Research Topics
| Ashley HaaseSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infectionJacob D Estes
Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
J Infect Dis 195:551-61. 2007....
Gene expression alterations in brains of mice infected with three strains of scrapiePamela J Skinner
Department of Veterinary and Biomedical Sciences, University of Minnesota, USA
BMC Genomics 7:114. 2006..Three strains of mouse scrapie that show striking differences in neuropathology were studied: ME7, 22L, and Chandler/RML...
Early events in sexual transmission of HIV and SIV and opportunities for interventionsAshley T Haase
Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Annu Rev Med 62:127-39. 2011....- Targeting early infection to prevent HIV-1 mucosal transmissionAshley T Haase
Department of Microbiology, University of Minnesota, Minnesota 55455, USA
Nature 464:217-23. 2010.... - Perils at mucosal front lines for HIV and SIV and their hostsAshley T Haase
Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street South East, Minneapolis, Minnesota 55455, USA
Nat Rev Immunol 5:783-92. 2005..Microbicides and vaccines could increase these viral vulnerabilities at mucosal front lines... - Glycerol monolaurate prevents mucosal SIV transmissionQingsheng Li
Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
Nature 458:1034-8. 2009.... - Functional genomic analysis of the response of HIV-1-infected lymphatic tissue to antiretroviral therapyQingsheng Li
Department of Microbiology, Department of Medicine, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
J Infect Dis 189:572-82. 2004..This model suggests that there could be a role for anti-inflammatory agents, alone or in combination with HAART, in treating HIV-1 infection by tipping this balance to mitigate pathology... - Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infectionQingsheng Li
Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
J Infect Dis 192:1269-76. 2005.... - Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infectionQingsheng Li
Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
Science 323:1726-9. 2009..This method highlights the importance of the location, timing, and magnitude of the immune response needed for a vaccine to be effective against agents of persistent infection, such as HIV-1... - Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infectionZhi-Qiang Zhang
Department of Microbiology, University of Minnesota Medical School, MMC 196, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 101:5640-5. 2004.... - Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infectionQingsheng Li
Department of Microbiology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 183:1975-82. 2009..These common and stage-specific gene expression signatures identify potential molecular mechanisms underlying the host response and the slow, natural course of HIV-1 infection... - Glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginal lactobacilli and is safe for chronic usePatrick M Schlievert
Department of Microbiology, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Antimicrob Agents Chemother 52:4448-54. 2008..The studies suggest that GML is safe for chronic use in monkeys when applied vaginally; it does not alter either mucosal microflora or integrity... - Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infectionTimothy W Schacker
Department of Medicine Infectious Diseases, University of Minnesota, MMC 250, 516 Delaware Street, Minneapolis, MN 55455, USA
Clin Vaccine Immunol 13:556-60. 2006.... - Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaquesJacob D Estes
Department of Microbiology, Medical School, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 180:6798-807. 2008..These findings point to early control of immune activation by host immunoregulatory mechanisms as a major determinant of the different disease outcomes in SIV infection of natural vs non-natural hosts... - Persistent abnormalities in lymphoid tissues of human immunodeficiency virus-infected patients successfully treated with highly active antiretroviral therapyTimothy W Schacker
Department of Medicine, University of Minnesota, MMC 250, 516 Delaware Street, Minneapolis MN 55455, USA
J Infect Dis 186:1092-7. 2002.... - Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasisTimothy W Schacker
Department of Medicine Infectious Diseases, University of Minnesota, MMC 250, 516 Delaware Street, Minneapolis, Minnesota 55455, USA
J Clin Invest 110:1133-9. 2002.... - Host genes associated with HIV-1 replication in lymphatic tissueAnthony J Smith
Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 185:5417-24. 2010..More importantly, genes that have a negative association with virus replication point to target cell availability and potentially new viral restriction factors as principal determinants of viral load... - Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell countTimothy W Schacker
Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
AIDS 19:2169-71. 2005..001). This suggests that collagen-targeted therapies might be of benefit... - Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cellsQingsheng Li
Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S.E, Minneapolis 55455, USA
Nature 434:1148-52. 2005..The scale of this CD4+ T-cell depletion has adverse effects on the immune system of the host, underscoring the importance of developing countermeasures to SIV that are effective before infection of GALT... - Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infectionQingsheng Li
Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
J Infect Dis 197:420-9. 2008..Apoptosis in early SIV infection is thus the common theme of the pathological processes that quickly afflict the innate as well as adaptive arms of the gut immune system... - Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infectionJacob D Estes
Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455, USA
J Infect Dis 193:703-12. 2006..We conclude that an early Treg cell response during acute SIV infection may contribute to viral persistence by prematurely limiting the antiviral immune response before infection is cleared... - Determination of simian immunodeficiency virus production by infected activated and resting cellsCavan Reilly
Division of Biostatistics, School of Public Health, University of Minnesota, MN 55455 0378, USA
AIDS 21:163-8. 2007..To determine the relative amount of virus produced by activated and resting CD4+ T cells... - A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infectionAnthony J Smith
Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
J Acquir Immune Defic Syndr 55:306-15. 2010..We thus propose a new mechanism in which claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion... - Collagen deposition limits immune reconstitution in the gutJacob Estes
Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Infect Dis 198:456-64. 2008.... - In situ tetramer stainingPamela J Skinner
Department of Microbiology and Great Lakes Center for AIDS Research, University of Minnesota Medical School, MMC 196, 420 Delaware St. SE, Minneapolis 55455, USA
J Immunol Methods 268:29-34. 2002..We describe two independently developed IST staining methodologies and discuss current uses, limitations, future uses and the interesting biology revealed by the use of IST staining... - In situ staining using MHC class I tetramersPamela J Skinner
University of Minnesota, Minneapolis, Minnesota, USA
Curr Protoc Immunol . 2005..Thus, IST is a useful and valuable component of MHC-tetramer technology... - Transmission, acute HIV-1 infection and the quest for strategies to prevent infectionMelissa Pope
Center for Biomedical Research, Population Council, 1230 York Avenue, New York 10021, USA
Nat Med 9:847-52. 2003..Research on mucosal barriers and the events immediately after heterosexual transmission that precede this acute stage could facilitate the development of effective microbicides and vaccines... - CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
J Exp Med 200:749-59. 2004.... - Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virusChristopher J Miller
Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA
J Virol 79:9217-27. 2005.... - Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeysNichole R Klatt
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 118:2039-49. 2008..Our results suggest that the availability of activated CD4+ T cells, rather than immune control of SIV replication, is the main determinant of set-point viral load during natural SIV infection of SMs... - Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT micePaul W Denton
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
PLoS Med 5:e16. 2008..Given the importance of this route of transmission, we investigated the susceptibility of humanized mice to intravaginal HIV-1 infection... - Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesisShari N Gordon
University of Pennsylvania School of Medicine, 705 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19143, USA
J Virol 82:3725-35. 2008.... - Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1Zhifeng Sun
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Exp Med 204:705-14. 2007.... - Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239Andrea M Weiler
AIDS Vaccine Laboratory, WNPRC, 555 Science Dr, Madison, WI 53711, USA
J Virol 82:4154-8. 2008....
Research Grants
- Topical Microbicide Against SIV and ChlamydiaAshley Haase; Fiscal Year: 2007....
- PATHOGENESIS OF HIV INDUCED IMMUNODEFICIENCYAshley Haase; Fiscal Year: 2007..abstract_text> ..
- Functional Genomic Analysis of HIV-1 Infection in Lymphatic TissuesAshley Haase; Fiscal Year: 2007..Collectively, insights into pathological and reparative processes could lead to new approaches to decreasing the pathological consequences of infection and to new therapeutic strategies to enhance immune reconstitution. ..
- PATHOGENESIS OF MUCOSAL TRANSMISSION/ACUTE SIV INFECTIONAshley Haase; Fiscal Year: 2003..The proposal involves a consortium of investigators headed by Ashley Haase and includes Christopher Miller, David Watkins and Steven Wolinsky...