Affiliation: University of Missouri
- Vijayan M, Xia C, Song Y, Ngo H, Studstill C, Drews K, et al. Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. J Immunol. 2017;199:677-687 pubmed publisher..This indicates that IKK? is crucial for SPL-mediated inhibition of influenza virus replication. Thus, the results illustrate the functional significance of the SPL-IKK?-IFN axis during host innate immunity against viral infection. ..
- Xia C, Wolf J, Vijayan M, Studstill C, Ma W, Hahm B. Casein kinase 1? mediates degradation of receptors for type I and type II interferons caused by hemagglutinin of influenza A virus. J Virol. 2018;: pubmed publisher..Thus, this study unveils a novel strategy employed by IAV to evade IFN-mediated antiviral activities. These findings may cast new insights into the interplay between IAV and host immunity to impact influenza pathogenicity. ..