B Hagenbuch

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Development of a Cell-Based High-Throughput Assay to Screen for Inhibitors of Organic Anion Transporting Polypeptides 1B1 and 1B3
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Curr Chem Genomics 4:1-8. 2010
  2. pmc The SLCO (former SLC21) superfamily of transporters
    Bruno Hagenbuch
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Mol Aspects Med 34:396-412. 2013
  3. pmc Drug uptake systems in liver and kidney: a historic perspective
    B Hagenbuch
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA
    Clin Pharmacol Ther 87:39-47. 2010
  4. ncbi request reprint Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family
    B Hagenbuch
    The University of Kansas Medical Center, Pharmacology, Toxicology and Therapeutics, Kansas City, KS 66160, USA
    Xenobiotica 38:778-801. 2008
  5. ncbi request reprint Cellular entry of thyroid hormones by organic anion transporting polypeptides
    Bruno Hagenbuch
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Best Pract Res Clin Endocrinol Metab 21:209-21. 2007
  6. pmc Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Comp Biochem Physiol C Toxicol Pharmacol 151:393-9. 2010
  7. pmc Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transport
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Pharmacol Res 60:50-6. 2009
  8. pmc Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Protein Sci 18:2298-306. 2009
  9. pmc Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae)
    Megan Roth
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 339:624-32. 2011
  10. pmc Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs
    Amanda Obaidat
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 337:479-86. 2011

Collaborators

  • Amanda Obaidat
  • M A Palladino
  • H Murer
  • H Koepsell
  • J J G Marin
  • Bruno Stieger
  • Diana Jung
  • Chunshan Gui
  • Megan Roth
  • Peter J Meier
  • Barbara N Timmermann
  • Yi M Weaver
  • Erik Pacyniak
  • Robert D Huber
  • Bo Gao
  • Gerd Folkers
  • Mine Yarim
  • Pascal Frei
  • Fabienne Meier-Abt
  • Oscar Briz
  • Jessica E van Montfoort
  • Juan J Araya
  • John L Butenhoff
  • Rathnam Chaguturu
  • Grace L Guo
  • David J Ehresman
  • Brett Wahlgren
  • Gerald H Lushington
  • Lucas Thompson
  • Yi Miao
  • Bret Wahlgren
  • Melissa Mock
  • Marguerite Anne Sidler Pfändler
  • Simone Leuthold
  • Wenting Zhang-Fu
  • Jurg Biber
  • Robert Huber
  • Chosei Kaseda
  • Alfonso Mate
  • Stefano Moro
  • Toru Kashima
  • Heinz Faulstich
  • Noemi Rebollo
  • Ilse Dore Adler
  • Maria Angeles Serrano
  • Thomas E Schmid

Detail Information

Publications25

  1. pmc Development of a Cell-Based High-Throughput Assay to Screen for Inhibitors of Organic Anion Transporting Polypeptides 1B1 and 1B3
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Curr Chem Genomics 4:1-8. 2010
    ..Ursolic acid was the most selective OATP1B3 inhibitor (IC(50) = 2.3 muM vs. 12.5 muM for OATP1B1). In conclusion, this cell-based assay should allow us to identify even more specific inhibitors by screening larger chemical libraries...
  2. pmc The SLCO (former SLC21) superfamily of transporters
    Bruno Hagenbuch
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Mol Aspects Med 34:396-412. 2013
    ....
  3. pmc Drug uptake systems in liver and kidney: a historic perspective
    B Hagenbuch
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA
    Clin Pharmacol Ther 87:39-47. 2010
    ....
  4. ncbi request reprint Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family
    B Hagenbuch
    The University of Kansas Medical Center, Pharmacology, Toxicology and Therapeutics, Kansas City, KS 66160, USA
    Xenobiotica 38:778-801. 2008
    ..4. Finally, some open questions are raised that need to be addressed to advance OATP research in the near future...
  5. ncbi request reprint Cellular entry of thyroid hormones by organic anion transporting polypeptides
    Bruno Hagenbuch
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Best Pract Res Clin Endocrinol Metab 21:209-21. 2007
    ..OATP4A1 is expressed in the placenta and could be important for maternal thyroid hormone transport to the developing fetus...
  6. pmc Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Comp Biochem Physiol C Toxicol Pharmacol 151:393-9. 2010
    ..In conclusion, the cloned canine Oatp1b4 will provide additional molecular basis to further characterize the species difference of the OATP1B family members...
  7. pmc Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transport
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Pharmacol Res 60:50-6. 2009
    ..The CoMFA results indicate that the substrate binding site of OATP1B1 consists of a large hydrophobic middle part with basic residues at both ends that could be very important for substrate binding...
  8. pmc Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Protein Sci 18:2298-306. 2009
    ..In conclusion, our results show that TM10 is critical for the function of OATP1B1...
  9. pmc Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae)
    Megan Roth
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 339:624-32. 2011
    ..These results demonstrate a mechanism through which the hepatic uptake of drug OATP substrates could be stimulated...
  10. pmc Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs
    Amanda Obaidat
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 337:479-86. 2011
    ....
  11. pmc Interactions of green tea catechins with organic anion-transporting polypeptides
    Megan Roth
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Drug Metab Dispos 39:920-6. 2011
    ..In addition, the diverse effects of EGCG on the transport of other OATP1B3 substrates suggest that different transport/binding sites are involved...
  12. pmc Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths
    Yi M Weaver
    Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 113:305-14. 2010
    ..4 (C8), 20.5 (C9), and 28.5microM (C10). These results suggest that Oat1 and Oat3 are involved in renal secretion of C7-C9, while Oatp1a1 can contribute to the reabsorption of C8 through C10, with highest affinities for C9 and C10...
  13. pmc Mechanism of polybrominated diphenyl ether uptake into the liver: PBDE congeners are substrates of human hepatic OATP transporters
    Erik Pacyniak
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 115:344-53. 2010
    ..81 microM; BDE99: K(m) = 0.87 microM; BDE153: K(m) = 0.65 microM). These results clearly suggest that uptake of PBDEs via these OATPs is a mechanism responsible for liver-specific accumulation of PBDEs...
  14. pmc Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biochemistry 47:9090-7. 2008
    ..In conclusion, we have identified three amino acid residues (Y537, S545, and T550) in TM10 of OATP1B3 that are important for CCK-8 transport...
  15. pmc Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA
    Eur J Pharmacol 584:57-65. 2008
    ..In summary, these results demonstrate that pregnane X receptor ligands, by inhibiting or stimulating OATP-mediated uptake, can lead to drug-drug interactions at the transporter level...
  16. ncbi request reprint Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver
    Pascal Frei
    Division of Clinical Pharmacology and Toxicology, Dept of Medicine, Univ Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 288:G771-8. 2005
    ..We conclude that NaPi-IIb is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration...
  17. ncbi request reprint Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties
    Bruno Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    Pflugers Arch 447:653-65. 2004
    ....
  18. ncbi request reprint Functional characterization of the mouse organic-anion-transporting polypeptide 2
    Jessica E van Montfoort
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Ramistr 100, CH 8091 Zurich, Switzerland
    Biochim Biophys Acta 1564:183-8. 2002
    ..Northern blot analysis demonstrated a predominant expression in the liver with additional signals in kidney and brain. Using fluorescence in situ hybridization, the Oatp2 gene (gene symbol Slc21a5) was mapped to chromosome 6G1-G3...
  19. ncbi request reprint Transport of xenobiotics across the blood-brain barrier
    Bruno Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    News Physiol Sci 17:231-4. 2002
    ..Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain...
  20. ncbi request reprint Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene
    Diana Jung
    Division of Gastroenterology and Hepatology, Dept of Internal Medicine, Univ Hospital, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 286:G752-61. 2004
    ..Bile acids may regulate NTCP/Ntcp indirectly by modulating the capacity of nuclear factors to activate gene expression...
  21. ncbi request reprint The sodium bile salt cotransport family SLC10
    Bruno Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    Pflugers Arch 447:566-70. 2004
    ..NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT)...
  22. ncbi request reprint Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain
    Robert D Huber
    Univ Hospital, Dept of Internal Medicine, Institute of Clinical Pharmacology and Toxicology, 8091 Zurich, Switzerland
    Am J Physiol Cell Physiol 292:C795-806. 2007
    ....
  23. ncbi request reprint Application of QSAR analysis to organic anion transporting polypeptide 1a5 (Oatp1a5) substrates
    Mine Yarim
    Institute of Pharmaceutical Sciences, ETH Zurich, D ANBI, Wintherthurerstrasse 190, CH 8057 Zurich, Switzerland
    Bioorg Med Chem 13:463-71. 2005
    ..705 and a no-cross-validated regression coefficient r2 value of 0.949. Based on the derived model we identified new potential Oatp1a5 substrates and confirmed their predicted apparent affinity values experimentally...
  24. ncbi request reprint Identification of phalloidin uptake systems of rat and human liver
    Fabienne Meier-Abt
    Department of Medicine, Division of Clinical Pharmacology and Toxicology, University Hospital, Ramistr 100, CH 8091, Zurich, Switzerland
    Biochim Biophys Acta 1664:64-9. 2004
    ..Therefore, we conclude that rat Oatp1b2 as well as human OATP1B1 and OATP1B3 are responsible for phalloidin uptake into rat and human hepatocytes...
  25. ncbi request reprint Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells
    Oscar Briz
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Mol Pharmacol 61:853-60. 2002
    ..These results suggest a role for carriers of organic anions and cations in Bamet-R2 and Bamet-UD2 uptake, which may determine their ability to accumulate in liver tumor cells and/or be taken up and efficiently excreted by hepatocytes...

Research Grants5

  1. Molecular Characterization of Hepatic Organic Anion Transporting Polypeptides
    Bruno Hagenbuch; Fiscal Year: 2007
    ..Once this knowledge is available, there is the promise that it will be possible to develop safer medication which will result in less hospitalizations. ..
  2. Molecular Characterization of Hepatic Organic Anion Transporting Polypeptides
    Bruno Hagenbuch; Fiscal Year: 2009
    ..Once this knowledge is available, there is the promise that it will be possible to develop safer medication which will result in less hospitalizations. ..
  3. Molecular Characterization of Hepatic Organic Anion Transporting Polypeptides
    Bruno Hagenbuch; Fiscal Year: 2009
    ..Once this knowledge is available, there is the promise that it will be possible to develop safer medication which will result in less hospitalizations. ..
  4. Molecular Characterization of Hepatic Organic Anion Transporting Polypeptides
    Bruno Hagenbuch; Fiscal Year: 2010
    ..Once this knowledge is available, there is the promise that it will be possible to develop safer medication which will result in less hospitalizations. ..