George Hajishengallis

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction
    George Hajishengallis
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Clin Diagn Lab Immunol 9:403-11. 2002
  2. pmc Counteracting interactions between lipopolysaccharide molecules with differential activation of toll-like receptors
    George Hajishengallis
    Department of Oral Biology, State University of New York at Buffalo, 14214, USA
    Infect Immun 70:6658-64. 2002
  3. ncbi request reprint Interactions of oral pathogens with toll-like receptors: possible role in atherosclerosis
    George Hajishengallis
    Department of Oral Biology, University at Buffalo, Buffalo, New York, USA
    Ann Periodontol 7:72-8. 2002
  4. pmc Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I)
    Hesham F Nawar
    Witebsky Center for Microbial Pathogenesis and Immunology and Department of Microbiology and Immunology, University at Buffalo, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Clin Vaccine Immunol 17:969-78. 2010
  5. pmc Structure-activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding
    Vivian Cody
    Structural Biology Department, Hauptman Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, USA
    Acta Crystallogr D Biol Crystallogr 68:1604-12. 2012
  6. pmc LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb
    Hesham F Nawar
    The Witebsky Center for Microbial Pathogenesis and Immunology, Department of Microbiology and Immunology, The University at Buffalo, The State University of New York at Buffalo, Buffalo, NY 14214, USA
    Vaccine 29:721-7. 2011
  7. pmc TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin
    Chang Hoon Lee
    Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY 14214, USA
    J Leukoc Biol 90:911-21. 2011
  8. pmc Mammalian cell ganglioside-binding specificities of E. coli enterotoxins LT-IIb and variant LT-IIb(T13I)
    Charles S Berenson
    Infectious Disease Division, Department of Veterans Affairs Western New York Healthcare System, State University of New York at Buffalo School of Medicine, Buffalo, NY 14215, USA
    Glycobiology 20:41-54. 2010
  9. pmc Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA
    Shinsuke Onishi
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, 3435 Main St, Buffalo, NY 14214 3092, USA
    Infect Immun 76:198-205. 2008
  10. pmc Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriae
    Mehmet A Eskan
    University of Louisville School of Dentistry, 501 South Preston Street, Room 204, Louisville, KY 40292, USA
    Infect Immun 75:892-8. 2007

Collaborators

Detail Information

Publications33

  1. pmc Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction
    George Hajishengallis
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Clin Diagn Lab Immunol 9:403-11. 2002
    ..Our data suggest that the CD14-TLR2/4 system is involved in cytokine production and tolerance induction upon interaction with certain proinflammatory bacterial protein adhesins...
  2. pmc Counteracting interactions between lipopolysaccharide molecules with differential activation of toll-like receptors
    George Hajishengallis
    Department of Oral Biology, State University of New York at Buffalo, 14214, USA
    Infect Immun 70:6658-64. 2002
    ..Interactions between TLR2 and TLR4 agonists may be important in the regulation of inflammatory reactions...
  3. ncbi request reprint Interactions of oral pathogens with toll-like receptors: possible role in atherosclerosis
    George Hajishengallis
    Department of Oral Biology, University at Buffalo, Buffalo, New York, USA
    Ann Periodontol 7:72-8. 2002
    ....
  4. pmc Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I)
    Hesham F Nawar
    Witebsky Center for Microbial Pathogenesis and Immunology and Department of Microbiology and Immunology, University at Buffalo, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Clin Vaccine Immunol 17:969-78. 2010
    ..The nontoxic mutant enterotoxin LT-IIb(T13I), therefore, is potentially a new and safe human mucosal adjuvant...
  5. pmc Structure-activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding
    Vivian Cody
    Structural Biology Department, Hauptman Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, USA
    Acta Crystallogr D Biol Crystallogr 68:1604-12. 2012
    ..These data are consistent with the lack of binding of the LT-IIb-B(5)(T13I) variant to GD1a ganglioside...
  6. pmc LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb
    Hesham F Nawar
    The Witebsky Center for Microbial Pathogenesis and Immunology, Department of Microbiology and Immunology, The University at Buffalo, The State University of New York at Buffalo, Buffalo, NY 14214, USA
    Vaccine 29:721-7. 2011
    ....
  7. pmc TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin
    Chang Hoon Lee
    Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY 14214, USA
    J Leukoc Biol 90:911-21. 2011
    ..Notably, this is the first report for any HLT to demonstrate in vivo the elicitation of strong, TLR2-dependent modulatory effects on DCs with respect to adjuvanticity...
  8. pmc Mammalian cell ganglioside-binding specificities of E. coli enterotoxins LT-IIb and variant LT-IIb(T13I)
    Charles S Berenson
    Infectious Disease Division, Department of Veterans Affairs Western New York Healthcare System, State University of New York at Buffalo School of Medicine, Buffalo, NY 14215, USA
    Glycobiology 20:41-54. 2010
    ..These studies underscore the high degree of specificity required for ganglioside-protein interactions...
  9. pmc Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA
    Shinsuke Onishi
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, 3435 Main St, Buffalo, NY 14214 3092, USA
    Infect Immun 76:198-205. 2008
    ..Thus, our findings suggest that BspA is an important modulator of host innate immune responses through activation of TLR2 in cooperation with TLR1...
  10. pmc Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriae
    Mehmet A Eskan
    University of Louisville School of Dentistry, 501 South Preston Street, Room 204, Louisville, KY 40292, USA
    Infect Immun 75:892-8. 2007
    ..gingivalis FimA differentially activates human monocytes and epithelial cells, perhaps reflecting different tactics used by P. gingivalis when interacting with different host cell types or a host strategy to limit inflammation...
  11. ncbi request reprint Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2/1/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells
    Martha Triantafilou
    Infection and Immunity Group, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Cell Microbiol 9:2030-9. 2007
    ..This antagonistic activity of H. pylori or P. gingivalis LPS, as well as their TLR2 activation capability may be associated with their ability to contribute to atherosclerosis...
  12. ncbi request reprint Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages
    Min Wang
    Department of Periodontics Oral Health and Systemic Disease, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 179:2349-58. 2007
    ..gingivalis that is surprisingly dependent upon minor constituents of its fimbriae, and support the concept that pathogens evolved to manipulate innate immunity for promoting adaptive fitness and thus their capacity to cause disease...
  13. ncbi request reprint Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo
    George Hajishengallis
    Division of Oral Health and Systemic Disease Department of Periodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 179:2359-67. 2007
    ..Therefore, CR3 blockade may represent a promising immunomodulatory approach for controlling human periodontitis and possibly associated systemic diseases...
  14. pmc Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function
    George Hajishengallis
    Division of Oral Health and Systemic Disease Department of Periodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Proc Natl Acad Sci U S A 105:13532-7. 2008
    ..However, a specific CXCR4 antagonist abrogates this immune evasion mechanism and offers a promising counterstrategy for the control of P. gingivalis periodontal or systemic infections...
  15. pmc Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages
    George Hajishengallis
    University of Louisville Health Sciences Center, 501 South Preston Street, Room 206, Louisville, KY 40292, USA
    Infect Immun 74:5658-66. 2006
    ..gingivalis internalization within macrophages. It therefore appears that P. gingivalis proactively modulates beta2 integrin adhesive activity for intracellular uptake...
  16. ncbi request reprint Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus
    George Hajishengallis
    Center for Oral Health and Systemic Disease and Department of Periodontics Endodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Cell Microbiol 8:1557-70. 2006
    ..In summary, TLR2 activation by P. gingivalis LPS or fimbriae involves differential dependence on accessory signalling or ligand-binding receptors, which may differentially influence innate immune responses...
  17. ncbi request reprint Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase
    Evlambia Harokopakis
    Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    Eur J Immunol 35:1201-10. 2005
    ..gingivalis has been implicated...
  18. ncbi request reprint Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors
    George Hajishengallis
    Center of Excellence in Oral and Craniofacial Biology and Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    J Biol Chem 280:38902-13. 2005
    ..Elucidation of pathogen interactions with PRRs at the molecular level may glean insight into host defense mechanisms as well as into microbial strategies that subvert innate immunity...
  19. ncbi request reprint Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra)
    Evlambia Harokopakis
    Department of Pedodontics, School of Dentistry, Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    J Periodontol 77:271-9. 2006
    ....
  20. pmc The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells
    George Hajishengallis
    Louisiana State University Health Sciences Center, Department of Microbiology, Immunology, and Parasitology, Center of Excellence in Oral and Craniofacial Biology, 1100 Florida Ave, Box 130, New Orleans 70119, USA
    Infect Immun 72:6351-8. 2004
    ..Moreover, the anti-inflammatory properties of the holotoxins may serve to suppress innate immunity and promote the survival of the pathogen...
  21. ncbi request reprint Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern-recognition receptors
    George Hajishengallis
    Center of Excellence in Oral and Craniofacial Biology, Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    Immunol Invest 33:157-72. 2004
    ..gingivalis fimbriae is essential for developing molecular approaches to control P. gingivalis-induced inflammatory responses in periodontal disease and perhaps atherosclerosis...
  22. pmc Downregulation of the DNA-binding activity of nuclear factor-kappaB p65 subunit in Porphyromonas gingivalis fimbria-induced tolerance
    George Hajishengallis
    Department of Microbiology, Immunology, and Parasitology, Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    Infect Immun 72:1188-91. 2004
    ..Moreover, expression of a NF-kappaB-dependent reporter gene was inhibited upon secondary stimulation with fimbriae. NF-kappaB p65 downregulation may thus contribute to induction of FimA tolerance...
  23. ncbi request reprint TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae
    Evlambia Harokopakis
    Center for Oral Health and Systemic Disease, University of Louisville Health Sciences Center, KY 40292, USA
    J Immunol 176:7645-56. 2006
    ..Thus, P. gingivalis fimbriae activate a novel proadhesive pathway in human monocytes, involving TLR2, Rac1, PI3K, and CD11b/CD18, which may constitute a mechanistic basis linking P. gingivalis to inflammatory atherosclerotic processes...
  24. pmc Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins
    George Hajishengallis
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University, Health Sciences Center, New Orleans, LA 70119, USA
    Infect Immun 73:1343-9. 2005
    ..TLR2-dependent activation of mononuclear cells by type II enterotoxin B subunits appears to be a novel mechanism whereby these molecules may exert their immunomodulatory and adjuvant activities...
  25. pmc Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infection
    Ping Zhang
    Departments of Microbiology Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294
    Infect Immun 70:6779-87. 2002
    ..The ability of SBR-GLU to induce responses effective in protection against colonization of S. mutans suggests its potential as a vaccine antigen for dental caries...
  26. pmc Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice
    George Hajishengallis
    Department of Periodontics Oral Health and Systemic Disease, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 181:4141-9. 2008
    ..Thus, although TLR2 may mediate destructive effects, as seen in models of experimental periodontitis and atherosclerosis, we have now shown that the same receptor confers protection against P. gingivalis in acute lung infection...
  27. pmc Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages
    Min Wang
    Department of Periodontics Oral Health and Systemic Disease, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Cell Microbiol 10:2029-42. 2008
    ..gingivalis, although it significantly inhibited signal transduction. In summary, P. gingivalis uses macrophage lipid rafts as signalling and entry platforms, which determine its intracellular fate to the pathogen's own advantage...
  28. pmc The use of rodent models to investigate host-bacteria interactions related to periodontal diseases
    Dana T Graves
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Clin Periodontol 35:89-105. 2008
    ....
  29. ncbi request reprint Porphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion?
    George Hajishengallis
    Department of Periodontics Endodondics, Division of Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA
    Front Biosci 12:4547-57. 2007
    ..gingivalis for evading innate immune clearance becomes a plausible hypothesis...
  30. ncbi request reprint Immunogenicity of Salmonella vector vaccines expressing SBR of Streptococcus mutans under the control of a T7-nirB (dual) promoter system
    Mohammad Abdus Salam
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, BBRB 258 5, 35294 2170, USA
    Vaccine 24:5003-15. 2006
    ..All Salmonella clones induced good anti-SBR responses following the boost on day 320...
  31. ncbi request reprint The A subunit of type IIb enterotoxin (LT-IIb) suppresses the proinflammatory potential of the B subunit and its ability to recruit and interact with TLR2
    Shuang Liang
    Center for Oral Health and Systemic Disease, Department of Periodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 178:4811-9. 2007
    ..coli may suppress TLR-mediated innate immunity through the action of the enterotoxin A subunit...
  32. ncbi request reprint Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin
    Shuang Liang
    Center for Oral Health and Systemic Disease and Department of Periodontics, University of Louisville Health Sciences Center, Louisville, Kentucky 40292, USA
    J Biol Chem 282:7532-42. 2007
    ..These findings establish a model of TLR2 coreceptor function and, moreover, suggest novel mechanisms of adjuvanticity by non-toxic derivatives of type II enterotoxins dependent upon GD1a/TLR2 cooperative activity...
  33. pmc Identification and characterization of a nonimmunoglobulin factor in human saliva that inhibits Streptococcus mutans glucosyltransferase
    Christina Jespersgaard
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 70:1136-42. 2002
    ..mutans colonization in the oral cavity...