Numsen Hail

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. doi request reprint Mitochondrial reactive oxygen species affect sensitivity to curcumin-induced apoptosis
    Numsen Hail
    Department of Pharmaceutical Sciences, The University of Colorado Denver School of Pharmacy, Denver, CO 80220, USA
    Free Radic Biol Med 44:1382-93. 2008
  2. doi request reprint Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state
    Numsen Hail
    Department of Pharmaceutical Sciences, The University of Colorado Denver School of Pharmacy, Aurora, CO 80045, USA
    Mol Nutr Food Res 53:49-67. 2009
  3. doi request reprint Cancer chemoprevention: a radical perspective
    Numsen Hail
    Department of Pharmaceutical Sciences, The University of Colorado Denver School of Pharmacy, Denver, CO 80220, USA
    Free Radic Biol Med 45:97-110. 2008
  4. ncbi request reprint Mitochondria: A novel target for the chemoprevention of cancer
    N Hail
    Department of Clinical Pharmacy, School of Pharmacy, The University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Apoptosis 10:687-705. 2005
  5. ncbi request reprint Mechanisms of fenretinide-induced apoptosis
    N Hail
    Department of Clinical Pharmacy, School of Pharmacy, The University of Colorado at Denver and Health Sciences Center, Box C238, 80262, USA
    Apoptosis 11:1677-94. 2006
  6. doi request reprint Teriflunomide encourages cytostatic and apoptotic effects in premalignant and malignant cutaneous keratinocytes
    Numsen Hail
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, Aurora, CO 80045, USA
    Apoptosis 15:1234-46. 2010
  7. doi request reprint Evidence supporting a role for dihydroorotate dehydrogenase, bioenergetics, and p53 in selective teriflunomide-induced apoptosis in transformed versus normal human keratinocytes
    Numsen Hail
    Department of Pharmaceutical Sciences, University of Colorado School of Pharmacy, 12850 E Montview Blvd, Mail Stop C238, Aurora, CO 80045, USA
    Apoptosis 17:258-68. 2012
  8. pmc Teriflunomide (leflunomide) promotes cytostatic, antioxidant, and apoptotic effects in transformed prostate epithelial cells: evidence supporting a role for teriflunomide in prostate cancer chemoprevention
    Numsen Hail
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, 12700 E 19th Avenue, Aurora, CO 80045, USA
    Neoplasia 12:464-75. 2010
  9. pmc The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells
    Numsen Hail
    Department of Pharmaceutical Sciences, University of Colorado School of Pharmacy, Aurora, CO 80045, USA
    Free Radic Biol Med 49:2001-9. 2010
  10. pmc Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis
    Numsen Hail
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 49:109-16. 2010

Collaborators

  • Ping Chen
  • R Lotan
  • Shi Yong Sun
  • Tadashi Honda
  • S Safe
  • Zhihong Zeng
  • Michael Andreeff
  • Marina Konopleva
  • Ismael Samudio
  • Peng Huang
  • Zeev Estrov
  • Ismael J Samudio
  • Olga Frolova
  • Gordon B Mills
  • Helene Pelicano
  • Weiguo Zhang
  • Yiling Lu
  • Wenjing Chen
  • Steven M Kornblau
  • David Harris
  • Michael Sporn
  • Gordon W Gribble
  • Randall Evans
  • Hiram F Gilbert
  • Teresa McQueen
  • Yue Xi Shi
  • Timothy Hsu

Detail Information

Publications18

  1. doi request reprint Mitochondrial reactive oxygen species affect sensitivity to curcumin-induced apoptosis
    Numsen Hail
    Department of Pharmaceutical Sciences, The University of Colorado Denver School of Pharmacy, Denver, CO 80220, USA
    Free Radic Biol Med 44:1382-93. 2008
    ....
  2. doi request reprint Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state
    Numsen Hail
    Department of Pharmaceutical Sciences, The University of Colorado Denver School of Pharmacy, Aurora, CO 80045, USA
    Mol Nutr Food Res 53:49-67. 2009
    ..In doing so, we will construct a paradigm supporting the notion that the bioenergetic and/or redox characteristics of the mitochondria in transformed cells are important targets in the chemoprevention of cancer...
  3. doi request reprint Cancer chemoprevention: a radical perspective
    Numsen Hail
    Department of Pharmaceutical Sciences, The University of Colorado Denver School of Pharmacy, Denver, CO 80220, USA
    Free Radic Biol Med 45:97-110. 2008
    ....
  4. ncbi request reprint Mitochondria: A novel target for the chemoprevention of cancer
    N Hail
    Department of Clinical Pharmacy, School of Pharmacy, The University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Apoptosis 10:687-705. 2005
    ..In doing so, I will construct a paradigm supporting the notion that the mitochondria are a novel target for the chemoprevention of cancer...
  5. ncbi request reprint Mechanisms of fenretinide-induced apoptosis
    N Hail
    Department of Clinical Pharmacy, School of Pharmacy, The University of Colorado at Denver and Health Sciences Center, Box C238, 80262, USA
    Apoptosis 11:1677-94. 2006
    ....
  6. doi request reprint Teriflunomide encourages cytostatic and apoptotic effects in premalignant and malignant cutaneous keratinocytes
    Numsen Hail
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, Aurora, CO 80045, USA
    Apoptosis 15:1234-46. 2010
    ..These novel mechanistic findings support a role for TFN in skin cancer chemoprevention and therapy...
  7. doi request reprint Evidence supporting a role for dihydroorotate dehydrogenase, bioenergetics, and p53 in selective teriflunomide-induced apoptosis in transformed versus normal human keratinocytes
    Numsen Hail
    Department of Pharmaceutical Sciences, University of Colorado School of Pharmacy, 12850 E Montview Blvd, Mail Stop C238, Aurora, CO 80045, USA
    Apoptosis 17:258-68. 2012
    ..Together, these results propose that TFN could be useful in the prevention or therapy of non-melanoma skin cancers and possibly other hyperproliferative keratinocytic diseases...
  8. pmc Teriflunomide (leflunomide) promotes cytostatic, antioxidant, and apoptotic effects in transformed prostate epithelial cells: evidence supporting a role for teriflunomide in prostate cancer chemoprevention
    Numsen Hail
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, 12700 E 19th Avenue, Aurora, CO 80045, USA
    Neoplasia 12:464-75. 2010
    ..These mechanistic findings advocate a role for TFN and mitochondrial bioenergetics in prostate cancer chemoprevention...
  9. pmc The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells
    Numsen Hail
    Department of Pharmaceutical Sciences, University of Colorado School of Pharmacy, Aurora, CO 80045, USA
    Free Radic Biol Med 49:2001-9. 2010
    ..Together, these results strongly implicate the hydroxyl functional group in the cytotoxic effects of 4HPR...
  10. pmc Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis
    Numsen Hail
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 49:109-16. 2010
    ..Conversely, colon carcinoma cells that lacked DHODH expression were markedly resistant to the pro-oxidant and cytotoxic effects of 4HPR. Together, these results strongly implicate DHODH in 4HPR-induced ROS production and apoptosis...
  11. pmc Selective apoptosis induction by the cancer chemopreventive agent N-(4-hydroxyphenyl)retinamide is achieved by modulating mitochondrial bioenergetics in premalignant and malignant human prostate epithelial cells
    Numsen Hail
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, C238 P15 Research 2, 12700 E 19th Avenue, Room 3008, Aurora, CO 80045, USA
    Apoptosis 14:849-63. 2009
    ....
  12. ncbi request reprint Apoptosis effector mechanisms: a requiem performed in different keys
    N Hail
    Department of Clinical Pharmacy, School of Pharmacy, Denver and Health Sciences Center, The University of Colorado, Denver, CO 80262, USA
    Apoptosis 11:889-904. 2006
    ....
  13. ncbi request reprint Examining the role of mitochondrial respiration in vanilloid-induced apoptosis
    Numsen Hail
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    J Natl Cancer Inst 94:1281-92. 2002
    ..We investigated the role of mitochondrial respiration in vanilloid-induced apoptosis...
  14. ncbi request reprint Apoptosis as a novel target for cancer chemoprevention
    Shi Yong Sun
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX77030 4095, USA
    J Natl Cancer Inst 96:662-72. 2004
    ..In this review, we construct a paradigm supporting apoptosis as a novel target for cancer chemoprevention by highlighting recent studies of several chemopreventive agents that engage apoptosis pathways...
  15. ncbi request reprint 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer
    Ismael Samudio
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:36273-82. 2005
    ..These results suggest that CDDO and its derivatives may offer a clinical benefit for the treatment of PC...
  16. ncbi request reprint Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO)
    Numsen Hail
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    J Biol Chem 279:11179-87. 2004
    ....
  17. ncbi request reprint Mechanisms of vanilloid-induced apoptosis
    Numsen Hail
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    Apoptosis 8:251-62. 2003
    ..This review will examine the cellular targets, cytotoxic effects, and the downstream effector mechanisms associated with vanilloid-induced apoptosis...
  18. ncbi request reprint Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia
    Zhihong Zeng
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:3737-46. 2006
    ..Taken together, our results show that the simultaneous inhibition of critical prosurvival kinases by KP372-1 leads to mitochondrial dysfunction and apoptosis of AML but not normal hematopoietic progenitor cells...