S Haffner

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial
    Robert M Califf
    Duke Transitional Medicine Institute, Durham, NC 27715, USA
    Am Heart J 156:623-32. 2008
  2. ncbi request reprint Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men?
    S M Haffner
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Obes Res 7:164-9. 1999
  3. ncbi request reprint Pre-diabetes, insulin resistance, inflammation and CVD risk
    Steven M Haffner
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, DTL, Room 5 606U, Mail Code 7873, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Diabetes Res Clin Pract 61:S9-S18. 2003
  4. ncbi request reprint Risk constellations in patients with the metabolic syndrome: epidemiology, diagnosis, and treatment patterns
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Med 119:S3-9. 2006
  5. ncbi request reprint Metabolic syndrome - a new risk factor of coronary heart disease?
    S Haffner
    University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Diabetes Obes Metab 5:359-70. 2003
  6. ncbi request reprint Diabetes and the metabolic syndrome--when is it best to intervene to prevent?
    Steven Haffner
    Department of Medicine, The University of Texas, Health Science Center of San Antonio, San Antonio, TX 78229 3900, USA
    Atheroscler Suppl 7:3-10. 2006
  7. ncbi request reprint Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus
    Steven M Haffner
    University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
    Circulation 106:679-84. 2002
  8. ncbi request reprint Rationale for new American Diabetes Association Guidelines: are national cholesterol education program goals adequate for the patient with diabetes mellitus?
    Steven Haffner
    University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Am J Cardiol 96:33E-36E. 2005
  9. ncbi request reprint The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Am J Cardiol 97:3A-11A. 2006
  10. ncbi request reprint Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: subgroup analyses in the Scandinavian Simvastatin Survival Study
    S M Haffner
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Arch Intern Med 159:2661-7. 1999

Research Grants

  1. The Look AHEAD Continuation: Action for Health in Diabetes
    Steven Haffner; Fiscal Year: 2007
  2. Post-DPP Follow-Up Study
    Steven Haffner; Fiscal Year: 2007
  3. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Steven Haffner; Fiscal Year: 2007
  4. IRAS FAMILY STUDY: GENETICS OF INSULIN RESISTANCE
    Steven Haffner; Fiscal Year: 2003
  5. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003

Detail Information

Publications94

  1. ncbi request reprint Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial
    Robert M Califf
    Duke Transitional Medicine Institute, Durham, NC 27715, USA
    Am Heart J 156:623-32. 2008
    ..The study was designed to evaluate whether reducing postprandial hyperglycemia, blockade of the renin-angiotensin-aldosterone system, or both interventions reduce the risk of T2DM or cardiovascular events in patients with IGT...
  2. ncbi request reprint Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men?
    S M Haffner
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Obes Res 7:164-9. 1999
    ..Recently, leptin, a hormone that regulates appetite, has been associated with both obesity and insulin resistance. However, the possible relation of leptin to the insulin resistance syndrome has been controversial...
  3. ncbi request reprint Pre-diabetes, insulin resistance, inflammation and CVD risk
    Steven M Haffner
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, DTL, Room 5 606U, Mail Code 7873, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Diabetes Res Clin Pract 61:S9-S18. 2003
    ..Statins also reduce CRP levels. Efforts to reduce CVD should include increased emphasis on improving glycaemic control, preventing development of diabetes and addressing cardiovascular risk factors in the pre-diabetic state...
  4. ncbi request reprint Risk constellations in patients with the metabolic syndrome: epidemiology, diagnosis, and treatment patterns
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Med 119:S3-9. 2006
    ..The program comprises ONTARGET and the Telmisartan Randomized Assessment Study in ACE-Intolerant Subjects with Cardiovascular Disease (TRANSCEND)...
  5. ncbi request reprint Metabolic syndrome - a new risk factor of coronary heart disease?
    S Haffner
    University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Diabetes Obes Metab 5:359-70. 2003
  6. ncbi request reprint Diabetes and the metabolic syndrome--when is it best to intervene to prevent?
    Steven Haffner
    Department of Medicine, The University of Texas, Health Science Center of San Antonio, San Antonio, TX 78229 3900, USA
    Atheroscler Suppl 7:3-10. 2006
    ..The data are unequivocal in the importance of the timely identification of at-risk subjects, and implementation of effective treatment strategies, which could potentially reduce diabetes- and CVD-related morbidity and mortality...
  7. ncbi request reprint Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus
    Steven M Haffner
    University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
    Circulation 106:679-84. 2002
    ....
  8. ncbi request reprint Rationale for new American Diabetes Association Guidelines: are national cholesterol education program goals adequate for the patient with diabetes mellitus?
    Steven Haffner
    University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Am J Cardiol 96:33E-36E. 2005
    ..Additionally, as reported in the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE-IT) study, high-dose lipid-lowering therapy has been shown to further reduce CAD event rates compared with conventional therapy...
  9. ncbi request reprint The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Am J Cardiol 97:3A-11A. 2006
    ..Further studies are required to identify a widely accepted criterion for the syndrome that will optimally predict the risk of diabetes and CVD. It is possible that such a definition will include a measure of inflammation...
  10. ncbi request reprint Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: subgroup analyses in the Scandinavian Simvastatin Survival Study
    S M Haffner
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Arch Intern Med 159:2661-7. 1999
    ..In a previous report from the Scandinavian Simvastatin Survival Study using a clinical case definition of DM (n = 202), simvastatin-treated patients had significantly fewer CHD events compared with placebo-treated control subjects...
  11. ncbi request reprint Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state
    S M Haffner
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Circulation 101:975-80. 2000
    ..However, it is not known whether these atherogenic changes in the prediabetic state are predominantly due to insulin resistance, decreased insulin secretion, or both...
  12. ncbi request reprint Obesity and the metabolic syndrome: the San Antonio Heart Study
    S M Haffner
    Department of Medicine, University of Texas Health Science Center at San Antonio 78229 3900, USA
    Br J Nutr 83:S67-70. 2000
    ..We have recently shown that only prediabetic subjects (those who later develop type 2 diabetes) who are insulin resistant and with upper body adiposity have increased triglycerides, decreased HDL cholesterol and high blood pressure...
  13. ncbi request reprint Epidemic obesity and the metabolic syndrome
    Steven Haffner
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Circulation 108:1541-5. 2003
  14. ncbi request reprint Introduction
    Steven M Haffner
    San Antonio, TX 78229, USA
    Postgrad Med 114:4-6. 2003
    ..ATP II reaffirmed that the level of CHD risk should determine the type and intensity of LDL-C-lowering therapy...
  15. ncbi request reprint Statin therapy for the treatment of diabetic dyslipidemia
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center at San Antonio, Texas 78284 7873, USA
    Diabetes Metab Res Rev 19:280-7. 2003
    ....
  16. ncbi request reprint Insulin resistance, inflammation, and the prediabetic state
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Am J Cardiol 92:18J-26J. 2003
    ..Rosiglitazone, an agent with insulin-sensitizing properties, decreases PAI-1 and CRP levels. Some of the adverse cardiovascular effects seen in patients with type 2 diabetes may be reversed by insulin-sensitizing agents...
  17. ncbi request reprint Relationship of metabolic risk factors and development of cardiovascular disease and diabetes
    Steven M Haffner
    Department of Medicine and Clinical Epidemiology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Obesity (Silver Spring) 14:121S-127S. 2006
    ....
  18. ncbi request reprint Abdominal adiposity and cardiometabolic risk: do we have all the answers?
    Steven M Haffner
    Department of Medicine and Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas 78240, USA
    Am J Med 120:S10-6; discussion S16-7. 2007
    ....
  19. ncbi request reprint Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes Care 26:2796-803. 2003
    ..To determine the meaning of S(i) = 0 derived from the frequently sampled intravenous glucose tolerance test...
  20. ncbi request reprint Glucose-tolerance testing in acute myocardial infarction
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Lancet 359:2127-8. 2002
  21. ncbi request reprint Lipoprotein disorders associated with type 2 diabetes mellitus and insulin resistance
    Steven M Haffner
    Department of Medicine, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Am J Cardiol 90:55i-61i. 2002
    ..An interesting future clinical trial would be to assess whether fibric acids make an additional contribution to reduce CAD in patients already on statin therapy...
  22. ncbi request reprint Carotid artery atherosclerosis in type-2 diabetic and nondiabetic subjects with and without symptomatic coronary artery disease (The Insulin Resistance Atherosclerosis Study)
    S M Haffner
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Am J Cardiol 85:1395-400. 2000
    ..These results support the suggestion that diabetic subjects should be treated as aggressively for cardiovascular risk factor management as subjects with pre-existing CAD...
  23. ncbi request reprint The relation of body fat mass and distribution to markers of chronic inflammation
    A Festa
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Texas, USA
    Int J Obes Relat Metab Disord 25:1407-15. 2001
    ..These associations were not explained by lower S(I) in obese subjects. Chronic, subclinical inflammation may be one pathophysiological mechanism explaining the increased risk of atherosclerotic disease associated with adiposity...
  24. ncbi request reprint Eight-year incidence of hypertension in Mexican-Americans and non-Hispanic whites. The San Antonio Heart Study
    S M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7873
    Am J Hypertens 5:147-53. 1992
    ..The cause of the relative protection from hypertension in MAs is unknown...
  25. doi request reprint Metabolic syndrome and alanine aminotransferase: a global perspective from the NAVIGATOR screening population
    M A Bethel
    Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Diabet Med 26:1204-11. 2009
    ....
  26. ncbi request reprint Insulin and 2-hour glucose levels are inversely related to Lp(a) concentrations controlled for LPA genotype
    D L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Tex 78245 0549, USA
    Arterioscler Thromb Vasc Biol 18:1335-41. 1998
    ..Thus, the results demonstrate that glucose-intolerant individuals have significantly lower residual Lp(a) concentrations and a significant increase of residual apo(a) size...
  27. ncbi request reprint Apolipoprotein B (apo B) signal peptide length polymorphisms are associated with apo B, low density lipoprotein cholesterol, and glucose levels in Mexican Americans
    C M Kammerer
    Genetics Department, Southwest Foundation for Biomedical Research, San Antonio, TX 78228 0147, USA
    Atherosclerosis 120:37-45. 1996
    ..Apo B signal peptide length polymorphism accounted for 4.2%, 3.5%, and 3.0% of the residual variation in LDL-C, apo B, and 2-h glucose levels, respectively, among the Mexican American families...
  28. ncbi request reprint C-reactive protein is more strongly related to post-glucose load glucose than to fasting glucose in non-diabetic subjects; the Insulin Resistance Atherosclerosis Study
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, TX 78228 3900, USA
    Diabet Med 19:939-43. 2002
    ..We hypothesized that subclinical inflammation, as indicated by elevated serum levels of C-reactive protein (CRP), may partially explain the association of cardiovascular disease with post-challenge glycaemia...
  29. ncbi request reprint Reversion from type 2 diabetes to nondiabetic status. Influence of the 1997 American Diabetes Association criteria
    J P Burke
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7873, USA
    Diabetes Care 21:1266-70. 1998
    ..Individuals who revert have been problematic for those developing criteria for the diagnosis of type 2 diabetes. Few studies have addressed this issue using 1979 National Diabetes Data Group/1980 World Health Organization (WHO) criteria...
  30. doi request reprint Risk of type 2 diabetes among individuals with high and low glomerular filtration rates
    C Lorenzo
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7873, USA
    Diabetologia 52:1290-7. 2009
    ..Metabolic abnormalities frequently develop prior to the diagnosis of type 2 diabetes and chronic kidney disease. However, it is not known whether GFR predicts the onset of type 2 diabetes...
  31. ncbi request reprint Detection and treatment of hypercholesterolemia in a biethnic community, 1979-1985
    J A Pugh
    Department of Medicine, University of Texas Health Science Center at San Antonio
    J Gen Intern Med 3:331-6. 1988
    ..Mexican-Americans were less likely to be aware of their hypercholesterolemia than non-Hispanic whites, but both ethnic groups had low levels of treatment...
  32. ncbi request reprint The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects
    L Mykkanen
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284, USA
    Diabetes 46:1990-5. 1997
    ..These results suggest that, in subjects with normal glucose tolerance, insulin resistance does not induce increased proinsulin relative to insulin secretion, but rather is associated with enhanced processing of proinsulin...
  33. ncbi request reprint Genetic relationship between measures of HDL phenotypes and insulin concentrations
    D L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Arterioscler Thromb Vasc Biol 17:3414-9. 1997
    ..Thus, these results suggest the existence of genes that pleiotropically influence variation in both HDLs and insulin levels and therefore contribute to the clustering of proatherogenic traits in the IRS...
  34. ncbi request reprint Genetic and environmental correlations among hormone levels and measures of body fat accumulation and topography
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228, USA
    J Clin Endocrinol Metab 81:597-600. 1996
    ..However, we also show that it is possible for significant genetic and environmental correlations to interact in such a way as to produce a phenotypic correlation that itself would not be considered significant...
  35. ncbi request reprint Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, TX 78284 7873, USA
    Arterioscler Thromb Vasc Biol 19:562-8. 1999
    ..These findings may have important clinical implications in the risk assessment and prevention of macrovascular disease, not only in patients with overt diabetes but also in nondiabetic subjects who are hyperinsulinemic...
  36. ncbi request reprint Low-density lipoprotein particle size is inversely related to plasminogen activator inhibitor-1 levels. The Insulin Resistance Atherosclerosis Study
    A Festa
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, TX, USA
    Arterioscler Thromb Vasc Biol 19:605-10. 1999
    ..The demonstrated inverse relation of LDL size and PAI-1 levels provides one possible explanation for the atherogeneity of small dense LDL particles...
  37. ncbi request reprint Trp64Arg polymorphism of the beta3-adrenergic receptor gene in pregnancy: association with mild gestational diabetes mellitus
    A Festa
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284 7873, USA
    J Clin Endocrinol Metab 84:1695-9. 1999
    ..The association with mild gestational diabetes suggests that the impact of the polymorphism may be clinically important during pregnancy, a state of physiological insulin resistance...
  38. ncbi request reprint Is QT interval a marker of subclinical atherosclerosis in nondiabetic subjects? The Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, USA
    Stroke 30:1566-71. 1999
    ..Prolonged heart rate-corrected QT interval is an unfavorable prognostic factor of cardiovascular morbidity and mortality, and QT interval prolongation may be the result of atherosclerosis...
  39. ncbi request reprint LDL particle size in relation to insulin, proinsulin, and insulin sensitivity. The Insulin Resistance Atherosclerosis Study
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7873
    Diabetes Care 22:1688-93. 1999
    ....
  40. ncbi request reprint Relative hypoleptinaemia in women with mild gestational diabetes mellitus
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Diabet Med 16:656-62. 1999
    ..Leptin is synthesized in the human placenta. The aim of this study was to relate serum leptin levels during pregnancy to glucose tolerance, body mass index (BMI) and specific metabolic variables, such as specific insulin and proinsulin...
  41. ncbi request reprint Was the historic contribution of Spain to the Mexican gene pool partially responsible for the higher prevalence of type 2 diabetes in mexican-origin populations? The Spanish Insulin Resistance Study Group, the San Antonio Heart Study, and the Mexico City
    C Lorenzo
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Diabetes Care 24:2059-64. 2001
    ..However, the higher prevalence of type 2 diabetes in Mexican-origin populations might be related, in part, not to Native American genetic admixture but to Spanish genetic admixture...
  42. ncbi request reprint Microalbuminuria and carotid artery intima-media thickness in nondiabetic and NIDDM subjects. The Insulin Resistance Atherosclerosis Study (IRAS)
    L Mykkanen
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7873, USA
    Stroke 28:1710-6. 1997
    ..We investigated the relationship between microalbuminuria and carotid artery IMT in 991 nondiabetic and 450 NIDDM subjects aged 40 to 69 years...
  43. ncbi request reprint NMR identifies atherogenic lipoprotein abnormalities in early diabetic nephropathy that are unrecognized by conventional analysis
    H Z Al-Shahrouri
    Division of Clinical Nephrology Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
    Clin Nephrol 73:180-9. 2010
    ..The aim of this study was to investigate the relationship between lipoproteins and early manifestations of CKD in the 517 Type 2 diabetes mellitus (T2DM) patients who participated in the Insulin Resistance Atherosclerosis Study (IRAS)...
  44. ncbi request reprint Impact of diabetes on mortality after the first myocardial infarction. The FINMONICA Myocardial Infarction Register Study Group
    H Miettinen
    Department of Medicine, University of Texas Health Science Center at San Antonio, USA
    Diabetes Care 21:69-75. 1998
    ..To study diabetic and nondiabetic patients with their first myocardial infarction to determine overall 1-year mortality, out-of-hospital mortality, 28-day mortality of hospitalized patients, and 1-year mortality of 28-day survivors...
  45. ncbi request reprint Genetic correlations between lipoprotein phenotypes and indicators of sex hormone levels in Mexican Americans
    C E Jaquish
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78228 0147, USA
    Atherosclerosis 122:117-25. 1996
    ..Thus, at least three separate groups of genes influence HDL-C levels in Mexican Americans: one group that has pleiotropic effects on HDL and TG, one group influences both HDL-C and SHBG and a third influences both HDL-C and DHEAS...
  46. ncbi request reprint Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78228 3900, USA
    Circulation 102:42-7. 2000
    ..Recently, some components of the insulin resistance syndrome (IRS) have been related to inflammatory markers. We hypothesized that insulin insensitivity, as directly measured, may be associated with inflammation in nondiabetic subjects...
  47. ncbi request reprint Sample exchange to compare insulin measurements between the San Antonio Heart Study and the Framingham Offspring Study
    J B Meigs
    The General Medicine Division, Department of Medicine, Massachusetts Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Epidemiol 54:1031-6. 2001
    ..Associated regression curves can be used to calibrate insulin levels to a common reference standard, allowing epidemiology studies to compare levels of insulin and associated risk factors...
  48. ncbi request reprint Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures
    B D Mitchell
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Tex 78228 0147, USA
    Arterioscler Thromb Vasc Biol 16:281-8. 1996
    ....
  49. ncbi request reprint A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor MRI Center, Winston Salem, NC 27157, USA
    Diabetes 54:290-5. 2005
    ..Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations...
  50. ncbi request reprint Insulin resistance and adiposity influence lipoprotein size and subclass concentrations. Results from the Insulin Resistance Atherosclerosis Study
    David C Goff
    Public Health Sciences and Internal Medicine, Wake Forest University School of Meicine, Winston Salem, NC 27157 1063, USA
    Metabolism 54:264-70. 2005
    ..We examined the association of insulin resistance and adiposity with lipoprotein particle size, concentration, and subclass concentrations...
  51. ncbi request reprint Inflammation and cardiovascular disease in patients with diabetes: lessons from the Diabetes Control and Complications Trial
    Andreas Festa
    Circulation 111:2414-5. 2005
  52. ncbi request reprint Comparison of the associations of apolipoprotein B and non-high-density lipoprotein cholesterol with other cardiovascular risk factors in patients with the metabolic syndrome in the Insulin Resistance Atherosclerosis Study
    Naveed Sattar
    Section of Vascular Biochemistry, North Glasgow Hospitals University NHS Trust, Glasgow Royal Infirmary, Glasgow, UK
    Circulation 110:2687-93. 2004
    ..Both apolipoprotein (apo)B and non-HDL cholesterol (NHDLC) have been proposed as an additional indicator to identify patients at higher risk in MetS patients...
  53. pmc Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin
    Abbas E Kitabchi
    Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA
    Diabetes 54:2404-14. 2005
    ..The better preventive effectiveness of intensive lifestyle may be due to improved insulin sensitivity concomitant with preservation of beta-cell function...
  54. ncbi request reprint Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Diabetes 54:3140-7. 2005
    ..In conclusion, NAFLD markers ALT and the AST-to-ALT ratio predict metabolic syndrome independently of potential confounding variables, including directly measured Si and AIR...
  55. ncbi request reprint Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes
    Steven E Kahn
    Department of Internal Medicine, Division of Metbolism, Endocrinology and Nurtrition, VA Puget Sound Health Care System, 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 55:2357-64. 2006
    ..Further, for CRP and fibrinogen this relationship is determined by body adiposity and not by insulin sensitivity or glucose control...
  56. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  57. ncbi request reprint Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    Steven E Kahn
    Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    N Engl J Med 355:2427-43. 2006
    ..The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known...
  58. ncbi request reprint The metabolic syndrome: risk factors and management
    Holly B Cassells
    School of Nursing and Health Professions, University of the Incarnate Word, San Antonio, Tex 78209, USA
    J Cardiovasc Nurs 21:306-13. 2006
    ....
  59. ncbi request reprint Progression of plasminogen activator inhibitor-1 and fibrinogen levels in relation to incident type 2 diabetes
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Circulation 113:1753-9. 2006
    ..We studied in the Insulin Resistance Atherosclerosis Study the relation of incident diabetes to dynamic changes of plasminogen activator inhibitor-1 (PAI-1) and fibrinogen...
  60. ncbi request reprint The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study
    Andreas Festa
    University of Texas Health Science Center, Department of Medicine, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 55:1114-20. 2006
    ..Failure to increase insulin secretion led to IGT, and a decrease in insulin secretion led to overt diabetes. This data may have important implications for the prevention and treatment of type 2 diabetes...
  61. ncbi request reprint Which obesity index best explains prevalence differences in type 2 diabetes mellitus?
    Carlos Lorenzo
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7873, USA
    Obesity (Silver Spring) 15:1294-301. 2007
    ..Obesity drives the diabetes epidemic. However, it is not known which obesity index best explains variations in type 2 diabetes mellitus prevalence across populations...
  62. ncbi request reprint Unmet needs in controlling metabolic disease
    Steven M Haffner
    Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas, USA
    Rev Cardiovasc Med 8:S17-24. 2007
    ..Such behavioral interventions were more effective than metformin in reducing the incidence of diabetes and of other components of the metabolic syndrome in one randomized, controlled study...
  63. pmc Relation of low glomerular filtration rate to metabolic disorders in individuals without diabetes and with normoalbuminuria
    Carlos Lorenzo
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7873, USA
    Clin J Am Soc Nephrol 3:783-9. 2008
    ..Low glomerular filtration rate is also associated with increased cardiovascular risk, but the relation of low glomerular filtration rate to metabolic disorders is not well understood...
  64. doi request reprint Beta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes 57:1638-44. 2008
    ..Methods to assess beta-cell function in clinical studies are limited. The aim of the current study was to compare a direct measure of insulin secretion with fasting surrogate markers in relation to glucose tolerance status...
  65. ncbi request reprint Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Mail Code 7873, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 53:2623-32. 2004
    ..In conclusion, AST and ALT independently predict type 2 diabetes. Baseline elevations of these markers may reflect NAFLD or related pathologies...
  66. ncbi request reprint Cardiovascular disease risk factors predict the development of type 2 diabetes: the insulin resistance atherosclerosis study
    RALPH B D'AGOSTINO
    Department of Public Health Science, Biostatistics Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes Care 27:2234-40. 2004
    ..Our objective was to determine whether the presence of CVD RFs predict the eventual development of diabetes after controlling for known RFs, such as directly measured insulin resistance and obesity...
  67. ncbi request reprint Metabolic and inflammation variable clusters and prediction of type 2 diabetes: factor analysis using directly measured insulin sensitivity
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Mail Code 7873, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 53:1773-81. 2004
    ..The findings support the emerging hypothesis that chronic subclinical inflammation is associated with insulin resistance and comprises a component of the metabolic syndrome...
  68. ncbi request reprint A population perspective on diabetes prevention: whom should we target for preventing weight gain?
    James P Burke
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Diabetes Care 26:1999-2004. 2003
    ..To examine the influence of obesity and prevention of weight gain on the incidence of type 2 diabetes...
  69. ncbi request reprint Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78228 3900, USA
    Circulation 107:2422-7. 2003
    ..The 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene has been related to cardiovascular disease...
  70. ncbi request reprint NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older
    Charles M Alexander
    Outcomes Research and Management, U S Medical and Scientific Affairs, Merck and Co, Inc, West Point, PA, USA
    Diabetes 52:1210-4. 2003
    ..However, individuals with diabetes without metabolic syndrome had no greater prevalence of CHD compared with those with neither...
  71. ncbi request reprint Diabetes and progression of carotid atherosclerosis: the insulin resistance atherosclerosis study
    Lynne E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
    Arterioscler Thromb Vasc Biol 23:1035-41. 2003
    ..We sought to determine the rate of progression of carotid atherosclerosis in persons with normal glucose tolerance, impaired glucose tolerance, and undiagnosed and diagnosed type 2 diabetes...
  72. ncbi request reprint Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center, San Antonio 78229, USA
    Diabetes 52:463-9. 2003
    ..This index may reflect other aspects of diabetes pathogenesis in addition to IR, which might explain its strong predictive abilities despite its moderate correlation with direct measures of IR...
  73. ncbi request reprint Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study
    Thang S Han
    Addenbrooke s Hospital, Cambridge University Medical School, Cambridge, U K
    Diabetes Care 25:2016-21. 2002
    ..We evaluated CRP as a possible risk factor of the development of diabetes and metabolic syndrome in a 6-year study of 515 men and 729 women from the Mexico City Diabetes Study...
  74. ncbi request reprint A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes
    Giancarlo Viberti
    Guy s, King s, and St Thomas School of Medicine, King s College, London, U K
    Diabetes Care 25:1737-43. 2002
    ....
  75. ncbi request reprint Analysis of obesity and hyperinsulinemia in the development of metabolic syndrome: San Antonio Heart Study
    Thang S Han
    Cambridge Clinical School, Cambridge, United Kingdom
    Obes Res 10:923-31. 2002
    ..To use standardized cut-offs of body mass index (BMI), waist circumference, waist-to-hip ratio, and fasting insulin levels to predict the development of metabolic disorders and metabolic syndrome...
  76. ncbi request reprint Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Diabetes Care 25:1177-84. 2002
    ....
  77. ncbi request reprint Elevated risk of cardiovascular disease prior to clinical diagnosis of type 2 diabetes
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Diabetes Care 25:1129-34. 2002
    ..To examine whether the risk of cardiovascular disease (CVD) is elevated before clinical diagnosis of type 2 diabetes in women...
  78. ncbi request reprint Identification of persons at high risk for type 2 diabetes mellitus: do we need the oral glucose tolerance test?
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900
    Ann Intern Med 136:575-81. 2002
    ..Because clinical trials have indicated that diabetes is preventable by using behavioral or pharmacologic interventions, less expensive methods of identifying high-risk persons are needed...
  79. ncbi request reprint Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Diabetes 51:1263-70. 2002
    ....
  80. ncbi request reprint Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study
    Naveed Sattar
    University Department of Pathological Biochemistry, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Circulation 108:414-9. 2003
    ..Information on the prospective association of this definition for coronary heart disease (CHD) and type 2 diabetes is currently limited...
  81. ncbi request reprint Sex steroid hormones, upper body obesity, and insulin resistance
    Nicola Abate
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:4522-7. 2002
    ..Low plasma levels of bioavailable testosterone do not independently predict excessive insulin resistance, beta-cell dysfunction, or hepatic glucose output in normogonadal men...
  82. ncbi request reprint Insulin sensitivity, body fat distribution, and family diabetes history: the IRAS Family Study
    Braxton D Mitchell
    University of Maryland School of Medicine, Division of Endocrinology, Diabetes, and Nutrition, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
    Obes Res 12:831-9. 2004
    ..Whether diabetes family history (FH) also predicts visceral fat accumulation and, if so, whether the increased insulin resistance in relatives of diabetic subjects occurs independently of visceral fat accumulation are not known...
  83. ncbi request reprint Differences in insulin resistance in nondiabetic subjects with isolated impaired glucose tolerance or isolated impaired fasting glucose
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Dr, MC 7873, San Antonio, TX 78229 3900, USA
    Diabetes 53:1549-55. 2004
    ..The risk factor pattern (including increased insulin resistance) seen in isolated IGT identifies a subgroup of nondiabetic individuals who are likely to benefit from early intervention...
  84. ncbi request reprint Insulin resistance and hypertension: the Insulin Resistance Atherosclerosis study
    Mohammed F Saad
    Division of Clinical Epidemiology, Department of Medicine, UCLA Medical School, 924 Westwood Blvd, Suite 335 Mail Box 15, Los Angeles, Calif 90024, USA
    Hypertension 43:1324-31. 2004
    ..Neither insulin resistance nor insulinemia was related to hypertension or blood pressure in patients with type 2 diabetes in the 3 ethnic groups...
  85. ncbi request reprint The prevalence of diabetic retinopathy among adults in the United States
    John H Kempen
    Department of Ophthalmology, Johns Hopkins School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Arch Ophthalmol 122:552-63. 2004
    ..To determine the prevalence of diabetic retinopathy among adults 40 years and older in the United States...
  86. ncbi request reprint Site-specific progression of carotid artery intimal-medial thickness
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 171:137-43. 2003
    ..To characterize the intercorrelation of changes in intimal-medial thickness (IMT) among carotid artery sites and examine the influence of diabetes and sex on these correlations...
  87. ncbi request reprint Plasma adiponectin is an independent predictor of type 2 diabetes in Asian indians
    Chamukuttan Snehalatha
    Diabetes Research Centre, M V Hospital for Diabetes, WHO Collaborating Centre for Research, Education and Training in Diabetes, Royapuram, Chennai, India
    Diabetes Care 26:3226-9. 2003
    ....
  88. ncbi request reprint Comparison of the associations of apolipoprotein B and low-density lipoprotein cholesterol with other cardiovascular risk factors in the Insulin Resistance Atherosclerosis Study (IRAS)
    Ken Williams
    Department of Medicine, University of Texas Health Science Center, San Antonio, USA
    Circulation 108:2312-6. 2003
    ..This study compares the associations of apolipoprotein B (apoB) and LDL cholesterol (LDLC) with a wide array of measures of these risk factors...
  89. ncbi request reprint Identification of subjects with insulin resistance and beta-cell dysfunction using alternative definitions of the metabolic syndrome
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center, San Antonio, Texas 78229 3900, USA
    Diabetes 52:2740-7. 2003
    ..The definitions are generally less useful for identifying those with low AIR or DI, although NCEP-MetS seems to differentiate black subjects with insulin secretion defects...
  90. ncbi request reprint The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart study
    Carlos Lorenzo
    Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas 78284 7873, USA
    Diabetes Care 26:3153-9. 2003
    ....
  91. ncbi request reprint Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
    Circulation 108:1822-30. 2003
    ..Previously, atherogenic changes in traditional CV risk factors in the prediabetic state were mainly seen in insulin-resistant subjects rather than in those with a predominant defect in insulin secretion...
  92. ncbi request reprint Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin
    Richard N Bergman
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Diabetes 52:2168-74. 2003
    ..Thus S(I), a direct measure of insulin sensitivity, is determined more by genetic factors rather than measures such as HOMA, which reflect fasting insulin...
  93. ncbi request reprint Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies
    James B Meigs
    Department of Medicine, General Medicine Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 52:2160-7. 2003
    ..S. By any criteria, subjects with the metabolic syndrome are more insulin resistant and at increased predicted risk for CHD versus those without the metabolic syndrome...
  94. ncbi request reprint Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study
    Andreas Festa
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78228 3900, USA
    Diabetes 51:1131-7. 2002
    ..61 [1.20-2.16]; P = 0.002). Chronic inflammation emerges as a new risk factor for the development of type 2 diabetes; PAI-1 predicts type 2 diabetes independent of insulin resistance and other known risk factors for diabetes...

Research Grants14

  1. The Look AHEAD Continuation: Action for Health in Diabetes
    Steven Haffner; Fiscal Year: 2007
    ..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..
  2. Post-DPP Follow-Up Study
    Steven Haffner; Fiscal Year: 2007
    ..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..
  3. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Steven Haffner; Fiscal Year: 2007
    ....
  4. IRAS FAMILY STUDY: GENETICS OF INSULIN RESISTANCE
    Steven Haffner; Fiscal Year: 2003
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin sensitivity, and consequently to risk of atherosclerosis. ..
  5. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..abstract_text> ..