V H Haase

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting
    Volker H Haase
    Department of Medicine, University of Pennsylvania School of Medicine, 700 CRB, 415 Curie Boulevard, Philadelphia, PA 19104 6144, USA
    Semin Cell Dev Biol 16:564-74. 2005
  2. ncbi request reprint Hypoxia-inducible factors in the kidney
    Volker H Haase
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol Renal Physiol 291:F271-81. 2006
  3. ncbi request reprint The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease
    V H Haase
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6144, USA
    Kidney Int 69:1302-7. 2006
  4. pmc The VHL tumor suppressor and HIF: insights from genetic studies in mice
    P P Kapitsinou
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Death Differ 15:650-9. 2008
  5. pmc Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
    Erinn B Rankin
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
    J Clin Invest 117:1068-77. 2007
  6. pmc Hypoxic regulation of erythropoiesis and iron metabolism
    Volker H Haase
    Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 299:F1-13. 2010
  7. pmc Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
    Pinelopi P Kapitsinou
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Blood 116:3039-48. 2010
  8. pmc Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
    Erinn B Rankin
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6144, USA
    Oncogene 27:5354-8. 2008
  9. pmc Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
    Mangatt P Biju
    Department of Medicine, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
    Mol Cell Biol 24:9038-47. 2004
  10. pmc Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    Debra F Higgins
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:3810-20. 2007

Research Grants

  1. Functional Studies of VHL by Conditional Gene Targeting
    Volker Haase; Fiscal Year: 2003
  2. VHL FUNCTION BY CONDITIONAL GENE TARGETING
    Volker Haase; Fiscal Year: 2003
  3. MOLECULAR MECHANISMS OF RENAL INJURY
    Volker Haase; Fiscal Year: 2007
  4. Hypoxic signaling in hepatocytes
    Volker Haase; Fiscal Year: 2007

Collaborators

Detail Information

Publications40

  1. pmc The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting
    Volker H Haase
    Department of Medicine, University of Pennsylvania School of Medicine, 700 CRB, 415 Curie Boulevard, Philadelphia, PA 19104 6144, USA
    Semin Cell Dev Biol 16:564-74. 2005
    ..Mouse knock out studies have provided novel mechanistic insights into VHL associated tumorigenesis and established a central role for HIF in the development of the VHL phenotype...
  2. ncbi request reprint Hypoxia-inducible factors in the kidney
    Volker H Haase
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol Renal Physiol 291:F271-81. 2006
    ..This review summarizes some of the most recent advances in the HIF field and discusses their relevance to renal development, normal kidney function and disease...
  3. ncbi request reprint The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease
    V H Haase
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6144, USA
    Kidney Int 69:1302-7. 2006
    ..This review summarizes some of the most recent advances in the VHL/HIF field and discusses their relevance for pathogenesis and treatment of acute ischemic renal failure, renal fibrosis, and renal cancer...
  4. pmc The VHL tumor suppressor and HIF: insights from genetic studies in mice
    P P Kapitsinou
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Death Differ 15:650-9. 2008
    ..In this review, we discuss the role of HIF in the development of the VHL phenotype...
  5. pmc Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
    Erinn B Rankin
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
    J Clin Invest 117:1068-77. 2007
    ....
  6. pmc Hypoxic regulation of erythropoiesis and iron metabolism
    Volker H Haase
    Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 299:F1-13. 2010
    ....
  7. pmc Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
    Pinelopi P Kapitsinou
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Blood 116:3039-48. 2010
    ..Furthermore, we provide evidence that hepatocyte-derived Hif-2 is involved in the regulation of iron metabolism genes, supporting a role for HIF-2 in the coordination of EPO synthesis with iron homeostasis...
  8. pmc Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
    Erinn B Rankin
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6144, USA
    Oncogene 27:5354-8. 2008
    ..These findings suggest that HIF-2 is the dominant HIF in the pathogenesis of VHL-associated vascular tumors and that pharmacologic targeting of HIF-2 may be an effective strategy for their treatment...
  9. pmc Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
    Mangatt P Biju
    Department of Medicine, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
    Mol Cell Biol 24:9038-47. 2004
    ..Our data suggest that tight regulation of Hif-1 via pVhl is required for normal thymocyte development and viability and that an increase in Hif-1 transcriptional activity enhances caspase 8-mediated apoptosis in thymocytes...
  10. pmc Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    Debra F Higgins
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:3810-20. 2007
    ....
  11. pmc Low oxygen stimulates the immune system
    J S Maltzman
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Kidney Int 73:797-9. 2008
    ..Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney...
  12. pmc Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease
    Min Peng
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 4:e1000061. 2008
    ..These data suggest that disease manifestations of CoQ deficiency relate to tissue-specific respiratory capacity thresholds, with glomerular podocytes displaying the greatest sensitivity to Pdss2 impairment...
  13. pmc The sweet side of HIF
    Volker H Haase
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Kidney Int 78:10-3. 2010
    ....
  14. ncbi request reprint Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease
    Kirsten Brukamp
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, USA
    Am J Physiol Renal Physiol 293:F1397-407. 2007
    ....
  15. pmc Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction
    Aaron K Neumann
    Department of Medicine and Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:17071-6. 2005
    ..These data suggest a unique mechanism for control of TCR signaling through Hif-1alpha, which may be operative at the physiologic oxygen tensions seen in solid lymphoid organs...
  16. ncbi request reprint Hypoxic induction of Ctgf is directly mediated by Hif-1
    Debra F Higgins
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6144, USA
    Am J Physiol Renal Physiol 287:F1223-32. 2004
    ..Our findings have important implications for a number of fibrotic disorders in which hypoxia, CTGF, and TGF-beta(1) are involved, including renal, dermal, hepatic, and pulmonary fibrosis...
  17. pmc Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice
    Erinn B Rankin
    Department of Medicine, 700 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
    Mol Cell Biol 25:3163-72. 2005
    ..Furthermore, we provide evidence that individual HIF transcription factors may play distinct roles in the development of specific VHL disease manifestations...
  18. pmc Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury
    Amandeep Bajwa
    Department of Medicine, Division of Nephrology, Box 800133, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Am Soc Nephrol 21:955-65. 2010
    ..Selective agonists of S1P1Rs may hold therapeutic potential for the prevention and treatment of acute kidney injury...
  19. pmc Hypoxia-inducible factor signaling in the development of tissue fibrosis
    Debra F Higgins
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Cell Cycle 7:1128-32. 2008
    ..Here we discuss the role of HIF signaling in the pathogenesis and progression of chronic kidney disease...
  20. pmc Hypoxia-inducible factor 2 regulates hepatic lipid metabolism
    Erinn B Rankin
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 29:4527-38. 2009
    ..These findings demonstrate that HIF-2 functions as an important regulator of hepatic lipid metabolism and identify HIF-2 as a potential target for the treatment of fatty liver disease...
  21. pmc Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease
    Volker H Haase
    Department of Medicine, Vanderbilt University Medical Center, C 3119A, MCN, 1161 21stAvenue, Nashville, TN 37232, USA
    Kidney Int 76:492-9. 2009
    ..Recent insights into potential molecular mechanisms underlying oxygen-dependent regulation of this process and their relevance to disease are discussed...
  22. pmc Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor
    Erinn B Rankin
    Department of Medicine and Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
    Cancer Res 66:2576-83. 2006
    ....
  23. pmc The VHL tumor suppressor: master regulator of HIF
    Volker H Haase
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Pharm Des 15:3895-903. 2009
    ..Here we focus on the contribution of individual HIF transcription factors to the development of VHL phenotypes and discuss how the pVHL/HIF axis could be exploited pharmacologically...
  24. pmc Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27
    Fiona A Mack
    University of Pennsylvania School of Medicine, Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:4565-78. 2005
    ..These results demonstrate that a loss of pVHL can induce growth arrest in certain cells types, which suggests that additional genetic mutations are necessary for VHL-associated tumorigenesis...
  25. pmc Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
    Bernhard Bielesz
    Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 120:4040-54. 2010
    ..In summary, our experiments establish that epithelial injury and Notch signaling play key roles in fibrosis development and indicate that Notch blockade may be a therapeutic strategy to reduce fibrosis and ESRD development...
  26. pmc Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade
    Yatrik M Shah
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 134:2036-48, 2048.e1-3. 2008
    ..A previous study has shown hypoxia-inducible factor (HIF) as a critical regulator of barrier protection during colon epithelial injury. However, the role of HIF signaling in colon mucosal immunity is not known...
  27. pmc Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
    Ying Liu
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 108:123-33. 2006
    ..Therefore, Fas and FasL are negative regulators of erythropoiesis. Epo-mediated suppression of erythroblast Fas and FasL is a novel stress response pathway that facilitates erythroblast expansion in vivo...
  28. pmc Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha
    Sang Ki Park
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0366, USA
    Mol Cell Biol 23:4959-71. 2003
    ....
  29. ncbi request reprint HIF-1alpha is essential for myeloid cell-mediated inflammation
    Thorsten Cramer
    Molecular Biology Section, Division of Biological Sciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 112:645-57. 2003
    ..This role for HIF-1alpha demonstrates its direct regulation of survival and function in the inflammatory microenvironment...
  30. ncbi request reprint von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase
    Sang Ki Park
    Division of Biological Sciences, University of California, San Diego, La Jolla 92093 0366, USA
    Int J Oncol 30:341-8. 2007
    ..Following VHL inactivation, one pathway causes oxygen-independent overexpression of classic hypoxia-inducible genes and the other one described here suppresses expression of the genes important for liver glucose metabolism...
  31. pmc pVHL function is essential for endothelial extracellular matrix deposition
    Nan Tang
    Molecular Biology Section, MC 0377, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093 0377, USA
    Mol Cell Biol 26:2519-30. 2006
    ....
  32. ncbi request reprint Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development
    David Pfander
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Development 131:2497-508. 2004
    ..This is the first study reporting the novel and intriguing findings that pVHL has a crucial role in endochondral bone development and is necessary for normal chondrocyte proliferation in vivo...
  33. pmc Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
    Jorn Karhausen
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 114:1098-106. 2004
    ..Taken together, these studies provide insight into tissue microenvironmental changes during model inflammatory bowel disease and identify HIF-1 as a critical factor for barrier protection during mucosal insult...
  34. ncbi request reprint Inflammatory hypoxia: role of hypoxia-inducible factor
    Jorn Karhausen
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Cycle 4:256-8. 2005
    ..Here, we review recent work addressing the influence of hypoxia on development of inflammatory lesions, with particular emphasis on molecular pathways regulated by hypoxia-inducible factor (HIF)...
  35. ncbi request reprint Protection of HIF-1-deficient primary renal tubular epithelial cells from hypoxia-induced cell death is glucose dependent
    Mangatt P Biju
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6144, USA
    Am J Physiol Renal Physiol 289:F1217-26. 2005
    ....
  36. pmc Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
    Carole Peyssonnaux
    Molecular Biology Section, Division of Biological Sciences, UCSD School of Medicine, La Jolla, CA 92093 0377, USA
    J Clin Invest 117:1926-32. 2007
    ..Through coordinate downregulation of hepcidin and upregulation of erythropoietin and ferroportin, the VHL-HIF pathway mobilizes iron to support erythrocyte production...
  37. doi request reprint Hemoglobin in the kidney: breaking with traditional dogma
    Volker H Haase
    J Am Soc Nephrol 19:1440-1. 2008
  38. ncbi request reprint Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression
    Jinzhao Wang
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    J Am Soc Nephrol 17:1875-85. 2006
    ..Therefore, the cytoprotective effects of hypoxia are independent of changes in cell ATP, pH, or HIF but may involve mitochondrial inhibition and the suppression of p53...
  39. pmc Epidermal sensing of oxygen is essential for systemic hypoxic response
    Adam T Boutin
    Molecular Biology Section, Division of Biological Sciences, UC San Diego, La Jolla, CA 92093, USA
    Cell 133:223-34. 2008
    ..These results demonstrate that in mice the skin is a critical mediator of systemic responses to environmental oxygen...
  40. pmc The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development
    Ying Wang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Clin Invest 117:1616-26. 2007
    ..These studies suggest that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone...

Research Grants4

  1. Functional Studies of VHL by Conditional Gene Targeting
    Volker Haase; Fiscal Year: 2003
    ..Volker H. Haase, who is an Assistant Professor of Medicine in the University of Pennsylvania's Renal Division. Dr. Michael Madaio, Professor of Medicine, will function as Dr. Haase's mentor for this grant. ..
  2. VHL FUNCTION BY CONDITIONAL GENE TARGETING
    Volker Haase; Fiscal Year: 2003
    ..He is absolutely committed to a career centered on basic research in an academic Nephrology division applying the techniques learned during the award period. ..
  3. MOLECULAR MECHANISMS OF RENAL INJURY
    Volker Haase; Fiscal Year: 2007
    ..Data generated from this grant would be used to guide a grant proposal for 5-year NIH funding. ..
  4. Hypoxic signaling in hepatocytes
    Volker Haase; Fiscal Year: 2007
    ..The data generated from this grant application will be used as basis for a five year NIH grant application that investigates HIF-dependent and HIF-independent hypoxic signaling in the context of liver disease. ..