Research Topics
Genomes and Genes | Angela HaczkuSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
The dendritic cell niche in chronic obstructive pulmonary diseaseAngela Haczku
Pulmonary, Allergy and Critical Care Division, Translational Research Laboratories, 125 South 31st Street, Philadelphia, PA 19104 3403, USA
Respir Res 13:80. 2012..Botelho and colleagues demonstrate here the importance of IL-1R1/IL-1α related mechanisms including CCL20 production in cigarette-smoke induced recruitment of dendritic cells and T cell activation in the mouse lung...
Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein DS Kierstein
University of Pennsylvania, Philadelphia, PA, USA
Respir Res 7:85. 2006..We have shown previously that SP-D plays a protective role in a mouse model of allergic airway inflammation. Here we studied the role and regulation of SP-D in O3-induced inflammatory changes in the lung...
Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c miceA Haczku
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104, USA
Am J Respir Cell Mol Biol 25:45-50. 2001..These changes may contribute significantly to the pathophysiology of Af-induced allergic airway hyperresponsiveness...
Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammationAngela Haczku
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Allergy Clin Immunol 122:861-79; quiz 880-1. 2008..This article reviews evidence supporting that the lung collectins play an immune-protective role and are essential for maintenance of the immunologic homeostasis in the lung...- The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in miceAngela Haczku
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical School, Philadelphia 19104, USA
Am J Physiol Lung Cell Mol Physiol 283:L755-65. 2002..Thus surfactant dysfunction induced by an IL-4-driven SP-B deficiency after allergen provocation may be an important part of the late asthmatic airway response... - IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway responseAngela Haczku
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
J Immunol 176:3557-65. 2006..This negative feedback regulatory circuit could be essential in protecting the airways from inflammatory damage after allergen inhalation... - Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary resultsAngela Haczku
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6100, USA
Acad Radiol 12:1362-70. 2005..The objective of this study was to investigate regional ventilation changes in the mouse lung following allergen sensitization and challenge... - Social stress and asthma: the role of corticosteroid insensitivityAngela Haczku
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
J Allergy Clin Immunol 125:550-8. 2010..Elucidation of the mechanisms of stress-induced impairment of glucocorticoid responsiveness and immune homeostasis may identify novel therapeutic targets that could improve asthma management... - Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitizationElena N Atochina
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
Respir Res 4:15. 2003..We hypothesized that an elevated SP-D production is associated with the impaired ability of C57BL/6 mice to develop allergic AHR... - Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen speciesElena N Atochina
Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Infect Immun 72:6002-11. 2004..These data support the concept that SP-A is a local effector molecule in the lung host defense against P. carinii in vivo... - Surfactant protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responsesSeth Thomas Scanlon
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Respir Res 6:97. 2005..The pulmonary surfactant protein (SP)-A has potent immunomodulatory activities but its role and regulation during allergic airway inflammation is unknown... - Surfactant protein D inhibits TNF-alpha production by macrophages and dendritic cells in miceLászló Hortobágyi
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Allergy Clin Immunol 122:521-8. 2008..Surfactant protein (SP) D shares target cells with the proinflammatory cytokine TNF-alpha, an important autocrine stimulator of dendritic cells and macrophages in the airways... - Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout miceElena N Atochina
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6061, USA
J Infect Dis 189:1528-39. 2004..These results indicate that SP-D plays a role in host defense against P. carinii in vivo by modulating clearance of organisms, lung inflammation, and metabolism of NO... - Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsivenessMiao Wang
Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
J Pharmacol Exp Ther 334:63-8. 2010..Pharmacologically targeting mPGES-1 may not predispose patients at risk to airway dysfunction... - Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsivenessDeepika Jain
Pulmonary and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Immunobiology 213:499-509. 2008..These data provide the first evidence that ASM-derived IFNbeta and CD38 may play a significant role in the development of TNFalpha-associated AHR... - Inhibition of myristoylated alanine-rich C kinase substrate (MARCKS) protein inhibits ozone-induced airway neutrophilia and inflammationGautam Damera
Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, 125 South 31st Street, Philadelphia, PA 19104 3403, USA
Exp Lung Res 36:75-84. 2010..BIO-11006 is being developed as a treatment for chronic obstructive pulmonary disorder (COPD) and is currently being evaluated in a phase 2 clinical study... - Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitisLaila D McVay
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 116:2914-23. 2006.... - Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4Guochang Yang
Center for Experimental Therapeutics, Rm 814BRBII III, Univ of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
Am J Physiol Lung Cell Mol Physiol 286:L992-1001. 2004..These results indicate that a selective hCysLT(1)R-induced contractile mechanism synergizes with allergic AHR. We speculate that hCysLT(1)R signaling contributes to a hypercontractile state of the airway smooth muscle... - Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional studyMichael W Sims
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Respir Res 9:13. 2008..Deficiency of this molecule induces emphysematous changes in murine lungs, but its significance in human COPD remains unclear... - Role and regulation of lung collectins in allergic airway sensitizationAngela Haczku
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, BRB II III 840, Philadelphia, 19104 6061, USA
Pharmacol Ther 110:14-34. 2006..This review will discuss their relevant structural-functional features and recent evidence supporting the hypothesis that SP-A and SP-D have a role in regulation of allergic airway sensitization... - IL-4 induces production of the lung collectin surfactant protein-DYang Cao
Pulmonary Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6061, USA
J Allergy Clin Immunol 113:439-44. 2004..Since SP-D has a potent anti-inflammatory function, this mechanism may be part of a negative feedback loop providing a regulatory link between adaptive and innate immunity during allergic inflammation... - Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized miceS Kierstein
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
Allergy 63:438-46. 2008..We used a murine model to characterize the effects of O(3) on allergic airway inflammation and hyperresponsiveness and to identify factors that might contribute to the O(3)-induced exacerbation of asthma... - The B-cell superantigen Finegoldia magna protein L causes pulmonary inflammation by a mechanism dependent on MyD88 but not B cells or immunoglobulinsAmy L Anderson
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Inflamm Res 61:161-9. 2012..To determine whether Finegoldia magna protein L (PL) causes lung inflammation and, if so, whether the response is dependent on its immunoglobulin (Ig)-binding B-cell superantigenic property... - SP-D and regulation of the pulmonary innate immune system in allergic airway changesL R Forbes
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Clin Exp Allergy 40:547-62. 2010..This paper will review recent findings on the mechanisms of immune-protective function of SP-D in the lung... - Effect of microbial heat shock proteins on airway inflammation and hyperresponsivenessYeong-Ho Rha
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 169:5300-7. 2002..These results indicate selective and distinctive properties among the hsp, and that M. leprae hsp may have a potential therapeutic role in the treatment of allergic airway inflammation and altered airway function...
Research Grants
- Surfactant-Protein Innate Immunity in an Asthma ModelAngela Haczku; Fiscal Year: 2007..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. ..
- Regulation of Inflammation in Asthma by Fas LigandAngela Haczku; Fiscal Year: 2009..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
- Mechanisms of social-stress enhanced allergic airway response in a mouse modelAngela Haczku; Fiscal Year: 2010..2. Elucidation of the cellular and molecular pathways of the glucocorticoid action on immune cell function and epithelial cell SP-D production in stress-induced exacerbation of the inflammatory airway response. ..