Husnain Kh Haider

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Bone marrow cells for cardiac regeneration and repair: current status and issues
    Husnain Kh Haider
    Department of Pathology and Laboratory of Medicine, 231 Albert Sabinway, Cinncinati, OH 45267 0529, USA
    Expert Rev Cardiovasc Ther 4:557-68. 2006
  2. ncbi request reprint Bone marrow stem cell transplantation for cardiac repair
    Husnain Kh Haider
    Dept of Pathology and Laboratory of Medicine, 231 Albert Sabinway, Univ of Cincinnati, Cinncinati, OH 45267 0529, USA
    Am J Physiol Heart Circ Physiol 288:H2557-67. 2005
  3. pmc MyoCell, a cell-based, autologous skeletal myoblast therapy for the treatment of cardiovascular diseases
    Husnain Kh Haider
    University of Cincinnati, Department of Pathology and Laboratory Medicine, Cincinnati, OH 45267 0529, USA
    Curr Opin Mol Ther 10:611-21. 2008
  4. pmc Angiomyogenesis for myocardial repair
    Husnain Kh Haider
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Antioxid Redox Signal 11:1929-44. 2009
  5. ncbi request reprint Skeletal muscle derived stem cells for myocardial repair
    Husnain K Haider
    Department of Pathology and Laboratory of Medicine, 231 Albert Sabin Way, University of Cincinnati Ohio 45267 0529, USA
    Recent Pat Cardiovasc Drug Discov 2:205-13. 2007
  6. pmc MicroRNA-21 is a key determinant in IL-11/Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts
    Khawaja Husnain Haider
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Cardiovasc Res 88:168-78. 2010
  7. doi request reprint Preconditioning and stem cell survival
    Husnain Kh Haider
    Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert, Sabin Way, OH 45267 0529, USA
    J Cardiovasc Transl Res 3:89-102. 2010
  8. doi request reprint Genetic modification of stem cells for improved therapy of the infarcted myocardium
    Husnain Kh Haider
    Department of Pathology and Lab Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Mol Pharm 8:1446-57. 2011
  9. pmc Preconditioning promotes survival and angiomyogenic potential of mesenchymal stem cells in the infarcted heart via NF-kappaB signaling
    Muhammad R Afzal
    Department of Pathology and Lab Medicine, 231 Albert Sabin Way, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0529, USA
    Antioxid Redox Signal 12:693-702. 2010
  10. ncbi request reprint Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair
    Shujia Jiang
    Department of Pathology and Laboratory Medicine, 231 Albert Sabin Way, University of Cincinnati, OH 45267 0529, USA
    Circ Res 99:776-84. 2006

Collaborators

  • Winston S N Shim
  • E K Sim
  • Gang Lu
  • Yigang Wang
  • Aleksey Porollo
  • Shi Zuo
  • Ye Lei
  • Juan-Carlos Chachques
  • Muhammad Ashraf
  • Lei Ye
  • Shujia Jiang
  • Khawaja H Haider
  • KHAWAJA HAIDER
  • Peter K Law
  • Ruowen Ge
  • Rafeeq P H Ahmed
  • Niagara Muhammad Idris
  • Wei Zhang
  • Liping Su
  • Changfa Guo
  • Ru San Tan
  • Longhu Li
  • Vien Khach Lai
  • Zeeshan Pasha
  • Koichi Igura
  • Jiang Shujia
  • Yoko Suzuki
  • Khawaja Husnain Haider
  • Muhammad R Afzal
  • Ha Won Kim
  • Ying Dai
  • RuSan Tan
  • Muhammad Idris Niagara
  • Yong Zhang
  • I Elmadbouh
  • Abd Jalil Rufaihah
  • Muhammad I Niagara
  • Boon Chin Heng
  • Muhammad Rizwan Afzal
  • Linlin Wang
  • Stephanie Buccini
  • Sulaiman Sheriff
  • Ryota Uemura
  • Meifeng Xu
  • Tingyu Li
  • Yan Shan Dai
  • Wahidah Bte Esa
  • Wee Chi Toh
  • WeeChi Toh
  • WeeBeng Tan
  • YeanTeng Lim
  • Philip Wong
  • Ping Z Ding
  • Asmat Salim
  • LiLi Beth Ramos
  • Niagara M Idris
  • Kwoon M Sim
  • Lieng H Ling
  • Valerie S W Koh
  • Soon Chye Ng
  • Kian K Poh
  • Yean T Lim
  • Tong Cao

Detail Information

Publications49

  1. ncbi request reprint Bone marrow cells for cardiac regeneration and repair: current status and issues
    Husnain Kh Haider
    Department of Pathology and Laboratory of Medicine, 231 Albert Sabinway, Cinncinati, OH 45267 0529, USA
    Expert Rev Cardiovasc Ther 4:557-68. 2006
    ..Moreover, it discusses the current status of BMC transplantation as a clinical modality and the relevant issues confronting this approach in light of the published data with clinical relevance...
  2. ncbi request reprint Bone marrow stem cell transplantation for cardiac repair
    Husnain Kh Haider
    Dept of Pathology and Laboratory of Medicine, 231 Albert Sabinway, Univ of Cincinnati, Cinncinati, OH 45267 0529, USA
    Am J Physiol Heart Circ Physiol 288:H2557-67. 2005
    ..This review is a synopsis of some interesting aspects of the fast-emerging field of bone marrow-derived stem cell therapy for cardiac repair...
  3. pmc MyoCell, a cell-based, autologous skeletal myoblast therapy for the treatment of cardiovascular diseases
    Husnain Kh Haider
    University of Cincinnati, Department of Pathology and Laboratory Medicine, Cincinnati, OH 45267 0529, USA
    Curr Opin Mol Ther 10:611-21. 2008
    ..MyoCell is undergoing phase II/III clinical development and has so far demonstrated safety and efficacy, including improvements in cardiac function in phase I/II clinical trials...
  4. pmc Angiomyogenesis for myocardial repair
    Husnain Kh Haider
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Antioxid Redox Signal 11:1929-44. 2009
    ..In providing an overview of both stem cell therapy and gene therapy, this article is an in-depth and critical appreciation of combined cell and gene therapy approach for myocardial repair...
  5. ncbi request reprint Skeletal muscle derived stem cells for myocardial repair
    Husnain K Haider
    Department of Pathology and Laboratory of Medicine, 231 Albert Sabin Way, University of Cincinnati Ohio 45267 0529, USA
    Recent Pat Cardiovasc Drug Discov 2:205-13. 2007
    ..Present article also includes recent patent review coverage on this topic...
  6. pmc MicroRNA-21 is a key determinant in IL-11/Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts
    Khawaja Husnain Haider
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Cardiovasc Res 88:168-78. 2010
    ....
  7. doi request reprint Preconditioning and stem cell survival
    Husnain Kh Haider
    Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert, Sabin Way, OH 45267 0529, USA
    J Cardiovasc Transl Res 3:89-102. 2010
    ....
  8. doi request reprint Genetic modification of stem cells for improved therapy of the infarcted myocardium
    Husnain Kh Haider
    Department of Pathology and Lab Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Mol Pharm 8:1446-57. 2011
    ....
  9. pmc Preconditioning promotes survival and angiomyogenic potential of mesenchymal stem cells in the infarcted heart via NF-kappaB signaling
    Muhammad R Afzal
    Department of Pathology and Lab Medicine, 231 Albert Sabin Way, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0529, USA
    Antioxid Redox Signal 12:693-702. 2010
    ..We conclude that activation of NF-kappaB by preconditioning promoted (PC)MSCs survival and angiomyogenic potential in the infarcted heart...
  10. ncbi request reprint Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair
    Shujia Jiang
    Department of Pathology and Laboratory Medicine, 231 Albert Sabin Way, University of Cincinnati, OH 45267 0529, USA
    Circ Res 99:776-84. 2006
    ..We conclude that supportive interaction between Ang-1 and Akt during MSC transplantation gave better prognosis via enhanced cell survival, improved angiomyogenesis, and restored global cardiac function...
  11. ncbi request reprint Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart
    Muhammad Idris Niagara
    Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45267 0529, USA
    Circ Res 100:545-55. 2007
    ..Transplantation of PC SkMs for heart cell therapy is an innovative approach in the clinical perspective...
  12. pmc Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas
    Yoko Suzuki
    Department of Pathology and Lab Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Am J Physiol Heart Circ Physiol 299:H1077-82. 2010
    ..Taken together, these data demonstrated that cytoprotection afforded by preconditioning of MSCs with DZ was regulated by miR-146a induction, which may be a novel therapeutic target in cardiac ischemic diseases...
  13. pmc Phosphodiesterase inhibition with tadalafil provides longer and sustained protection of stem cells
    Husnain Kh Haider
    Department of Pathology, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Am J Physiol Heart Circ Physiol 299:H1395-404. 2010
    ..PDE5A inhibition using long-acting tadalafil is an innovative approach to promote stem cell survival and proliferation in the infarcted heart...
  14. pmc Ex vivo delivered stromal cell-derived factor-1alpha promotes stem cell homing and induces angiomyogenesis in the infarcted myocardium
    I Elmadbouh
    Department of Pathology and Laboratory Medicine, 231 Albert Sabin Way, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    J Mol Cell Cardiol 42:792-803. 2007
    ..05) as compared with groups-1 and -2. We conclude that ex vivo SDF-1alpha transgene delivery promotes stem and progenitor cell migration to the heart, activates cell survival signaling and enhances angiomyogenesis in the infarcted heart...
  15. doi request reprint IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1alpha/CXCR4 signaling to promote myocardial repair
    Husnain Kh Haider
    Department of Pathology and Laboratory of Medicine, 231 Albert Sabin Way, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Circ Res 103:1300-8. 2008
    ..05). In conclusion, the strategy of IGF-1 transgene expression induced massive stem cell mobilization via SDF-1alpha signaling and culminated in extensive angiomyogenesis in the infarcted heart...
  16. pmc Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells
    Zeeshan Pasha
    Department of Pathology, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e23667. 2011
    ..The aim of this study was to develop and optimize a non-viral method without genetic manipulation for reprogramming of skeletal myoblasts (SMs) using small molecules...
  17. pmc Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation
    Husnain Kh Haider
    Department of Pathology and Laboratory Medicine, 231 Albert Sabin Way, University of Cincinnati, OH 45267 0529, USA
    J Mol Cell Cardiol 45:554-66. 2008
    ..The use of pharmacological preconditioning for up-regulation of pro-survival proteins and cardiogenic markers in the transplanted stem cells will be discussed...
  18. doi request reprint Non-hypoxic stabilization of HIF-Iα during coordinated interaction between Akt and angiopoietin-1 enhances endothelial commitment of bone marrow stem cells
    Vien Khach Lai
    Department of Pathology, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267 0529, USA
    J Mol Med (Berl) 90:719-30. 2012
    ..Given the ease of availability of MSC and simplicity of approach to co-overexpress Ang-1 and Akt to enhance their endothelial commitment, the strategy will be significant for cellular angiogenesis to treat ischemic heart...
  19. pmc Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction
    Longhu Li
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Am J Physiol Heart Circ Physiol 302:H2112-21. 2012
    ..These findings suggest that PDE5 inhibition with Ad-shPDE5a is a novel approach for treatment of myocardial infarction...
  20. ncbi request reprint Evidence for ischemia induced host-derived bone marrow cell mobilization into cardiac allografts
    Yigang Wang
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0529, USA
    J Mol Cell Cardiol 41:478-87. 2006
    ..In addition, BMSC attracted to the site of ischemic injury participate in cardiac repair...
  21. pmc Mobilized bone marrow progenitor cells serve as donors of cytoprotective genes for cardiac repair
    Ying Dai
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    J Mol Cell Cardiol 44:607-17. 2008
    ..In contrast, transfection of BMSCs with GATA-4 provided increased protection of myocytes against apoptosis. It is concluded that MPCs are highly cytoprotective and carry protective genes responsible for cardiac repair...
  22. pmc Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells
    Koichi Igura
    Department of Pathology and Laboratory of Medicine, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Rejuvenation Res 14:393-403. 2011
    ..Stimulation of old bone marrow cells by NPY treatment rejuvenated the growth characteristics of aging bone marrow cells as a result of Y5R overexpression...
  23. pmc Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells
    Gang Lu
    Department of Pathology and Lab Medicine, University of Cincinnati, Cincinnati, OH 45220, USA
    Cardiovasc Res 88:277-86. 2010
    ..We posit that these preconditioning effects could be simulated by mitochondria-specific overexpression of Cx-43...
  24. pmc Cardiac tumorigenic potential of induced pluripotent stem cells in an immunocompetent host with myocardial infarction
    Rafeeq P H Ahmed
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Regen Med 6:171-8. 2011
    ..This study was designed to examine the effectiveness of skeletal myoblast-derived induced pluripotent stem cells (SkiPS) from young male Oct4/GFP transgenic mice for regeneration of the infarcted heart...
  25. ncbi request reprint Bone marrow cell transplantation in clinical perspective
    Husnain Kh Haider
    Department of Pathology and Laboratory Medicine, 231 Albert Sabinway, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    J Mol Cell Cardiol 38:225-35. 2005
    ....
  26. ncbi request reprint RE: Heng BC, Tong c: the differentiation status of stem cells and their derivatives: A key consideration in transplantation medicine. ASAIO J 50: 626-627, 2004
    Husnain Kh Haider
    ASAIO J 51:301; author reply 302. 2005
  27. ncbi request reprint Angiomyogenesis for cardiac repair using human myoblasts as carriers of human vascular endothelial growth factor
    Husnain Kh Haider
    National University Medical Institutes, National University of Singapore, 10 Medical Drive, 117597, Singapore
    J Mol Med (Berl) 82:539-49. 2004
    ..25+/-4.09% to 43.0+/-2.68% at 6 weeks in group 3. Human myoblasts are potential transgene carriers for the myocardium, in addition to strengthening the weakened myocardium through myogenesis...
  28. ncbi request reprint New strategy for cardiac repair: genetically modified skeletal myoblasts
    Eugene K W Sim
    Asian Cardiovasc Thorac Ann 15:183-4. 2007
  29. ncbi request reprint Adult stem cells for cardiac repair: a choice between skeletal myoblasts and bone marrow stem cells
    Lei Ye
    National University Medical Institute, National University of Singapore, Singapore 117597
    Exp Biol Med (Maywood) 231:8-19. 2006
    ..The present article discusses the pros and cons of using SkM and BMC individually or in combination for cardiac repair, and critically analyzes the progress made with each cell type...
  30. ncbi request reprint Reversal of myocardial injury using genetically modulated human skeletal myoblasts in a rodent cryoinjured heart model
    Lei Ye
    Department of Cardiothoracic and Vascular Surgery, National University of Singapore 117597, Singapore
    Eur J Heart Fail 7:945-52. 2005
    ..We hypothesized that combination therapy using human myoblasts and VEGF165 will lead to better prognosis in a failing heart...
  31. ncbi request reprint Angiopoietin-1 for myocardial angiogenesis: a comparison between delivery strategies
    Lei Ye
    National University Medical Institutes, National University of Singapore, Singapore
    Eur J Heart Fail 9:458-65. 2007
    ....
  32. ncbi request reprint Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro
    Boon Chin Heng
    Department of Obstetrics and Gynaecology, Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074
    Cardiovasc Res 62:34-42. 2004
    ..This review therefore critically examines the various techniques that could possibly be used to direct and control the cardiomyogenic differentiation of stem cells in vitro...
  33. ncbi request reprint Role of pharmacologically mobilized endogenous bone marrow stem cells for cardiac repair
    Husnain Kh Haider
    J Heart Lung Transplant 24:1996-7. 2005
  34. ncbi request reprint Therapeutic angiogenesis. Devising new strategies based on past experiences
    Ye Lei
    Department of Cardiothoracic and Vascular Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Basic Res Cardiol 99:121-32. 2004
    ....
  35. ncbi request reprint Myoblast transplantation for cardiac repair: a clinical perspective
    Husnain Kh Haider
    National University Medical Institutes, National University of Singapore, 119074
    Mol Ther 9:14-23. 2004
    ..Preliminary results show that the procedure is safe and leads to improved myocardial function. This paper reviews and summarizes the outcome of these phase I trials involving skeletal myoblast transplantation...
  36. ncbi request reprint High efficiency transduction of human VEGF165 into human skeletal myoblasts: in vitro studies
    Lei Ye
    Department of Cardiothoracic and Vascular Surgery, National University of Singapore, Singapore 117597
    Exp Mol Med 35:412-20. 2003
    ..These studies suggest that human myoblast are potential carriers of human VEGF165 to achieve concurrent angiomyogenesis for cardiac repair...
  37. ncbi request reprint Immunosuppression and xenotransplantation of cells for cardiac repair
    Husnain Kh Haider
    Ann Thorac Surg 77:1133; author reply 1133-4. 2004
  38. ncbi request reprint Autologous skeletal myoblasts transduced with a new adenoviral bicistronic vector for treatment of hind limb ischemia
    Muhammad I Niagara
    Department of Surgery, National University of Singapore
    J Vasc Surg 40:774-85. 2004
    ....
  39. ncbi request reprint Improved angiogenic response in pig heart following ischaemic injury using human skeletal myoblast simultaneously expressing VEGF165 and angiopoietin-1
    Lei Ye
    Department of Surgery, National University of Singapore 119074, Singapore
    Eur J Heart Fail 9:15-22. 2007
    ..To achieve angiogenic interaction between VEGF(165) and angiopoietin-1 (Ang-1) using a novel adenoviral bicistronic vector (Ad-Bic) encoding the two factors and delivered ex vivo using sex-mismatched human skeletal myoblasts...
  40. ncbi request reprint Cell-based ex vivo delivery of angiogenic growth factors for cardiac repair
    Husnain Kh Haider
    Arterioscler Thromb Vasc Biol 25:e144. 2005
  41. ncbi request reprint Developing "super cells" by modification with super anti-apoptotic factor
    Husnain Kh Haider
    J Mol Cell Cardiol 42:478-80. 2007
  42. ncbi request reprint Avoiding compliance with histocompatibility dogma using immune privileged cell xenografts
    Husnain Kh Haider
    Ann Thorac Surg 76:339-40; author reply 340. 2003
  43. ncbi request reprint In vitro functional assessment of human skeletal myoblasts after transduction with adenoviral bicistronic vector carrying human VEGF165 and angiopoietin-1
    Lei Ye
    Department of Cardiothoracic and Vascular Surgery, National University of Singapore, Singapore
    J Heart Lung Transplant 24:1393-402. 2005
    ..We report in vitro functional assessment of human skeletal myoblasts with adenoviral bicistronic vector carrying human vascular endothelial growth factor-165 (hVEGF165) and angiopoietin-1 (Ang-1)...
  44. ncbi request reprint Transplantation of nanoparticle transfected skeletal myoblasts overexpressing vascular endothelial growth factor-165 for cardiac repair
    Lei Ye
    National University Medical Institutes, National University of Singapore, Singapore
    Circulation 116:I113-20. 2007
    ..We investigated the feasibility and efficacy of polyethylenimine (PEI) based human vascular endothelial growth factor-165 (hVEGF165) gene transfer into human skeletal myoblasts (HSM) for cell based delivery to the infarcted myocardium...
  45. ncbi request reprint Myoblast-based cardiac repair: xenomyoblast versus allomyoblast transplantation
    Changfa Guo
    Department of Surgery, National University of Singapore, Singapore
    J Thorac Cardiovasc Surg 134:1332-9. 2007
    ..We sought to investigate immune cell kinetics in relation to skeletal myoblast survival and heart function improvement after nonautologous skeletal myoblast transplantation in a rat model of myocardial infarction...
  46. ncbi request reprint Nonviral vector-based gene transfection of primary human skeletal myoblasts
    Lei Ye
    National University Medical Institutes, National University of Singapore, 10 Medical Drive, Singapore 117597
    Exp Biol Med (Maywood) 232:1477-87. 2007
    ..This study demonstrated that therapeutic angiogenic gene transfer through CD or PEI is feasible and safe after optimization. It could be a potential strategy for treatment of ischemic disease for angiomyogenesis...
  47. ncbi request reprint Cell-based VEGF delivery prevents donor cell apoptosis after transplantation
    Lei Ye
    Ann Thorac Surg 83:1233-4; author reply 1234. 2007
  48. doi request reprint Angiomyogenesis using liposome based vascular endothelial growth factor-165 transfection with skeletal myoblast for cardiac repair
    Lei Ye
    National University Medical Institutes, National University of Singapore, Singapore
    Biomaterials 29:2125-37. 2008
    ....
  49. ncbi request reprint Cardioprotective effect of des-Aspartate-angiotensin-I (DAA-I) on cytokine gene expression profile in ligation model of myocardial infarction
    Abd Jalil Rufaihah
    Department of Cardiac, Thoracic and Vascular Surgery, National University of Singapore, Singapore
    Life Sci 78:1341-51. 2006
    ..We conclude that DAA-I prevented infarct expansion through suppression of inflammatory cytokines and immune cell infiltration in the infarct region...

Research Grants6

  1. Preconditioning and re-programming of stem cells for cardiac repair
    KHAWAJA HAIDER; Fiscal Year: 2009
    ..Put together, our combined therapeutic approach for preconditioning and re-programming of donor cells before transplantation is expected to give better prognosis in the treatment of ischemically injured myocardium. ..
  2. Preconditioning and re-programming of stem cells for cardiac repair
    Khawaja H Haider; Fiscal Year: 2010
    ..Put together, our combined therapeutic approach for preconditioning and re-programming of donor cells before transplantation is expected to give better prognosis in the treatment of ischemically injured myocardium. ..
  3. Simltaneous recruitment of cardiac and bone marrow stem cells for cardiac repair
    Khawaja H Haider; Fiscal Year: 2010
    ..NARRATIVE: Bone marrow derived stem cells and resident cardiac stem cells have shown promise in myocardial repair. Our proposal is based on concomitant mobilization of both these stem cell populations by multiple cytokine therapy. ..