Research Topics
Genomes and Genes | Samy L HabibSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Tuberin inhibits production of the matrix protein fibronectin in diabetesSamy L Habib
Department of Cellular and Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
J Am Soc Nephrol 23:1652-62. 2012..Taken together, these data suggest that tuberin plays a central role in the development of renal hypertrophy and in modulating the production of the matrix protein fibronectin in diabetes...- Molecular mechanism of regulation of OGG1: tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YASamy L Habib
South Texas Veterans Healthcare System, Geriatric Research, Education and Clinical Center, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
J Mol Signal 4:8. 2009..These data define a novel mechanism of regulation of OGG1 through tuberin. This mechanism may be important in the pathogenesis of kidney tumors in patients with TSC disease... - The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetesChakradhar Velagapudi
The University of Texas Health Science Center, Department of Medicine MSC 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
J Am Soc Nephrol 22:262-73. 2011..Furthermore, gene silencing of tuberin with siRNA decreased cleavage of PARP. These data show that the tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes, mediated in part by cleavage of PARP by YY1... - Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cellsSamy L Habib
Department of Geriatrics, Geriatric Research, Education, and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX 78229, USA
Carcinogenesis 31:2022-30. 2010..These data indicate a novel role for tuberin in the regulation of OGG1 through the transcription factor AP4. This regulation may be important in the pathogenesis of kidney tumours in patients with TSC disease... 
Tuberous sclerosis complex and DNA repairSamy L Habib
South Texas Veterans Healthcare System, Geriatric Research, Education and Clinical Center and Department of Medicine, The University of Texas Health Science Center, San Antonio, TX 78229, USA
Adv Exp Med Biol 685:84-94. 2010....
Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibitionSamy L Habib
Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, TX, USA
Eur J Cancer 46:2806-20. 2010..These data comprise the first report to provide one mechanism whereby rapamycin might prevent or inhibit the formation and progression of certain cancers...- Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patientsSamy L Habib
Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA
Mol Cancer 8:13. 2009..In addition we evaluated the phophorylation level of downstream targets of mTOR, phospho-S70K, in kidney tumor tissue from TSC patients... - Genetic polymorphisms in OGG1 and their association with angiomyolipoma, a benign kidney tumor in patients with tuberous sclerosisSamy L Habib
George O Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Cancer Biol Ther 7:23-7. 2008..Taken together, our findings suggest that Ser(326)Cys variant of OGG1 may confer risk for development of angiomyolipomas by increasing oxidative DNA damage... - Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumorsSamy L Habib
O Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
Mol Cancer 7:10. 2008..We investigated the distribution of protein expression and the activity of OGG1 and 8-oxo-dG and correlated it with the expression of tuberin in kidneys of wild type and Eker rats and tumor from Eker rat... - Tuberin regulates the DNA repair enzyme OGG1Samy L Habib
George O Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
Am J Physiol Renal Physiol 294:F281-90. 2008..These data provide the first evidence that tuberin regulates a specific DNA repair enzyme, OGG1. This regulation may be important in the pathogenesis of kidney tumors in patients with TSC... - Novel adenine adducts, N7-guanine-AFB1 adducts, and p53 mutations in patients with schistosomiasis and aflatoxin exposureSamy L Habib
Department of Community and Environmental Medicine, College of Medicine, University of California at Irvine, Irvine, CA 92697, USA
Cancer Detect Prev 30:491-8. 2006..Schistosomiasis is known to cause p53 mutation. We hypothesized that the combination of schistosomiasis and aflatoxin B1 increases the incidence of p53 gene mutation... - Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylaseSimona Simone
George O Brien Kidney Research Center, Department of Medicine, Division of Nephrology, University of Texas Health Science Center, San Antonio, Texas, USA
Diabetes 57:2626-36. 2008..To investigate potential mechanisms of oxidative DNA damage in a rat model of type 1 diabetes and in murine proximal tubular epithelial cells and primary culture of rat proximal tubular epithelial cells... - TSC2 deficiency increases PTEN via HIF1alphaLenin Mahimainathan
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
J Biol Chem 284:27790-8. 2009..These data suggest that PTEN may safeguard against developing malignant tumors in patients with TSC deficiency... - Role of tuberin in neuronal degenerationSamy L Habib
Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
Neurochem Res 33:1113-6. 2008..Our data provide new information regarding the possible role of tuberin dysfunction in major neurodegenerative disorders, such as AD and PD, whereby inhibition of tuberin function may trigger an onset of neuronal cell death... - Regulation of PI 3-K, PTEN, p53, and mTOR in Malignant and Benign Tumors Deficient in TuberinSamy L Habib
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, TX, USA
Genes Cancer 2:1051-60. 2011.... - Fibronectin induces ureteric bud cells branching and cellular cord and tubule formationPeng Ye
Department of Pediatrics and Department of Internal Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Kidney Int 66:1356-64. 2004..Only an antibody to alpha(3)beta(1) integrin substantially blocks the effect of fibronectin. Other mechanisms, including unidentified integrins, are likely involved in fibronectin-induced cord and tubule formation... - Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker ratSamy L Habib
Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712-1074, USA
Carcinogenesis 24:573-82. 2003..In keeping with this view, acute TGHQ-induced cytotoxicity was greater in Tsc-2(EK/+) rats than in Tsc-2(+/+) rats. The mechanism(s) coupling tuberin expression to the regulation of OGG1 are not known and are under investigation... - Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancerAlaa F Badawi
Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Cancer Invest 20:651-6. 2002..The observed over-expression of COX-2 gene in human urinary bladder and the concomitant increases in PG synthesis may explain, at least in part, the mechanism by which cigarette smoking influences the development of urothelial neoplasia...