B H Hahn

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors
    Bevra H Hahn
    Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 175:7728-37. 2005
  2. doi request reprint Targeted therapies in systemic lupus erythematosus: successes, failures and future
    Bevra H Hahn
    Correspondence to Dr Bevra H Hahn, Division of Rheumatology, David Geffen School of Medicine at UCLA, 1000 Veteran Avenue, Room 32 59, Los Angeles, CA 90095, USA
    Ann Rheum Dis 70:i64-i66. 2011
  3. ncbi request reprint The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia
    Bevra H Hahn
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    J Autoimmun 28:69-75. 2007
  4. pmc Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis
    Bevra H Hahn
    Division of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    Arthritis Res Ther 10:213. 2008
  5. doi request reprint Atherosclerosis and systemic lupus erythematosus: the role of altered lipids and of autoantibodies
    B H Hahn
    David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Lupus 17:368-70. 2008
  6. doi request reprint Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients
    Bevra H Hahn
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 58:2488-97. 2008
  7. pmc Pro-inflammatory high-density lipoproteins and atherosclerosis are induced in lupus-prone mice by a high-fat diet and leptin
    B H Hahn
    Division of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    Lupus 19:913-7. 2010
  8. pmc Cellular and molecular mechanisms of regulation of autoantibody production in lupus
    Bevra H Hahn
    Division of Rheumatology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 91436, USA
    Ann N Y Acad Sci 1051:433-41. 2005
  9. pmc Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus
    R R Singh
    Autoimmunity and Tolerance Laboratory, Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Clin Invest 102:1841-9. 1998
  10. ncbi request reprint CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression
    Ram Pyare Singh
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1001 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 178:7649-57. 2007

Research Grants

Detail Information

Publications74

  1. ncbi request reprint Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors
    Bevra H Hahn
    Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 175:7728-37. 2005
    ....
  2. doi request reprint Targeted therapies in systemic lupus erythematosus: successes, failures and future
    Bevra H Hahn
    Correspondence to Dr Bevra H Hahn, Division of Rheumatology, David Geffen School of Medicine at UCLA, 1000 Veteran Avenue, Room 32 59, Los Angeles, CA 90095, USA
    Ann Rheum Dis 70:i64-i66. 2011
    ..The author's goal is to review recent phase III clinical trials in patients with systemic lupus erythematosus (SLE), with emphasis on outcomes and on mechanisms by which the experimental drugs/biological agents suppress autoimmunity...
  3. ncbi request reprint The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia
    Bevra H Hahn
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    J Autoimmun 28:69-75. 2007
    ..In this review we will discuss the mechanisms involved as well as an overview of the natural history in pathobiology...
  4. pmc Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis
    Bevra H Hahn
    Division of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    Arthritis Res Ther 10:213. 2008
    ....
  5. doi request reprint Atherosclerosis and systemic lupus erythematosus: the role of altered lipids and of autoantibodies
    B H Hahn
    David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Lupus 17:368-70. 2008
    ..Thus, piHDL and anti-OxPL promote plaque formation, plaque instability and thrombosis, accounting for some of the large increase in atherosclerosis and coronary artery events in SLE...
  6. doi request reprint Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients
    Bevra H Hahn
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 58:2488-97. 2008
    ..This study was undertaken to test the possibility that functional human Treg cells can be induced by exposure to anti-DNA Ig-based peptides...
  7. pmc Pro-inflammatory high-density lipoproteins and atherosclerosis are induced in lupus-prone mice by a high-fat diet and leptin
    B H Hahn
    Division of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    Lupus 19:913-7. 2010
    ..These data suggest that environmental factors associated with obesity and metabolic syndrome can accelerate atherosclerosis and disease in a lupus-prone background...
  8. pmc Cellular and molecular mechanisms of regulation of autoantibody production in lupus
    Bevra H Hahn
    Division of Rheumatology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 91436, USA
    Ann N Y Acad Sci 1051:433-41. 2005
    ..Therefore, strategies described here might ultimately be useful in therapy of the human disease...
  9. pmc Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus
    R R Singh
    Autoimmunity and Tolerance Laboratory, Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Clin Invest 102:1841-9. 1998
    ..Thus, determinant spreading and degenerate recognition in T cells coupled with recurring use of T cell determinant sequences among autoantibodies result in polyclonality that is restricted to certain autoantigens...
  10. ncbi request reprint CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression
    Ram Pyare Singh
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1001 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 178:7649-57. 2007
    ....
  11. ncbi request reprint Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus
    B H Hahn
    University of California, Los Angeles, USA
    Arthritis Rheum 44:432-41. 2001
    ..A striking effect is the ability of the peptide to tolerize T cell help for anti-DNA that is induced by multiple, structurally unrelated self antigens...
  12. pmc Interferon-inducible gene 202b controls CD8(+) T cell-mediated suppression in anti-DNA Ig peptide-treated (NZB × NZW) F1 lupus mice
    R Dinesh
    Division of Rheumatology, Department of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Genes Immun 12:360-9. 2011
    ..Our findings indicate a potential role for Ifi202b in the suppressive capacity of peptide-induced regulatory CD8(+) Ti cells through effects on the expression of Foxp3 and the synthesis of TGFβ...
  13. ncbi request reprint Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodies
    Gabriela Riemekasten
    University of California, Los Angeles, USA
    Arthritis Rheum 48:475-85. 2003
    ..This study was undertaken to test the hypothesis that SmD1(83-119)-reactive T cells play a crucial role in the generation of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies...
  14. ncbi request reprint Protection against renal disease in (NZB x NZW)F(1) lupus-prone mice after somatic B cell gene vaccination with anti-DNA immunoglobulin consensus peptide
    Francesca Ferrera
    David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Arthritis Rheum 56:1945-53. 2007
    ..The purpose of the present study was to test our hypothesis that T cells that recognize an Ig consensus sequence presented by B cells will modulate lupus-like disease in mice...
  15. pmc Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus
    B P Tsao
    University of California, Los Angeles, USA
    J Clin Invest 99:725-31. 1997
    ..01). We concluded that this candidate 1q41-q42 region probably contains a susceptibility gene(s) that confers risk for SLE in multiple ethnic groups...
  16. doi request reprint Distinct gene signature revealed in white blood cells, CD4(+) and CD8(+) T cells in (NZBx NZW) F1 lupus mice after tolerization with anti-DNA Ig peptide
    R P Singh
    Division of Rheumatology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Genes Immun 11:294-309. 2010
    ..However, silencing of Foxp3 reduced expression of Foxp3, Ifi202b and PD1-all of which are involved in the suppressive capacity of CD8(+) Treg in this model...
  17. ncbi request reprint Reciprocal T-B determinant spreading develops spontaneously in murine lupus: implications for pathogenesis
    R R Singh
    Department of Medicine, University of California, Los Angeles 90095 1670, USA
    Immunol Rev 164:201-8. 1998
    ..Understanding the diversification patterns in autoimmune responses has enormous implications in developing peptide-targeted therapies...
  18. doi request reprint Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease
    S D Liu
    University of California, Los Angeles, CA, USA
    Lupus 20:473-84. 2011
    ..Together, the findings highlight galectin-1 as a novel potential therapeutic immune modulator for treatment of lupus-like disease...
  19. pmc Some antiphospholipid antibodies recognize conformational epitopes shared by beta2-glycoprotein I and the homologous catalytic domains of several serine proteases
    Wei Shiang Lin
    University of California, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 56:1638-47. 2007
    ....
  20. ncbi request reprint Assessment of American College of Rheumatology quality criteria for rheumatoid arthritis in a pre-quality criteria patient cohort
    K L Kahn
    University of California at Los Angeles, California 90095 1736, USA
    Arthritis Rheum 57:707-15. 2007
    ..To evaluate the American College of Rheumatology (ACR) starter set of quality measures for rheumatoid arthritis (RA) in an actual patient cohort that preceded publication of the quality measures...
  21. pmc Low physical activity is associated with proinflammatory high-density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosus
    Elizabeth R Volkmann
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1670, USA
    Arthritis Care Res (Hoboken) 62:258-65. 2010
    ..To investigate the association between physical activity, functional activity of high-density lipoprotein (HDL), and subclinical cardiovascular disease in patients with systemic lupus erythematosus (SLE)...
  22. pmc Modulation of p38 MAPK activity in regulatory T cells after tolerance with anti-DNA Ig peptide in (NZB x NZW)F1 lupus mice
    Elaine V Lourenço
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 182:7415-21. 2009
    ..Transfer experiments confirmed the role of p38 in Tregs on disease activity in the NZB/W mice. These data indicate that the modulation of p38 activity in lupus Tregs can significantly influence the disease activity...
  23. pmc Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone mice
    Brian J Skaggs
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Hum Immunol 69:790-6. 2008
    ..This review will discuss the similarities and differences in CD8(+) Ts subsets, the concept of tolerance as a therapy, and the current understanding of CD8(+) Ts in mouse SLE models...
  24. ncbi request reprint Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis
    Maureen McMahon
    University of California at Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Arthritis Rheum 54:2541-9. 2006
    ..This study was undertaken to determine whether patients with SLE, who have chronic inflammation that causes oxidative damage, have more proinflammatory HDL and higher levels of ox-LDL, thus predisposing them to atherosclerosis...
  25. ncbi request reprint Potential for anti-DNA immunoglobulin peptide therapy in systemic lupus erythematosus
    Noriko Iikuni
    University of California Los Angeles, Division of Rheumatology, Department of Medicine, 1000 Veteran Avenue 32 59, Los Angeles, California 90095 1670, USA
    Expert Opin Biol Ther 9:201-6. 2009
    ..Some patients may not respond well to some treatments because of inter-individual variability of the disease. More specific and safer therapies are needed...
  26. ncbi request reprint Development and evaluation of a patient self-report case-finding method for rheumatoid arthritis
    Andrew L Wong
    Olive View UCLA Medical Center, Sylmar, CA 91342, USA
    Semin Arthritis Rheum 34:484-99. 2004
    ..To describe the development and evaluation of a patient self-report case-finding method for rheumatoid arthritis (RA) not dependent on direct contact with the treating physicians...
  27. ncbi request reprint Tuning immune suppression in systemic autoimmunity with self-derived peptides
    Ram Pyare Singh
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32 59, Los Angeles, CA 90095 1670, USA
    Inflamm Allergy Drug Targets 7:253-9. 2008
    ....
  28. ncbi request reprint The complexity of care for patients with rheumatoid arthritis: metrics for better understanding chronic disease care
    Katherine L Kahn
    University of California at Los Angeles, Greater Los Angeles VA Healthcare System, Los Angeles, California 90095 1736, USA
    Med Care 45:55-65. 2007
    ..Patients with rheumatoid arthritis (RA) provide an important opportunity for understanding care of patients with a serious chronic condition...
  29. pmc Atherosclerosis and systemic lupus erythematosus: mechanistic basis of the association
    Maureen McMahon
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA
    Curr Opin Immunol 19:633-9. 2007
    ..As in the pathogenesis of many lupus disease processes, the increased risk of atherosclerosis seen in SLE is likely due to the complex interplay of many of these inflammatory and immune mediators...
  30. ncbi request reprint pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules
    Ram Pyare Singh
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 180:2069-80. 2008
    ..Our data suggest that tolerization with pCons activates different subsets of inhibitory/cytotoxic CD8+ T cells whose targets are both CD4+CD25- effector T cells and B cells...
  31. pmc Cutaneous vasculitis in breast cancer treated with chemotherapy
    Maida Wong
    Department of Medicine, Division of Rheumatology, University of California Los Angeles, FOCIS Center of Excellence, Los Angeles, CA 90095 1670, USA
    Clin Immunol 129:3-9. 2008
    ....
  32. ncbi request reprint Manipulation of immune regulation in systemic lupus erythematosus
    Antonio La Cava
    Division of Rheumatology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    Autoimmun Rev 4:515-9. 2005
    ....
  33. ncbi request reprint Familiality and co-occurrence of clinical features of systemic lupus erythematosus
    Betty P Tsao
    Division of Rheumatology, Department of Medicine, Rehabilitation Center, Room 32 59, University of California Los Angeles School of Medicine, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 46:2678-85. 2002
    ..To evaluate familiality of 15 clinical and laboratory features in systemic lupus erythematosus (SLE)-affected sibpairs, and to estimate correlations with the age at SLE diagnosis in affected sibpairs and parent-offspring pairs...
  34. ncbi request reprint Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosus
    Betty P Tsao
    Department of Medicine, Rehabilitation Center, Room 32 59, 1000 Veteran Avenue, UCLA School of Medicine, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 46:2928-36. 2002
    ....
  35. pmc A thrombin-cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein C
    Kwan Ki Hwang
    Medicine Rheumatology, University of California, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 48:1622-30. 2003
    ..To test the hypotheses that some thrombin-reactive anticardiolipin antibodies (aCL) may bind to protein C (PC) and/or activated PC (APC), and that some of the PC- and APC-reactive aCL may inhibit PC activation and/or the function of APC...
  36. ncbi request reprint Leptin-based immune intervention: current status and future directions
    Antonio La Cava
    Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32 59, Los Angeles, CA 90095 1670, USA
    Curr Opin Investig Drugs 4:1327-32. 2003
    ..This review presents current preclinical evidence and potential applications for leptin-based immune approaches aimed at improving therapy for chronic and autoimmune conditions...
  37. doi request reprint Blockade of programmed death-1 in young (New Zealand black x New Zealand white)F1 mice promotes the activity of suppressive CD8+ T cells that protect from lupus-like disease
    Maida Wong
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    J Immunol 185:6563-71. 2010
    ..PD-1 regulation could represent a target to preserve tolerance and prevent autoimmunity...
  38. pmc Dysfunctional, pro-inflammatory HDL directly upregulates monocyte PDGFRβ, chemotaxis and TNFα production
    Brian J Skaggs
    Division of Rheumatology, David Geffen UCLA School of Medicine, 32 59 Rehab Center, Los Angeles, CA 90095, USA
    Clin Immunol 137:147-56. 2010
    ..Dysfunctional piHDL directly influences expression of a small number of transcripts and proteins, and piHDL inhibition through reducing piHDL oxidation or blocking PDGFRβ kinase activity restored normal monocyte chemotaxis...
  39. ncbi request reprint Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA
    Antonio La Cava
    Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 173:3542-8. 2004
    ..These findings suggest possible relevance of Ag specificity in the mechanism of T(R)-mediated immune tolerance to Ig-derived peptides in NZB/W F(1) mice...
  40. ncbi request reprint Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23
    Rita M Cantor
    David Geffen School of Medicine, University of California, Los Angeles, 90095 7088, USA
    Arthritis Rheum 50:3203-10. 2004
    ..To identify chromosome regions likely to harbor genes that predispose to the development of systemic lupus erythematosus (SLE) by analyzing a full genome scan in nuclear families ascertained for siblings with SLE...
  41. ncbi request reprint Systemic lupus erythematosus: modern strategies for management: a moving target
    Jennifer K King
    University of California Los Angeles, Division of Rheumatology, Rehab Center 32 59, Los Angeles, CA 90095, USA
    Best Pract Res Clin Rheumatol 21:971-87. 2007
    ..Recent clinical trials have also shed light on the optimal utility of several traditional therapies used in our SLE armamentarium...
  42. pmc Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosus
    Maureen McMahon
    David Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, CA 90095, USA
    Arthritis Rheum 60:2428-37. 2009
    ..The aim of this study was to determine whether dysfunctional proinflammatory HDL (piHDL) is associated with subclinical atherosclerosis in SLE...
  43. pmc Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic intervention
    Maureen McMahon
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA
    Expert Rev Clin Immunol 7:227-41. 2011
    ..Future preventive strategies may include therapies that counteract the immunologic responses that lead to plaque formation...
  44. pmc PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus
    B P Tsao
    Division of Rheumatology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1670
    J Clin Invest 103:1135-40. 1999
    ..004). Similar TDT analyses of TGFB2 and HLX1 polymorphisms yielded no evidence for association with SLE. These results suggest that PARP may be (or is close to) the susceptibility gene within the chromosome 1q41-q42 region linked to SLE...
  45. doi request reprint Oral administration of different forms of a tolerogenic peptide to define the preparations and doses that delay anti-DNA antibody production and nephritis and prolong survival in SLE-prone mice
    B J Skaggs
    University of California, Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA
    Lupus 20:912-20. 2011
    ..Induction of oral tolerance using modified pCons peptides could lead to a novel targeted therapy for human SLE...
  46. doi request reprint Some antiphospholipid antibodies bind to various serine proteases in hemostasis and tip the balance toward hypercoagulant states
    P P Chen
    Department of Medicine, Division of Rheumatology, University of California at Los Angeles, Los Angeles, CA, USA
    Lupus 19:365-9. 2010
    ....
  47. ncbi request reprint Identification of anti-plasmin antibodies in the antiphospholipid syndrome that inhibit degradation of fibrin
    Cheng De Yang
    Department of Medicine, Division of Rheumatology, University of California, Los Angeles, CA 90095, USA
    J Immunol 172:5765-73. 2004
    ....
  48. ncbi request reprint Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombin
    Yao Hsu Yang
    Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 182:1674-80. 2009
    ..Because FIXa is an upstream procoagulant factor, impaired AT regulation of FIXa might contribute more toward thrombosis than the dysregulation of the downstream FXa and thrombin...
  49. pmc CD8+ Tregs in lupus, autoimmunity, and beyond
    Ravi K Dinesh
    Division of Rheumatology, Dept of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    Autoimmun Rev 9:560-8. 2010
    ..We also discuss the potential role of CD8(+) Tregs in other diseases, including chronic infection and cancer...
  50. ncbi request reprint Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease
    Hui Wu
    David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Arthritis Rheum 52:2396-402. 2005
    ..We performed family-based association studies of this polymorphism in 4 independent cohorts containing SLE patients and their parents and/or other family members...
  51. pmc A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, 1959 Northeast Pacific Street, Seattle, WA 98105, USA
    Proc Natl Acad Sci U S A 102:10593-7. 2005
    ..These data support a role for flagellated bacteria and the innate immune response in the development of SLE with implications for novel immunomodulatory treatment strategies...
  52. pmc Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus
    Hui Wu
    Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:3961-6. 2007
    ..Our findings reveal that CR2 is a likely susceptibility gene for human lupus at 1q32.2, extending previous studies suggesting that CR2 participates in the pathogenesis of systemic lupus erythematosus...
  53. ncbi request reprint Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin by antithrombin
    K K Hwang
    Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 167:7192-8. 2001
    ..Because the latter anti-thrombin Ab are likely to promote clotting, it will be important to develop specific assays for such Ab and study their roles in thrombosis in APS patients...
  54. pmc The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures
    H Liu
    Department of Medicine, University of Alabama at Birmingham 35294, USA
    J Virol 69:7630-8. 1995
    ..These results indicate that Vif represents an integral component of HIV and SIV particles and raise the possibility that it plays a direct role in early replication events...
  55. pmc PD-1, gender, and autoimmunity
    Ravi K Dinesh
    Division of Rheumatology, Department of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    Autoimmun Rev 9:583-7. 2010
    ..Exploring the effects of sex hormones on the PD-1:PD-L pathway could shed light on the gender biased nature of many autoimmune conditions as well as aide in the development of therapeutics targeting the immune system...
  56. ncbi request reprint Leptin in non-autoimmune inflammation
    Chunlin Cai
    Department of Medicine, University of California Los Angeles, Los Angeles, California 90095 1670, USA
    Inflamm Allergy Drug Targets 8:285-91. 2009
    ..This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behçet's disease and endometriosis...
  57. pmc Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus
    Noriko Iikuni
    Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 183:1518-22. 2009
    ..These results indicate that one way by which natural Tregs attempt to limit humoral autoimmunity in SLE is by directly targeting autoreactive B cells...
  58. ncbi request reprint Nephritogenic anti-DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cells
    Xiaoping Qing
    Division of Rheumatology, Forchheimer 701N, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Arthritis Rheum 54:2198-210. 2006
    ..We undertook this study to determine if pathogenic anti-DNA antibodies may also contribute to renal damage by directly influencing mesangial gene expression...
  59. pmc Antibodies against the activated coagulation factor X (FXa) in the antiphospholipid syndrome that interfere with the FXa inactivation by antithrombin
    Yao Hsu Yang
    Division of Rheumatology, Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 177:8219-25. 2006
    ..Combined, these results indicate that anti-FXa Ab may contribute to thrombosis by interfering with the anticoagulant function of AT on FXa in some APS patients...
  60. pmc Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome
    Cai Sheng Lu
    University of California, Los Angeles, CA 90095, USA
    Arthritis Rheum 52:4018-27. 2005
    ..To test the hypotheses that some plasmin-reactive anticardiolipin antibodies (aCL) may bind to tissue plasminogen activator (tPA) and that some of the tPA-reactive aCL may inhibit tPA activity...
  61. ncbi request reprint Peptides from antibodies to DNA elicit cytokine release from peripheral blood mononuclear cells of patients with systemic lupus erythematosus: relation of cytokine pattern to disease duration
    J K Kalsi
    Division of Rheumatology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    Lupus 13:490-500. 2004
    ....
  62. ncbi request reprint Application of explicit process of care measurement to rheumatoid arthritis: Moving from evidence to practice
    K L Kahn
    Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1736, USA
    Arthritis Rheum 55:884-91. 2006
    ..To construct quality measures with measurement validity and meaning for clinicians...
  63. ncbi request reprint Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c
    P A Sieling
    Division of Dermatology and Rheumatology, University of California School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 165:5338-44. 2000
    ..The data suggest that CD1c-restricted T cells from SLE patients can provide help to CD1c(+) B cells for IgG production and could therefore promote pathogenic autoantibody responses in SLE...
  64. ncbi request reprint Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus
    Xuebing Feng
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 54:2951-62. 2006
    ..To study 5 type I interferon (IFN)-inducible genes (LY6E, OAS1, OASL, MX1, and ISG15) in patients with systemic lupus erythematosus (SLE) and to correlate expression levels with disease activity and/or clinical manifestations...
  65. ncbi request reprint Induction of autoantibody production is limited in nonautoimmune mice
    Ram Raj Singh
    Department of Internal Medicine, University of Cincinnati College of Medicine and Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 169:587-94. 2002
    ..The induction of such inhibitory T cells may play a role in protecting nonautoimmune mice from developing chronic autoimmunity...
  66. pmc Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model
    George A Karpouzas
    Rheumatology, Harbor UCLA Medical Center, Torrance, USA
    Eur J Immunol 34:2489-99. 2004
    ..Understanding these defects might identify targets for therapy in systemic lupus erythematosus...
  67. pmc Identification and characterization of a peptide mimetic that may detect a species of disease-associated anticardiolipin antibodies in patients with the antiphospholipid syndrome
    Sudha Visvanathan
    University of California at Los Angeles, 90095, USA
    Arthritis Rheum 48:737-45. 2003
    ..To test the feasibility of applying a mimetic (specific for a patient-derived prothrombotic anticardiolipin antibody [aCL]) to study the homologous, disease-associated aCL in patients with antiphospholipid syndrome (APS)...
  68. ncbi request reprint Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type 1 regulatory T cells
    Gabriela Riemekasten
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Immunol 173:5835-42. 2004
    ..In conclusion, these results indicate that SmD1 83-119 peptide may play a dominant role in the activation of helper and regulatory T cells that influence autoantibody generation and murine lupus...
  69. ncbi request reprint Maternal HLA class II compatibility in men with systemic lupus erythematosus
    Anne M Stevens
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
    Arthritis Rheum 52:2768-73. 2005
    ..Male subjects were selected in order to avoid confounding due to fetal microchimerism, which may occur in women...
  70. ncbi request reprint The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial
    Jill P Buyon
    Hospital for Joint Diseases, New York University School of Medicine, New York, New York, USA
    Ann Intern Med 142:953-62. 2005
    ..There is concern that exogenous female hormones may worsen disease activity in women with systemic lupus erythematosus (SLE)...
  71. ncbi request reprint Combined oral contraceptives in women with systemic lupus erythematosus
    Michelle Petri
    Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 353:2550-8. 2005
    ..In this double-blind, randomized, noninferiority trial, we prospectively evaluated the effect of oral contraceptives on lupus activity in premenopausal women with systemic lupus erythematosus...
  72. ncbi request reprint Improving joint disease in patients with rheumatoid arthritis: is this enough to treat the accompanying dyslipidemias?
    Bevra H Hahn
    Am J Med 113:247-8. 2002
  73. ncbi request reprint Fcgamma receptor IIIA polymorphism in Korean patients with systemic lupus erythematosus
    Eun Bong Lee
    Department of Internal Medicine, Clinical Research Institute, Seoul National University College of Medicine, Korea
    Rheumatol Int 21:222-6. 2002
    ..In conclusion, FcgammaRIIIA-176F/V polymorphism is not associated with SLE in Koreans...
  74. ncbi request reprint Gene vaccination for the induction of immune tolerance
    Francesca Ferrera
    Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    Ann N Y Acad Sci 1110:99-111. 2007
    ..We review here the experimental evidence and most recent data supporting the use of DNA vaccination in the induction of immune tolerance...

Research Grants2

  1. MECHANISMS OF IMMUNE TOLERANCE INDUCED IN MURINE LUPUS
    Bevra Hahn; Fiscal Year: 2007
    ..Since patients with SLE have T cells that recognize Ig-derived peptides from humanmonoclonal antibodies to DNA, the information from these experiments may suggest a novel therapeutic approach to this disease. ..