FRANCOISE J HAESELEER

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195 6485, USA
    Adv Exp Med Biol 514:303-17. 2002
  2. ncbi Gene transfer mediated by recombinant baculovirus into mouse eye
    F Haeseleer
    Department of Ophthalmology, University of Washington, 1959 NE Pacific Street, Box 356 485, Seattle, WA 98195 6485, USA
    Invest Ophthalmol Vis Sci 42:3294-300. 2001
  3. ncbi Interaction and colocalization of CaBP4 and Unc119 (MRG4) in photoreceptors
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    Invest Ophthalmol Vis Sci 49:2366-75. 2008
  4. ncbi Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Box 356485, Seattle, Washington 98195, USA
    Nat Neurosci 7:1079-87. 2004
  5. ncbi A critical role of CaBP4 in the cone synapse
    Tadao Maeda
    Department of Ophthalmology, University of Washington, Seattle, 98195, USA
    Invest Ophthalmol Vis Sci 46:4320-7. 2005
  6. ncbi Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators
    Izabela Sokal
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195-6485, USA
    Biochemistry 41:251-7. 2002
  7. ncbi Characterization of Ca2+-binding protein 5 knockout mouse retina
    Fred Rieke
    Department of 2Physiology and Biophysics, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Invest Ophthalmol Vis Sci 49:5126-35. 2008
  8. ncbi Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1
    Amy Lee
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195 7280, USA
    Nat Neurosci 5:210-7. 2002
  9. ncbi Calcium-binding proteins: intracellular sensors from the calmodulin superfamily
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    Biochem Biophys Res Commun 290:615-23. 2002
  10. ncbi Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:45537-46. 2002

Research Grants

  1. Regulation of L-type calcium channels by CaBP4
    FRANCOISE J HAESELEER; Fiscal Year: 2010
  2. CaBP4, a Photoreceptor Specific Calcium-Binding Protein
    Francoise Haeseleer; Fiscal Year: 2005

Detail Information

Publications10

  1. ncbi Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195 6485, USA
    Adv Exp Med Biol 514:303-17. 2002
    ..CaBPs could be cell-type specific proteins that play a key role in the Ca2+ signaling of specialized retinal neurons...
  2. ncbi Gene transfer mediated by recombinant baculovirus into mouse eye
    F Haeseleer
    Department of Ophthalmology, University of Washington, 1959 NE Pacific Street, Box 356 485, Seattle, WA 98195 6485, USA
    Invest Ophthalmol Vis Sci 42:3294-300. 2001
    ..To determine the efficiency of baculoviruses (BVs) to transfer recombinant genes in vivo into murine ocular tissues...
  3. ncbi Interaction and colocalization of CaBP4 and Unc119 (MRG4) in photoreceptors
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    Invest Ophthalmol Vis Sci 49:2366-75. 2008
    ..To characterize the interaction of the neuron-specific protein CaBP4 with the synaptic photoreceptor protein Unc119 homolog (MRG4)...
  4. ncbi Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Box 356485, Seattle, Washington 98195, USA
    Nat Neurosci 7:1079-87. 2004
    ..These observations indicate that CaBP4 is important for normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals...
  5. ncbi A critical role of CaBP4 in the cone synapse
    Tadao Maeda
    Department of Ophthalmology, University of Washington, Seattle, 98195, USA
    Invest Ophthalmol Vis Sci 46:4320-7. 2005
    ..In this study, double CaBP4/rod alpha-transducin knockout (Cabp4(-/-)Gnat1(-/-)) mice lacking the rod-mediated component of electrophysiologic responses were generated and analyzed to investigate the role of CaBP4 in cones...
  6. ncbi Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators
    Izabela Sokal
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195-6485, USA
    Biochemistry 41:251-7. 2002
    ..Thus, fusion proteins may provide an important advance for further structural studies of photoreceptor GCs and other sTMRs with and without different forms of regulatory proteins...
  7. ncbi Characterization of Ca2+-binding protein 5 knockout mouse retina
    Fred Rieke
    Department of 2Physiology and Biophysics, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Invest Ophthalmol Vis Sci 49:5126-35. 2008
    ..The authors also tested whether CaBP5 can modulate expressed Ca(v)1.2 voltage-activated calcium channels...
  8. ncbi Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1
    Amy Lee
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195 7280, USA
    Nat Neurosci 5:210-7. 2002
    ..Our results identify an interaction between Ca2+ channels and CaBP1 that may regulate Ca2+-dependent forms of synaptic plasticity by inhibiting Ca2+ influx into neurons...
  9. ncbi Calcium-binding proteins: intracellular sensors from the calmodulin superfamily
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    Biochem Biophys Res Commun 290:615-23. 2002
    ..A large number of NCBP and CaBP subfamily members would benefit from their potentially specialized role in Ca(2+)-dependent cellular processes. Pinpointing the role of these proteins will be a challenging task for further research...
  10. ncbi Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina
    Francoise Haeseleer
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:45537-46. 2002
    ..These newly identified enzymes add new elements to important retinoid metabolic pathways that have not been explained by previous genetic and biochemical studies...

Research Grants2

  1. Regulation of L-type calcium channels by CaBP4
    FRANCOISE J HAESELEER; Fiscal Year: 2010
    ..This research will may reveal how dysregulation of Ca2+ signals leads to CSNB2 and pave the way for the development of new therapies for CSNB2 and other visual disorders. ..
  2. CaBP4, a Photoreceptor Specific Calcium-Binding Protein
    Francoise Haeseleer; Fiscal Year: 2005
    ..The mechanism of interaction of CaBP4 with its target will also be examined using both in vitro and in vivo procedures. ..