Research Topics
Species | Daphne A Haas-KoganSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastomaJack S Chen
Department of Radiation Oncology, Comprehensive Cancer Center at the University of California at San Francisco, San Francisco, California, USA
Mol Cancer Ther 7:841-50. 2008..In conclusion, PI3K inhibitors are promising agents in the treatment of glioblastomas, especially when used in combination with ionizing radiation...
Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survivalSean M McBride
Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA
J Neurooncol 97:33-40. 2010..04) and negatively with PTEN expression (P = 0.03). Survival of LGG patients correlates with phosphorylation of S6 protein. This relationship supports the use of selective mTOR inhibitors in the treatment of low grade glioma...- PTEN in brain tumorsDaphne Haas-Kogan
Department of Radiation Oncology, University of California, San Francisco, CA 94143 1708, USA
Expert Rev Neurother 8:599-610. 2008..Thus, targeting PTEN and its signaling affiliates sows the seeds for combating not only cancer but also neurocognitive disorders... - Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomideGautam Prasad
Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA
Neuro Oncol 13:384-92. 2011..05) with a trend toward improvement in median survival (logrank p = 0.09) compared with TMZ alone. XL765 shows activity as monotherapy and in combination with conventional therapeutics in a range of genetically diverse GBM xenografts... - Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomasDaphne A Haas-Kogan
University of California San Francisco, San Francisco, CA, USA
Neuro Oncol 13:298-306. 2011..Biopsies and molecular analyses of pediatric BSGs are vital for identification of new agents and for rational use of targeted agents... 
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinibDaphne A Haas-Kogan
Department of Neurosurgery, Brain Tumor Research Center, University of California San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143, USA
J Natl Cancer Inst 97:880-7. 2005....- Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastomaHumsa S Venkatesh
University of California, San Francisco, San Francisco, CA 94158, USA
Neuro Oncol 14:315-25. 2012..This study highlights the potential of PC and hyperpolarized lactate as noninvasive MR biomarkers of response to targeted inhibitors in GBM... - Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanismAlexander R Gottschalk
Radiation Oncology, University of California, 1600 Divisadero St, San Francisco, CA 94143, USA
Int J Radiat Oncol Biol Phys 61:1183-8. 2005..To identify whether inhibition of phosphatidylinositol-3-kinase (PI3K) causes apoptosis through inhibition of protein kinase B (PKB), implicating PKB as an important therapeutic target in prostate cancer... - Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem gliomaDaphne A Haas-Kogan
University of California, San Francisco, San Francisco, CA, USA
Neuro Oncol 10:341-7. 2008..The MTD of tipifarnib with concurrent radiation is 125 mg/m(2)/dose b.i.d. One-year survival and progression-free survival estimates are 36.4% (SE 16.7%) and 9.4% (SE 6.3%), respectively... - Signal transduction molecules in gliomas of all gradesRalph P Ermoian
Department of Radiation Oncology, The University of California, San Francisco, 1600 Divisadero St Suite H1031, San Francisco, CA, 94143 1708, USA
J Neurooncol 91:19-26. 2009..To address the multiple comparisons, first an overall analysis was done comparing the four groups using Spearman's Correlation Coefficient. Only if this analysis was statistically significant were individual pairwise comparisons done... - PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomasJean L Nakamura
Department of Radiation Oncology, The University of California, San Francisco, CA 94143, USA
J Neurooncol 71:215-22. 2005..Thus PI3-kinase dysregulation may contribute to the notable radioresistance of GM tumors and inhibition of PKB/Akt offers an excellent target to enhance radiosensitivity... - Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopyChristopher S Ward
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94158, USA
Cancer Res 70:1296-305. 2010.... - Radiation is an important component of multimodality therapy for pediatric non-pineal supratentorial primitive neuroectodermal tumorsSean M McBride
Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
Int J Radiat Oncol Biol Phys 72:1319-23. 2008..To review a historical cohort of pediatric patients with supratentorial primitive neuroectodermal tumors (sPNET), to clarify the role of radiation in the treatment of these tumors... - Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year updateKavita K Mishra
Department of Radiation Oncology, University of California, San Francisco, 1600 Divisadero, San Francisco, CA 94143, USA
J Neurooncol 100:121-7. 2010..2% and 15-year PFS of 23.4%. No survival benefit is demonstrated for greater extent of resection. Age is a significant prognostic factor for progression and survival... - The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomasKavita K Mishra
Brain Tumor Research Center and Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuro Oncol 8:166-74. 2006..We were unable to demonstrate a benefit for administering radiation as part of initial treatment. An outcome benefit was seen with greater extent of resection... - Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanismsSabine Mueller
Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0106, USA
Cancer Lett 306:223-9. 2011..DNA repair enzyme Ku-86 was reduced in several neuroblastoma cells treated with vorinostat. Thus, vorinostat potentiates anti-neoplastic effects of radiation in neuroblastoma possibly due to down-regulation of DNA repair enzyme Ku-86... - p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenograftsEduard B Dinca
Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
Cancer Res 68:10034-9. 2008..In total, our results indicate that the p53 active and precursor inhibitor pair enhances TMZ cytotoxicity in vitro and in vivo, respectively, and do so in a p53-dependent manner... - Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanismAlexander R Gottschalk
Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
Int J Radiat Oncol Biol Phys 63:1221-7. 2005..To identify whether inhibition of phosphatidylinositol-3-kinase (PI3K) causes increased radiosensitivity through inhibition of protein kinase B (PKB), implicating PKB as an important therapeutic target in prostate cancer... - Glioma invasiveness responds variably to irradiation in a co-culture modelJean L Nakamura
Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143, USA
Int J Radiat Oncol Biol Phys 69:880-6. 2007.... - Successful treatment of high risk and recurrent pediatric desmoids using radiation as a component of multimodality therapySiavash Jabbari
Department of Radiation Oncology, University of California, San Francisco, CA, USA
Int J Radiat Oncol Biol Phys 75:177-82. 2009..To evaluate the role of radiation therapy (RT) as a component of multimodality therapy for pediatric desmoids... - PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoterNabendu Pore
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Res 63:236-41. 2003..Therefore, in human glioblastoma cells, PTEN mutation can cooperate with EGFR activation to increase VEGF mRNA levels by transcriptionally up-regulating the proximal VEGF promoter via the PI3K/Akt pathway... - Radiation therapy for intracranial germ cell tumorsDaphne A Haas-Kogan
Department of Radiation Oncology, University of California, San Francisco, CA 94143, USA
Int J Radiat Oncol Biol Phys 56:511-8. 2003.... - DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expressionShichun Zheng
Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Center, 1450 3rd Street, San Francisco, CA 94158, USA
Neuro Oncol 13:280-9. 2011..DNA methylation markers are useful in characterizing distinct glioma subtypes and may hold promise for clinical applications... - Biomarkers to predict response to epidermal growth factor receptor inhibitorsDaphne A Haas-Kogan
Department of Radiation Oncology, University of California San Francisco, USA
Cell Cycle 4:1369-72. 2005..Ultimately the goal of these studies is to allow selection of patients who will preferentially respond to EGFR inhibitors... - High failure rate in spinal ependymomas with long-term follow-upDaniel R Gomez
Department of Radiation Oncology, University of California, San Francisco, CA 94143, USA
Neuro Oncol 7:254-9. 2005..The overall high rate of recurrence leads us to recommend radiation to doses of 45 to 54 Gy for all patients who do not have gross total resections, and long, close follow-up... - Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor ConsortiumKatherine A Zukotynski
Department of Imaging, Dana Farber Cancer Institute, Boston, Massachusetts, USA
J Nucl Med 52:188-95. 2011.... - Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytesNannette Jelluma
Department of Radiation Oncology, University of California at San Francisco, San Francisco, California, USA
Mol Cancer Res 4:319-30. 2006..This study implicates glycolysis as a potentially efficient and selective target for glioblastoma multiforme treatment... - Radiation-induced gliomasGautam Prasad
University of California San Francisco, Helen Diller Family Cancer Center, Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143 1708, USA
Expert Rev Neurother 9:1511-7. 2009..However, available data suggest that aggressive intervention can lead to improved outcomes in patients with radiation-induced gliomas... - Impact of radiotherapy for high-risk neuroblastoma: a Children's Cancer Group studyDaphne A Haas-Kogan
Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA
Int J Radiat Oncol Biol Phys 56:28-39. 2003..To assess the effect of local radiation administered to primary disease sites in children with high-risk neuroblastoma... - Radiation-induced caspase-8 mediates p53-independent apoptosis in glioma cellsGolnar Afshar
Department of Radiation Oncology, University of California at San Francisco, 94143-1708, USA
Cancer Res 66:4223-32. 2006..This model may explain why p53 mutations in adult gliomas paradoxically correlate with improved survival and enhanced response to radiation... - Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systemsSwati S More
Departments of Bioengineering and Therapeutic Sciences, UCSF School of Medicine and UCSF Benioff Children s Hospital, San Francisco, California 94158, USA
Clin Cancer Res 17:2339-49. 2011.... - Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcomaMichael D Prados
University of California, San Francisco, CA 94143, USA
J Clin Oncol 27:579-84. 2009..The objectives were to determine efficacy of this treatment as measured by survival and to explore the relationship between molecular markers and treatment response... - PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcomeSabine Mueller
Department of Pediatrics, University of California, San Francisco, CA, USA
Neuro Oncol 14:1146-52. 2012..0475). Tumors with no PTEN expression had a higher MIB labeling index (P= .007). The majority of pediatric gliomas show activation of the PI3K/Akt/mTOR pathway, with methylation of the PTEN promoter occurring commonly in these tumors... - Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapyAnne Laprie
Department of Radiology, University of California, San Francisco, San Francisco, CA 94107-1739, USA
Int J Radiat Oncol Biol Phys 62:20-31. 2005..Longitudinal multivoxel MRSI measurements have potential value in assessing response to radiation or other therapies, because they offer more coverage than single-voxel techniques and provide reliable spectral data... - The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agentsYuichi Hirose
UCSF Cancer Center, Department of Neurological Surgery, University of California-San Francisco, 2340 Sutter Street, San Francisco, CA 94115-0875, USA
Mol Cell Biol 23:8306-15. 2003..The p38 pathway may therefore represent a new target for the development of agents to sensitize tumor cells to chemotherapeutic methylating agents... - Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group studyKatherine K Matthay
University of California School of Medicine, 505 Parnassus Ave, Room M647, San Francisco, CA, 94143 0106, USA
J Clin Oncol 27:1007-13. 2009.... - Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft modelYoungho Seo
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
Mol Imaging Biol 14:735-42. 2012.... - Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survivalRalph P Ermoian
Department of Radiation Oncology, The University of California, San Francisco 94143, USA
Clin Cancer Res 8:1100-6. 2002..11). CONCLUSIONS: Reduced PTEN expression is ubiquitous among GBM tumors and may play a role in the development of low-grade gliomas. PTEN inactivation in gliomas portends a particularly aggressive clinical behavior... - Nutrient-sensitive, antagonistically pleiotropic genes and their contribution to malignant behaviorSean M McBride
Department of Radiation Oncology, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94115, USA
Med Hypotheses 70:444-53. 2008..Finally, we explore how this model may help to explain oncogene addiction, tumor dormancy, and spontaneous regression... - Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitroNils D Arvold
Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143-1932, USA
Int J Radiat Oncol Biol Phys 62:207-12. 2005..28 +/- 0.09 and nearly identical oxygen enhancement ratios at 2-log cell kill. CONCLUSION: In our system of transformed mouse embryonic fibroblasts, hypoxia-mediated radiation resistance is independent of HIF-1alpha... - Higher radiation dose with a shorter treatment duration improves outcome for locally advanced carcinoma of anal canalKim Huang
Department of Radiation Oncology, Suite H1031, PO Box 1708, University of California, San Francisco, 1600 Divisidero St, San Francisco, CA 941151708, USA
World J Gastroenterol 13:895-900. 2007..To assess whether radiation dose and duration of treatment influence local control and survival of patients with locally advanced anal cancer treated with definitive chemoradiation... - Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastomaAmy M Gillis
Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94115 1708, USA
Int J Radiat Oncol Biol Phys 69:858-64. 2007..To review a historical cohort of consecutively accrued patients with high-risk neuroblastoma treated with intraoperative radiotherapy (IORT) to determine the therapeutic effect and late complications of this treatment... - Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitroGarret Yount
California Pacific Medical Center Research Institute, California Pacific Medical Center Research Institute, San Francisco, CA 94115, USA
J Exp Ther Oncol 4:137-43. 2004..These data suggest that berberine could be integrated with postoperative radiotherapy to selectively promote residual GBM tumor cell death.. - EGFR signals to mTOR through PKC and independently of Akt in gliomaQi Wen Fan
Department of Neurology, University of California, 533 Parnassus Avenue, San Francisco, CA 94143, USA
Sci Signal 2:ra4. 2009..These findings underline the importance of signaling between EGFR and mTOR in glioma, identify PKCalpha as essential to this network, and question the necessity of Akt as a critical intermediate coupling EGFR and mTOR in glioma...