GEORGIOS HAJISHENGALLIS

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors
    George Hajishengallis
    Center of Excellence in Oral and Craniofacial Biology and Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    J Biol Chem 280:38902-13. 2005
  2. pmc Pathogenic microbes and community service through manipulation of innate immunity
    George Hajishengallis
    School of Dentistry, Oral Health and Systemic Disease, University of Louisville, Louisville, KY 40292, USA
    Adv Exp Med Biol 946:69-85. 2012
  3. pmc Microbial manipulation of receptor crosstalk in innate immunity
    George Hajishengallis
    University of Louisville, Department of Microbiology and Immunology, Louisville, Kentucky 40292, USA
    Nat Rev Immunol 11:187-200. 2011
  4. pmc Complement and periodontitis
    George Hajishengallis
    Department of Microbiology and Immunology, University of Louisville School of Dentistry, Loueisville, KY 40292, USA
    Biochem Pharmacol 80:1992-2001. 2010
  5. pmc Too old to fight? Aging and its toll on innate immunity
    George Hajishengallis
    Oral Health and Systemic Disease, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY 40292, USA
    Mol Oral Microbiol 25:25-37. 2010
  6. pmc Crosstalk pathways between Toll-like receptors and the complement system
    George Hajishengallis
    University of Louisville School of Dentistry, Division of Oral Health and Systemic Disease, Louisville, KY, USA
    Trends Immunol 31:154-63. 2010
  7. pmc Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?
    George Hajishengallis
    Department of Periodontics Oral Health and Systemic Disease, School of Dentistry, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Microbes Infect 11:637-45. 2009
  8. pmc Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice
    George Hajishengallis
    Department of Periodontics Oral Health and Systemic Disease, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 181:4141-9. 2008
  9. ncbi request reprint Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo
    George Hajishengallis
    Division of Oral Health and Systemic Disease Department of Periodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 179:2359-67. 2007
  10. ncbi request reprint Porphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion?
    George Hajishengallis
    Department of Periodontics Endodondics, Division of Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA
    Front Biosci 12:4547-57. 2007

Research Grants

  1. Pattern Recognition of P. gingivalis Virulence Factors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010
  2. Oral Pathogen Exploitation of Innate Recognition as a Function of Age
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010
  3. Oral Immunity and Adjuvant Receptors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010
  4. Pattern Recognition of P. gingivalis Virulence Factors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2009
  5. Oral Pathogen Exploitation of Innate Recognition as a Function of Age
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2007
  6. Pattern Recognition of P. gingivalis Virulence Factors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2007
  7. Oral Immunity and Adjuvant Receptors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2007
  8. Oral Immunity and Adjuvant Receptors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010

Detail Information

Publications13

  1. ncbi request reprint Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors
    George Hajishengallis
    Center of Excellence in Oral and Craniofacial Biology and Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    J Biol Chem 280:38902-13. 2005
    ..Elucidation of pathogen interactions with PRRs at the molecular level may glean insight into host defense mechanisms as well as into microbial strategies that subvert innate immunity...
  2. pmc Pathogenic microbes and community service through manipulation of innate immunity
    George Hajishengallis
    School of Dentistry, Oral Health and Systemic Disease, University of Louisville, Louisville, KY 40292, USA
    Adv Exp Med Biol 946:69-85. 2012
    ..This review summarizes important immune subversive tactics of P. gingivalis which might enable it to exert a supportive impact on the oral microbial community...
  3. pmc Microbial manipulation of receptor crosstalk in innate immunity
    George Hajishengallis
    University of Louisville, Department of Microbiology and Immunology, Louisville, Kentucky 40292, USA
    Nat Rev Immunol 11:187-200. 2011
    ..Understanding how pathogens exploit host receptor crosstalk mechanisms and infiltrate the host signalling network is essential for developing interventions to redirect the host response and achieve protective immunity...
  4. pmc Complement and periodontitis
    George Hajishengallis
    Department of Microbiology and Immunology, University of Louisville School of Dentistry, Loueisville, KY 40292, USA
    Biochem Pharmacol 80:1992-2001. 2010
    ..This information is essential as it may reveal which specific pathways need to be blocked to counteract microbial evasion and inflammatory pathology or, conversely, kept intact to promote host immunity...
  5. pmc Too old to fight? Aging and its toll on innate immunity
    George Hajishengallis
    Oral Health and Systemic Disease, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY 40292, USA
    Mol Oral Microbiol 25:25-37. 2010
    ....
  6. pmc Crosstalk pathways between Toll-like receptors and the complement system
    George Hajishengallis
    University of Louisville School of Dentistry, Division of Oral Health and Systemic Disease, Louisville, KY, USA
    Trends Immunol 31:154-63. 2010
    ..Further elucidation of regulatory links between complement and TLRs is essential for understanding their complex roles in health and disease...
  7. pmc Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?
    George Hajishengallis
    Department of Periodontics Oral Health and Systemic Disease, School of Dentistry, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Microbes Infect 11:637-45. 2009
    ..The sophisticated stealth and sabotage tactics used by P. gingivalis may additionally benefit co-habiting organisms occupying the same niche...
  8. pmc Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice
    George Hajishengallis
    Department of Periodontics Oral Health and Systemic Disease, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 181:4141-9. 2008
    ..Thus, although TLR2 may mediate destructive effects, as seen in models of experimental periodontitis and atherosclerosis, we have now shown that the same receptor confers protection against P. gingivalis in acute lung infection...
  9. ncbi request reprint Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo
    George Hajishengallis
    Division of Oral Health and Systemic Disease Department of Periodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 179:2359-67. 2007
    ..Therefore, CR3 blockade may represent a promising immunomodulatory approach for controlling human periodontitis and possibly associated systemic diseases...
  10. ncbi request reprint Porphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion?
    George Hajishengallis
    Department of Periodontics Endodondics, Division of Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA
    Front Biosci 12:4547-57. 2007
    ..gingivalis for evading innate immune clearance becomes a plausible hypothesis...
  11. pmc Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages
    George Hajishengallis
    University of Louisville Health Sciences Center, 501 South Preston Street, Room 206, Louisville, KY 40292, USA
    Infect Immun 74:5658-66. 2006
    ..gingivalis internalization within macrophages. It therefore appears that P. gingivalis proactively modulates beta2 integrin adhesive activity for intracellular uptake...
  12. ncbi request reprint Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus
    George Hajishengallis
    Center for Oral Health and Systemic Disease and Department of Periodontics Endodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Cell Microbiol 8:1557-70. 2006
    ..In summary, TLR2 activation by P. gingivalis LPS or fimbriae involves differential dependence on accessory signalling or ligand-binding receptors, which may differentially influence innate immune responses...
  13. pmc Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement
    George Hajishengallis
    Department of Microbiology and Immunology, University of Louisville School of Medicine, KY 40292, USA
    Cell Host Microbe 10:497-506. 2011
    ..The identification and targeting of similar low-abundance pathogens with community-wide impact may be important for treating inflammatory diseases of polymicrobial etiology...

Research Grants18

  1. Pattern Recognition of P. gingivalis Virulence Factors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010
    ..We believe that CXCR4 antagonists may find therapeutic application in human periodontitis and, in this context;we will test a CXCR4 antagonist (AMD3100) for its ability to inhibit P. gingivalis-induced periodontitis in a mouse model. ..
  2. Oral Pathogen Exploitation of Innate Recognition as a Function of Age
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010
    ....
  3. Oral Immunity and Adjuvant Receptors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010
    ..abstract_text> ..
  4. Pattern Recognition of P. gingivalis Virulence Factors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2009
    ..We believe that CXCR4 antagonists may find therapeutic application in human periodontitis and, in this context; we will test a CXCR4 antagonist (AMD3100) for its ability to inhibit P. gingivalis-induced periodontitis in a mouse model. ..
  5. Oral Pathogen Exploitation of Innate Recognition as a Function of Age
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2007
    ....
  6. Pattern Recognition of P. gingivalis Virulence Factors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2007
    ..gingivalis has also been implicated. ..
  7. Oral Immunity and Adjuvant Receptors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2007
    ....
  8. Oral Immunity and Adjuvant Receptors
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010
    ..This work is timely and important given the paucity of safe and effective vaccine adjuvants and the tremendous health impact of infectious diseases. ..