacy of Flax Seed in the Prevention of Ovarian Cancer
    DALE HALES; Fiscal Year: 2007

Collaborators

  • Animesh Barua
  • Mary Hunzicker-Dunn
  • T Diemer
  • Eishichi Miyamoto
  • Hideyuki Yamamoto
  • Serdar Bulun
  • Luis M Garcia-Segura
  • Michael Schumacher
  • Kristine Ansenberger
  • John A Allen
  • Janice M Bahr
  • Alain Fleury
  • Cassandra Richards
  • Yan Zhuge
  • Judith L Luborsky
  • Erkut Attar
  • Karen Stammer
  • Paul Janus
  • Karen Held Hales
  • Yasmina Benmessahel
  • Lyne Ducharme
  • Jean-Guy LeHoux
  • Jean Guy LeHoux
  • Amanda Sierra
  • Lisa M Salvador
  • Bilgin Gurates
  • Jo Ann J Lagman
  • Hideki Tokunaga
  • David Redwine
  • Nobuo Yaegashi
  • Rukset Attar
  • M Bertan Yilmaz
  • Michael Putman
  • Gonca Imir
  • Seby L Edassery
  • Pincas Bitterman
  • Tristan Shankara
  • Steve Buck
  • Axel P Mathieu
  • Ghislaine Groyer
  • Jean-Denis Troadec
  • Rachida Guennoun
  • Margarita Perez-Martin
  • Esteban Lavaque
  • Inigo Azcoitia
  • Evelyn Maizels

Detail Information

Publications17

  1. ncbi Arginine vasopressin inhibition of cytochrome P450c17 and testosterone production in mouse Leydig cells
    D B Hales
    Department of Physiology and Biophysics, University of Illinois at Chicago 60612 7342, USA
    Endocrine 8:19-28. 1998
    ..The implications of AVP-mediated inhibition of steroidogenesis and potential role of MARCKS phosphorylation are discussed...
  2. ncbi Role of cytokines in testicular function
    D B Hales
    Department of Physiology and Biophysics, University of Illinois at Chicago, 60612 7342, USA
    Endocrine 10:201-17. 1999
    ....
  3. ncbi Testicular macrophage modulation of Leydig cell steroidogenesis
    Dale Buchanan Hales
    Department of Physiology and Biophysics M C901, University of Illinois at Chicago, Chicago, IL 60612 7342, USA
    J Reprod Immunol 57:3-18. 2002
    ....
  4. ncbi Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus)
    Dale Buchanan Hales
    Department of Physiology and Biophysics, University of Illinois College of Medicine at Chicago, 835 S Wolcott Ave, Chicago, IL 60612 7342, USA
    Endocrine 33:235-44. 2008
    ....
  5. ncbi Mitochondrial function in Leydig cell steroidogenesis
    Dale B Hales
    Department of Physiology and Biophysics, University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612 7342, USA
    Ann N Y Acad Sci 1061:120-34. 2005
    ..These results suggest that mitochondria must be energized, polarized, and actively respiring to support Leydig cell steroidogenesis and alterations in the state of mitochondria may be involved in regulating steroid biosynthesis...
  6. ncbi Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis
    Thorsten Diemer
    Department of Physiology and Biophysics, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612 7342, USA
    Endocrinology 144:2882-91. 2003
    ..This mechanism likely contributes to a host of pathophysiological events evident in testicular disorders such as infection, reperfusion injury, aging, cryptorchidism, and varicocele...
  7. ncbi E-cadherin expression in ovarian cancer in the laying hen, Gallus domesticus, compared to human ovarian cancer
    Kristine Ansenberger
    Department of Physiology and Biophysics M C 901, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA
    Gynecol Oncol 113:362-9. 2009
    ..Our objective was to evaluate E-cadherin expression in the hen ovary and compare its expression to human ovarian cancer...
  8. ncbi Decreased severity of ovarian cancer and increased survival in hens fed a flaxseed-enriched diet for 1 year
    Kristine Ansenberger
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA
    Gynecol Oncol 117:341-7. 2010
    ..The objective of this study was to determine if a flaxseed-enriched diet had a chemopreventive effect on ovarian cancer in the laying hen...
  9. ncbi Selenium-Binding Protein 1 expression in ovaries and ovarian tumors in the laying hen, a spontaneous model of human ovarian cancer
    Karen Stammer
    Department of Pharmacology, Rush University Medical Center, Chicago, IL 60612, USA
    Gynecol Oncol 109:115-21. 2008
    ....
  10. ncbi Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis
    John A Allen
    Department of Physiology and Biophysics (MC 901, University of Illinois at Chicago, Chicago, Illinois 60612-7342, USA
    Endocrinology 147:3924-35. 2006
    ..These results suggest that mitochondria must be energized, polarized, and actively respiring to support Leydig cell steroidogenesis, and alterations in the state of mitochondria may be involved in regulating steroid biosynthesis...
  11. ncbi Bacterial endotoxin lipopolysaccharide and reactive oxygen species inhibit Leydig cell steroidogenesis via perturbation of mitochondria
    John A Allen
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612-7342, USA
    Endocrine 25:265-75. 2004
    ..The acute effects of LPS demonstrate how sensitive Leydig cell mitochondrial steroidogenesis is to inflammation-induced oxidative stress...
  12. ncbi Acute signaling by the LH receptor is independent of protein kinase C activation
    Lisa M Salvador
    Department of Cell Biology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Endocrinology 143:2986-94. 2002
    ..Unexpectedly, PKCs were partially activated in the absence of LH receptor activation, and LH receptor activation did not elicit further detectable PKC activation...
  13. ncbi Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis
    Erkut Attar
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 303 East Superior Street, 4 123, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 94:623-31. 2009
    ....
  14. ncbi Phosphorylation of the hamster adrenal steroidogenic acute regulatory protein as analyzed by two-dimensional polyacrylamide gel electrophoreses
    Jean Guy LeHoux
    Department of Biochemistry, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Que, Canada J1H 5N4
    Mol Cell Endocrinol 215:127-34. 2004
    ..Finally we found that, in addition to phosphorylation, the formation of different StAR species was also due to the hydrolysis of the molecule at its N-terminal and to a lesser degree at its C-terminal...
  15. ncbi Downregulation of steroidogenic acute regulatory protein (StAR) gene expression by cyclic AMP in cultured Schwann cells
    Yasmina Benmessahel
    INSERM U488, , France
    Glia 45:213-28. 2004
    ..Since StAR gene expression is stimulated by cAMP in classical steroidogenic cells, our work is the first demonstration of a negative regulation of StAR gene by cAMP...
  16. ncbi Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury
    Amanda Sierra
    Instituto Cajal, C S I C, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Eur J Neurosci 18:1458-67. 2003
    ..This raises the possibility that the up-regulation of StAR expression and the subsequent modifications in steroidogenesis may be part of the mechanisms used by the brain to cope with neurodegeneration...
  17. ncbi Phosphorylation and function of the hamster adrenal steroidogenic acute regulatory protein (StAR)
    Alain Fleury
    Department of Biochemistry, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    J Steroid Biochem Mol Biol 91:259-71. 2004
    ..The increased quantity of StAR upon (Bu)(2)-cAMP stimulation could be due to an augmentation of its mRNA or protein synthesis stability, or both; this is yet to be determined...

Research Grants2

  1. Therapeutic Efficacy of Flax Seed in the Prevention of Ovarian Cancer
    DALE HALES; Fiscal Year: 2007
    ..Using the hen as our model we will investigate the use of omega-3/flax seed diet as a way to prevent ovarian cancer. ..