Robert Haile

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
    Sharon N Teraoka
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 0717, USA
    Breast Cancer Res 13:R114. 2011
  2. doi request reprint A review of cancer in U.S. Hispanic populations
    Robert W Haile
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Prev Res (Phila) 5:150-63. 2012
  3. ncbi request reprint BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50
    Robert W Haile
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006
  4. ncbi request reprint A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma
    Robert W Haile
    USC Norris Cancer Center, Keck School of Medicine, Department of Preventive Medicine, University of Southern California, 1441 Eastlake Ave, Suite 4455, Los Angeles, CA 90033, USA
    Clin Colorectal Cancer 4:390-5. 2005
  5. doi request reprint Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Clin Oncol 26:1411-8. 2008
  6. pmc Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033 9176, USA
    Cancer Epidemiol Biomarkers Prev 17:3208-15. 2008
  7. ncbi request reprint The MnSOD A16V mitochondrial targeting sequence polymorphism is not associated with increased risk of distal colorectal adenomas: data from a sigmoidoscopy-based case control study
    A Joan Levine
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 11:1140-1. 2002
  8. pmc Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:525-36. 2010
  9. pmc Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 20:758-66. 2011
  10. ncbi request reprint Role of lipid peroxidation in the epidemiology and prevention of breast cancer
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
    Cancer Epidemiol Biomarkers Prev 14:2829-39. 2005

Research Grants

  1. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2009
  2. USC Consortium:Colorectal Cancer Family Registry
    Robert Haile; Fiscal Year: 2007
  3. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2007
  4. A Pilot Study of Colorectal Cancer in Galicia, Spain
    Robert Haile; Fiscal Year: 2005
  5. Molecular Epidemiology of Colorectal Adenomas
    Robert Haile; Fiscal Year: 2005
  6. RISK OF CANCER IN A-T FAMILIES
    Robert Haile; Fiscal Year: 2003
  7. DNA METHYLATION AND COLORECTAL POLYPS
    Robert Haile; Fiscal Year: 2003

Detail Information

Publications53

  1. pmc Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
    Sharon N Teraoka
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 0717, USA
    Breast Cancer Res 13:R114. 2011
    ..A subset of these SNPs, selected upon their main effects on contralateral breast cancer risk was further evaluated for interaction with treatment modalities and estrogen receptor (ER) status...
  2. doi request reprint A review of cancer in U.S. Hispanic populations
    Robert W Haile
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Prev Res (Phila) 5:150-63. 2012
    ..We review the literature and discuss study design options and features that should be considered in future studies...
  3. ncbi request reprint BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50
    Robert W Haile
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006
    ..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice...
  4. ncbi request reprint A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma
    Robert W Haile
    USC Norris Cancer Center, Keck School of Medicine, Department of Preventive Medicine, University of Southern California, 1441 Eastlake Ave, Suite 4455, Los Angeles, CA 90033, USA
    Clin Colorectal Cancer 4:390-5. 2005
    ..The results suggest that at least part of the protective effect of NSAIDs on the risk of colorectal adenoma involves a COX-mediated pathway...
  5. doi request reprint Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Clin Oncol 26:1411-8. 2008
    ..To investigate whether oral contraceptive (OC) use and postmenopausal hormones (PMH) are associated with an increased risk of developing asynchronous bilateral breast cancer among women diagnosed with breast cancer younger than 55 years...
  6. pmc Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033 9176, USA
    Cancer Epidemiol Biomarkers Prev 17:3208-15. 2008
    ..These results reinforce the importance of distinguishing between the underlying causes of MSI in studies of etiology and prognosis...
  7. ncbi request reprint The MnSOD A16V mitochondrial targeting sequence polymorphism is not associated with increased risk of distal colorectal adenomas: data from a sigmoidoscopy-based case control study
    A Joan Levine
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 11:1140-1. 2002
  8. pmc Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:525-36. 2010
    ..Overall, our results do not provide evidence for a role of common genetic variants in VDR or GC in susceptibility to CRC...
  9. pmc Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 20:758-66. 2011
    ..Therefore, it is unclear whether current hits are modified by environmental exposures or whether there are additional hits whose effects are dependent on environmental exposures...
  10. ncbi request reprint Role of lipid peroxidation in the epidemiology and prevention of breast cancer
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
    Cancer Epidemiol Biomarkers Prev 14:2829-39. 2005
    ....
  11. pmc Folic acid and risk of prostate cancer: results from a randomized clinical trial
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
    J Natl Cancer Inst 101:432-5. 2009
    ..These findings highlight the potential complex role of folate in prostate cancer and the possibly different effects of folic acid-containing supplements vs natural sources of folate...
  12. ncbi request reprint XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk
    Mariana C Stern
    University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 15:2384-90. 2006
    ..04). Our data suggest that the effects of smoking and alcohol may vary depending on the genetic background of proteins that participate in the base excision repair and nucleotide excision repair pathways...
  13. pmc Colorectal adenomas in a randomized folate trial: the role of baseline dietary and circulating folate levels
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2625-31. 2008
    ..Our findings support the idea that although moderate doses of folate may be protective compared with deficiency, at some point of sufficiency, supplementation provides no additional benefit...
  14. pmc MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial
    A Joan Levine
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2409-15. 2008
    ..Our findings indicate that the MTHFR genotype does not change adenoma risk in a manner similar to its effect on colorectal cancer, and does not modify the effect of folate supplementation on metachronous adenoma risk...
  15. pmc Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street Room 1509B, Los Angeles CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2136-45. 2008
    ..In this study, we examined the associations between dietary and circulating plasma levels of vitamins B(2), B(6), and B(12) and risk colorectal adenomas...
  16. ncbi request reprint Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, NOR4411A, Los Angeles, CA 90089 9175, USA
    Cancer Res 67:11128-32. 2007
    ..These data suggest that common variants may play important roles in the risk of CRC...
  17. pmc Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 18:1041-9. 2009
    ..Little is known about the relationships between global hypomethylation and lifestyle, demographics, dietary measures, and genetic factors...
  18. pmc Recent developments in genomewide association scans: a workshop summary and review
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Am J Hum Genet 77:337-45. 2005
    ....
  19. pmc Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA, 90033, USA
    Breast Cancer Res Treat 120:175-83. 2010
    ....
  20. ncbi request reprint XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 14:609-15. 2005
    ....
  21. pmc Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Cancer Causes Control 21:839-46. 2010
    ..In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers...
  22. pmc Genes involved with folate uptake and distribution and their association with colorectal cancer risk
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1450 Biggy Street Room 1509J, Los Angeles, CA 90033, USA
    Cancer Causes Control 21:597-608. 2010
    ..In conclusion, we found no significant evidence that genetic variants in FOLR1, GGH, FPGS and SLC19A1 are associated with the risk of colorectal cancer...
  23. pmc A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:1812-21. 2010
    ..Folate-associated one-carbon metabolism (FOCM) may play an important role in colorectal carcinogenesis. Variation in FOCM genes may explain some of the underlying risk of colorectal cancer...
  24. pmc Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street, Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:89-100. 2010
    ..The MTHFR C677T TT genotype is associated with a 15% to 18% reduction in colorectal cancer risk, but it is not clear if other variants of the gene are associated with colorectal cancer risk...
  25. pmc Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Cancer Causes Control 22:541-52. 2011
    ..Folate-associated one-carbon metabolism (FOCM) is an important pathway in colorectal neoplasia risk but data on genetic variation in this pathway are largely limited to studies of single SNPs in selected genes...
  26. pmc Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat
    Asgeir Brevik
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 19:3167-73. 2010
    ..Carcinogens generated during meat cooking have been implicated as causal agents and can induce oxidative DNA damage, which elicits repair by the base excision repair (BER) pathway...
  27. pmc Associations between smoking, alcohol consumption, and colorectal cancer, overall and by tumor microsatellite instability status
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 18:2745-50. 2009
    ..Reports have suggested that these associations may differ by tumor molecular subtype, with stronger associations for microsatellite unstable (MSI-H) tumors...
  28. pmc Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk
    Amit D Joshi
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, CA 90089, USA
    Carcinogenesis 30:472-9. 2009
    ..These findings highlight the possible contribution of diets high in red meat to the formation of lesions that elicit the NER pathway, such as carcinogen-induced bulky adducts...
  29. pmc Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    Cancer Res 68:6486-91. 2008
    ..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53...
  30. ncbi request reprint A randomized trial of aspirin to prevent colorectal adenomas
    John A Baron
    Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    N Engl J Med 348:891-9. 2003
    ..Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel...
  31. ncbi request reprint No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years
    Valerie McGuire
    Department of Health Research and Policy, Stanford University School of Medicine, Health Research and Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 15:1565-7. 2006
  32. pmc Variation of breast cancer risk among BRCA1/2 carriers
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    JAMA 299:194-201. 2008
    ..The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers...
  33. ncbi request reprint Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology Study
    Lisbeth Bertelsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    J Natl Cancer Inst 100:32-40. 2008
    ..However, less is known about how long the risk is reduced and the impact of factors such as age and menopausal status...
  34. ncbi request reprint Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control study
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, EPS, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Carcinogenesis 26:637-42. 2005
    ..49 (95% CI, 0.28-0.85)]. We did not identify any association with consumption of individual HCAs and colorectal adenoma risk. These results support the hypothesis that BP contributes to colorectal carcinogenesis...
  35. ncbi request reprint Effect of calcium supplementation on the risk of large bowel polyps
    Kristin Wallace
    Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Natl Cancer Inst 96:921-5. 2004
    ..However, few studies have examined the effect of calcium on the risk of different types of colorectal lesions or dietary determinants of this effect...
  36. pmc Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res 6:R199-214. 2004
    ..Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated...
  37. ncbi request reprint Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial
    Maria V Grau
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
    J Natl Cancer Inst 95:1765-71. 2003
    ..Although these nutrients are inter-related metabolically in bone and in the normal intestine, their potential interactions in large-bowel carcinogenesis are not well understood...
  38. ncbi request reprint Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Hum Mutat 21:542-50. 2003
    ..Finally, we report novel mutations in the ATM gene identified both in patients with ataxia-telangiectasia and in patients with unilateral or bilateral breast cancer...
  39. ncbi request reprint Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia
    Henry J Lin
    Division of Medical Genetics, Department of Pediatrics, and the Research and Education Institute at Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
    Cancer Epidemiol Biomarkers Prev 11:1305-15. 2002
    ..28-1.56; 138 cases and 258 controls). Consistency of the results across all three of the studies is potentially compatible with a protective effect of the polymorphism, mimicking aspirin...
  40. ncbi request reprint Reliability in the classification of advanced colorectal adenomas
    Mary Beth Terry
    Department of Epidemiology, Joseph L Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 11:660-3. 2002
    ....
  41. ncbi request reprint Risk factors for advanced colorectal adenomas: a pooled analysis
    Mary Beth Terry
    Department of Epidemiology, Joseph L Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 11:622-9. 2002
    ....
  42. ncbi request reprint Breast cancer risks for BRCA1/2 carriers
    Douglas F Easton
    Science 306:2187-91; author reply 2187-91. 2004
  43. ncbi request reprint Colorectal cancer in patients under close colonoscopic surveillance
    Douglas J Robertson
    Section of Gastroenterology, VA Medical Center, White River Junction, Vermont 05009, USA
    Gastroenterology 129:34-41. 2005
    ..We determined the incidence of CRC in patients under colonoscopic surveillance and examined the circumstances and risk factors for CRC and adenoma with high-grade dysplasia...
  44. ncbi request reprint Accuracy of colorectal polyp self-reports: findings from the colon cancer family registry
    Lisa Madlensky
    Moores UCSD Cancer Center, 3855 Health Sciences Drive, MC0901, La Jolla, CA 92093 0901, USA
    Cancer Epidemiol Biomarkers Prev 16:1898-901. 2007
    ..However, it is not known how accurately patients are able to self-report the presence or absence of adenomas following colonoscopy...
  45. ncbi request reprint Folic acid for the prevention of colorectal adenomas: a randomized clinical trial
    Bernard F Cole
    Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
    JAMA 297:2351-9. 2007
    ..Laboratory and epidemiological data suggest that folic acid may have an antineoplastic effect in the large intestine...
  46. ncbi request reprint Reproductive history and risk of second primary breast cancer: the WECARE study
    Joan A Largent
    Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, CA 92697 7555, USA
    Cancer Epidemiol Biomarkers Prev 16:906-11. 2007
    ..Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results...
  47. ncbi request reprint Prolonged effect of calcium supplementation on risk of colorectal adenomas in a randomized trial
    Maria V Grau
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
    J Natl Cancer Inst 99:129-36. 2007
    ..Calcium supplementation has been shown to decrease the risk of recurrence of colorectal adenomas in randomized trials. However, the duration of this protective effect after cessation of active supplementation is not known...
  48. ncbi request reprint Aspirin may be more effective in preventing colorectal adenomas in patients with higher BMI (United States)
    Sangmi Kim
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Cancer Causes Control 17:1299-304. 2006
    ..The more pronounced effect of 325 mg aspirin in individuals with higher BMI suggests a possible protective role of anti-inflammatory aspirin against increased adipose-driven cytokines among obese subjects...
  49. ncbi request reprint Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention
    Elizabeth L R Barry
    Department of Community and Family Medicine, Dartmouth Medical School, 46 Centerra Parkway, Ste 300, Lebanon, NH 03766, USA
    J Natl Cancer Inst 98:1494-500. 2006
    ..Previous research suggests that the G315A single-nucleotide polymorphism in the ornithine decarboxylase (ODC) gene may be a genetic marker for risk of colorectal neoplasia and may also modify the association of aspirin use with risk...
  50. ncbi request reprint K-ras mutations in incident sporadic colorectal adenomas
    Elizabeth L R Barry
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03766, USA
    Cancer 106:1036-40. 2006
    ..In the current study, the authors investigated associations with K-ras mutation in incident sporadic colorectal adenomas that occurred during a chemoprevention trial of calcium supplementation...
  51. ncbi request reprint Interaction of calcium supplementation and nonsteroidal anti-inflammatory drugs and the risk of colorectal adenomas
    Maria V Grau
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hamsphire, USA
    Cancer Epidemiol Biomarkers Prev 14:2353-8. 2005
    ..Calcium and aspirin have both been found to be chemopreventive against colorectal neoplasia. However, the joint effect of the two agents has not been well investigated...
  52. ncbi request reprint Glutathione transferase GSTT1, broccoli, and prevalence of colorectal adenomas
    Henry J Lin
    Division of Medical Genetics and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Pharmacogenetics 12:175-9. 2002
  53. ncbi request reprint Comparison of techniques for the successful detection of BRCA1 mutations in fixed paraffin-embedded tissue
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Epidemiol Biomarkers Prev 11:809-14. 2002
    ..We concluded that DNA derived from PET that archived for less than 18 years can be used successfully for detecting BRCA1 gene mutations if quality control is strictly maintained...

Research Grants17

  1. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2009
    ..Genotyping will primarily involve SNP-based haplotypes. For both pathways, analyses of gene-gene and gene-environment interactions will be included as appropriate. ..
  2. USC Consortium:Colorectal Cancer Family Registry
    Robert Haile; Fiscal Year: 2007
    ..fs20\par \par } ..
  3. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2007
    ..Genotyping will primarily involve SNP-based haplotypes. For both pathways, analyses of gene-gene and gene-environment interactions will be included as appropriate. ..
  4. A Pilot Study of Colorectal Cancer in Galicia, Spain
    Robert Haile; Fiscal Year: 2005
    ..In addition, by completing this pilot study, we will demonstrate the feasibility of conducting the larger full-scale study. ..
  5. Molecular Epidemiology of Colorectal Adenomas
    Robert Haile; Fiscal Year: 2005
    ..Thomas and Cortessis, we will apply this method to data generated by this study. ..
  6. RISK OF CANCER IN A-T FAMILIES
    Robert Haile; Fiscal Year: 2003
    ..We propose no new mutation screening in the current proposal. We believe this is a scientifically defensible compromise and hope that it will allow us to begin this important study. ..
  7. DNA METHYLATION AND COLORECTAL POLYPS
    Robert Haile; Fiscal Year: 2003
    ..Peter Laird, that is more sensitive and quantitative than other assay with our ongoing study will provide a powerful means of addressing important questions about methylation and its role on cancer etiology. ..