Research Topics
Genomes and Genes | Chang Gyu HahnSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
The current understanding of lamotrigine as a mood stabilizerChang Gyu Hahn
Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104, USA
J Clin Psychiatry 65:791-804. 2004..To examine whether lamotrigine has a unique role in the treatment of bipolar disorder, we evaluated the results of recent clinical trials and molecular and cell biological studies on lamotrigine...- In vivo and in vitro neurogenesis in human olfactory epitheliumChang Gyu Hahn
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Comp Neurol 483:154-63. 2005..These data highlight species-related differences in OE development and demonstrate the utility of explant culture for experimental studies of human neuronal development... - Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorderChang Gyu Hahn
Department of Psychiatry, University of Pennsylvania, 549 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
Am J Psychiatry 162:616-8. 2005..The authors examined the feasibility of using olfactory receptor neurons from living patients to test whether calcium signaling is altered in a neuronal cell population in bipolar disorder... 
The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnessesChang Gyu Hahn
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
PLoS ONE 4:e5251. 2009..This approach may foster novel postmortem brain research paradigms in which the stoichiometry and protein composition of specific microdomains are examined...- Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophreniaChang Gyu Hahn
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Med 12:824-8. 2006..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia... 
Neuropathology of the olfactory mucosa in chronic rhinosinusitisKaren K Yee
Monell Chemmical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
Am J Rhinol Allergy 24:110-20. 2010..Chronic rhinosinusitis (CRS) is a complex heterogeneous inflammatory disease that affects the nasal cavity, but the pathological examination of the olfactory mucosa (OM) in this disease has been limited...- Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorderRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
Biol Psychiatry 62:17-24. 2007..It was hypothesized that patients with MDD would exhibit lower frontal cortical concentrations of docosahexaenoic acid (DHA), the principal omega-3 fatty acid in brain, relative to normal controls... - Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophreniaKonrad Talbot
Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
J Clin Invest 113:1353-63. 2004..Such changes may contribute to the cognitive deficits common in schizophrenia... - Scents and nonsense: olfactory dysfunction in schizophreniaBruce I Turetsky
Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Bull 35:1117-31. 2009..This could help to clarify underlying brain mechanisms and facilitate identification of clinically relevant biomarkers... - Dysbindin-1 is a synaptic and microtubular protein that binds brain snapinKonrad Talbot
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Hum Mol Genet 15:3041-54. 2006..The function of dysbindin-1 in presynaptic, postsynaptic and microtubule locations may all be related to known functions of snapin... - Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expressionJunxia Tang
Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
Hum Mol Genet 18:3851-63. 2009.... - Neurodevelopment, neuroplasticity, and new genes for schizophreniaSteven E Arnold
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Prog Brain Res 147:319-45. 2005..Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity... - Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactionsRichard S Ehrlichman
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Brain Res 1294:116-27. 2009..Event-related potentials (ERPs) were recorded to assess auditory gating and novel stimulus detection... - Biochemical Fractionation and Stable Isotope Dilution Liquid Chromatography-mass Spectrometry for Targeted and Microdomain-specific Protein Quantification in Human Postmortem Brain TissueMatthew L MacDonald
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104
Mol Cell Proteomics 11:1670-81. 2012..These findings demonstrate that biochemical fractionation methods paired with targeted proteomic strategies can be used in human brain tissues, with important implications for the study of neuropsychiatric disease... - Neuregulin 1-erbB4 pathway in schizophrenia: From genes to an interactomeAnamika Banerjee
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, United States
Brain Res Bull 83:132-9. 2010.... - Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type miceChristina L Bodarky
Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
J Pharmacol Exp Ther 331:308-18. 2009..In addition, NR1 reduction decreased GABA(A) receptor-mediated effects on ERPs while causing increased GABA(B) receptor-mediated effects. Future studies will examine changes in GABA receptor subunits after reductions in NR1 expression... - Smoking-associated squamous metaplasia in olfactory mucosa of patients with chronic rhinosinusitisKaren K Yee
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
Toxicol Pathol 37:594-8. 2009..The impact of primary cigarette smoke on olfaction and a possible role of squamous metaplasia in preserving olfactory neurogenesis are discussed... - Olfactory receptor neuron dysfunction in schizophreniaBruce I Turetsky
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 34:767-74. 2009..It unambiguously demonstrates that neurophysiological disturbances in schizophrenia are not limited to cortical and subcortical structures, but rather include even the most peripheral sensory neurons... - Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorderRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Psychiatry Res 160:285-99. 2008..low alcohol abuse severity. These results add to a growing body of evidence implicating omega-3 fatty acid deficiency as well as the OFC in the pathoaetiology of bipolar disorder... - Are we getting closer to valid translational models for major depression?Olivier Berton
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 338:75-9. 2012..We review recent progress and highlight some of the best leads to diversify and improve discovery end points for preclinical depression research... - Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patientsChang-Gyu Hahn
Medical College of Pennsylvania, Philadelphia, PA, USA
J Psychiatr Res 39:355-63. 2005..Thus, increased membrane-associated PKC, cytosol to membrane PKC translocation and receptor-G protein coupling in platelets of BD manic patients were alleviated by lithium or valproic acid treatments...
Research Grants
- Olfactory neurons from bipolar patientsChang Gyu Hahn; Fiscal Year: 2006..2) To identify therapeutically relevant changes in ICa homeostasis following lithium treatment. 3) To characterize ORN cultures from bipolar patients using odorant induced ICa responses. ..
- Neuregulin 1-erbB signaling in schizophreniaChang Gyu Hahn; Fiscal Year: 2007..Aim 2 will specifically address protein protein interactions among erbB4 and other PSD proteins. Aim 3, will further characterize the impact of erbB4 dysregulation on NMDAR signaling and explore possible mechanisms. ..
- Lithium responsivenessChang Gyu Hahn; Fiscal Year: 2009....
- Neuregulin 1-erbB signaling in schizophreniaChang Gyu Hahn; Fiscal Year: 2009..Aim 2 will specifically address protein protein interactions among erbB4 and other PSD proteins. Aim 3, will further characterize the impact of erbB4 dysregulation on NMDAR signaling and explore possible mechanisms. ..
- Lithium responsivenessChang Gyu Hahn; Fiscal Year: 2010....