G S Hageman

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint A role for local inflammation in the formation of drusen in the aging eye
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
    Am J Ophthalmol 134:411-31. 2002
  2. ncbi request reprint Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 78:243-56. 2004
  3. ncbi request reprint Late development of vitelliform lesions and flecks in a patient with best disease: clinicopathologic correlation
    Robert F Mullins
    Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Arch Ophthalmol 123:1588-94. 2005
  4. ncbi request reprint Age-related macular degeneration--emerging pathogenetic and therapeutic concepts
    Karen M Gehrs
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52240, USA
    Ann Med 38:450-71. 2006
  5. pmc A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
    Proc Natl Acad Sci U S A 102:7227-32. 2005
  6. ncbi request reprint Molecular composition of drusen as related to substructural phenotype
    G S Hageman
    The University of Iowa Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52240, USA
    Mol Vis 5:28. 1999
  7. pmc Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, The University of Iowa, 11190E PFP, 200 Hawkins Drive, Iowa City, Iowa 52240, USA
    Ann Med 38:592-604. 2006
  8. ncbi request reprint An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
    G S Hageman
    Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, PFP 11190E, 200 Hawkins Drive, The University of Iowa, Iowa City, IA 52240, USA
    Prog Retin Eye Res 20:705-32. 2001
  9. ncbi request reprint Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration
    S R Russell
    University of Iowa Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City 52242 1091, USA
    Am J Ophthalmol 129:205-14. 2000
  10. ncbi request reprint Organization of the human IMPG2 gene and its evaluation as a candidate gene in age-related macular degeneration and other retinal degenerative disorders
    M H Kuehn
    Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, 11190 PFP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Invest Ophthalmol Vis Sci 42:3123-9. 2001

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint A role for local inflammation in the formation of drusen in the aging eye
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
    Am J Ophthalmol 134:411-31. 2002
    ..Identifying the origin and molecular composition of these deposits, therefore, has been an important, yet elusive, objective for many decades. Recently, a more complete profile of the molecular composition of drusen has emerged...
  2. ncbi request reprint Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 78:243-56. 2004
    ..We characterized the ultrastructural organization and histochemical staining properties of these Abeta-containing elements in order to further assess their significance in drusen formation and AMD pathogenesis...
  3. ncbi request reprint Late development of vitelliform lesions and flecks in a patient with best disease: clinicopathologic correlation
    Robert F Mullins
    Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Arch Ophthalmol 123:1588-94. 2005
    ....
  4. ncbi request reprint Age-related macular degeneration--emerging pathogenetic and therapeutic concepts
    Karen M Gehrs
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52240, USA
    Ann Med 38:450-71. 2006
    ..The emergence of this new paradigm of AMD pathogenesis should hasten the development of novel diagnostic and therapeutic approaches for this disease that will dramatically improve the quality of our prolonged lifespan...
  5. pmc A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
    Proc Natl Acad Sci U S A 102:7227-32. 2005
    ..We propose that genetic variation in a regulator of the alternative complement pathway, when combined with a triggering event, such as infection, underlie a major proportion of AMD in the human population...
  6. ncbi request reprint Molecular composition of drusen as related to substructural phenotype
    G S Hageman
    The University of Iowa Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52240, USA
    Mol Vis 5:28. 1999
    ..It is anticipated that a more complete understanding of drusen composition, as it relates to phenotype, will provide significant new insight into the biology and etiology of various clinically manifested forms of AMD...
  7. pmc Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, The University of Iowa, 11190E PFP, 200 Hawkins Drive, Iowa City, Iowa 52240, USA
    Ann Med 38:592-604. 2006
    ..Aims and Methods. In this study, the structural and evolutionary relationships between these genes and AMD was refined using a combined genetic, molecular and immunohistochemical approach...
  8. ncbi request reprint An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
    G S Hageman
    Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, PFP 11190E, 200 Hawkins Drive, The University of Iowa, Iowa City, IA 52240, USA
    Prog Retin Eye Res 20:705-32. 2001
    ..It is our hope that other investigators will test, validate and/or refute various aspects of this hypothesis, and in so doing, increase our overall understanding of the biological pathways associated with early AMD...
  9. ncbi request reprint Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration
    S R Russell
    University of Iowa Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City 52242 1091, USA
    Am J Ophthalmol 129:205-14. 2000
    ..To determine whether basal laminar drusen differ in their location, ultrastructure, or composition from drusen associated with aging and age-related macular degeneration...
  10. ncbi request reprint Organization of the human IMPG2 gene and its evaluation as a candidate gene in age-related macular degeneration and other retinal degenerative disorders
    M H Kuehn
    Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, 11190 PFP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Invest Ophthalmol Vis Sci 42:3123-9. 2001
    ....
  11. pmc Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)
    M A Abrera-Abeleda
    Department of Otolaryngology, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    J Med Genet 43:582-9. 2006
    ....
  12. ncbi request reprint Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis
    R F Mullins
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City 52240, USA
    Eye 15:390-5. 2001
    ....
  13. ncbi request reprint Molecular characterization of the murine orthologue of the human retinal proteoglycan IPM 150
    M H Kuehn
    Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA 52240, USA
    Mol Vis 6:148-56. 2000
    ....
  14. ncbi request reprint Insoluble interphotoreceptor matrix in human vitreous after rhegmatogenous retinal detachment
    S R Russell
    Anheuser Busch Eye Institute, Department of Ophthalmology, St Louis University School of Medicine, Missouri, USA
    Am J Ophthalmol 123:386-91. 1997
    ..To determine whether insoluble interphotoreceptor matrix is present in the vitreous of human eyes after rhegmatogenous retinal detachment...
  15. ncbi request reprint Comparison of color to fluorescein angiographic images from patients with early-adult onset grouped drusen suggests drusen substructure
    Stephen R Russell
    Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 1091, USA
    Am J Ophthalmol 137:924-30. 2004
    ..To assess the nature of the corelike structures observed clinically, we evaluated color photographs and fluorescein angiograms from patients with early-adult onset grouped drusen (EAOGD)...
  16. ncbi request reprint New approaches to the treatment of dense deposit disease
    Richard J H Smith
    Department of Internal Medicine and Otolaryngology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    J Am Soc Nephrol 18:2447-56. 2007
    ..As the understanding of DDD increases, novel therapies should be integrated into existing protocols for DDD and evaluated using an open-label Bayesian study design...
  17. ncbi request reprint Molecular genetics of age-related macular degeneration
    E M Stone
    Department of Ophthalmology, The University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Hum Mol Genet 10:2285-92. 2001
    ..These studies, when combined with the power of genetic approaches, are likely to ultimately reveal a set of genes responsible for a sizeable fraction of AMD...
  18. ncbi request reprint A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy
    E M Stone
    The Department of Ophthalmology, The University of Iowa College of Medicine, Iowa City, USA
    Nat Genet 22:199-202. 1999
    ..Identification of this mutation may aid in the development of an animal model for drusen, as well as in the identification of other genes involved in human macular degeneration...
  19. ncbi request reprint Optic disc, foveal, and extrafoveal damage due to surgical separation of the vitreous
    S R Russell
    Department of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Dr, Room 11196 I, Iowa City, IA 52242, USA
    Arch Ophthalmol 119:1653-8. 2001
    ..To evaluate the morphologic outcomes resulting from surgical vitreoretinal separation in young adult primates...
  20. ncbi request reprint Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan
    M H Kuehn
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa 52240, USA
    Matrix Biol 18:509-18. 1999
    ..Characterization of IPM 150 proteoglycan core protein and identification of its site of synthesis are important steps towards understanding the architecture and biology of the IPM...
  21. ncbi request reprint Molecular characterization and genomic mapping of human IPM 200, a second member of a novel family of proteoglycans
    M H Kuehn
    Department of Ophthalmology and Visual Sciences, University of Iowa Center for Macular Degeneration, Iowa City 52240, USA
    Mol Cell Biol Res Commun 2:103-10. 1999
    ..IMPG2 maps to human chromosome 3q12.2-12.3. Based on homologies within their amino acid sequences we propose that IPM 200 and a previously described human proteoglycan, IPM 150, form a new family of extracellular matrix glycoconjugates...
  22. pmc Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degeneration
    N H Victor Chong
    Department of Ophthalmology and Visual Sciences, Center for Macular Degeneration, The University of Iowa, 11190E PFP, 200 Hawkins Dr, Iowa City, IA 52240, USA
    Am J Pathol 166:241-51. 2005
    ..These structural properties of the macular EL correspond spatially to the distribution of macular lesions associated with AMD and may help to explain why the macula is more susceptible to degenerative events that occur in this disease...
  23. ncbi request reprint Complement, age-related macular degeneration and a vision of the future
    Karen M Gehrs
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, USA
    Arch Ophthalmol 128:349-58. 2010
    ..Indeed, we are poised to witness a new era of a personalized approach toward the assessment, management, and treatment of this debilitating, chronic disease...
  24. pmc Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
    Bert Gold
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Nat Genet 38:458-62. 2006
    ..These data expand and refine our understanding of the genetic risk for AMD...
  25. ncbi request reprint Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein
    Matti Laine
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, FI 00014 Helsinki, Finland
    J Immunol 178:3831-6. 2007
    ....
  26. ncbi request reprint Fibroblast growth factor receptor (FGFR) and candidate signaling molecule distribution within rat and human retina
    Norbert Kinkl
    Institut fur Humangenetik, GSF Forschungszentrum, Ingoldstaedter Landstrasse 1, Neuherberg, D 85764, Germany
    Mol Vis 8:149-60. 2002
    ..To map the expression and distribution of FGFR and potential FGFR-related signaling molecules within rat and human retina...

Research Grants2

  1. Development of Complement Modulating Therapeutics for AMD
    Gregory Hageman; Fiscal Year: 2007
    ....