Beatrice H Hahn
Affiliation: University of Pennsylvania
Moeller A, Li Y, Mpoudi Ngole E, Ahuka Mundeke S, Lonsdorf E, Pusey A, et al
. Rapid changes in the gut microbiome during human evolution. Proc Natl Acad Sci U S A. 2014;111:16431-5 pubmed publisher
..These results indicate that humanity has experienced a depletion of the gut flora since diverging from Pan. ..
D arc M, Ayouba A, Esteban A, Learn G, BouÃ© V, Liegeois F, et al
. Origin of the HIV-1 group O epidemic in western lowland gorillas. Proc Natl Acad Sci U S A. 2015;112:E1343-52 pubmed publisher
..These data indicate that HIV-1 group O, which spreads epidemically in west central Africa and is estimated to have infected around 100,000 people, originated by cross-species transmission from western lowland gorillas. ..
Li H, Wang S, Kong R, Ding W, Lee F, Parker Z, et al
. Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques. Proc Natl Acad Sci U S A. 2016;113:E3413-22 pubmed publisher
Kluge S, Mack K, Iyer S, Pujol F, Heigele A, Learn G, et al
. Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin. Cell Host Microbe. 2014;16:639-50 pubmed publisher
..Thus, Nef-mediated antagonism of human tetherin evolved prior to the spread of HIV-1 group O and likely facilitated secondary virus transmission. Our results may explain the epidemic spread of HIV-1 group O. ..
Barbian H, Decker J, Bibollet Ruche F, Galimidi R, West A, Learn G, et al
. Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas. MBio. 2015;6: pubmed publisher
..These reagents provide an important first step toward translating intervention strategies currently developed to treat and prevent AIDS in humans to SIV-infected apes. ..
Hraber P, Korber B, Wagh K, Giorgi E, Bhattacharya T, Gnanakaran S, et al
. Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants. Viruses. 2015;7:5443-75 pubmed publisher
Loy D, Liu W, Li Y, Learn G, Plenderleith L, Sundararaman S, et al
. Out of Africa: origins and evolution of the human malaria parasites Plasmodium falciparum and Plasmodium vivax. Int J Parasitol. 2017;47:87-97 pubmed publisher
Heigele A, Kmiec D, Regensburger K, Langer S, Peiffer L, Stürzel C, et al
. The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild. Cell Host Microbe. 2016;20:381-391 pubmed publisher
..Thus, Nef-mediated SERINC5 antagonism may determine the ability of primate lentiviruses to spread within natural hosts. ..
Iyer S, Bibollet Ruche F, Sherrill Mix S, Learn G, Plenderleith L, Smith A, et al
. Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness. Proc Natl Acad Sci U S A. 2017;114:E590-E599 pubmed publisher
..Thus, the mucosal bottleneck selects for viruses that are able to replicate and spread efficiently in the face of a potent innate immune response. ..