Chang Gyu Hahn

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 4:e5251. 2009
  2. ncbi request reprint The current understanding of lamotrigine as a mood stabilizer
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Clin Psychiatry 65:791-804. 2004
  3. ncbi request reprint In vivo and in vitro neurogenesis in human olfactory epithelium
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Comp Neurol 483:154-63. 2005
  4. ncbi request reprint Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, 549 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    Am J Psychiatry 162:616-8. 2005
  5. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
  6. doi request reprint Neuropathology of the olfactory mucosa in chronic rhinosinusitis
    Karen K Yee
    Monell Chemmical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Am J Rhinol Allergy 24:110-20. 2010
  7. ncbi request reprint Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 62:17-24. 2007
  8. pmc Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    Konrad Talbot
    Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    J Clin Invest 113:1353-63. 2004
  9. pmc Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
    Junxia Tang
    Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
    Hum Mol Genet 18:3851-63. 2009
  10. pmc Scents and nonsense: olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 35:1117-31. 2009

Research Grants

  1. Olfactory neurons from bipolar patients
    Chang Gyu Hahn; Fiscal Year: 2006
  2. Neuregulin 1-erbB signaling in schizophrenia
    Chang Gyu Hahn; Fiscal Year: 2006
  3. Neuregulin 1-erbB signaling in schizophrenia
    Chang Gyu Hahn; Fiscal Year: 2007
  4. Lithium responsiveness
    Chang Gyu Hahn; Fiscal Year: 2009
  5. Neuregulin 1-erbB signaling in schizophrenia
    Chang Gyu Hahn; Fiscal Year: 2009
  6. Lithium responsiveness
    Chang Gyu Hahn; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. pmc The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 4:e5251. 2009
    ..This approach may foster novel postmortem brain research paradigms in which the stoichiometry and protein composition of specific microdomains are examined...
  2. ncbi request reprint The current understanding of lamotrigine as a mood stabilizer
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Clin Psychiatry 65:791-804. 2004
    ..To examine whether lamotrigine has a unique role in the treatment of bipolar disorder, we evaluated the results of recent clinical trials and molecular and cell biological studies on lamotrigine...
  3. ncbi request reprint In vivo and in vitro neurogenesis in human olfactory epithelium
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Comp Neurol 483:154-63. 2005
    ..These data highlight species-related differences in OE development and demonstrate the utility of explant culture for experimental studies of human neuronal development...
  4. ncbi request reprint Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania, 549 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    Am J Psychiatry 162:616-8. 2005
    ..The authors examined the feasibility of using olfactory receptor neurons from living patients to test whether calcium signaling is altered in a neuronal cell population in bipolar disorder...
  5. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
  6. doi request reprint Neuropathology of the olfactory mucosa in chronic rhinosinusitis
    Karen K Yee
    Monell Chemmical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Am J Rhinol Allergy 24:110-20. 2010
    ..Chronic rhinosinusitis (CRS) is a complex heterogeneous inflammatory disease that affects the nasal cavity, but the pathological examination of the olfactory mucosa (OM) in this disease has been limited...
  7. ncbi request reprint Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 62:17-24. 2007
    ..It was hypothesized that patients with MDD would exhibit lower frontal cortical concentrations of docosahexaenoic acid (DHA), the principal omega-3 fatty acid in brain, relative to normal controls...
  8. pmc Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    Konrad Talbot
    Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    J Clin Invest 113:1353-63. 2004
    ..Such changes may contribute to the cognitive deficits common in schizophrenia...
  9. pmc Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
    Junxia Tang
    Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
    Hum Mol Genet 18:3851-63. 2009
    ....
  10. pmc Scents and nonsense: olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 35:1117-31. 2009
    ..This could help to clarify underlying brain mechanisms and facilitate identification of clinically relevant biomarkers...
  11. ncbi request reprint Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin
    Konrad Talbot
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Mol Genet 15:3041-54. 2006
    ..The function of dysbindin-1 in presynaptic, postsynaptic and microtubule locations may all be related to known functions of snapin...
  12. pmc Biochemical fractionation and stable isotope dilution liquid chromatography-mass spectrometry for targeted and microdomain-specific protein quantification in human postmortem brain tissue
    Matthew L MacDonald
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Proteomics 11:1670-81. 2012
    ..These findings demonstrate that biochemical fractionation methods paired with targeted proteomic strategies can be used in human brain tissues, with important implications for the study of neuropsychiatric disease...
  13. ncbi request reprint Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia
    Harry Pantazopoulos
    Department of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Translational Neuroscience Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Schizophr Res 150:366-72. 2013
    ..Given the role CSPGs play in OE cell differentiation and axon guidance, we suggest that altered CSPG expression may contribute to ORN lineage dysregulation, and olfactory identification abnormalities, observed in SZ. ..
  14. pmc Meta-analysis of olfactory function in schizophrenia, first-degree family members, and youths at-risk for psychosis
    Paul J Moberg
    To whom correspondence should be addressed 10 Gates, HUP, 3400 Spruce Street, Philadelphia, PA 19104, US tel 215 615 3608, fax 215 662 7903, E mail
    Schizophr Bull 40:50-9. 2014
    ..Thus, the current meta-analysis was undertaken to incorporate additional studies, risk cohorts, olfactory test domains, and moderator variable analyses...
  15. pmc Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type mice
    Christina L Bodarky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Pharmacol Exp Ther 331:308-18. 2009
    ..In addition, NR1 reduction decreased GABA(A) receptor-mediated effects on ERPs while causing increased GABA(B) receptor-mediated effects. Future studies will examine changes in GABA receptor subunits after reductions in NR1 expression...
  16. ncbi request reprint Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patients
    Chang Gyu Hahn
    Medical College of Pennsylvania, Philadelphia, PA, USA
    J Psychiatr Res 39:355-63. 2005
    ..Thus, increased membrane-associated PKC, cytosol to membrane PKC translocation and receptor-G protein coupling in platelets of BD manic patients were alleviated by lithium or valproic acid treatments...
  17. pmc Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions
    Richard S Ehrlichman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Brain Res 1294:116-27. 2009
    ..Using mutant mice heterozygous for Nrg1 (Nrg1(+/-)) we studied the effects of Nrg1 signaling on behavioral and electrophysiological measures relevant to schizophrenia...
  18. ncbi request reprint Neurodevelopment, neuroplasticity, and new genes for schizophrenia
    Steven E Arnold
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Prog Brain Res 147:319-45. 2005
    ..Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity...
  19. pmc Olfactory receptor neuron dysfunction in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:767-74. 2009
    ..It unambiguously demonstrates that neurophysiological disturbances in schizophrenia are not limited to cortical and subcortical structures, but rather include even the most peripheral sensory neurons...
  20. ncbi request reprint Smoking-associated squamous metaplasia in olfactory mucosa of patients with chronic rhinosinusitis
    Karen K Yee
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Toxicol Pathol 37:594-8. 2009
    ..The impact of primary cigarette smoke on olfaction and a possible role of squamous metaplasia in preserving olfactory neurogenesis are discussed...
  21. doi request reprint Neuregulin 1-erbB4 pathway in schizophrenia: From genes to an interactome
    Anamika Banerjee
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, United States
    Brain Res Bull 83:132-9. 2010
    ....
  22. pmc Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Psychiatry Res 160:285-99. 2008
    ..low alcohol abuse severity. These results add to a growing body of evidence implicating omega-3 fatty acid deficiency as well as the OFC in the pathoaetiology of bipolar disorder...
  23. doi request reprint Are we getting closer to valid translational models for major depression?
    Olivier Berton
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 338:75-9. 2012
    ..We review recent progress and highlight some of the best leads to diversify and improve discovery end points for preclinical depression research...

Research Grants8

  1. Olfactory neurons from bipolar patients
    Chang Gyu Hahn; Fiscal Year: 2006
    ..2) To identify therapeutically relevant changes in ICa homeostasis following lithium treatment. 3) To characterize ORN cultures from bipolar patients using odorant induced ICa responses. ..
  2. Neuregulin 1-erbB signaling in schizophrenia
    Chang Gyu Hahn; Fiscal Year: 2006
    ..Aim 2 will specifically address protein protein interactions among erbB4 and other PSD proteins. Aim 3, will further characterize the impact of erbB4 dysregulation on NMDAR signaling and explore possible mechanisms. ..
  3. Neuregulin 1-erbB signaling in schizophrenia
    Chang Gyu Hahn; Fiscal Year: 2007
    ..Aim 2 will specifically address protein protein interactions among erbB4 and other PSD proteins. Aim 3, will further characterize the impact of erbB4 dysregulation on NMDAR signaling and explore possible mechanisms. ..
  4. Lithium responsiveness
    Chang Gyu Hahn; Fiscal Year: 2009
    ....
  5. Neuregulin 1-erbB signaling in schizophrenia
    Chang Gyu Hahn; Fiscal Year: 2009
    ..Aim 2 will specifically address protein protein interactions among erbB4 and other PSD proteins. Aim 3, will further characterize the impact of erbB4 dysregulation on NMDAR signaling and explore possible mechanisms. ..
  6. Lithium responsiveness
    Chang Gyu Hahn; Fiscal Year: 2010
    ....