Samy L Habib

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Diabetes and risk of renal cell carcinoma
    Samy L Habib
    1 Geriatric Research, Education, and, Clinical Center, South Texas, Veterans Healthcare System, San Antonio, Texas 78229, USA
    J Cancer 3:42-8. 2012
  2. pmc Mechanism of Activation of AMPK and Upregulation of OGG1 by Rapamycin in Cancer Cells
    Samy L Habib
    The University of Texas Health Science Center, Department of Cellular and Structural Biology
    Oncotarget 2:958-9. 2011
  3. pmc Diabetes and risk of cancer
    Samy L Habib
    Department of Geriatric, Geriatric Research, Education, and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX 78229, USA Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    ISRN Oncol 2013:583786. 2013
  4. pmc Tuberin inhibits production of the matrix protein fibronectin in diabetes
    Samy L Habib
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Am Soc Nephrol 23:1652-62. 2012
  5. pmc Molecular mechanism of regulation of OGG1: tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YA
    Samy L Habib
    South Texas Veterans Healthcare System, Geriatric Research, Education and Clinical Center, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Mol Signal 4:8. 2009
  6. ncbi request reprint Tuberous sclerosis complex and DNA repair
    Samy L Habib
    South Texas Veterans Healthcare System, Geriatric Research, Education and Clinical Center and Department of Medicine, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Adv Exp Med Biol 685:84-94. 2010
  7. pmc Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells
    Samy L Habib
    Department of Geriatrics, Geriatric Research, Education, and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX 78229, USA
    Carcinogenesis 31:2022-30. 2010
  8. pmc The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes
    Chakradhar Velagapudi
    The University of Texas Health Science Center, Department of Medicine MSC 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Am Soc Nephrol 22:262-73. 2011
  9. doi request reprint Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition
    Samy L Habib
    Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, TX, USA
    Eur J Cancer 46:2806-20. 2010
  10. pmc Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients
    Samy L Habib
    Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA
    Mol Cancer 8:13. 2009

Collaborators

Detail Information

Publications24

  1. pmc Diabetes and risk of renal cell carcinoma
    Samy L Habib
    1 Geriatric Research, Education, and, Clinical Center, South Texas, Veterans Healthcare System, San Antonio, Texas 78229, USA
    J Cancer 3:42-8. 2012
    ..There is evidence that the incidence of solid tumors is markedly increased in patients with diabetes mellitus. In the current study, we investigate the association between diabetes and renal cancer...
  2. pmc Mechanism of Activation of AMPK and Upregulation of OGG1 by Rapamycin in Cancer Cells
    Samy L Habib
    The University of Texas Health Science Center, Department of Cellular and Structural Biology
    Oncotarget 2:958-9. 2011
    ..These data strongly suggest that rapamycin may acts as a direct activator of AMPK to phosphorylate raptor at Ser722/Ser792 and inhibit mTOR that lead to activate the DNA repair enzyme OGG1 in cancer cells...
  3. pmc Diabetes and risk of cancer
    Samy L Habib
    Department of Geriatric, Geriatric Research, Education, and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX 78229, USA Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    ISRN Oncol 2013:583786. 2013
    ..Additionally, we have discussed the possible pathophysiological mechanisms that likely may be involved in promoting carcinogenesis in diabetes and the potential of different antidiabetic therapies to influence cancer incidence...
  4. pmc Tuberin inhibits production of the matrix protein fibronectin in diabetes
    Samy L Habib
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Am Soc Nephrol 23:1652-62. 2012
    ..Taken together, these data suggest that tuberin plays a central role in the development of renal hypertrophy and in modulating the production of the matrix protein fibronectin in diabetes...
  5. pmc Molecular mechanism of regulation of OGG1: tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YA
    Samy L Habib
    South Texas Veterans Healthcare System, Geriatric Research, Education and Clinical Center, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Mol Signal 4:8. 2009
    ..These data define a novel mechanism of regulation of OGG1 through tuberin. This mechanism may be important in the pathogenesis of kidney tumors in patients with TSC disease...
  6. ncbi request reprint Tuberous sclerosis complex and DNA repair
    Samy L Habib
    South Texas Veterans Healthcare System, Geriatric Research, Education and Clinical Center and Department of Medicine, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Adv Exp Med Biol 685:84-94. 2010
    ....
  7. pmc Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells
    Samy L Habib
    Department of Geriatrics, Geriatric Research, Education, and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX 78229, USA
    Carcinogenesis 31:2022-30. 2010
    ..These data indicate a novel role for tuberin in the regulation of OGG1 through the transcription factor AP4. This regulation may be important in the pathogenesis of kidney tumours in patients with TSC disease...
  8. pmc The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes
    Chakradhar Velagapudi
    The University of Texas Health Science Center, Department of Medicine MSC 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Am Soc Nephrol 22:262-73. 2011
    ..Furthermore, gene silencing of tuberin with siRNA decreased cleavage of PARP. These data show that the tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes, mediated in part by cleavage of PARP by YY1...
  9. doi request reprint Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition
    Samy L Habib
    Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, TX, USA
    Eur J Cancer 46:2806-20. 2010
    ..These data comprise the first report to provide one mechanism whereby rapamycin might prevent or inhibit the formation and progression of certain cancers...
  10. pmc Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients
    Samy L Habib
    Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA
    Mol Cancer 8:13. 2009
    ..In addition we evaluated the phophorylation level of downstream targets of mTOR, phospho-S70K, in kidney tumor tissue from TSC patients...
  11. ncbi request reprint Novel adenine adducts, N7-guanine-AFB1 adducts, and p53 mutations in patients with schistosomiasis and aflatoxin exposure
    Samy L Habib
    Department of Community and Environmental Medicine, College of Medicine, University of California at Irvine, Irvine, CA 92697, USA
    Cancer Detect Prev 30:491-8. 2006
    ..Schistosomiasis is known to cause p53 mutation. We hypothesized that the combination of schistosomiasis and aflatoxin B1 increases the incidence of p53 gene mutation...
  12. ncbi request reprint Genetic polymorphisms in OGG1 and their association with angiomyolipoma, a benign kidney tumor in patients with tuberous sclerosis
    Samy L Habib
    George O Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Cancer Biol Ther 7:23-7. 2008
    ..Taken together, our findings suggest that Ser(326)Cys variant of OGG1 may confer risk for development of angiomyolipomas by increasing oxidative DNA damage...
  13. ncbi request reprint Tuberin regulates the DNA repair enzyme OGG1
    Samy L Habib
    George O Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Am J Physiol Renal Physiol 294:F281-90. 2008
    ..These data provide the first evidence that tuberin regulates a specific DNA repair enzyme, OGG1. This regulation may be important in the pathogenesis of kidney tumors in patients with TSC...
  14. pmc Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors
    Samy L Habib
    O Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Mol Cancer 7:10. 2008
    ..We investigated the distribution of protein expression and the activity of OGG1 and 8-oxo-dG and correlated it with the expression of tuberin in kidneys of wild type and Eker rats and tumor from Eker rat...
  15. pmc Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase
    Simona Simone
    George O Brien Kidney Research Center, Department of Medicine, Division of Nephrology, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes 57:2626-36. 2008
    ..To investigate potential mechanisms of oxidative DNA damage in a rat model of type 1 diabetes and in murine proximal tubular epithelial cells and primary culture of rat proximal tubular epithelial cells...
  16. pmc TSC2 deficiency increases PTEN via HIF1alpha
    Lenin Mahimainathan
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 284:27790-8. 2009
    ..These data suggest that PTEN may safeguard against developing malignant tumors in patients with TSC deficiency...
  17. pmc Novel mechanism of regulation of fibrosis in kidney tumor with tuberous sclerosis
    Sitai Liang
    Geriatric Research, Education and Clinical Department, South Texas Veterans Health Care System, San Antonio, TX, USA
    Mol Cancer 12:49. 2013
    ..The mechanisms by which tuberin regulates fibrosis in kidney angiomyolipomas (AMLs) of tuberous sclerosis patients are not fully known...
  18. ncbi request reprint Role of tuberin in neuronal degeneration
    Samy L Habib
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
    Neurochem Res 33:1113-6. 2008
    ..Our data provide new information regarding the possible role of tuberin dysfunction in major neurodegenerative disorders, such as AD and PD, whereby inhibition of tuberin function may trigger an onset of neuronal cell death...
  19. pmc Regulation of PI 3-K, PTEN, p53, and mTOR in Malignant and Benign Tumors Deficient in Tuberin
    Samy L Habib
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, TX, USA
    Genes Cancer 2:1051-60. 2011
    ....
  20. pmc Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes
    Samy L Habib
    Department of Geriatric, Geriatric Research, Education, and Clinical Center, South Texas Veterans Healthcare System
    Oncotarget 5:2542-50. 2014
    ..These data suggest that Akt/tuberin/mTOR pathway plays an important role in the regulation DNA damage and repair pathways that may predispose diabetic kidneys to pathogenesis of renal cell carcinoma. ..
  21. ncbi request reprint Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation
    Peng Ye
    Department of Pediatrics and Department of Internal Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Kidney Int 66:1356-64. 2004
    ..The extracellular matrix (ECM) protein fibronectin is involved in several stages of embryogenesis. Fibronectin exerts its effect through interaction with cellular integrin and nonintegrin receptors...
  22. ncbi request reprint Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat
    Samy L Habib
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712 1074, USA
    Carcinogenesis 24:573-82. 2003
    ..In keeping with this view, acute TGHQ-induced cytotoxicity was greater in Tsc-2(EK/+) rats than in Tsc-2(+/+) rats. The mechanism(s) coupling tuberin expression to the regulation of OGG1 are not known and are under investigation...
  23. ncbi request reprint Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancer
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Cancer Invest 20:651-6. 2002
    ..The observed over-expression of COX-2 gene in human urinary bladder and the concomitant increases in PG synthesis may explain, at least in part, the mechanism by which cigarette smoking influences the development of urothelial neoplasia...