Daphne A Haas-Kogan

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma
    Jack S Chen
    Department of Radiation Oncology, Comprehensive Cancer Center at the University of California at San Francisco, San Francisco, California, USA
    Mol Cancer Ther 7:841-50. 2008
  2. pmc Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival
    Sean M McBride
    Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA
    J Neurooncol 97:33-40. 2010
  3. pmc Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide
    Gautam Prasad
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 13:384-92. 2011
  4. pmc Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas
    Daphne A Haas-Kogan
    University of California San Francisco, San Francisco, CA, USA
    Neuro Oncol 13:298-306. 2011
  5. doi request reprint PTEN in brain tumors
    Daphne Haas-Kogan
    Department of Radiation Oncology, University of California, San Francisco, CA 94143 1708, USA
    Expert Rev Neurother 8:599-610. 2008
  6. ncbi request reprint Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
    Daphne A Haas-Kogan
    Department of Neurosurgery, Brain Tumor Research Center, University of California San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143, USA
    J Natl Cancer Inst 97:880-7. 2005
  7. pmc Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma
    Humsa S Venkatesh
    University of California, San Francisco, San Francisco, CA 94158, USA
    Neuro Oncol 14:315-25. 2012
  8. pmc Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma
    Daphne A Haas-Kogan
    University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 10:341-7. 2008
  9. ncbi request reprint Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism
    Alexander R Gottschalk
    Radiation Oncology, University of California, 1600 Divisadero St, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 61:1183-8. 2005
  10. pmc Signal transduction molecules in gliomas of all grades
    Ralph P Ermoian
    Department of Radiation Oncology, The University of California, San Francisco, 1600 Divisadero St Suite H1031, San Francisco, CA, 94143 1708, USA
    J Neurooncol 91:19-26. 2009

Detail Information

Publications47

  1. doi request reprint Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma
    Jack S Chen
    Department of Radiation Oncology, Comprehensive Cancer Center at the University of California at San Francisco, San Francisco, California, USA
    Mol Cancer Ther 7:841-50. 2008
    ..In conclusion, PI3K inhibitors are promising agents in the treatment of glioblastomas, especially when used in combination with ionizing radiation...
  2. pmc Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival
    Sean M McBride
    Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA
    J Neurooncol 97:33-40. 2010
    ..04) and negatively with PTEN expression (P = 0.03). Survival of LGG patients correlates with phosphorylation of S6 protein. This relationship supports the use of selective mTOR inhibitors in the treatment of low grade glioma...
  3. pmc Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide
    Gautam Prasad
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 13:384-92. 2011
    ..05) with a trend toward improvement in median survival (logrank p = 0.09) compared with TMZ alone. XL765 shows activity as monotherapy and in combination with conventional therapeutics in a range of genetically diverse GBM xenografts...
  4. pmc Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas
    Daphne A Haas-Kogan
    University of California San Francisco, San Francisco, CA, USA
    Neuro Oncol 13:298-306. 2011
    ..Biopsies and molecular analyses of pediatric BSGs are vital for identification of new agents and for rational use of targeted agents...
  5. doi request reprint PTEN in brain tumors
    Daphne Haas-Kogan
    Department of Radiation Oncology, University of California, San Francisco, CA 94143 1708, USA
    Expert Rev Neurother 8:599-610. 2008
    ..Thus, targeting PTEN and its signaling affiliates sows the seeds for combating not only cancer but also neurocognitive disorders...
  6. ncbi request reprint Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
    Daphne A Haas-Kogan
    Department of Neurosurgery, Brain Tumor Research Center, University of California San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143, USA
    J Natl Cancer Inst 97:880-7. 2005
    ....
  7. pmc Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma
    Humsa S Venkatesh
    University of California, San Francisco, San Francisco, CA 94158, USA
    Neuro Oncol 14:315-25. 2012
    ..This study highlights the potential of PC and hyperpolarized lactate as noninvasive MR biomarkers of response to targeted inhibitors in GBM...
  8. pmc Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma
    Daphne A Haas-Kogan
    University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 10:341-7. 2008
    ..The MTD of tipifarnib with concurrent radiation is 125 mg/m(2)/dose b.i.d. One-year survival and progression-free survival estimates are 36.4% (SE 16.7%) and 9.4% (SE 6.3%), respectively...
  9. ncbi request reprint Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism
    Alexander R Gottschalk
    Radiation Oncology, University of California, 1600 Divisadero St, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 61:1183-8. 2005
    ..To identify whether inhibition of phosphatidylinositol-3-kinase (PI3K) causes apoptosis through inhibition of protein kinase B (PKB), implicating PKB as an important therapeutic target in prostate cancer...
  10. pmc Signal transduction molecules in gliomas of all grades
    Ralph P Ermoian
    Department of Radiation Oncology, The University of California, San Francisco, 1600 Divisadero St Suite H1031, San Francisco, CA, 94143 1708, USA
    J Neurooncol 91:19-26. 2009
    ..To address the multiple comparisons, first an overall analysis was done comparing the four groups using Spearman's Correlation Coefficient. Only if this analysis was statistically significant were individual pairwise comparisons done...
  11. ncbi request reprint PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas
    Jean L Nakamura
    Department of Radiation Oncology, The University of California, San Francisco, CA 94143, USA
    J Neurooncol 71:215-22. 2005
    ..Thus PI3-kinase dysregulation may contribute to the notable radioresistance of GM tumors and inhibition of PKB/Akt offers an excellent target to enhance radiosensitivity...
  12. pmc Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy
    Christopher S Ward
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:1296-305. 2010
    ....
  13. doi request reprint Radiation is an important component of multimodality therapy for pediatric non-pineal supratentorial primitive neuroectodermal tumors
    Sean M McBride
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
    Int J Radiat Oncol Biol Phys 72:1319-23. 2008
    ..To review a historical cohort of pediatric patients with supratentorial primitive neuroectodermal tumors (sPNET), to clarify the role of radiation in the treatment of these tumors...
  14. pmc Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update
    Kavita K Mishra
    Department of Radiation Oncology, University of California, San Francisco, 1600 Divisadero, San Francisco, CA 94143, USA
    J Neurooncol 100:121-7. 2010
    ..2% and 15-year PFS of 23.4%. No survival benefit is demonstrated for greater extent of resection. Age is a significant prognostic factor for progression and survival...
  15. pmc The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas
    Kavita K Mishra
    Brain Tumor Research Center and Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 8:166-74. 2006
    ..We were unable to demonstrate a benefit for administering radiation as part of initial treatment. An outcome benefit was seen with greater extent of resection...
  16. pmc Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms
    Sabine Mueller
    Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0106, USA
    Cancer Lett 306:223-9. 2011
    ..DNA repair enzyme Ku-86 was reduced in several neuroblastoma cells treated with vorinostat. Thus, vorinostat potentiates anti-neoplastic effects of radiation in neuroblastoma possibly due to down-regulation of DNA repair enzyme Ku-86...
  17. pmc PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome
    Sabine Mueller
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Neuro Oncol 14:1146-52. 2012
    ..0475). Tumors with no PTEN expression had a higher MIB labeling index (P= .007). The majority of pediatric gliomas show activation of the PI3K/Akt/mTOR pathway, with methylation of the PTEN promoter occurring commonly in these tumors...
  18. pmc p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts
    Eduard B Dinca
    Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
    Cancer Res 68:10034-9. 2008
    ..In total, our results indicate that the p53 active and precursor inhibitor pair enhances TMZ cytotoxicity in vitro and in vivo, respectively, and do so in a p53-dependent manner...
  19. ncbi request reprint Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
    Alexander R Gottschalk
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 63:1221-7. 2005
    ..To identify whether inhibition of phosphatidylinositol-3-kinase (PI3K) causes increased radiosensitivity through inhibition of protein kinase B (PKB), implicating PKB as an important therapeutic target in prostate cancer...
  20. ncbi request reprint Glioma invasiveness responds variably to irradiation in a co-culture model
    Jean L Nakamura
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 69:880-6. 2007
    ....
  21. doi request reprint Successful treatment of high risk and recurrent pediatric desmoids using radiation as a component of multimodality therapy
    Siavash Jabbari
    Department of Radiation Oncology, University of California, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 75:177-82. 2009
    ..To evaluate the role of radiation therapy (RT) as a component of multimodality therapy for pediatric desmoids...
  22. ncbi request reprint PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 63:236-41. 2003
    ..Therefore, in human glioblastoma cells, PTEN mutation can cooperate with EGFR activation to increase VEGF mRNA levels by transcriptionally up-regulating the proximal VEGF promoter via the PI3K/Akt pathway...
  23. ncbi request reprint Radiation therapy for intracranial germ cell tumors
    Daphne A Haas-Kogan
    Department of Radiation Oncology, University of California, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 56:511-8. 2003
    ....
  24. pmc Poly (ADP-Ribose) polymerase inhibitor MK-4827 together with radiation as a novel therapy for metastatic neuroblastoma
    Sabine Mueller
    Department of Neurology, University of California, San Francisco, 675 Nelson Ring, Sandler Neuroscience Center, UCSF, San Francisco, CA 94148, USA
    Anticancer Res 33:755-62. 2013
    ..To assess poly (ADP-ribose) polymerase (PARP) inhibitor MK-4827 together with radiation for the treatment of neuroblastoma...
  25. pmc DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression
    Shichun Zheng
    Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Center, 1450 3rd Street, San Francisco, CA 94158, USA
    Neuro Oncol 13:280-9. 2011
    ..DNA methylation markers are useful in characterizing distinct glioma subtypes and may hold promise for clinical applications...
  26. ncbi request reprint Biomarkers to predict response to epidermal growth factor receptor inhibitors
    Daphne A Haas-Kogan
    Department of Radiation Oncology, University of California San Francisco, USA
    Cell Cycle 4:1369-72. 2005
    ..Ultimately the goal of these studies is to allow selection of patients who will preferentially respond to EGFR inhibitors...
  27. pmc High failure rate in spinal ependymomas with long-term follow-up
    Daniel R Gomez
    Department of Radiation Oncology, University of California, San Francisco, CA 94143, USA
    Neuro Oncol 7:254-9. 2005
    ..The overall high rate of recurrence leads us to recommend radiation to doses of 45 to 54 Gy for all patients who do not have gross total resections, and long, close follow-up...
  28. pmc Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium
    Katherine A Zukotynski
    Department of Imaging, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Nucl Med 52:188-95. 2011
    ....
  29. ncbi request reprint Impact of radiotherapy for high-risk neuroblastoma: a Children's Cancer Group study
    Daphne A Haas-Kogan
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 56:28-39. 2003
    ..To assess the effect of local radiation administered to primary disease sites in children with high-risk neuroblastoma...
  30. ncbi request reprint Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes
    Nannette Jelluma
    Department of Radiation Oncology, University of California at San Francisco, San Francisco, California, USA
    Mol Cancer Res 4:319-30. 2006
    ..This study implicates glycolysis as a potentially efficient and selective target for glioblastoma multiforme treatment...
  31. ncbi request reprint Radiation-induced caspase-8 mediates p53-independent apoptosis in glioma cells
    Golnar Afshar
    Department of Radiation Oncology, University of California at San Francisco, 94143 1708, USA
    Cancer Res 66:4223-32. 2006
    ..This model may explain why p53 mutations in adult gliomas paradoxically correlate with improved survival and enhanced response to radiation...
  32. doi request reprint Radiation-induced gliomas
    Gautam Prasad
    University of California San Francisco, Helen Diller Family Cancer Center, Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143 1708, USA
    Expert Rev Neurother 9:1511-7. 2009
    ..However, available data suggest that aggressive intervention can lead to improved outcomes in patients with radiation-induced gliomas...
  33. pmc Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model
    Youngho Seo
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
    Mol Imaging Biol 14:735-42. 2012
    ....
  34. pmc Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
    Michael D Prados
    University of California, San Francisco, CA 94143, USA
    J Clin Oncol 27:579-84. 2009
    ..The objectives were to determine efficacy of this treatment as measured by survival and to explore the relationship between molecular markers and treatment response...
  35. pmc Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems
    Swati S More
    Departments of Bioengineering and Therapeutic Sciences, UCSF School of Medicine and UCSF Benioff Children s Hospital, San Francisco, California 94158, USA
    Clin Cancer Res 17:2339-49. 2011
    ....
  36. ncbi request reprint Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy
    Anne Laprie
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94107 1739, USA
    Int J Radiat Oncol Biol Phys 62:20-31. 2005
    ..treatment-related changes. In this study, we determined the feasibility and accuracy of multivoxel proton magnetic resonance spectroscopic imaging (1H-MRSI) for monitoring pediatric patients with DIPG...
  37. pmc The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents
    Yuichi Hirose
    UCSF Cancer Center, Department of Neurological Surgery, University of California San Francisco, 2340 Sutter Street, San Francisco, CA 94115 0875, USA
    Mol Cell Biol 23:8306-15. 2003
    ..The p38 pathway may therefore represent a new target for the development of agents to sensitize tumor cells to chemotherapeutic methylating agents...
  38. pmc Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study
    Katherine K Matthay
    University of California School of Medicine, 505 Parnassus Ave, Room M647, San Francisco, CA, 94143 0106, USA
    J Clin Oncol 27:1007-13. 2009
    ....
  39. doi request reprint Genotype-dependent cooperation of ionizing radiation with BRAF inhibition in BRAF V600E-mutated carcinomas
    Tina Dasgupta
    Department of Radiation Oncology, University of California, San Francisco, 1600 Divisadero Street, Suite H 1031, San Francisco, CA, 94143 1708, USA
    Invest New Drugs 31:1136-41. 2013
    ..Our data has potential for translation into the multimodality treatment of BRAF V600E-mutated cancers. ..
  40. ncbi request reprint Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival
    Ralph P Ermoian
    Department of Radiation Oncology, The University of California, San Francisco 94143, USA
    Clin Cancer Res 8:1100-6. 2002
    ..This study assessed whether putative effectors of phosphatidylinositol3-kinase, including PTEN, protein kinase B (PKB), and p27(kip1), correlate with each other, with glioma histology, and with patient outcome...
  41. pmc Molecular targets and mechanisms of radiosensitization using DNA damage response pathways
    David R Raleigh
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA
    Future Oncol 9:219-33. 2013
    ..Moreover, it reviews the therapeutic implications of these compounds, provides an overview of relevant clinical trials and offers a viewpoint on the evolution of the field in the years to come...
  42. ncbi request reprint Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitro
    Nils D Arvold
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1932, USA
    Int J Radiat Oncol Biol Phys 62:207-12. 2005
    ..We sought to determine whether hypoxia-induced radioresistance is mediated by the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha)...
  43. ncbi request reprint Nutrient-sensitive, antagonistically pleiotropic genes and their contribution to malignant behavior
    Sean M McBride
    Department of Radiation Oncology, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94115, USA
    Med Hypotheses 70:444-53. 2008
    ..Finally, we explore how this model may help to explain oncogene addiction, tumor dormancy, and spontaneous regression...
  44. ncbi request reprint Higher radiation dose with a shorter treatment duration improves outcome for locally advanced carcinoma of anal canal
    Kim Huang
    Department of Radiation Oncology, Suite H1031, PO Box 1708, University of California, San Francisco, 1600 Divisidero St, San Francisco, CA 941151708, USA
    World J Gastroenterol 13:895-900. 2007
    ..To assess whether radiation dose and duration of treatment influence local control and survival of patients with locally advanced anal cancer treated with definitive chemoradiation...
  45. ncbi request reprint Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma
    Amy M Gillis
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94115 1708, USA
    Int J Radiat Oncol Biol Phys 69:858-64. 2007
    ..To review a historical cohort of consecutively accrued patients with high-risk neuroblastoma treated with intraoperative radiotherapy (IORT) to determine the therapeutic effect and late complications of this treatment...
  46. ncbi request reprint Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro
    Garret Yount
    California Pacific Medical Center Research Institute, California Pacific Medical Center Research Institute, San Francisco, CA 94115, USA
    J Exp Ther Oncol 4:137-43. 2004
    ..These data suggest that berberine could be integrated with postoperative radiotherapy to selectively promote residual GBM tumor cell death..
  47. pmc EGFR signals to mTOR through PKC and independently of Akt in glioma
    Qi Wen Fan
    Department of Neurology, University of California, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Sci Signal 2:ra4. 2009
    ..These findings underline the importance of signaling between EGFR and mTOR in glioma, identify PKCalpha as essential to this network, and question the necessity of Akt as a critical intermediate coupling EGFR and mTOR in glioma...