Research Topics
| Suzanne HaberSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
The concept of the ventral striatum in nonhuman primatesS N Haber
Department of Neurobiology and Anatomy, University of Rochester School of Medicine, New York 14642, USA
Ann N Y Acad Sci 877:33-48. 1999..This paper uses the afferent connections to the ventral striatum to define this region in monkeys. Furthermore the shell and core subterritories are discussed with respect to their histochemistry and specific connections...- Cognitive and limbic circuits that are affected by deep brain stimulationSuzanne N Haber
Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
Front Biosci 14:1823-34. 2009..As more knowledge is obtained concerning the details of these connections, more precise targets may be possible... - Parallel and integrative processing through the Basal Ganglia reward circuit: lessons from addictionSuzanne Haber
Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York 14642, USA
Biol Psychiatry 64:173-4. 2008 - Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learningSuzanne N Haber
Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Neurosci 26:8368-76. 2006..Furthermore, areas of convergence may be particularly sensitive to dopamine modulation during decision making and habit formation... 
The reward circuit: linking primate anatomy and human imagingSuzanne N Haber
Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA
Neuropsychopharmacology 35:4-26. 2010..Advances in neuroimaging techniques allow better spatial and temporal resolution. These studies now demonstrate that human functional and structural imaging results map increasingly close to primate anatomy...- The primate basal ganglia: parallel and integrative networksSuzanne N Haber
Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Chem Neuroanat 26:317-30. 2003..Information is channeled from limbic, to cognitive, to motor circuits. Action decision-making processes are thus influenced by motivation and cognitive inputs, allowing the animal to respond appropriate to environmental cues... - The place of the thalamus in frontal cortical-basal ganglia circuitsS Haber
Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, New York 14642, USA
Neuroscientist 7:315-24. 2001..These two recent developments indicate a more dynamic role for the thalamus in basal ganglia information processing than a passive relay... - Defining the caudal ventral striatum in primates: cellular and histochemical featuresJulie L Fudge
Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 22:10078-82. 2002..In addition, Bcl-2 is expressed in and near both poles of the ventral striatum, suggesting that these areas maintain a heightened capacity for growth and plasticity compared with other striatal sectors... - Thalamic relay nuclei of the basal ganglia form both reciprocal and nonreciprocal cortical connections, linking multiple frontal cortical areasNikolaus R McFarland
Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci 22:8117-32. 2002..Together, these experiments indicate a dual role for VA-VL and MD nuclei: (1) to relay basal ganglia output within specific cortical circuits and (2) to mediate information flow between cortical circuits... - Relationship between the corticostriatal terminals from areas 9 and 46, and those from area 8A, dorsal and rostral premotor cortex and area 24c: an anatomical substrate for cognition to actionRoberta Calzavara
Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, New York 14642, USA
Eur J Neurosci 26:2005-24. 2007..These features of the corticostriatal frontal pathways suggest a potential integrative striatal network for learning... - Enhanced synchrony among primary motor cortex neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's diseaseJoshua A Goldberg
Department of Physiology, The Hebrew University Hadassah Medical School, The Interdisciplinary Center for Neural Computation, The Hebrew University, Jerusalem 91120, Israel
J Neurosci 22:4639-53. 2002..Abnormal MI firing patterns and synchronization, rather than reduced firing rates, may underlie PD akinesia and persistent muscle rigidity... - Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatumDiana Martinez
Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
J Cereb Blood Flow Metab 23:285-300. 2003.... - A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorderScott L Rauch
Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosurg 104:558-65. 2006..The purpose of the current study was to test hypotheses regarding changes in regional cerebral blood flow (rCBF) during acute DBS at the VC/VS target in patients with OCD who were participating in a clinical DBS trial... 
Low-pass filter properties of basal ganglia cortical muscle loops in the normal and MPTP primate model of parkinsonismMichal Rivlin-Etzion
Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
J Neurosci 28:633-49. 2008..The low-pass properties of the pathways connecting GP to MI to muscles suggest that parkinsonian tremor is not directly driven by the BG 5-10 Hz burst oscillations despite their similar frequencies...- Prefrontal cortical projections to the midbrain in primates: evidence for a sparse connectionWilliam Gordon Frankle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
Neuropsychopharmacology 31:1627-36. 2006..Thus, while, based on these anatomical studies, direct cortical control of DA neurons remains debatable in primates; the cortex may directly impact other sources of glutamatergic control...
Research Grants
- Dopamine system plasticity after a partial lesionSuzanne Haber; Fiscal Year: 2005....
- The Neural Network of Deep Brain Stimulation in OCDSuzanne Haber; Fiscal Year: 2009..A better understanding of the underlying neural circuitry of psychiatric disorders is a key element for developing the next generation of effective treatments. ..
- BASAL GANGLIA--CHEMICAL AND FUNCTIONAL CIRCUITRYSuzanne Haber; Fiscal Year: 2002..These studies will link together how the OMPFC and thalamic inputs to the VS are related to the shell and core sub-territories, and the mu and GluR1 receptors and follow the outputs via the VP/SNr to the MD. ..
- Regulation and Development of the Prefrontal CortexSuzanne Haber; Fiscal Year: 2005..A specific emphasis is on recruiting young scientists to the field. Therefore each workshop will engage at least one young scientist in a leadership role, (as facilitator, scribe, or presenter). ..
- CONTINUITY OF LIMBIC CIRCUIT THROUGH THE BASAL GANGLIASuzanne Haber; Fiscal Year: 2007..characterize bcl-2-positive neurons and newly formed cells and determine whether the unique cellular characteristics of the VS differ during adolescence, and whether they are particularly vulnerable to stimulation. ..
- Reward, Compulsions and Habit FormationSuzanne Haber; Fiscal Year: 2007..2005; Kelley and Berridge, 2002), as well as the commonalities and differences in other compulsive disorders such as OCD and Tourette's Syndrome. ..
- CONTINUITY OF LIMBIC CIRCUIT THROUGH THE BASAL GANGLIASuzanne Haber; Fiscal Year: 2009..This developmental period is also the time when there is a great deal of anatomical refinement of circuits. ..
- The Ventral Striatal Network in Emotional ProcessingSuzanne Haber; Fiscal Year: 2002..This unique format, which was very successful at our last meeting, encourages free exchange of ideas to address the question "what is the role of the ventral striatal network in emotional processing? ..
- THE BASAL GANGLIA: CHEMICAL & FUNCTIONAL CIRCUITRYSuzanne Haber; Fiscal Year: 1993..Finally, the distributions of neurotransmitter systems in animals and human ganglia will be compared. These studies will contribute to the understanding of the organization of these structures in the human...
- CONTINUITY OF LIMBIC CIRCUIT THROUGH THE BASAL GANGLIASuzanne Haber; Fiscal Year: 2001..how the midbrain dopamine circuitry can integrate different functional domains, and 2. how the midbrain dopamine circuitry can differentially regulate various cortical and striatal pathways through levels of DAT and receptor subtypes. ..
- CONTINUITY OF LIMBIC CIRCUIT THROUGH THE BASAL GANGLIASuzanne N Haber; Fiscal Year: 2010..This developmental period is also the time when there is a great deal of anatomical refinement of circuits. ..