Tobias B Halene

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Predator odor modulates auditory event-related potentials in mice
    Tobias B Halene
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuroreport 20:1260-4. 2009
  2. ncbi Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type mice
    Christina L Bodarky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Pharmacol Exp Ther 331:308-18. 2009
  3. ncbi Male and female mice differ for baseline and nicotine-induced event related potentials
    Laura C Amann
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, PA, USA
    Behav Neurosci 122:982-90. 2008
  4. ncbi Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials
    Laura C Amann
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Dis 35:311-7. 2009
  5. ncbi Mouse behavioral endophenotypes for schizophrenia
    Laura C Amann
    Stanley Medical Research Institute for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Brain Res Bull 83:147-61. 2010
  6. ncbi Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials
    Robert E Featherstone
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e39775. 2012
  7. ncbi Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
    Gregory C Carlson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Proc Natl Acad Sci U S A 108:E962-70. 2011
  8. ncbi PDE inhibitors in psychiatry--future options for dementia, depression and schizophrenia?
    Tobias B Halene
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Translational Research Laboratories, 125 S 31st Street, Philadelphia, PA 19104, United States
    Drug Discov Today 12:870-8. 2007

Collaborators

Detail Information

Publications8

  1. ncbi Predator odor modulates auditory event-related potentials in mice
    Tobias B Halene
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuroreport 20:1260-4. 2009
    ..NR1 knockdown mice do not have deficits in this task, suggesting that sensory integration may rely on non-N-methyl-D-aspartate receptor mediated circuits...
  2. ncbi Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type mice
    Christina L Bodarky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Pharmacol Exp Ther 331:308-18. 2009
    ..In addition, NR1 reduction decreased GABA(A) receptor-mediated effects on ERPs while causing increased GABA(B) receptor-mediated effects. Future studies will examine changes in GABA receptor subunits after reductions in NR1 expression...
  3. ncbi Male and female mice differ for baseline and nicotine-induced event related potentials
    Laura C Amann
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, PA, USA
    Behav Neurosci 122:982-90. 2008
    ..Whether this electrophysiological sexual dimorphism has functional consequences for sensory or cognitive abilities requires additional research. (PsycINFO Database Record (c) 2008 APA, all rights reserved)...
  4. ncbi Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials
    Laura C Amann
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Dis 35:311-7. 2009
    ..Though no interactions were found involving test week, stimulus and treatment condition, these results suggest that repeated ketamine administration impairs fear memory and has lasting effects on encoding of sensory stimuli...
  5. ncbi Mouse behavioral endophenotypes for schizophrenia
    Laura C Amann
    Stanley Medical Research Institute for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Brain Res Bull 83:147-61. 2010
    ..We also, address the viability and validity of using such measures regarding their potential clinical implications, and suggest several practices that could increase the translatability of preclinical data...
  6. ncbi Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials
    Robert E Featherstone
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e39775. 2012
    ..Although the role of nicotine receptor subtypes in augmentation of ERPs has received some attention, less is known about how these receptor subtypes regulate the effect of nicotine on evoked gamma activity...
  7. ncbi Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
    Gregory C Carlson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Proc Natl Acad Sci U S A 108:E962-70. 2011
    ..Furthermore, these data implicate reduced fast-phasic inhibition as a common underlying mechanism of schizophrenia-associated intermediate phenotypes...
  8. ncbi PDE inhibitors in psychiatry--future options for dementia, depression and schizophrenia?
    Tobias B Halene
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Translational Research Laboratories, 125 S 31st Street, Philadelphia, PA 19104, United States
    Drug Discov Today 12:870-8. 2007
    ..Adverse effects are a major impediment for clinical approval. It is therefore necessary to search for more specific inhibitors at the level of different PDE sub-families and isoforms...