Affiliation: University of Missouri
Xia C, Seo Y, Studstill C, Vijayan M, Wolf J, Hahm B. Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice. Antiviral Res. 2018;158:171-177 pubmed publisher
..Collectively, our results indicate that both SphK1 and SphK2 function as proviral factors during IAV infection in vivo. Therefore, SphK1 and SphK2 represent potential host targets for therapeutics against influenza. ..
Hahm B. Hostile communication of measles virus with host innate immunity and dendritic cells. Curr Top Microbiol Immunol. 2009;330:271-87 pubmed
..This review focuses on versatile actions of MV-induced type I IFNs causing beneficial or deleterious influence on host immunity and the interplay between MV and heterogeneous DCs at distinct locations. ..
Pritzl C, Seo Y, Xia C, Vijayan M, Stokes Z, Hahm B. A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections. J Immunol. 2015;194:4339-49 pubmed publisher
..Collectively, these findings provide new insights into ceramide-mediated regulation of DC responses against virus infection and help us establish a foundation for novel immune-stimulatory therapeutics. ..
Xia C, Anderson P, Hahm B. Viral dedication to vigorous destruction of interferon receptors. Virology. 2018;522:19-26 pubmed publisher
..In this review, viral mechanisms that remove IFN receptors are summarized with an emphasis on the mechanisms for virus-induced degradation of IFN receptors. ..
Sherman M, Pritzl C, Xia C, Miller M, Zaghouani H, Hahm B. Lactoferrin acts as an adjuvant during influenza vaccination of neonatal mice. Biochem Biophys Res Commun. 2015;467:766-70 pubmed publisher
..01). Controls had no anti-H1N1 antibody. Neonates given lactoferrin had no anaphylaxis when challenged four weeks later. Lactoferrin is a safe and effective adjuvant for inducing antibody against influenza in neonates. ..
Xia C, Vijayan M, Pritzl C, Fuchs S, McDermott A, Hahm B. Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1. J Virol. 2015;90:2403-17 pubmed publisher
..This discovery could help us understand how IAV regulates the host innate immune response to create an environment optimized for viral survival in host cells. ..
Vijayan M, Xia C, Song Y, Ngo H, Studstill C, Drews K, et al
. Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. J Immunol. 2017;199:677-687 pubmed publisher
..This indicates that IKK? is crucial for SPL-mediated inhibition of influenza virus replication. Thus, the results illustrate the functional significance of the SPL-IKK?-IFN axis during host innate immunity against viral infection. ..
Xia C, Wolf J, Vijayan M, Studstill C, Ma W, Hahm B. Casein Kinase 1? Mediates the Degradation of Receptors for Type I and Type II Interferons Caused by Hemagglutinin of Influenza A Virus. J Virol. 2018;92: pubmed publisher
..Thus, this study unveils a novel strategy employed by IAV to evade IFN-mediated antiviral activities. These findings may provide new insights into the interplay between IAV and host immunity to impact influenza virus pathogenicity. ..