Research Topics
Genomes and Genes
Species | James M HagbergSummaryAffiliation: University of Maryland Country: USA Publications
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Detail Information
Publications
VO2 max is associated with ACE genotype in postmenopausal womenJ M Hagberg
Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Appl Physiol 85:1842-6. 1998..However, this difference is the result of genotype-dependent differences in maximal a-vDO2 and not of maximal stroke volume and maximal cardiac output...- ACE insertion/deletion polymorphism and submaximal exercise hemodynamics in postmenopausal womenJames M Hagberg
Division of Cardiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Appl Physiol 92:1083-8. 2002..Thus the common ACE locus polymorphic variation is associated with many submaximal exercise cardiovascular hemodynamic responses... - Specific genetic markers of endurance performance and VO2maxJ M Hagberg
Department of Kinesiology, University of Maryland, College Park, Maryland, USA
Exerc Sport Sci Rev 29:15-9. 2001..A recent genome-wide scan study also has provided candidate loci requiring further study... - APO E gene and gene-environment effects on plasma lipoprotein-lipid levelsJ M Hagberg
Department of Kinesiology, University of Maryland, College Park, Maryland 20742 2611, USA
Physiol Genomics 4:101-108. 2000.... - Determinants of body composition in postmenopausal womenJ M Hagberg
Division of Cardiology, University of Pittsburgh Medical Center, Pennsylvania, USA
J Gerontol A Biol Sci Med Sci 55:M607-12. 2000.... - The role of exercise training in the treatment of hypertension: an updateJ M Hagberg
Department of Kinesiology, University of Maryland, College Park 20742 2611, USA
Sports Med 30:193-206. 2000..These results continue to support the recommendation that exercise training is an important initial or adjunctive step that is highly efficacious in the treatment of individuals with mild to moderate elevations in BP... - Exercise training-induced blood pressure and plasma lipid improvements in hypertensives may be genotype dependentJ M Hagberg
Department of Kinesiology, University of Maryland, College Park, MD, USA
Hypertension 34:18-23. 1999..These results are consistent with the possibility that apoE, ACE, and LPL genotypes may identify hypertensives who will improve blood pressure, lipoprotein lipids, and cardiovascular disease risk the most with exercise training... - Physical activity, hormone replacement therapy and plasma lipoprotein-lipid levels in postmenopausal womenJ M Hagberg
Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Int J Sports Med 24:22-9. 2003.... 
Endurance exercise training effects on body fatness, VO2max, HDL-C subfractions, and glucose tolerance are influenced by a PLIN haplotype in older CaucasiansNathan T Jenkins
Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742 2611, USA
J Appl Physiol 108:498-506. 2010..Furthermore, these data contribute to the growing understanding of PLIN as a candidate gene for human obesity and the cardiometabolic consequences of excess adiposity...- FABP2 Ala54Thr genotype is associated with glucoregulatory function and lipid oxidation after a high-fat meal in sedentary nondiabetic men and womenEdward P Weiss
Department of Kinesiology, University of Maryland, College Park, MD, USA
Am J Clin Nutr 85:102-8. 2007..However, most of those studies have not accounted for the interactive and potentially confounding effects of habitual physical activity and diet... - Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adultsBrian D Hand
Dept of Kinesiology, Univ of Maryland, College Park, MD 20742, USA
J Appl Physiol 103:1678-87. 2007..These data suggest that two of the three IGF pathway gene polymorphisms identified in this study influence muscle phenotypic responses to ST in both black and white older men and women... - Beta2- and beta3-adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal womenSteve D McCole
Division of Cardiology, University of Pittsburgh, Pennsylvania 15213, USA
J Appl Physiol 96:526-30. 2004.... - Angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopausal womenSteve D McCole
Division of Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Physiol Genomics 10:63-9. 2002.... - Association between body fat response to exercise training and multilocus ADR genotypesDana A Phares
Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
Obes Res 12:807-15. 2004..To examine the contribution of adrenergic receptor (ADR) gene polymorphisms and their gene-gene interactions to the variability of exercise training-induced body fat response... - C-reactive protein genotype affects exercise training-induced changes in insulin sensitivityThomas O Obisesan
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
Metabolism 55:453-60. 2006.... - Influence of the interleukin-6 -174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexesJennifer A McKenzie
Dept of Kinesiology, Univ of Maryland, College Park, MD 20742 2611, USA
J Appl Physiol 97:1338-42. 2004..In conclusion, fasting glucose and the extent to which glucose tolerance changes with exercise training may be influenced by the IL-6 -174 gene polymorphism... - Relationship between circulating progenitor cells, vascular function and oxidative stress with long-term training and short-term detraining in older menSarah Witkowski
Department of Kinesiology, University of Maryland College Park School of Public Health, College Park, MD 20742, U S A
Clin Sci (Lond) 118:303-11. 2010..These results reveal that changes in reactive hyperaemic FBF are closely related to activity dependent dynamic changes in CD34+/VEGFR2+ cell number, which may be influenced by alterations in oxidative stress... - Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertensionDeborah L Feairheller
Hypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, Philadelphia, PA 19122, USA
Med Sci Sports Exerc 41:1421-8. 2009..The involvement of genetic variation in the p22phox (CYBA) subunit genes in individual oxidative stress responses to aerobic exercise training has yet to be examined in Pre and Stage 1 hypertensives... - Prior endurance exercise prevents postprandial lipaemia-induced increases in reactive oxygen species in circulating CD31+ cellsNathan T Jenkins
Department of Kinesiology, School of Public Health, University of Maryland College Park, College Park, MD 20742 2611, USA
J Physiol 589:5539-53. 2011..The mechanisms underlying the effects of exercise on CAC function appear to vary among specific CAC types... - Aerobic exercise training increases circulating insulin-like growth factor binding protein-1 concentration, but does not attenuate the reduction in circulating insulin-like growth factor binding protein-1 after a high-fat mealSteven J Prior
Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Metabolism 61:310-6. 2012.... - Effects of acute and chronic endurance exercise on intracellular nitric oxide and superoxide in circulating CD34⁺ and CD34⁻ cellsNathan T Jenkins
Dept of Kinesiology, Univ of Maryland, College Park, MD, USA
J Appl Physiol 111:929-37. 2011..Overall, our data suggest an association between the sedentary state and increased nitro-oxidative stress in CD34⁺ cells... - Independent and combined influence of AGTR1 variants and aerobic exercise on oxidative stress in hypertensivesNicola Fenty-Stewart
Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD, USA
Blood Press 18:204-12. 2009..01) with AEXT in individuals with two risk alleles only. Our findings suggest that variation in the AGTR1 gene is associated with differential changes in plasma AngII but not oxidative stress... - Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levelsTina E Brinkley
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
Exp Physiol 93:1085-90. 2008..These associations remained significant after adjusting for age, sex, race and body mass index. In conclusion, variation in the LOX-1 gene is associated with plasma sLOX-1 levels in older men and women... - Plasma fetuin-A concentrations in young and older high- and low-active menNathan T Jenkins
Department of Kinesiology, School of Public Health, University of Maryland College Park, MD 20742, USA
Metabolism 60:265-71. 2011..Therefore, the maintenance of low levels of circulating fetuin-A may be a novel mechanism contributing to enhanced insulin sensitivity with regular physical activity... - High-density lipoprotein-cholesterol, its subfractions, and responses to exercise training are dependent on endothelial lipase genotypeAmy Halverstadt
Department of Kinesiology, University of Maryland, College Park 20742-2611, USA
Metabolism 52:1505-11. 2003..2 +/- 0.8 v 0.5 +/- 0.6 mg/dL; P=.08) in the CC compared to the CT/TT group. We conclude that the LIPG genotype is associated with interindividual variability in HDL-C and its subfractions and their response to exercise training... - Hemostatic response to postprandial lipemia before and after exercise trainingChad M Paton
Department of Kinesiology, University of Maryland, College Park, USA
J Appl Physiol 101:316-21. 2006..We conclude that aerobic exercise training reduces the potential for coagulation, improves fibrinolytic potential, and reduces leukocyte TNF-alpha gene expression after the ingestion of a high-fat meal... - Endurance training-induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator-activated receptor-gamma2 Pro12Ala genotype in men but not in womenEdward P Weiss
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
Metabolism 54:97-102. 2005..However, these men are particularly responsive with respect to the magnitude of endurance training-induced improvement in insulin action... - APOE genotype affects black-white responses of high-density lipoprotein cholesterol subspecies to aerobic exercise trainingThomas O Obisesan
Department of Kinesiology, University of Maryland College Park, MD 21201, USA
Metabolism 57:1669-76. 2008..APOE2/3 blacks may benefit more from aerobic fitness to reduce cardiovascular risk... - Interleukin-6 genotype is associated with high-density lipoprotein cholesterol responses to exercise trainingAmy Halverstadt
Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
Biochim Biophys Acta 1734:143-51. 2005..The interleukin-6 (IL6)-174G/C polymorphism may be associated with HDL-C levels. We hypothesized that the IL6-174G/C polymorphism would be associated with plasma HDL-C response to exercise training... - NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensivesJoon Young Park
Department of Kinesiology, College of Health Professions, Temple University, Philadelphia, Pennsylvania 19122, USA
Am J Physiol Heart Circ Physiol 293:H2320-7. 2007..We conclude that the (-94)NFKB1 I/D promoter variation contributes to the modulation of vascular function and adaptability to exercise-induced flow shear stress, most likely due to differences in NFKB1 gene transactivity... 
Advances in exercise, fitness, and performance genomics in 2011Stephen M Roth
Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD, USA
Med Sci Sports Exerc 44:809-17. 2012..We conclude that a strong exercise genomics corpus of evidence would not only translate into powerful genomic predictors but also have a major effect on exercise biology and exercise behavior research...- Hepatic lipase gene -514C>T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipaseTina E Brinkley
Dept of Kinesiology, Univ of Maryland, College Park, MD 20742 2611, USA
J Appl Physiol 111:1871-6. 2011.... - Plasma nitrate/nitrite response to an oral glucose load and the effect of endurance trainingEdward P Weiss
Department of Kinesiology, University of Maryland, College Park, MD, USA
Metabolism 53:673-9. 2004.... - Sequence variation in hypoxia-inducible factor 1alpha (HIF1A): association with maximal oxygen consumptionSteven J Prior
Department of Kinesiology, University of Maryland, College Park, Maryland 20742, USA
Physiol Genomics 15:20-6. 2003..Based on these findings, we conclude that HIF1A sequence variation is associated with VO2 max before and after aerobic exercise training in older humans... - Thrombin and exercise similarly influence expression of cell cycle genes in cultured putative endothelial progenitor cellsMichael M Lockard
Department of Kinesiology, University of Maryland College Park School of Public Health, College Park, MD 20742 2611, USA
J Appl Physiol 108:1682-90. 2010..Exercise-induced changes in putative EPC gene expression are associated with thrombin production and may be modulated by long-term exercise training... - Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic trainingKarma M Rabon-Stith
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
Exp Physiol 90:653-61. 2005..058) compared to f homozygotes. There were no significant genotype relationships in the AT group. These data indicate that VDR FokI genotype may influence femoral neck BMD response to ST, but not AT... - Enhancing treatment for cardiovascular disease: exercise and circulating angiogenic cellsSarah Witkowski
The University of Massachusetts, Department of Kinesiology, Amherst, MA 01003, USA
Exerc Sport Sci Rev 39:93-101. 2011..We will describe the influence of acute exercise and exercise training on CAC characteristics and evidence for mechanisms that may be important in the optimization of CAC potential... - NADPH oxidase p22phox gene variants are associated with systemic oxidative stress biomarker responses to exercise trainingJoon Young Park
Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
J Appl Physiol 99:1905-11. 2005..05). We found that p22phox polymorphisms, especially A640G, were associated with differential changes in systemic oxidative stress with aerobic exercise training... - Changes in high-density lipoprotein-cholesterol subfractions with exercise training may be dependent on cholesteryl ester transfer protein (CETP) genotypeKenneth R Wilund
Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
Metabolism 51:774-8. 2002..Thus, CETP genotype may contribute to the interindividual differences in plasma HDL-C subfraction changes occurring with endurance exercise training in sedentary middle- to older-aged men and women... - Human gender differences in fibrinolytic responses to exercise training and their determinantsOnanong Kulaputana
Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA
Exp Physiol 90:881-7. 2005..These findings suggest that training-induced improvements in endogenous fibrinolysis markers are somewhat greater in men compared to women and may be more strongly associated with abdominal obesity in men... - DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumptionSteven J Prior
Department of Kinesiology, University of Maryland, College Park, Maryland, USA
Am J Physiol Heart Circ Physiol 290:H1848-55. 2006..These results have potential implications for aerobic exercise training and may prove relevant in the study of pathological conditions that can be affected by angiogenesis, such as coronary artery disease and peripheral artery disease... - Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and womenAmy Halverstadt
Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
Metabolism 56:444-50. 2007..1+/-0.0 nm, P=.04). These results show that 24 weeks of endurance exercise training induced favorable changes in plasma lipoprotein and lipid profiles independent of diet and baseline or change in body fat... - C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levelsThomas O Obisesan
Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
Arterioscler Thromb Vasc Biol 24:1874-9. 2004..The goal of this study is to determine whether C-reactive protein (CRP) gene variants affect baseline and training-induced changes in plasma CRP levels... - Aerobic training effects on glucose tolerance in prediabetic and normoglycemic humansNathan T Jenkins
Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742 2611, USA
Med Sci Sports Exerc 43:2231-40. 2011.... - Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal womenTina E Brinkley
Department of Kinesiology, University of Maryland, College Park, Maryland, USA
Obesity (Silver Spring) 16:1454-6. 2008..In conclusion, obese women have higher sLOX-1 levels, which may reflect increased LOX-1 expression in adipose tissue... - Fatty acid binding protein-2 gene variants and insulin resistance: gene and gene-environment interaction effectsEdward P Weiss
Department of Kinesiology, University of Maryland, College Park 20742-2611, USA
Physiol Genomics 10:145-57. 2002..These results highlight the importance of including behavioral and environmental factors in the design of studies seeking to assess the impact of genes on physiological and clinical outcome phenotypes... - The effect of endurance exercise training on plasma lipoprotein AI and lipoprotein AI:AII concentrations in sedentary adultsKenneth R Wilund
Department of Kinesiology, University of Maryland College Park, College Park, MD, USA
Metabolism 51:1053-60. 2002.... - Do genetic variations alter the effects of exercise training on cardiovascular disease and can we identify the candidate variants now or in the future?James M Hagberg
Dept of Kinesiology, School of Public Health, Univ of Maryland, College Park, MD 20742 2611, USA
J Appl Physiol 111:916-28. 2011.... - Selected genetic polymorphisms and plasma coagulation factor VII changes with exercise trainingIoana A Ghiu
Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
J Appl Physiol 96:985-90. 2004..045). We conclude that plasma FVII-Ag changes with exercise training are more closely related to selected lipid-related genotypes than FVII gene promoter variants... - Advances in exercise, fitness, and performance genomics in 2010James M Hagberg
Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD, USA
Med Sci Sports Exerc 43:743-52. 2011..We conclude that progress is being made but that high-quality research designs and replication studies with large sample sizes are urgently needed... - Effects of acute and chronic endurance exercise on intracellular nitric oxide in putative endothelial progenitor cells: role of NAPDH oxidaseNathan T Jenkins
Department of Kinesiology, School of Public Health, University of Maryland College Park College Park, MD 20742, USA
Am J Physiol Heart Circ Physiol 297:H1798-805. 2009..However, differences due to chronic exercise must involve additional factors. Our findings support exercise as a means to improve putative EPC function and suggest a novel mechanism that may explain this effect... - Identification of a novel mutation combination in factor XIII deficiency: genetic update to the first reported case in the United StatesAmy Halverstadt
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
Int J Hematol 83:144-6. 2006.... - Exercise training-induced changes in coagulation factors in older adultsMichael M Lockard
Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
Med Sci Sports Exerc 39:587-92. 2007..Aerobic training is known to reduce CVD risk, and an improved coagulation profile may contribute to this reduction... - The relationship of age and cardiovascular fitness to cognitive and motor processesCharles H Hillman
Department of Kinesiology, University of Maryland, College Park, USA
Psychophysiology 39:303-12. 2002..Therefore, physical fitness is associated with attenuation of cognitive decline in older individuals and greater economy of motor preparation for both young and older participants... - Association between KCNJ11 E23K genotype and cardiovascular and glucose metabolism phenotypes in older men and womenYang Yi
Institute of Health Science, Wuhan Institute of Physical Education, Wuhan 430079, China
Exp Physiol 93:95-103. 2008..However, this variant has no significant effect on training-induced CV and glucose and insulin metabolism adaptations... - The human gene map for performance and health-related fitness phenotypes: the 2004 updateBernd Wolfarth
Department of Preventive and Rehabilitative Sports Medicine, Technical University Munich, Munich, Germany
Med Sci Sports Exerc 37:881-903. 2005..But exercise science and sports medicine is generally lagging behind in terms of utilizing the advances in genetic and genomic technologies... - Reduction in midthigh low-density muscle with aerobic exercise training and weight loss impacts glucose tolerance in older menSteven J Prior
Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 92:880-6. 2007..Intramuscular lipid content increases with aging and obesity and is directly related to impaired glucose tolerance and insulin resistance... - The human gene map for performance and health-related fitness phenotypes: the 2005 updateTuomo Rankinen
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808-4124, USA
Med Sci Sports Exerc 38:1863-88. 2006.... - Progenitor cells and age: can we fight aging with exercise?Sarah Witkowski
J Appl Physiol 102:834-5. 2007 - Abdominal adiposity is a stronger predictor of insulin resistance than fitness among 50-95 year oldsSusan B Racette
Washington University School of Medicine, Campus Box 8502, 4444 Forest Park Avenue, St Louis, MO 63108 2212, USA
Diabetes Care 29:673-8. 2006..The aim of this study was to determine whether cardiovascular fitness, whole-body adiposity, or abdominal adiposity is the strongest predictor of insulin resistance into old age...