Angela Haczku

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The dendritic cell niche in chronic obstructive pulmonary disease
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Translational Research Laboratories, 125 South 31st Street, Philadelphia, PA 19104 3403, USA
    Respir Res 13:80. 2012
  2. pmc Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D
    S Kierstein
    University of Pennsylvania, Philadelphia, PA, USA
    Respir Res 7:85. 2006
  3. ncbi request reprint Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice
    A Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 25:45-50. 2001
  4. ncbi request reprint IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:3557-65. 2006
  5. pmc Social stress and asthma: the role of corticosteroid insensitivity
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    J Allergy Clin Immunol 125:550-8. 2010
  6. doi request reprint Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation
    Angela Haczku
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Allergy Clin Immunol 122:861-79; quiz 880-1. 2008
  7. pmc Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization
    Elena N Atochina
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Respir Res 4:15. 2003
  8. ncbi request reprint The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical School, Philadelphia 19104, USA
    Am J Physiol Lung Cell Mol Physiol 283:L755-65. 2002
  9. ncbi request reprint Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6100, USA
    Acad Radiol 12:1362-70. 2005
  10. pmc Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species
    Elena N Atochina
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 72:6002-11. 2004

Collaborators

Detail Information

Publications28

  1. pmc The dendritic cell niche in chronic obstructive pulmonary disease
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Translational Research Laboratories, 125 South 31st Street, Philadelphia, PA 19104 3403, USA
    Respir Res 13:80. 2012
    ..Botelho and colleagues demonstrate here the importance of IL-1R1/IL-1α related mechanisms including CCL20 production in cigarette-smoke induced recruitment of dendritic cells and T cell activation in the mouse lung...
  2. pmc Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D
    S Kierstein
    University of Pennsylvania, Philadelphia, PA, USA
    Respir Res 7:85. 2006
    ..We have shown previously that SP-D plays a protective role in a mouse model of allergic airway inflammation. Here we studied the role and regulation of SP-D in O3-induced inflammatory changes in the lung...
  3. ncbi request reprint Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice
    A Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 25:45-50. 2001
    ..These changes may contribute significantly to the pathophysiology of Af-induced allergic airway hyperresponsiveness...
  4. ncbi request reprint IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:3557-65. 2006
    ..This negative feedback regulatory circuit could be essential in protecting the airways from inflammatory damage after allergen inhalation...
  5. pmc Social stress and asthma: the role of corticosteroid insensitivity
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    J Allergy Clin Immunol 125:550-8. 2010
    ..Elucidation of the mechanisms of stress-induced impairment of glucocorticoid responsiveness and immune homeostasis may identify novel therapeutic targets that could improve asthma management...
  6. doi request reprint Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation
    Angela Haczku
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Allergy Clin Immunol 122:861-79; quiz 880-1. 2008
    ..This article reviews evidence supporting that the lung collectins play an immune-protective role and are essential for maintenance of the immunologic homeostasis in the lung...
  7. pmc Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization
    Elena N Atochina
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Respir Res 4:15. 2003
    ..We hypothesized that an elevated SP-D production is associated with the impaired ability of C57BL/6 mice to develop allergic AHR...
  8. ncbi request reprint The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical School, Philadelphia 19104, USA
    Am J Physiol Lung Cell Mol Physiol 283:L755-65. 2002
    ..Thus surfactant dysfunction induced by an IL-4-driven SP-B deficiency after allergen provocation may be an important part of the late asthmatic airway response...
  9. ncbi request reprint Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6100, USA
    Acad Radiol 12:1362-70. 2005
    ..The objective of this study was to investigate regional ventilation changes in the mouse lung following allergen sensitization and challenge...
  10. pmc Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species
    Elena N Atochina
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 72:6002-11. 2004
    ..These data support the concept that SP-A is a local effector molecule in the lung host defense against P. carinii in vivo...
  11. doi request reprint Surfactant protein D inhibits TNF-alpha production by macrophages and dendritic cells in mice
    László Hortobágyi
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 122:521-8. 2008
    ..Surfactant protein (SP) D shares target cells with the proinflammatory cytokine TNF-alpha, an important autocrine stimulator of dendritic cells and macrophages in the airways...
  12. pmc Surfactant protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses
    Seth Thomas Scanlon
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Respir Res 6:97. 2005
    ..The pulmonary surfactant protein (SP)-A has potent immunomodulatory activities but its role and regulation during allergic airway inflammation is unknown...
  13. ncbi request reprint Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice
    Elena N Atochina
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6061, USA
    J Infect Dis 189:1528-39. 2004
    ..These results indicate that SP-D plays a role in host defense against P. carinii in vivo by modulating clearance of organisms, lung inflammation, and metabolism of NO...
  14. pmc Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness
    Miao Wang
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 334:63-8. 2010
    ..Pharmacologically targeting mPGES-1 may not predispose patients at risk to airway dysfunction...
  15. pmc Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Immunobiology 213:499-509. 2008
    ..These data provide the first evidence that ASM-derived IFNbeta and CD38 may play a significant role in the development of TNFalpha-associated AHR...
  16. pmc Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis
    Laila D McVay
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 116:2914-23. 2006
    ....
  17. ncbi request reprint Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4
    Guochang Yang
    Center for Experimental Therapeutics, Rm 814BRBII III, Univ of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Am J Physiol Lung Cell Mol Physiol 286:L992-1001. 2004
    ..These results indicate that a selective hCysLT(1)R-induced contractile mechanism synergizes with allergic AHR. We speculate that hCysLT(1)R signaling contributes to a hypercontractile state of the airway smooth muscle...
  18. doi request reprint Inhibition of myristoylated alanine-rich C kinase substrate (MARCKS) protein inhibits ozone-induced airway neutrophilia and inflammation
    Gautam Damera
    Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, 125 South 31st Street, Philadelphia, PA 19104 3403, USA
    Exp Lung Res 36:75-84. 2010
    ..BIO-11006 is being developed as a treatment for chronic obstructive pulmonary disorder (COPD) and is currently being evaluated in a phase 2 clinical study...
  19. pmc Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study
    Michael W Sims
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Respir Res 9:13. 2008
    ..Deficiency of this molecule induces emphysematous changes in murine lungs, but its significance in human COPD remains unclear...
  20. ncbi request reprint Role and regulation of lung collectins in allergic airway sensitization
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, BRB II III 840, Philadelphia, 19104 6061, USA
    Pharmacol Ther 110:14-34. 2006
    ..This review will discuss their relevant structural-functional features and recent evidence supporting the hypothesis that SP-A and SP-D have a role in regulation of allergic airway sensitization...
  21. pmc The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice
    Zhilong Jiang
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA
    Respir Res 13:100. 2012
    ..The aim of this study was to investigate whether Lp-PLA2 gene deficiency increases the risk of PAF and IgE-mediated inflammatory responses in vitro and in vivo using mouse models...
  22. ncbi request reprint IL-4 induces production of the lung collectin surfactant protein-D
    Yang Cao
    Pulmonary Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6061, USA
    J Allergy Clin Immunol 113:439-44. 2004
    ..Allergic airway inflammation significantly increases SP-D levels in the bronchoalveolar lavage fluid in asthmatic patients and mouse models, but the mechanisms involved remain unknown...
  23. doi request reprint Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice
    S Kierstein
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Allergy 63:438-46. 2008
    ..We used a murine model to characterize the effects of O(3) on allergic airway inflammation and hyperresponsiveness and to identify factors that might contribute to the O(3)-induced exacerbation of asthma...
  24. doi request reprint Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation
    Won Keun Kim
    1 Department of Pathobiology, School of Veterinary Medicine, and
    Am J Respir Crit Care Med 189:437-48. 2014
    ....
  25. pmc The B-cell superantigen Finegoldia magna protein L causes pulmonary inflammation by a mechanism dependent on MyD88 but not B cells or immunoglobulins
    Amy L Anderson
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Inflamm Res 61:161-9. 2012
    ..To determine whether Finegoldia magna protein L (PL) causes lung inflammation and, if so, whether the response is dependent on its immunoglobulin (Ig)-binding B-cell superantigenic property...
  26. doi request reprint T cell factor 1 is required for group 2 innate lymphoid cell generation
    Qi Yang
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 38:694-704. 2013
    ..These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells...
  27. doi request reprint SP-D and regulation of the pulmonary innate immune system in allergic airway changes
    L R Forbes
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Clin Exp Allergy 40:547-62. 2010
    ..This paper will review recent findings on the mechanisms of immune-protective function of SP-D in the lung...
  28. ncbi request reprint Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness
    Yeong Ho Rha
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 169:5300-7. 2002
    ..These results indicate selective and distinctive properties among the hsp, and that M. leprae hsp may have a potential therapeutic role in the treatment of allergic airway inflammation and altered airway function...

Research Grants8

  1. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2007
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. ..
  2. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  3. Mechanisms of social-stress enhanced allergic airway response in a mouse model
    Angela Haczku; Fiscal Year: 2010
    ..2. Elucidation of the cellular and molecular pathways of the glucocorticoid action on immune cell function and epithelial cell SP-D production in stress-induced exacerbation of the inflammatory airway response. ..