Ashley Haase

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection
    Jacob D Estes
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Infect Dis 195:551-61. 2007
  2. pmc Glycerol monolaurate prevents mucosal SIV transmission
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
    Nature 458:1034-8. 2009
  3. pmc Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy
    Ming Zeng
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Pathog 8:e1002437. 2012
  4. pmc Gene expression alterations in brains of mice infected with three strains of scrapie
    Pamela J Skinner
    Department of Veterinary and Biomedical Sciences, University of Minnesota, USA
    BMC Genomics 7:114. 2006
  5. doi request reprint Targeting early infection to prevent HIV-1 mucosal transmission
    Ashley T Haase
    Department of Microbiology, University of Minnesota, Minnesota 55455, USA
    Nature 464:217-23. 2010
  6. ncbi request reprint Perils at mucosal front lines for HIV and SIV and their hosts
    Ashley T Haase
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street South East, Minneapolis, Minnesota 55455, USA
    Nat Rev Immunol 5:783-92. 2005
  7. doi request reprint Early events in sexual transmission of HIV and SIV and opportunities for interventions
    Ashley T Haase
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Annu Rev Med 62:127-39. 2011
  8. ncbi request reprint Functional genomic analysis of the response of HIV-1-infected lymphatic tissue to antiretroviral therapy
    Qingsheng Li
    Department of Microbiology, Department of Medicine, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Infect Dis 189:572-82. 2004
  9. pmc Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Science 323:1726-9. 2009
  10. ncbi request reprint Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection
    Qingsheng Li
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Infect Dis 192:1269-76. 2005

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection
    Jacob D Estes
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Infect Dis 195:551-61. 2007
    ....
  2. pmc Glycerol monolaurate prevents mucosal SIV transmission
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
    Nature 458:1034-8. 2009
    ....
  3. pmc Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy
    Ming Zeng
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Pathog 8:e1002437. 2012
    ..Moreover, our findings also point to the potential use of adjunctive anti-fibrotic therapies to avert or moderate the pathological consequences of LT fibrosis, thereby improving immune reconstitution...
  4. pmc Gene expression alterations in brains of mice infected with three strains of scrapie
    Pamela J Skinner
    Department of Veterinary and Biomedical Sciences, University of Minnesota, USA
    BMC Genomics 7:114. 2006
    ..Three strains of mouse scrapie that show striking differences in neuropathology were studied: ME7, 22L, and Chandler/RML...
  5. doi request reprint Targeting early infection to prevent HIV-1 mucosal transmission
    Ashley T Haase
    Department of Microbiology, University of Minnesota, Minnesota 55455, USA
    Nature 464:217-23. 2010
    ....
  6. ncbi request reprint Perils at mucosal front lines for HIV and SIV and their hosts
    Ashley T Haase
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street South East, Minneapolis, Minnesota 55455, USA
    Nat Rev Immunol 5:783-92. 2005
    ..Microbicides and vaccines could increase these viral vulnerabilities at mucosal front lines...
  7. doi request reprint Early events in sexual transmission of HIV and SIV and opportunities for interventions
    Ashley T Haase
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Annu Rev Med 62:127-39. 2011
    ....
  8. ncbi request reprint Functional genomic analysis of the response of HIV-1-infected lymphatic tissue to antiretroviral therapy
    Qingsheng Li
    Department of Microbiology, Department of Medicine, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Infect Dis 189:572-82. 2004
    ..This model suggests that there could be a role for anti-inflammatory agents, alone or in combination with HAART, in treating HIV-1 infection by tipping this balance to mitigate pathology...
  9. pmc Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Science 323:1726-9. 2009
    ..This method highlights the importance of the location, timing, and magnitude of the immune response needed for a vaccine to be effective against agents of persistent infection, such as HIV-1...
  10. ncbi request reprint Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection
    Qingsheng Li
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Infect Dis 192:1269-76. 2005
    ....
  11. pmc Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection
    Zhi qiang Zhang
    Department of Microbiology, University of Minnesota Medical School, MMC 196, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 101:5640-5. 2004
    ....
  12. pmc Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infection
    Qingsheng Li
    Department of Microbiology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:1975-82. 2009
    ..These common and stage-specific gene expression signatures identify potential molecular mechanisms underlying the host response and the slow, natural course of HIV-1 infection...
  13. ncbi request reprint Persistent abnormalities in lymphoid tissues of human immunodeficiency virus-infected patients successfully treated with highly active antiretroviral therapy
    Timothy W Schacker
    Department of Medicine, University of Minnesota, MMC 250, 516 Delaware Street, Minneapolis MN 55455, USA
    J Infect Dis 186:1092-7. 2002
    ....
  14. pmc Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis
    Timothy W Schacker
    Department of Medicine Infectious Diseases, University of Minnesota, MMC 250, 516 Delaware Street, Minneapolis, Minnesota 55455, USA
    J Clin Invest 110:1133-9. 2002
    ....
  15. pmc Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection
    Timothy W Schacker
    Department of Medicine Infectious Diseases, University of Minnesota, MMC 250, 516 Delaware Street, Minneapolis, MN 55455, USA
    Clin Vaccine Immunol 13:556-60. 2006
    ....
  16. pmc Host genes associated with HIV-1 replication in lymphatic tissue
    Anthony J Smith
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 185:5417-24. 2010
    ..More importantly, genes that have a negative association with virus replication point to target cell availability and potentially new viral restriction factors as principal determinants of viral load...
  17. ncbi request reprint Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count
    Timothy W Schacker
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    AIDS 19:2169-71. 2005
    ..001). This suggests that collagen-targeted therapies might be of benefit...
  18. pmc Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques
    Jacob D Estes
    Department of Microbiology, Medical School, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:6798-807. 2008
    ..These findings point to early control of immune activation by host immunoregulatory mechanisms as a major determinant of the different disease outcomes in SIV infection of natural vs non-natural hosts...
  19. pmc Glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginal lactobacilli and is safe for chronic use
    Patrick M Schlievert
    Department of Microbiology, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Antimicrob Agents Chemother 52:4448-54. 2008
    ..The studies suggest that GML is safe for chronic use in monkeys when applied vaginally; it does not alter either mucosal microflora or integrity...
  20. ncbi request reprint Determination of simian immunodeficiency virus production by infected activated and resting cells
    Cavan Reilly
    Division of Biostatistics, School of Public Health, University of Minnesota, MN 55455 0378, USA
    AIDS 21:163-8. 2007
    ..To determine the relative amount of virus produced by activated and resting CD4+ T cells...
  21. doi request reprint Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection
    Qingsheng Li
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Infect Dis 197:420-9. 2008
    ..Apoptosis in early SIV infection is thus the common theme of the pathological processes that quickly afflict the innate as well as adaptive arms of the gut immune system...
  22. ncbi request reprint Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection
    Jacob D Estes
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455, USA
    J Infect Dis 193:703-12. 2006
    ..We conclude that an early Treg cell response during acute SIV infection may contribute to viral persistence by prematurely limiting the antiviral immune response before infection is cleared...
  23. ncbi request reprint Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis 55455, USA
    Nature 434:1148-52. 2005
    ..The scale of this CD4+ T-cell depletion has adverse effects on the immune system of the host, underscoring the importance of developing countermeasures to SIV that are effective before infection of GALT...
  24. pmc A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection
    Anthony J Smith
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Acquir Immune Defic Syndr 55:306-15. 2010
    ..We thus propose a new mechanism in which claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion...
  25. pmc Collagen deposition limits immune reconstitution in the gut
    Jacob Estes
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Infect Dis 198:456-64. 2008
    ....
  26. ncbi request reprint In situ tetramer staining
    Pamela J Skinner
    Department of Microbiology and Great Lakes Center for AIDS Research, University of Minnesota Medical School, MMC 196, 420 Delaware St SE, Minneapolis 55455, USA
    J Immunol Methods 268:29-34. 2002
    ..We describe two independently developed IST staining methodologies and discuss current uses, limitations, future uses and the interesting biology revealed by the use of IST staining...
  27. doi request reprint In situ staining using MHC class I tetramers
    Pamela J Skinner
    University of Minnesota, Minneapolis, Minnesota, USA
    Curr Protoc Immunol . 2005
    ..Thus, IST is a useful and valuable component of MHC-tetramer technology...
  28. ncbi request reprint Transmission, acute HIV-1 infection and the quest for strategies to prevent infection
    Melissa Pope
    Center for Biomedical Research, Population Council, 1230 York Avenue, New York 10021, USA
    Nat Med 9:847-52. 2003
    ..Research on mucosal barriers and the events immediately after heterosexual transmission that precede this acute stage could facilitate the development of effective microbicides and vaccines...
  29. pmc CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
    J Exp Med 200:749-59. 2004
    ....
  30. pmc Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus
    Christopher J Miller
    Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA
    J Virol 79:9217-27. 2005
    ....
  31. pmc Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys
    Nichole R Klatt
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2039-49. 2008
    ..Our results suggest that the availability of activated CD4+ T cells, rather than immune control of SIV replication, is the main determinant of set-point viral load during natural SIV infection of SMs...
  32. pmc Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
    Paul W Denton
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 5:e16. 2008
    ..Given the importance of this route of transmission, we investigated the susceptibility of humanized mice to intravaginal HIV-1 infection...
  33. pmc Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis
    Shari N Gordon
    University of Pennsylvania School of Medicine, 705 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19143, USA
    J Virol 82:3725-35. 2008
    ....
  34. pmc Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1
    Zhifeng Sun
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Exp Med 204:705-14. 2007
    ....
  35. pmc Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239
    Andrea M Weiler
    AIDS Vaccine Laboratory, WNPRC, 555 Science Dr, Madison, WI 53711, USA
    J Virol 82:4154-8. 2008
    ....

Research Grants14

  1. PATHOGENESIS OF MUCOSAL TRANSMISSION/ACUTE SIV INFECTION
    Ashley Haase; Fiscal Year: 2000
    ..The proposal involves a consortium of investigators headed by Ashley Haase and includes Christopher Miller, David Watkins and Steven Wolinsky...
  2. Topical Microbicide Against SIV and Chlamydia
    Ashley Haase; Fiscal Year: 2007
    ....
  3. PATHOGENESIS OF HIV INDUCED IMMUNODEFICIENCY
    Ashley Haase; Fiscal Year: 2007
    ..abstract_text> ..
  4. Functional Genomic Analysis of HIV-1 Infection in Lymphatic Tissues
    Ashley Haase; Fiscal Year: 2007
    ..Collectively, insights into pathological and reparative processes could lead to new approaches to decreasing the pathological consequences of infection and to new therapeutic strategies to enhance immune reconstitution. ..
  5. Functional Genomic Analysis of HIV-1 Infection in LTs
    Ashley Haase; Fiscal Year: 2006
    ..Collectively, insights into pathological and reparative processes could lead to new approaches to decreasing the pathological consequences of infection and to new therapeutic strategies to enhance immune reconstitution. ..
  6. Functional Genomic Analysis of HIV-1 Infection in LTs
    Ashley Haase; Fiscal Year: 2005
    ..Collectively, insights into pathological and reparative processes could lead to new approaches to decreasing the pathological consequences of infection and to new therapeutic strategies to enhance immune reconstitution. ..
  7. Functional Genomic Analysis of HIV-1 Infection in LTs
    Ashley Haase; Fiscal Year: 2004
    ..Collectively, insights into pathological and reparative processes could lead to new approaches to decreasing the pathological consequences of infection and to new therapeutic strategies to enhance immune reconstitution. ..
  8. PATHOGENESIS OF MUCOSAL TRANSMISSION/ACUTE SIV INFECTION
    Ashley Haase; Fiscal Year: 2003
    ..The proposal involves a consortium of investigators headed by Ashley Haase and includes Christopher Miller, David Watkins and Steven Wolinsky...
  9. PATHOGENESIS OF MUCOSAL TRANSMISSION/ACUTE SIV INFECTION
    Ashley Haase; Fiscal Year: 2002
    ..The proposal involves a consortium of investigators headed by Ashley Haase and includes Christopher Miller, David Watkins and Steven Wolinsky...
  10. PATHOGENESIS OF MUCOSAL TRANSMISSION/ACUTE SIV INFECTION
    Ashley Haase; Fiscal Year: 2001
    ..The proposal involves a consortium of investigators headed by Ashley Haase and includes Christopher Miller, David Watkins and Steven Wolinsky...