Research Topics
Genomes and Genes | G S HagemanSummaryAffiliation: University of Iowa Country: USA Publications
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Publications
A role for local inflammation in the formation of drusen in the aging eyeDon H Anderson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
Am J Ophthalmol 134:411-31. 2002..Identifying the origin and molecular composition of these deposits, therefore, has been an important, yet elusive, objective for many decades. Recently, a more complete profile of the molecular composition of drusen has emerged...- Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degenerationDon H Anderson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Exp Eye Res 78:243-56. 2004..We characterized the ultrastructural organization and histochemical staining properties of these Abeta-containing elements in order to further assess their significance in drusen formation and AMD pathogenesis... - Late development of vitelliform lesions and flecks in a patient with best disease: clinicopathologic correlationRobert F Mullins
Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
Arch Ophthalmol 123:1588-94. 2005..The distribution of bestrophin in the RPE suggests that the protein may be mistargeted in those with Best disease who have the Y227N mutation, and that this may be a cause of the associated RPE and photoreceptor dysfunction... - Age-related macular degeneration--emerging pathogenetic and therapeutic conceptsKaren M Gehrs
Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52240, USA
Ann Med 38:450-71. 2006..The emergence of this new paradigm of AMD pathogenesis should hasten the development of novel diagnostic and therapeutic approaches for this disease that will dramatically improve the quality of our prolonged lifespan... - A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degenerationGregory S Hageman
Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
Proc Natl Acad Sci U S A 102:7227-32. 2005..We propose that genetic variation in a regulator of the alternative complement pathway, when combined with a triggering event, such as infection, underlie a major proportion of AMD in the human population... - Molecular composition of drusen as related to substructural phenotypeG S Hageman
The University of Iowa Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52240, USA
Mol Vis 5:28. 1999..It is anticipated that a more complete understanding of drusen composition, as it relates to phenotype, will provide significant new insight into the biology and etiology of various clinically manifested forms of AMD... - Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implicationsGregory S Hageman
Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, The University of Iowa, 11190E PFP, 200 Hawkins Drive, Iowa City, Iowa 52240, USA
Ann Med 38:592-604. 2006..Aims and Methods. In this study, the structural and evolutionary relationships between these genes and AMD was refined using a combined genetic, molecular and immunohistochemical approach... - An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degenerationG S Hageman
Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, PFP 11190E, 200 Hawkins Drive, The University of Iowa, Iowa City, IA 52240, USA
Prog Retin Eye Res 20:705-32. 2001..It is our hope that other investigators will test, validate and/or refute various aspects of this hypothesis, and in so doing, increase our overall understanding of the biological pathways associated with early AMD... - Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degenerationS R Russell
University of Iowa Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City 52242 1091, USA
Am J Ophthalmol 129:205-14. 2000..To determine whether basal laminar drusen differ in their location, ultrastructure, or composition from drusen associated with aging and age-related macular degeneration... - Organization of the human IMPG2 gene and its evaluation as a candidate gene in age-related macular degeneration and other retinal degenerative disordersM H Kuehn
Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, 11190 PFP, 200 Hawkins Drive, Iowa City, IA 52242, USA
Invest Ophthalmol Vis Sci 42:3123-9. 2001.... - Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)M A Abrera-Abeleda
Department of Otolaryngology, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
J Med Genet 43:582-9. 2006.... - Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesisR F Mullins
Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City 52240, USA
Eye 15:390-5. 2001.... - Molecular characterization of the murine orthologue of the human retinal proteoglycan IPM 150M H Kuehn
Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA 52240, USA
Mol Vis 6:148-56. 2000.... - Insoluble interphotoreceptor matrix in human vitreous after rhegmatogenous retinal detachmentS R Russell
Anheuser Busch Eye Institute, Department of Ophthalmology, St Louis University School of Medicine, Missouri, USA
Am J Ophthalmol 123:386-91. 1997..To determine whether insoluble interphotoreceptor matrix is present in the vitreous of human eyes after rhegmatogenous retinal detachment... - Comparison of color to fluorescein angiographic images from patients with early-adult onset grouped drusen suggests drusen substructureStephen R Russell
Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 1091, USA
Am J Ophthalmol 137:924-30. 2004..To assess the nature of the corelike structures observed clinically, we evaluated color photographs and fluorescein angiograms from patients with early-adult onset grouped drusen (EAOGD)... - New approaches to the treatment of dense deposit diseaseRichard J H Smith
Department of Internal Medicine and Otolaryngology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
J Am Soc Nephrol 18:2447-56. 2007..As the understanding of DDD increases, novel therapies should be integrated into existing protocols for DDD and evaluated using an open-label Bayesian study design... - Molecular genetics of age-related macular degenerationE M Stone
Department of Ophthalmology, The University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Hum Mol Genet 10:2285-92. 2001..These studies, when combined with the power of genetic approaches, are likely to ultimately reveal a set of genes responsible for a sizeable fraction of AMD... - A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophyE M Stone
The Department of Ophthalmology, The University of Iowa College of Medicine, Iowa City, USA
Nat Genet 22:199-202. 1999..Identification of this mutation may aid in the development of an animal model for drusen, as well as in the identification of other genes involved in human macular degeneration... - Optic disc, foveal, and extrafoveal damage due to surgical separation of the vitreousS R Russell
Department of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Dr, Room 11196 I, Iowa City, IA 52242, USA
Arch Ophthalmol 119:1653-8. 2001..To evaluate the morphologic outcomes resulting from surgical vitreoretinal separation in young adult primates... - Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycanM H Kuehn
Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa 52240, USA
Matrix Biol 18:509-18. 1999..Characterization of IPM 150 proteoglycan core protein and identification of its site of synthesis are important steps towards understanding the architecture and biology of the IPM... - Molecular characterization and genomic mapping of human IPM 200, a second member of a novel family of proteoglycansM H Kuehn
Department of Ophthalmology and Visual Sciences, University of Iowa Center for Macular Degeneration, Iowa City 52240, USA
Mol Cell Biol Res Commun 2:103-10. 1999..IMPG2 maps to human chromosome 3q12.2-12.3. Based on homologies within their amino acid sequences we propose that IPM 200 and a previously described human proteoglycan, IPM 150, form a new family of extracellular matrix glycoconjugates... - Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degenerationN H Victor Chong
Department of Ophthalmology and Visual Sciences, Center for Macular Degeneration, The University of Iowa, 11190E PFP, 200 Hawkins Dr, Iowa City, IA 52240, USA
Am J Pathol 166:241-51. 2005..These structural properties of the macular EL correspond spatially to the distribution of macular lesions associated with AMD and may help to explain why the macula is more susceptible to degenerative events that occur in this disease... - Complement, age-related macular degeneration and a vision of the futureKaren M Gehrs
Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, USA
Arch Ophthalmol 128:349-58. 2010..Indeed, we are poised to witness a new era of a personalized approach toward the assessment, management, and treatment of this debilitating, chronic disease... - Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degenerationBert Gold
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
Nat Genet 38:458-62. 2006..These data expand and refine our understanding of the genetic risk for AMD... - Y402H polymorphism of complement factor H affects binding affinity to C-reactive proteinMatti Laine
Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, FI 00014 Helsinki, Finland
J Immunol 178:3831-6. 2007.... - Fibroblast growth factor receptor (FGFR) and candidate signaling molecule distribution within rat and human retinaNorbert Kinkl
Institut fur Humangenetik, GSF Forschungszentrum, Ingoldstaedter Landstrasse 1, Neuherberg, D 85764, Germany
Mol Vis 8:149-60. 2002..To map the expression and distribution of FGFR and potential FGFR-related signaling molecules within rat and human retina...
Research Grants
- Development of Complement Modulating Therapeutics for AMDGregory Hageman; Fiscal Year: 2007....