Affiliation: University of California
- Chemical cues identify gender and individuality in Giant pandas (Ailuropoda melanoleuca)Lee Hagey
Center for Reproduction of Endangered Species, Zoological Society of San Diego, Post Office Box 551, San Diego, California 92112 0551, USA
J Chem Ecol 29:1479-88. 2003..Since radiocollaring is currently banned in China, the techniques described in this paper give field biologists a new means to identify and track pandas in the wild...
- Microbial biotransformations of bile acids as detected by electrospray mass spectrometryLee R Hagey
Department of Medicine, University of California at San Diego, USA
Adv Nutr 4:29-35. 2013..Here we offer a classification scheme that can serve as an initial guide to interpret the different bile acid patterns expressed in vertebrate feces...
- A novel varanic acid epimer--(24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monsterLee R Hagey
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 063, USA
Steroids 77:1510-21. 2012..The structure was established by mass spectroscopy and by (1)H and (13)C nuclear magnetic spectroscopy, as well as by synthesis of the compound...
- Functional evolution of the vitamin D and pregnane X receptorsErica J Reschly
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
BMC Evol Biol 7:222. 2007..In addition, several assays were used to search for evidence of PXR-mediated hepatic effects in three model non-mammalian species: sea lamprey (Petromyzon marinus), zebrafish (Danio rerio), and African clawed frog (Xenopus laevis)...
- Evolution of pharmacologic specificity in the pregnane X receptorSean Ekins
Collaborations in Chemistry, Inc, Jenkintown, PA, USA
BMC Evol Biol 8:103. 2008....
- The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian speciesMatthew D Krasowski
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
BMC Biochem 12:5. 2011..We utilize homology modelling, docking, and pharmacophore studies to understand the structural features of the Tetraodon receptors...
- Comparative urinary androstanes in the great apesL R Hagey
Zoological Society of San Diego, P O Box 120551, San Diego, California 92112, USA
Gen Comp Endocrinol 130:64-9. 2003..The RIA measurement of urinary testosterone in part records additional androstane metabolites, which vary even between closely related genera, making the results neither equivalent with nor comparable to different species...
- Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathwayLee R Hagey
Department of Medicine, University of California San Diego, MC 0063, La Jolla, California 92093, USA
Physiol Biochem Zool 83:308-21. 2010..Analysis of the evolution of bile salt synthetic pathways provides a rich model system for the molecular evolution of a complex biochemical pathway in vertebrates...
- Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolitesLee R Hagey
Department of Medicine, University of California San Diego, La Jolla, CA, USA
BMC Evol Biol 10:133. 2010..We greatly extend prior surveys of bile salt diversity in both reptiles and mammals, including analysis of 8,000 year old human coprolites and coprolites from the extinct Shasta ground sloth (Nothrotherium shastense)...
- A novel primary bile acid in the Shoebill stork and herons and its phylogenetic significanceL R Hagey
Zoological Society of San Diego, San Diego, CA 92112, USA
J Lipid Res 43:685-90. 2002..The presence of this biochemical trait in the Shoebill stork and certain herons suggests that these birds are closely related...
- Physicochemical and physiological properties of 5alpha-cyprinol sulfate, the toxic bile salt of cyprinid fishT Goto
Division of Gastroenterology, Department of Medicine, University of California, San Diego, CA 92093 0813, USA
J Lipid Res 44:1643-51. 2003..These studies indicate that 5alpha-cyprinol sulfate is an excellent digestive detergent and suggest that a micellar phase is present during digestion in cyprinid fish...
- Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeuticsA F Hofmann
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0063, USA
Cell Mol Life Sci 65:2461-83. 2008..Bile acids are used therapeutically to correct deficiency states, to decrease the cholesterol saturation of bile, or to decrease the cytotoxicity of retained bile acids in cholestatic liver disease...
- Bile acid absorption after near-total proctocolectomy in dogs: ileal pouch vs. jejunal pouch-distal rectal anastomosisF V Teixeira
Department of Surgery, Mayo Clinic Scottsdale, Scottsdale, AZ 85259
J Gastrointest Surg 5:540-5. 2001..The resultant passive absorption of unconjugated bile acids appears to compensate for any loss of active ileal absorption of conjugated bile acids, and bile acid malabsorption does not occur...