J G Hacia
Affiliation: University of Southern California
- Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cellsAnn B Moser
Department of Biochemistry and Molecular Biology, Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA 90089, USA
Lipids Health Dis 12:10. 2013..In contrast, humans cannot derive PA from chlorophyll and instead normally obtain it only from meat, dairy, and fish products...
- Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expressionZhong Wang
Pharmacyclics, Inc, Sunnyvale, California, USA
Mol Cancer 6:9. 2007..However, the mechanisms for their anticancer activity have not been fully elucidated...
- Human and great ape red blood cells differ in plasmalogen levels and compositionAnn B Moser
Hugo W Moser Research Institute at Kennedy Krieger, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Lipids Health Dis 10:101. 2011..Plasmalogen deficiency is also found in the brain tissue of individuals with Alzheimer disease...
- Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functionsPaul A Watkins
Department ofNeurology, Johns Hopkins University School of Medicine, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
BMC Physiol 10:19. 2010..Furthermore, phytanic acid is an activator of the PPAR-alpha transcription factor that influences the expression of genes relevant to lipid metabolism...
- mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograftDarren Magda
Department of Biochemistry and Molecular Biology, University of Southern California, 2250 Alcazar Street, IGM 240, Los Angeles, CA 90089, USA
BMC Genomics 9:521. 2008..In order to address this issue, we characterized the gene expression profiles of A549 lung cancer cells and their mtDNA-depleted rho0 counterparts grown in culture and as tumor xenografts in immune-deficient mice...
- Genome of the apesJ G Hacia
The Institute for Genetic Medicine, University of Southern California, 2250 Alcazar Street, IGM 240, Los Angeles, CA 90089, USA
Trends Genet 17:637-45. 2001..Recent studies comparing the primate genomes have the potential to affect many aspects of human biomedical research and could benefit primate conservation efforts...
- Molecular pathology of head and neck cancerD L Crowe
Center for Craniofacial Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
Histol Histopathol 17:909-14. 2002..This review will focus on the molecular changes which occur in these pathways and how they contribute to the pathogenesis of HNSCC...