Sen itiroh Hakomori

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc The glycosynapse
    Sen itiroh Hakomori Si
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122 4327, USA
    Proc Natl Acad Sci U S A 99:225-32. 2002
  2. doi request reprint Carbohydrate to carbohydrate interaction in development process and cancer progression
    Kazuko Handa
    Pacific Northwest Research Institude, WA 98122, USA
    Glycoconj J 29:627-37. 2012
  3. ncbi request reprint Glycosphingolipid antigens and cancer therapy
    S Hakomori
    Pacific Northwest Research Foundation, Biomembrane Division, University of Washington, 720 Broadway, Seattle, WA 98122, USA
    Chem Biol 4:97-104. 1997
  4. doi request reprint N-glycosylation status of beta-haptoglobin in sera of patients with colon cancer, chronic inflammatory diseases and normal subjects
    Seung Yeol Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
    Int J Cancer 126:142-55. 2010
  5. pmc Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility
    Sen itiroh Hakomori
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, WA 98122, USA
    FEBS Lett 584:1901-6. 2010
  6. ncbi request reprint Carbohydrate-to-carbohydrate interaction, through glycosynapse, as a basis of cell recognition and membrane organization
    Senitiroh Hakomori
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122 4302, USA
    Glycoconj J 21:125-37. 2004
  7. ncbi request reprint Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling
    Senitiroh Hakomori
    Pacific Northwest Research Institute, Seattle, WA 98122 4302, USA
    An Acad Bras Cienc 76:553-72. 2004
  8. ncbi request reprint Carbohydrate-to-carbohydrate interaction in basic cell biology: a brief overview
    Senitiroh Hakomori
    Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Arch Biochem Biophys 426:173-81. 2004
  9. ncbi request reprint Structure, organization, and function of glycosphingolipids in membrane
    Senitiroh Hakomori
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Curr Opin Hematol 10:16-24. 2003
  10. pmc Glycosylation defining cancer malignancy: new wine in an old bottle
    Senitiroh Hakomori
    Pacific Northwest Research Institute, and Department of Pathobiology, University of Washington, Seattle, WA 98122 4327, USA
    Proc Natl Acad Sci U S A 99:10231-3. 2002

Research Grants

  1. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2009
  2. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 1999
  3. GLYCOLIPID MICRODOMAINS IN TUMOR CELL ADHESION /SIGNALIN
    Sen itiroh Hakomori; Fiscal Year: 2003
  4. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 2003
  5. Glycosynapses in cancer cell adhesion and signaling
    Senitiroh Hakomori; Fiscal Year: 2005
  6. Carbohydrate-carbohydrate interaction in cell biology
    Senitiroh Hakomori; Fiscal Year: 2005
  7. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2006
  8. Carbohydrate-carbohydrate interaction in basic cell biology
    Sen itiroh Hakomori; Fiscal Year: 2006
  9. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2007
  10. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2008

Collaborators

Detail Information

Publications38

  1. pmc The glycosynapse
    Sen itiroh Hakomori Si
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122 4327, USA
    Proc Natl Acad Sci U S A 99:225-32. 2002
    ..The possibility is discussed that glycosynapses give rise to a high degree of diversity and complexity of phenotypes...
  2. doi request reprint Carbohydrate to carbohydrate interaction in development process and cancer progression
    Kazuko Handa
    Pacific Northwest Research Institude, WA 98122, USA
    Glycoconj J 29:627-37. 2012
    ..Since CCI research is still limited, more examples of CCI in biological processes in development, and cancer progression will be revealed in the future...
  3. ncbi request reprint Glycosphingolipid antigens and cancer therapy
    S Hakomori
    Pacific Northwest Research Foundation, Biomembrane Division, University of Washington, 720 Broadway, Seattle, WA 98122, USA
    Chem Biol 4:97-104. 1997
    ..Tumor-associated GSL antigens have been used in the development of antitumor vaccines. GSLs and sphingolipids involved in adhesion and signaling are therefore targets for cancer therapy...
  4. doi request reprint N-glycosylation status of beta-haptoglobin in sera of patients with colon cancer, chronic inflammatory diseases and normal subjects
    Seung Yeol Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
    Int J Cancer 126:142-55. 2010
    ..The identified glycans were sialylated or nonsialylated, bi-antennary or tri-antennary structures, with or without terminal fucosylation...
  5. pmc Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility
    Sen itiroh Hakomori
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, WA 98122, USA
    FEBS Lett 584:1901-6. 2010
    ..Some of these processes are shared with epithelial-mesenchymal transition induced by TGFbeta or under hypoxia, particularly that associated with cancer progression...
  6. ncbi request reprint Carbohydrate-to-carbohydrate interaction, through glycosynapse, as a basis of cell recognition and membrane organization
    Senitiroh Hakomori
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122 4302, USA
    Glycoconj J 21:125-37. 2004
    ..This modulation may occur in part via interaction of GSLs with N -linked glycans of the receptor, termed " cis interactio"...
  7. ncbi request reprint Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling
    Senitiroh Hakomori
    Pacific Northwest Research Institute, Seattle, WA 98122 4302, USA
    An Acad Bras Cienc 76:553-72. 2004
    ..Various data indicate a functional role of glycosynapses during differentiation, development, and oncogenic transformation...
  8. ncbi request reprint Carbohydrate-to-carbohydrate interaction in basic cell biology: a brief overview
    Senitiroh Hakomori
    Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Arch Biochem Biophys 426:173-81. 2004
  9. ncbi request reprint Structure, organization, and function of glycosphingolipids in membrane
    Senitiroh Hakomori
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Curr Opin Hematol 10:16-24. 2003
    ..Functional roles of myeloglycan in neutrophils during inflammatory processes are discussed...
  10. pmc Glycosylation defining cancer malignancy: new wine in an old bottle
    Senitiroh Hakomori
    Pacific Northwest Research Institute, and Department of Pathobiology, University of Washington, Seattle, WA 98122 4327, USA
    Proc Natl Acad Sci U S A 99:10231-3. 2002
  11. ncbi request reprint Signal transduction through glyco(sphingo)lipids. Introduction and recent studies on glyco(sphingo)lipid-enriched microdomains
    S Hakomori
    Pacific Northwest Research Foundation, Seattle, Washington 98122, USA
    Ann N Y Acad Sci 845:1-10. 1998
    ....
  12. ncbi request reprint Cell adhesion/recognition and signal transduction through glycosphingolipid microdomain
    S I Hakomori
    Pacific Northwest Research Institute, Seattle, WA 98122 4327, USA
    Glycoconj J 17:143-51. 2000
    ..GSL-dependent cell adhesion in microdomain causes activation of the signal transducers, leading to cell phenotypic changes. A retrospective of the development of this concept, and current status of our studies, are presented...
  13. pmc Structure and function of glycosphingolipids and sphingolipids: recollections and future trends
    Sen itiroh Hakomori
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Biochim Biophys Acta 1780:325-46. 2008
    ..Future trends in GSL and glycosyl epitope research are considered, including stem cell biology and epithelial-mesenchymal transition (EMT) process...
  14. ncbi request reprint Traveling for the glycosphingolipid path
    S Hakomori
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Glycoconj J 17:627-47. 2000
    ..e., contraceptive) is discussed. For each approach, development of mimetics of key GSLs or glycoepitopes is an important subject of future study...
  15. ncbi request reprint Dimeric Le(a) (Le(a)-on-Le(a)) status of beta-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects
    Seung Yeol Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    Int J Oncol 36:1291-7. 2010
    ..ii) Strong reactivity of Colo205 supernatant with ST421 was reduced clearly by pre-incubation of cells with benzyl-alpha-GalNAc...
  16. ncbi request reprint Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse
    Adriane Regina Todeschini
    Division of Biomembrane Research, Pacific Northwest Research Institute, and Department of Pathobiology, University of Washington, Seattle, Washington 98122 4302, USA
    J Biol Chem 282:8123-33. 2007
    ..These findings indicate that GSL, particularly GM2, forms a complex with CD82, and that such complex interacts with Met and thereby inhibits HGF-induced Met tyrosine kinase activity, as well as integrin to Met cross-talk...
  17. ncbi request reprint Interaction of N-linked glycans, having multivalent GlcNAc termini, with GM3 ganglioside
    Seon Joo Yoon
    Division of Biomembrane Research, Pacific Northwest Research Institute, and Department of Pathobiology, University of Washington, Seattle, WA, USA
    Glycoconj J 23:639-49. 2006
    ..Natural occurrence of such interaction to define cell biological phenomena is under investigation...
  18. ncbi request reprint N-glycosylation status of beta-haptoglobin in sera of patients with prostate cancer vs. benign prostate diseases
    Seon Joo Yoon
    Division of Biomembrane Research, Pacific Northwest Research Institute and Departments of Pathobiology and Global Health, University of Washington, Seattle, WA 98122, USA
    Int J Oncol 36:193-203. 2010
    ..Thus, binding of PHA-L to affinity-purified beta-haptoglobin from sera of patients could lead to development of useful tools for differential diagnosis of prostate cancer vs. benign prostate diseases...
  19. pmc Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor
    Seon Joo Yoon
    Pacific Northwest Research Institute and University of Washington, Seattle, WA 98122, USA
    Proc Natl Acad Sci U S A 103:18987-91. 2006
    ..These findings indicate that N-linked glycan with GlcNAc termini linked to EGFR is the target to interact with GM3, causing inhibition of EGF-induced EGFR tyrosine kinase...
  20. ncbi request reprint Regulation of epidermal growth factor receptor through interaction of ganglioside GM3 with GlcNAc of N-linked glycan of the receptor: demonstration in ldlD cells
    Feng Guan
    Division of Biomembrane Research, Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Neurochem Res 36:1645-53. 2011
    ..3) GM3-, but not GM1-, coated beads bound to EGFR in lysate of -Gal cells, which have highly exposed GlcNAc termini. Such binding was inhibited in the presence of EDTA, similarly to other carbohydrate-carbohydrate interactions...
  21. ncbi request reprint Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate
    Seon Joo Yoon
    Division of Biomembrane Research, Pacific Northwest Research Institute, Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
    Glycobiology 17:1007-14. 2007
    ..B-Cer coated plate was significantly higher than binding of GM3 liposomes. Other GSL liposomes showed no binding. Thus, self-recognition of Os Fr. B-Cer was clearly demonstrated using ceramide mimetic conjugates...
  22. ncbi request reprint Lyso-GM3, its dimer, and multimer: their synthesis, and their effect on epidermal growth factor-induced receptor tyrosine kinase
    Yoshimi Murozuka
    Pacific Northwest Research Institute, University of Washington, Seattle, WA 98122, USA
    Glycoconj J 24:551-63. 2007
    ..Thus, lyso-GM3 and its dimer exert an auxiliary effect on GM3-induced inhibition of EGFR kinase and cell growth, and lyso-GM3 dimer may be a good candidate for pharmacological inhibitor of epidermal tumor growth...
  23. pmc Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines
    Feng Guan
    Division of Biomembrane Research, Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Proc Natl Acad Sci U S A 106:7461-6. 2009
    ..These observations indicate that specific GSLs play key roles in defining phenotypes associated with EMT and its reverse process (i.e., mesenchymal-to-epithelial transition)...
  24. doi request reprint Control of cell motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 versus KB epidermoid tumor cells
    Seung Yeol Park
    Division of Biomembrane Research, Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122 4302, USA
    Carbohydr Res 344:1479-86. 2009
    ..This is in contrast to our previous studies that indicate that motility of many types of tumor cells is inhibited by a high level of CD9 or CD82, together with growth factor receptors and integrins...
  25. doi request reprint Self-recognition of high-mannose type glycans mediating adhesion of embryonal fibroblasts
    Seon Joo Yoon
    Division of Biomembrane Research, Pacific Northwest Research Institute, and Department of Global Health, University of Washington, Seattle, WA 98122, USA
    Glycoconj J 30:485-96. 2013
    ..Further studies are to be addressed on auto-adhesion of other types of cells based on self interaction of high mannose type glycans...
  26. pmc Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition process
    Leonardo Freire-de-Lima
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Proc Natl Acad Sci U S A 108:17690-5. 2011
    ..These findings indicate the important functional role of expression of onfFN, defined by site-specific O-glycosylation at IIICS domain, in the EMT process...
  27. ncbi request reprint Le(x) glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: a preliminary note
    Kazuko Handa
    Division of Biomembrane Research, Pacific Northwest Research Institute, Department of Pathobiology, University of Washington, Seattle, WA 98122, USA
    Biochem Biophys Res Commun 358:247-52. 2007
    ..Thus, ES or EC cells display autoaggregation and strong adhesion to Le(x)-coated plates in the absence of Ecad, further supporting the notion of Le(x) self-recognition (i.e., Le(x)-to-Le(x) interaction) in cell adhesion...
  28. pmc Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells
    Yuh Jin Liang
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Proc Natl Acad Sci U S A 110:4968-73. 2013
    ..Our results provide insight into GSL profiles in human breast CSCs, indicate a functional role of GD2 and GD3 in CSCs, and suggest a possible novel approach in targeting human breast CSCs to interfere with cancer recurrence...
  29. pmc Functional role of gangliotetraosylceramide in epithelial-to-mesenchymal transition process induced by hypoxia and by TGF-{beta}
    Feng Guan
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    FASEB J 24:4889-903. 2010
    ....
  30. pmc Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains
    Adriane Regina Todeschini
    Division of Biomembrane Research, Pacific Northwest Research Institute, University of Washington, Seattle, WA, USA
    Biochim Biophys Acta 1780:421-33. 2008
    ..Data present here suggest that the organizational status of glycosynapse strongly affects cellular phenotype influencing tumor cell malignancy...
  31. pmc Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin
    Yao Ding
    Division of Biomembrane Research, Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    FEBS Lett 586:1813-20. 2012
    ....
  32. doi request reprint Glycosyl conjugates of biotinylated diaminopyridine applied for study of carbohydrate-to-carbohydrate interaction
    Natalia Utkina
    Division of Biomembrane Research, Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122 4302, USA
    Glycoconj J 27:601-11. 2010
    ..Thus, cell adhesion processes based on homotypic CCI between N-linked glycans having multiple GlcNAc termini, and heterotypic CCI between GM3 and such glycans, were clearly observed using BAP conjugates of glycosyl epitopes...
  33. pmc Binding of rainbow trout sperm to egg is mediated by strong carbohydrate-to-carbohydrate interaction between (KDN)GM3 (deaminated neuraminyl ganglioside) and Gg3-like epitope
    Song Yu
    Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Proc Natl Acad Sci U S A 99:2854-9. 2002
    ....
  34. ncbi request reprint Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects
    Tsutomu Fujimura
    Department of Pathobiology, University of Washington and Pacific Northwest Research Institute, 720 Broadway, Seattle, WA, USA
    Int J Cancer 122:39-49. 2008
    ..In summary, levels of haptoglobin are enhanced in sera of prostate cancer patients, and the N-glycans attached to a defined peptide region of its beta-chain are characterized by enhanced branching as well as antenna fucosylation...
  35. pmc Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway
    Adriane Regina Todeschini
    Division of Biomembrane Research, Pacific Northwest Research Institute, and Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:1925-30. 2008
    ..Thus, a previously uncharacterized GM2/GM3 heterodimer complexed with CD82 inhibits cell motility through CD82-cMet or integrin-cMet pathway...
  36. ncbi request reprint Sialosyl-Le(x) expression defines invasive and metastatic properties of bladder carcinoma
    Kenji Numahata
    Department of Urology, Tohoku University, School of Medicine, Sendai, Japan
    Cancer 94:673-85. 2002
    ..However, there is no specific predictor at early stages for later invasive and metastatic clinical outcome of patients with type B tumors...
  37. ncbi request reprint Introduction. Professor Yasuo Inoue: 1934-2005
    Ken Kitajima
    Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan
    Glycoconj J 23:273-6. 2006
  38. ncbi request reprint Establishment and characterization of a new erythroblastic leukemia cell line, EEB: phosphatidylglucoside-mediated erythroid differentiation and apoptosis
    Chizuru Kawano-Yamamoto
    Division of Hematology, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi 329 0498, Japan
    Leuk Res 30:829-39. 2006
    ..The GL-7-mediated erythroid differentiation was associated with apoptosis. These results suggest that direct signaling to PhGlc mediates erythroid differentiation and apoptosis in EEB cells...

Research Grants21

  1. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2009
    ....
  2. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 1999
    ..In the inhibitory effect is confirmed, its mechanism will be studied in relation to activities of SDKs, MAPK, bcl-2, and other signal transducers. ..
  3. GLYCOLIPID MICRODOMAINS IN TUMOR CELL ADHESION /SIGNALIN
    Sen itiroh Hakomori; Fiscal Year: 2003
    ....
  4. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 2003
    ..In the inhibitory effect is confirmed, its mechanism will be studied in relation to activities of SDKs, MAPK, bcl-2, and other signal transducers. ..
  5. Glycosynapses in cancer cell adhesion and signaling
    Senitiroh Hakomori; Fiscal Year: 2005
    ....
  6. Carbohydrate-carbohydrate interaction in cell biology
    Senitiroh Hakomori; Fiscal Year: 2005
    ..abstract_text> ..
  7. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2006
    ....
  8. Carbohydrate-carbohydrate interaction in basic cell biology
    Sen itiroh Hakomori; Fiscal Year: 2006
    ..abstract_text> ..
  9. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2007
    ....
  10. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2008
    ....
  11. PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTOR
    Senitiroh Hakomori; Fiscal Year: 2003
    ..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..
  12. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 2002
    ..In the inhibitory effect is confirmed, its mechanism will be studied in relation to activities of SDKs, MAPK, bcl-2, and other signal transducers. ..
  13. GLYCOLIPID MICRODOMAINS IN TUMOR CELL ADHESION /SIGNALIN
    Senitiroh Hakomori; Fiscal Year: 2002
    ....
  14. GLYCOLIPID MICRODOMAINS IN TUMOR CELL ADHESION /SIGNALIN
    Senitiroh Hakomori; Fiscal Year: 1999
    ....
  15. PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTOR
    Senitiroh Hakomori; Fiscal Year: 2000
    ..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..
  16. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 2000
    ..In the inhibitory effect is confirmed, its mechanism will be studied in relation to activities of SDKs, MAPK, bcl-2, and other signal transducers. ..
  17. GLYCOLIPID MICRODOMAINS IN TUMOR CELL ADHESION /SIGNALIN
    Senitiroh Hakomori; Fiscal Year: 2000
    ....
  18. PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTOR
    Senitiroh Hakomori; Fiscal Year: 2001
    ..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..
  19. GLYCOLIPID MICRODOMAINS IN TUMOR CELL ADHESION /SIGNALIN
    Senitiroh Hakomori; Fiscal Year: 2001
    ....
  20. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 2001
    ..In the inhibitory effect is confirmed, its mechanism will be studied in relation to activities of SDKs, MAPK, bcl-2, and other signal transducers. ..
  21. PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTOR
    Senitiroh Hakomori; Fiscal Year: 2002
    ..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..