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Genomes and Genes | V H HaaseSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targetingVolker H Haase
Department of Medicine, University of Pennsylvania School of Medicine, 700 CRB, 415 Curie Boulevard, Philadelphia, PA 19104 6144, USA
Semin Cell Dev Biol 16:564-74. 2005..Mouse knock out studies have provided novel mechanistic insights into VHL associated tumorigenesis and established a central role for HIF in the development of the VHL phenotype...- Hypoxia-inducible factors in the kidneyVolker H Haase
Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
Am J Physiol Renal Physiol 291:F271-81. 2006..This review summarizes some of the most recent advances in the HIF field and discusses their relevance to renal development, normal kidney function and disease... - The VHL/HIF oxygen-sensing pathway and its relevance to kidney diseaseV H Haase
Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6144, USA
Kidney Int 69:1302-7. 2006..This review summarizes some of the most recent advances in the VHL/HIF field and discusses their relevance for pathogenesis and treatment of acute ischemic renal failure, renal fibrosis, and renal cancer... 
The VHL tumor suppressor and HIF: insights from genetic studies in miceP P Kapitsinou
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cell Death Differ 15:650-9. 2008..In this review, we discuss the role of HIF in the development of the VHL phenotype...
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivoErinn B Rankin
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
J Clin Invest 117:1068-77. 2007....- Hypoxic regulation of erythropoiesis and iron metabolismVolker H Haase
Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
Am J Physiol Renal Physiol 299:F1-13. 2010.... - Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemiaPinelopi P Kapitsinou
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
Blood 116:3039-48. 2010..Furthermore, we provide evidence that hepatocyte-derived Hif-2 is involved in the regulation of iron metabolism genes, supporting a role for HIF-2 in the coordination of EPO synthesis with iron homeostasis... - Hypoxia-inducible factor-2 regulates vascular tumorigenesis in miceErinn B Rankin
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6144, USA
Oncogene 27:5354-8. 2008..These findings suggest that HIF-2 is the dominant HIF in the pathogenesis of VHL-associated vascular tumors and that pharmacologic targeting of HIF-2 may be an effective strategy for their treatment... - Vhlh gene deletion induces Hif-1-mediated cell death in thymocytesMangatt P Biju
Department of Medicine, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
Mol Cell Biol 24:9038-47. 2004..Our data suggest that tight regulation of Hif-1 via pVhl is required for normal thymocyte development and viability and that an increase in Hif-1 transcriptional activity enhances caspase 8-mediated apoptosis in thymocytes... - Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transitionDebra F Higgins
Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 117:3810-20. 2007.... - Low oxygen stimulates the immune systemJ S Maltzman
Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Kidney Int 73:797-9. 2008..Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney... - Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal diseaseMin Peng
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS Genet 4:e1000061. 2008..These data suggest that disease manifestations of CoQ deficiency relate to tissue-specific respiratory capacity thresholds, with glomerular podocytes displaying the greatest sensitivity to Pdss2 impairment... - The sweet side of HIFVolker H Haase
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
Kidney Int 78:10-3. 2010.... - Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular diseaseKirsten Brukamp
Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, USA
Am J Physiol Renal Physiol 293:F1397-407. 2007.... - Hypoxia inducible factor 1 alpha regulates T cell receptor signal transductionAaron K Neumann
Department of Medicine and Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:17071-6. 2005..These data suggest a unique mechanism for control of TCR signaling through Hif-1alpha, which may be operative at the physiologic oxygen tensions seen in solid lymphoid organs... - Hypoxic induction of Ctgf is directly mediated by Hif-1Debra F Higgins
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6144, USA
Am J Physiol Renal Physiol 287:F1223-32. 2004..Our findings have important implications for a number of fibrotic disorders in which hypoxia, CTGF, and TGF-beta(1) are involved, including renal, dermal, hepatic, and pulmonary fibrosis... - Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in miceErinn B Rankin
Department of Medicine, 700 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
Mol Cell Biol 25:3163-72. 2005..Furthermore, we provide evidence that individual HIF transcription factors may play distinct roles in the development of specific VHL disease manifestations... - Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injuryAmandeep Bajwa
Department of Medicine, Division of Nephrology, Box 800133, University of Virginia Health System, Charlottesville, VA 22908, USA
J Am Soc Nephrol 21:955-65. 2010..Selective agonists of S1P1Rs may hold therapeutic potential for the prevention and treatment of acute kidney injury... - Hypoxia-inducible factor signaling in the development of tissue fibrosisDebra F Higgins
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Cell Cycle 7:1128-32. 2008..Here we discuss the role of HIF signaling in the pathogenesis and progression of chronic kidney disease... - Hypoxia-inducible factor 2 regulates hepatic lipid metabolismErinn B Rankin
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mol Cell Biol 29:4527-38. 2009..These findings demonstrate that HIF-2 functions as an important regulator of hepatic lipid metabolism and identify HIF-2 as a potential target for the treatment of fatty liver disease... - Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to diseaseVolker H Haase
Department of Medicine, Vanderbilt University Medical Center, C 3119A, MCN, 1161 21stAvenue, Nashville, TN 37232, USA
Kidney Int 76:492-9. 2009..Recent insights into potential molecular mechanisms underlying oxygen-dependent regulation of this process and their relevance to disease are discussed... - Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressorErinn B Rankin
Department of Medicine and Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
Cancer Res 66:2576-83. 2006.... - The VHL tumor suppressor: master regulator of HIFVolker H Haase
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Curr Pharm Des 15:3895-903. 2009..Here we focus on the contribution of individual HIF transcription factors to the development of VHL phenotypes and discuss how the pVHL/HIF axis could be exploited pharmacologically... - Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27Fiona A Mack
University of Pennsylvania School of Medicine, Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
Mol Cell Biol 25:4565-78. 2005..These results demonstrate that a loss of pVHL can induce growth arrest in certain cells types, which suggests that additional genetic mutations are necessary for VHL-associated tumorigenesis... - Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humansBernhard Bielesz
Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine, New York, New York 10461, USA
J Clin Invest 120:4040-54. 2010..In summary, our experiments establish that epithelial injury and Notch signaling play key roles in fibrosis development and indicate that Notch blockade may be a therapeutic strategy to reduce fibrosis and ESRD development... - Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascadeYatrik M Shah
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Gastroenterology 134:2036-48, 2048.e1-3. 2008..A previous study has shown hypoxia-inducible factor (HIF) as a critical regulator of barrier protection during colon epithelial injury. However, the role of HIF signaling in colon mucosal immunity is not known... - Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivoYing Liu
Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
Blood 108:123-33. 2006..Therefore, Fas and FasL are negative regulators of erythropoiesis. Epo-mediated suppression of erythroblast Fas and FasL is a novel stress response pathway that facilitates erythroblast expansion in vivo... - Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alphaSang Ki Park
Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0366, USA
Mol Cell Biol 23:4959-71. 2003.... - HIF-1alpha is essential for myeloid cell-mediated inflammationThorsten Cramer
Molecular Biology Section, Division of Biological Sciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Cell 112:645-57. 2003..This role for HIF-1alpha demonstrates its direct regulation of survival and function in the inflammatory microenvironment... - von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphataseSang Ki Park
Division of Biological Sciences, University of California, San Diego, La Jolla 92093 0366, USA
Int J Oncol 30:341-8. 2007..Following VHL inactivation, one pathway causes oxygen-independent overexpression of classic hypoxia-inducible genes and the other one described here suppresses expression of the genes important for liver glucose metabolism... - pVHL function is essential for endothelial extracellular matrix depositionNan Tang
Molecular Biology Section, MC 0377, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093 0377, USA
Mol Cell Biol 26:2519-30. 2006.... - Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate developmentDavid Pfander
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Development 131:2497-508. 2004..This is the first study reporting the novel and intriguing findings that pVHL has a crucial role in endochondral bone development and is necessary for normal chondrocyte proliferation in vivo... - Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitisJorn Karhausen
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Clin Invest 114:1098-106. 2004..Taken together, these studies provide insight into tissue microenvironmental changes during model inflammatory bowel disease and identify HIF-1 as a critical factor for barrier protection during mucosal insult... - Inflammatory hypoxia: role of hypoxia-inducible factorJorn Karhausen
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cell Cycle 4:256-8. 2005..Here, we review recent work addressing the influence of hypoxia on development of inflammatory lesions, with particular emphasis on molecular pathways regulated by hypoxia-inducible factor (HIF)... - Protection of HIF-1-deficient primary renal tubular epithelial cells from hypoxia-induced cell death is glucose dependentMangatt P Biju
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6144, USA
Am J Physiol Renal Physiol 289:F1217-26. 2005.... - Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)Carole Peyssonnaux
Molecular Biology Section, Division of Biological Sciences, UCSD School of Medicine, La Jolla, CA 92093 0377, USA
J Clin Invest 117:1926-32. 2007..Through coordinate downregulation of hepcidin and upregulation of erythropoietin and ferroportin, the VHL-HIF pathway mobilizes iron to support erythrocyte production... - Hemoglobin in the kidney: breaking with traditional dogmaVolker H Haase
J Am Soc Nephrol 19:1440-1. 2008 - Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppressionJinzhao Wang
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
J Am Soc Nephrol 17:1875-85. 2006..Therefore, the cytoprotective effects of hypoxia are independent of changes in cell ATP, pH, or HIF but may involve mitochondrial inhibition and the suppression of p53... - Epidermal sensing of oxygen is essential for systemic hypoxic responseAdam T Boutin
Molecular Biology Section, Division of Biological Sciences, UC San Diego, La Jolla, CA 92093, USA
Cell 133:223-34. 2008..These results demonstrate that in mice the skin is a critical mediator of systemic responses to environmental oxygen... - The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal developmentYing Wang
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
J Clin Invest 117:1616-26. 2007..These studies suggest that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone...
Research Grants
- Functional Studies of VHL by Conditional Gene TargetingVolker Haase; Fiscal Year: 2003..Volker H. Haase, who is an Assistant Professor of Medicine in the University of Pennsylvania's Renal Division. Dr. Michael Madaio, Professor of Medicine, will function as Dr. Haase's mentor for this grant. ..
- VHL FUNCTION BY CONDITIONAL GENE TARGETINGVolker Haase; Fiscal Year: 2003..He is absolutely committed to a career centered on basic research in an academic Nephrology division applying the techniques learned during the award period. ..
- MOLECULAR MECHANISMS OF RENAL INJURYVolker Haase; Fiscal Year: 2007..Data generated from this grant would be used to guide a grant proposal for 5-year NIH funding. ..
- Hypoxic signaling in hepatocytesVolker Haase; Fiscal Year: 2007..The data generated from this grant application will be used as basis for a five year NIH grant application that investigates HIF-dependent and HIF-independent hypoxic signaling in the context of liver disease. ..